1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	W	K	G	S	G	Q	E	T	V	G	A	E	P	T	L	W	A	I	S	D	L	H	T	G	H	L	G	N	K	P	V	A	E	S	L	Y	P	S	S	P	D	D	W	L	I	V	A	G	D	V	A	E	R	T	D	E	I	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		W	S	L	D	L	L	R	R	R	F	A	K	V	I	W	V	P	G	N	H	E	L	W	T	T	N	R	D	P	M	Q	I	F	G	R	A	R	Y	D	Y	L	V	N	M	C	D	E	M	G	V	V	T	P	E	H	P	F	P	V	W
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	E	R	G	G	P	A	T	I	V	P	M	F	L	L	Y	D	Y	S	F	L	P	E	G	A	N	S	K	A	E	G	V	A	I	A	K	E	R	N	V	V	A	T	D	E	F	L	L	S	P	E	P	Y	P	T	R	D	A	W	C
Secondary structure
SS confidence
Disorder																								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		H	E	R	V	A	A	T	R	A	R	L	E	Q	L	D	W	M	Q	P	T	V	L	V	N	H	F	P	L	L	R	Q	P	C	D	A	L	F	Y	P	E	F	S	L	W	C	G	T	T	K	T	A	D	W	H	T	R	Y	N	A	V
Secondary structure
SS confidence
Disorder														?	?	?														?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		C	S	V	Y	G	H	L	H	I	P	R	T	T	W	Y	D	G	V	R	F	E	E	V	S	V	G	Y	P	R	E	W	R	R	R	K	P	Y	S	W	L	R	Q	V	L	P	D	P	Q	Y	A	P	G	Y	L	N	D	F	G	G	H
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.
Sequence		F	V	I	T	P	E	M	R	T	Q	A	A	Q	F	R	E	R	L	R	Q	R	Q	S	R
Secondary structure
SS confidence
Disorder																						?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 35%) Beta strand ( 15%)

Rank Aligned region

PDB 2yvt chain A domain 1 Region: 15 - 269 Aligned: 208 Modelled: 225 Confidence: 99.9% Identity: 13% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: TT1561-like Phyre2 PDB 3ib7 chain A Region: 9 - 268 Aligned: 203 Modelled: 207 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:icc protein; PDBTitle: crystal structure of full length rv0805 Phyre2 PDB 2xmo chain B Region: 13 - 257 Aligned: 213 Modelled: 218 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:lmo2642 protein; PDBTitle: the crystal structure of lmo2642 Phyre2 PDB 1uf3 chain A Region: 15 - 269 Aligned: 202 Modelled: 223 Confidence: 99.9% Identity: 12% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: TT1561-like Phyre2 PDB 3rl4 chain A Region: 15 - 265 Aligned: 204 Modelled: 213 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:metallophosphoesterase mpped2; PDBTitle: rat metallophosphodiesterase mpped2 g252h mutant Phyre2 PDB 3d03 chain A domain 1 Region: 16 - 264 Aligned: 196 Modelled: 200 Confidence: 99.9% Identity: 17% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: GpdQ-like Phyre2 PDB 2hy1 chain A domain 1 Region: 12 - 264 Aligned: 196 Modelled: 200 Confidence: 99.9% Identity: 17% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: GpdQ-like Phyre2 PDB 2hy1 chain A Region: 12 - 264 Aligned: 196 Modelled: 200 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:rv0805; PDBTitle: crystal structure of rv0805 Phyre2 PDB 1nnw chain A Region: 15 - 317 Aligned: 225 Modelled: 238 Confidence: 99.8% Identity: 10% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: Phosphoesterase-related Phyre2 PDB 3qfn chain A Region: 16 - 280 Aligned: 192 Modelled: 198 Confidence: 99.8% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of streptococcal asymmetric ap4a hydrolase and2 phosphodiesterase spr1479/saph in complex with inorganic phosphate Phyre2 PDB 2nxf chain A domain 1 Region: 14 - 264 Aligned: 237 Modelled: 251 Confidence: 99.8% Identity: 14% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: ADPRibase-Mn-like Phyre2 PDB 3av0 chain A Region: 12 - 271 Aligned: 195 Modelled: 208 Confidence: 99.8% Identity: 17% PDB header:recombination Chain: A: PDB Molecule:dna double-strand break repair protein mre11; PDBTitle: crystal structure of mre11-rad50 bound to atp s Phyre2 PDB 4lty chain D Region: 16 - 291 Aligned: 248 Modelled: 260 Confidence: 99.8% Identity: 16% PDB header:hydrolase Chain: D: PDB Molecule:exonuclease subunit sbcd; PDBTitle: crystal structure of e.coli sbcd at 1.8 a resolution Phyre2 PDB 3rqz chain C Region: 15 - 280 Aligned: 181 Modelled: 194 Confidence: 99.8% Identity: 22% PDB header:hydrolase Chain: C: PDB Molecule:metallophosphoesterase; PDBTitle: crystal structure of metallophosphoesterase from sphaerobacter2 thermophilus Phyre2 PDB 5k8k chain A Region: 16 - 264 Aligned: 198 Modelled: 205 Confidence: 99.8% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:udp-2,3-diacylglucosamine hydrolase; PDBTitle: structure of the haemophilus influenzae lpxh-lipid x complex Phyre2 PDB 5ebb chain A Region: 12 - 265 Aligned: 220 Modelled: 224 Confidence: 99.8% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:acid sphingomyelinase-like phosphodiesterase 3a; PDBTitle: structure of human sphingomyelinase phosphodiesterase like 3a2 (smpdl3a) with zn2+ Phyre2 PDB 3auz chain A Region: 12 - 283 Aligned: 207 Modelled: 230 Confidence: 99.8% Identity: 16% PDB header:recombination Chain: A: PDB Molecule:dna double-strand break repair protein mre11; PDBTitle: crystal structure of mre11 with manganese Phyre2 PDB 2a22 chain A domain 1 Region: 16 - 304 Aligned: 168 Modelled: 175 Confidence: 99.8% Identity: 18% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: YfcE-like Phyre2 PDB 3qg5 chain D Region: 15 - 283 Aligned: 219 Modelled: 238 Confidence: 99.8% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:mre11; PDBTitle: the mre11:rad50 complex forms an atp dependent molecular clamp in dna2 double-strand break repair Phyre2 PDB 1z2w chain A domain 1 Region: 16 - 303 Aligned: 158 Modelled: 186 Confidence: 99.8% Identity: 19% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: YfcE-like Phyre2 1 d2yvta1 2 c3ib7A_ 3 c2xmoB_ 4 d1uf3a_ 5 c3rl4A_ 6 d3d03a1 7 d2hy1a1 8 c2hy1A_ 9 d1nnwa_ 10 c3qfnA_ 11 d2nxfa1 12 c3av0A_ 13 c4ltyD_ 14 c3rqzC_ 15 c5k8kA_ 16 c5ebbA_ 17 c3auzA_ 18 d2a22a1 19 c3qg5D_ 20 d1z2wa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125