1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	R	R	S	P	A	D	P	A	A	A	L	A	P	R	R	T	T	L	P	G	G	L	R	V	V	T	E	F	L	P	A	V	H	S	A	S	V	G	V	W	V	G	V	G	S	R	D	E	G	A	T	V	A	G	A	A	H	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	E	H	L	L	F	K	S	T	P	T	R	S	A	V	D	I	A	Q	A	M	D	A	V	G	G	E	L	N	A	F	T	A	K	E	H	T	C	Y	Y	A	H	V	L	G	S	D	L	P	L	A	V	D	L	V	A	D	V	V	L
Secondary structure
SS confidence
Disorder													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	G	R	C	A	A	D	D	V	E	V	E	R	D	V	V	L	E	E	I	A	M	R	D	D	D	P	E	D	A	L	A	D	M	F	L	A	A	L	F	G	D	H	P	V	G	R	P	V	I	G	S	A	Q	S	V	S	V	M	T
Secondary structure
SS confidence
Disorder																								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	A	Q	L	Q	S	F	H	L	R	R	Y	T	P	E	R	M	V	V	A	A	A	G	N	V	D	H	D	G	L	V	A	L	V	R	E	H	F	G	S	R	L	V	R	G	R	R	P	V	A	P	R	K	G	T	G	R	V	N	G
Secondary structure
SS confidence
Disorder																																												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	P	R	L	T	L	V	S	R	D	A	E	Q	T	H	V	S	L	G	I	R	T	P	G	R	G	W	E	H	R	W	A	L	S	V	L	H	T	A	L	G	G	G	L	S	S	R	L	F	Q	E	V	R	E	T	R	G	L	A	Y
Secondary structure
SS confidence
Disorder																																									?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	V	Y	S	A	L	D	L	F	A	D	S	G	A	L	S	V	Y	A	A	C	L	P	E	R	F	A	D	V	M	R	V	T	A	D	V	L	E	S	V	A	R	D	G	I	T	E	A	E	C	G	I	A	K	G	S	L	R	G	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	V	L	G	L	E	D	S	S	S	R	M	S	R	L	G	R	S	E	L	N	Y	G	K	H	R	S	I	E	H	T	L	R	Q	I	E	Q	V	T	V	E	E	V	N	A	V	A	R	H	L	L	S	R	R	Y	G	A	A	V	L
Secondary structure
SS confidence
Disorder				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.
Sequence		G	P	H	G	S	K	R	S	L	P	Q	Q	L	R	A	M	V	G
Secondary structure
SS confidence
Disorder						?	?										?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 46%) Beta strand ( 16%)

Rank Aligned region

PDB 1hr9 chain D Region: 13 - 434 Aligned: 422 Modelled: 422 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: D: PDB Molecule:mitochondrial processing peptidase beta subunit; PDBTitle: yeast mitochondrial processing peptidase beta-e73q mutant2 complexed with malate dehydrogenase signal peptide Phyre2 PDB 1sqp chain A Region: 12 - 437 Aligned: 423 Modelled: 426 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:ubiquinol-cytochrome-c reductase complex core protein i, PDBTitle: crystal structure analysis of bovine bc1 with myxothiazol Phyre2 PDB 1nu1 chain A Region: 12 - 437 Aligned: 423 Modelled: 426 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:ubiquinol-cytochrome c reductase complex core protein i, PDBTitle: crystal structure of mitochondrial cytochrome bc1 complexed with 2-2 nonyl-4-hydroxyquinoline n-oxide (nqno) Phyre2 PDB 1hr6 chain C Region: 14 - 437 Aligned: 422 Modelled: 420 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: C: PDB Molecule:mitochondrial processing peptidase alpha subunit; PDBTitle: yeast mitochondrial processing peptidase Phyre2 PDB 3hdi chain A Region: 15 - 425 Aligned: 405 Modelled: 411 Confidence: 100.0% Identity: 38% PDB header:hydrolase Chain: A: PDB Molecule:processing protease; PDBTitle: crystal structure of bacillus halodurans metallo peptidase Phyre2 PDB 5euf chain A Region: 12 - 422 Aligned: 409 Modelled: 411 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:protease; PDBTitle: the crystal structure of a protease from helicobacter pylori Phyre2 PDB 3eoq chain B Region: 16 - 425 Aligned: 404 Modelled: 410 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: B: PDB Molecule:putative zinc protease; PDBTitle: the crystal structure of putative zinc protease beta-2 subunit from thermus thermophilus hb8 Phyre2 PDB 1l0l chain B Region: 6 - 425 Aligned: 407 Modelled: 420 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: B: PDB Molecule:ubiquinol-cytochrome c reductase complex core protein 2; PDBTitle: structure of bovine mitochondrial cytochrome bc1 complex with a bound2 fungicide famoxadone Phyre2 PDB 5hxk chain C Region: 15 - 422 Aligned: 398 Modelled: 401 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: C: PDB Molecule:zinc-dependent peptidase; PDBTitle: structure of ttha1265 Phyre2 PDB 3ami chain B Region: 11 - 422 Aligned: 412 Modelled: 412 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:zinc peptidase; PDBTitle: the crystal structure of the m16b metallopeptidase subunit from2 sphingomonas sp. a1 Phyre2 PDB 3gwb chain A Region: 13 - 428 Aligned: 408 Modelled: 416 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:peptidase m16 inactive domain family protein; PDBTitle: crystal structure of peptidase m16 inactive domain from pseudomonas2 fluorescens. northeast structural genomics target plr293l Phyre2 PDB 3amj chain B Region: 12 - 423 Aligned: 406 Modelled: 408 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:zinc peptidase inactive subunit; PDBTitle: the crystal structure of the heterodimer of m16b peptidase from2 sphingomonas sp. a1 Phyre2 PDB 4nnz chain B Region: 14 - 422 Aligned: 388 Modelled: 388 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:probable zinc protease; PDBTitle: subunit pa0372 of heterodimeric zinc protease pa0371-pa0372 Phyre2 PDB 3cx5 chain L Region: 15 - 438 Aligned: 411 Modelled: 424 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: L: PDB Molecule:cytochrome b-c1 complex subunit 1, mitochondrial; PDBTitle: structure of complex iii with bound cytochrome c in reduced state and2 definition of a minimal core interface for electron transfer. Phyre2 PDB 4xea chain A Region: 9 - 422 Aligned: 407 Modelled: 414 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:peptidase m16 domain protein; PDBTitle: crystal structure of putative m16-like peptidase from alicyclobacillus2 acidocaldarius Phyre2 PDB 6b05 chain A Region: 10 - 432 Aligned: 422 Modelled: 423 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:putative zinc protease; PDBTitle: the crystal structure of the ferredoxin protease fusc e83a mutant in2 complex with arabidopsis ferredoxin Phyre2 PDB 1q2l chain A Region: 16 - 424 Aligned: 408 Modelled: 409 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:protease iii; PDBTitle: crystal structure of pitrilysin Phyre2 PDB 3go9 chain A Region: 2 - 436 Aligned: 430 Modelled: 435 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:insulinase family protease; PDBTitle: predicted insulinase family protease from yersinia pestis Phyre2 PDB 2wk3 chain A Region: 8 - 425 Aligned: 417 Modelled: 418 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:insulin degrading enzyme; PDBTitle: crystal structure of human insulin-degrading enzyme in2 complex with amyloid-beta (1-42) Phyre2 PDB 2jbu chain B Region: 3 - 426 Aligned: 424 Modelled: 424 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:insulin-degrading enzyme; PDBTitle: crystal structure of human insulin degrading enzyme complexed with co-2 purified peptides. Phyre2 1 c1hr9D_ 2 c1sqpA_ 3 c1nu1A_ 4 c1hr6C_ 5 c3hdiA_ 6 c5eufA_ 7 c3eoqB_ 8 c1l0lB_ 9 c5hxkC_ 10 c3amiB_ 11 c3gwbA_ 12 c3amjB_ 13 c4nnzB_ 14 c3cx5L_ 15 c4xeaA_ 16 c6b05A_ 17 c1q2lA_ 18 c3go9A_ 19 c2wk3A_ 20 c2jbuB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99