1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	T	A	V	E	V	G	W	R	D	P	C	G	L	A	V	G	E	L	R	C	A	P	A	V	S	D	Q	P	V	V	G	C	A	G	C	P	L	V	D	M	V	D	F	A	P	V	T	G	C	V	A	V	G	S	T	M	G	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?																			?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	P	A	L	L	R	V	R	F	P	W	P	P	F	E	P	D	V	R	L	S	P	Y	L	A	L	H	G	I	C	R	W	G	G	S	D	S	C	D	R	T	T	V	Q	V	F	H	L	H	S	I	N	K	R	L	T	A	H	A	G
Secondary structure
SS confidence
Disorder				?																																																						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.
Sequence		F	G	A	A	A	V	V	G	L	E	D	G	P	V
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 7%) Beta strand ( 46%)

Rank Aligned region

PDB 2ari chain A Region: 53 - 68 Aligned: 16 Modelled: 16 Confidence: 30.1% Identity: 56% PDB header:viral protein Chain: A: PDB Molecule:envelope polyprotein gp160; PDBTitle: solution structure of micelle-bound fusion domain of hiv-12 gp41 Phyre2 PDB 2mxq chain A Region: 89 - 97 Aligned: 9 Modelled: 9 Confidence: 21.6% Identity: 67% PDB header:antimicrobial protein Chain: A: PDB Molecule:paneth cell-specific alpha-defensin 1; PDBTitle: the solution structure of defa1, a highly potent antimicrobial peptide2 from the horse Phyre2 PDB 2odx chain A Region: 24 - 38 Aligned: 15 Modelled: 15 Confidence: 19.4% Identity: 40% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c oxidase polypeptide iv; PDBTitle: solution structure of zn(ii)cox4 Phyre2 PDB 1omb chain A Region: 88 - 98 Aligned: 11 Modelled: 11 Confidence: 14.7% Identity: 55% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: omega toxin-like Family: Spider toxins Phyre2 PDB 1erf chain A Region: 53 - 60 Aligned: 8 Modelled: 8 Confidence: 14.4% Identity: 88% PDB header:viral protein Chain: A: PDB Molecule:transmembrane glycoprotein; PDBTitle: conformational mapping of the n-terminal fusion peptide of2 hiv-1 gp41 using 13c-enhanced fourier transform infrared3 spectroscopy (ftir) Phyre2 PDB 2jnr chain B Region: 53 - 60 Aligned: 8 Modelled: 8 Confidence: 13.8% Identity: 88% PDB header:viral protein Chain: B: PDB Molecule:env polyprotein; PDBTitle: discovery and optimization of a natural hiv-1 entry2 inhibitor targeting the gp41 fusion peptide Phyre2 PDB 1p5a chain A Region: 53 - 60 Aligned: 8 Modelled: 8 Confidence: 13.2% Identity: 88% PDB header:viral protein Chain: A: PDB Molecule:envelope polyprotein gp160; PDBTitle: conformational mapping of the n-terminal peptide of hiv-12 gp41 in lipid detergent and aqueous environments using 13c-3 enhanced fourier transform infrared spectroscopy Phyre2 PDB 1agg chain A Region: 88 - 98 Aligned: 11 Modelled: 11 Confidence: 13.1% Identity: 55% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: omega toxin-like Family: Spider toxins Phyre2 PDB 2pjv chain A Region: 53 - 60 Aligned: 8 Modelled: 8 Confidence: 11.2% Identity: 75% PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein; PDBTitle: solution structure of hiv-1 gp41 fusion domain bound to dpc micelle Phyre2 PDB 5we0 chain J Region: 88 - 92 Aligned: 5 Modelled: 5 Confidence: 10.5% Identity: 100% PDB header:gene regulation Chain: J: PDB Molecule:protection of telomeres protein poz1; PDBTitle: structural basis for shelterin bridge assembly Phyre2 PDB 1xhj chain A Region: 33 - 42 Aligned: 10 Modelled: 10 Confidence: 10.4% Identity: 30% Fold: Alpha-lytic protease prodomain-like Superfamily: Fe-S cluster assembly (FSCA) domain-like Family: NifU C-terminal domain-like Phyre2 PDB 4tvp chain B Region: 53 - 67 Aligned: 15 Modelled: 15 Confidence: 10.0% Identity: 60% PDB header:viral protein/immune system Chain: B: PDB Molecule:envelope glycoprotein gp160; PDBTitle: crystal structure of the hiv-1 bg505 sosip.664 env trimer ectodomain,2 comprising atomic-level definition of pre-fusion gp120 and gp41, in3 complex with human antibodies pgt122 and 35o22 Phyre2 PDB 1yws chain A domain 1 Region: 29 - 47 Aligned: 19 Modelled: 19 Confidence: 9.9% Identity: 32% Fold: Rubredoxin-like Superfamily: CSL zinc finger Family: CSL zinc finger Phyre2 PDB 1wge chain A domain 1 Region: 29 - 47 Aligned: 19 Modelled: 19 Confidence: 9.3% Identity: 26% Fold: Rubredoxin-like Superfamily: CSL zinc finger Family: CSL zinc finger Phyre2 PDB 2rps chain A Region: 72 - 77 Aligned: 6 Modelled: 6 Confidence: 8.5% Identity: 83% PDB header:immune system Chain: A: PDB Molecule:chemokine; PDBTitle: solution structure of a novel insect chemokine isolated from2 integument Phyre2 PDB 2p5z chain X domain 1 Region: 65 - 132 Aligned: 35 Modelled: 34 Confidence: 7.8% Identity: 26% Fold: OB-fold Superfamily: gp5 N-terminal domain-like Family: gp4 N-terminal domain-like Phyre2 PDB 1t3t chain A domain 5 Region: 65 - 102 Aligned: 38 Modelled: 38 Confidence: 7.7% Identity: 21% Fold: Bacillus chorismate mutase-like Superfamily: PurM N-terminal domain-like Family: PurM N-terminal domain-like Phyre2 PDB 1i8d chain A domain 2 Region: 65 - 90 Aligned: 26 Modelled: 26 Confidence: 7.0% Identity: 8% Fold: Reductase/isomerase/elongation factor common domain Superfamily: Riboflavin synthase domain-like Family: Riboflavin synthase Phyre2 PDB 4p3x chain A Region: 35 - 44 Aligned: 10 Modelled: 10 Confidence: 6.6% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:quinolinate synthase a; PDBTitle: structure of the fe4s4 quinolinate synthase nada from thermotoga2 maritima Phyre2 PDB 1veh chain A Region: 33 - 42 Aligned: 10 Modelled: 10 Confidence: 6.6% Identity: 30% Fold: Alpha-lytic protease prodomain-like Superfamily: Fe-S cluster assembly (FSCA) domain-like Family: NifU C-terminal domain-like Phyre2 1 c2ariA_ 2 c2mxqA_ 3 c2odxA_ 4 d1omba_ 5 c1erfA_ 6 c2jnrB_ 7 c1p5aA_ 8 d1agga_ 9 c2pjvA_ 10 c5we0J_ 11 d1xhja_ 12 c4tvpB_ 13 d1ywsa1 14 d1wgea1 15 c2rpsA_ 16 d2p5zx1 17 d1t3ta5 18 d1i8da2 19 c4p3xA_ 20 d1veha_ 21 22 23 24 25 26 27 28 29