1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	R	L	Q	A	H	T	G	G	P	P	V	A	L	R	Q	E	T	T	G	G	P	S	P	T	N	D	L	I	T	E	P	P	R	H	Y	K	Q	Q	T	R	V	R	Q	A	P	A	L	L	T	V	S	A	G	T	G	V	P	V	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?		?	?												?	?	?	?	?																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	E	E	L	A	K	L	G	R	T	L	W	R	C	R	H	D	V	L	A	Y	F	D	H	H	A	S	N	G	P	T	E	A	I	N	G	R	L	E	A	L	C	R	N	A	L	G	F	R	N	L	T	H	Y	R	I	R	S	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.
Sequence		H	C	G	N	L	A	Q	L	I	H	A	L
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 63%) Beta strand ( 2%)

Rank Aligned region

PDB 1hyv chain A Region: 84 - 122 Aligned: 39 Modelled: 39 Confidence: 64.6% Identity: 13% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 3f9k chain V Region: 84 - 122 Aligned: 39 Modelled: 39 Confidence: 52.3% Identity: 18% PDB header:viral protein, recombination Chain: V: PDB Molecule:integrase; PDBTitle: two domain fragment of hiv-2 integrase in complex with ledgf ibd Phyre2 PDB 1k6y chain B Region: 76 - 121 Aligned: 46 Modelled: 46 Confidence: 46.5% Identity: 11% PDB header:transferase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of a two-domain fragment of hiv-1 integrase Phyre2 PDB 1ex4 chain A Region: 84 - 104 Aligned: 21 Modelled: 21 Confidence: 35.5% Identity: 24% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: hiv-1 integrase catalytic core and c-terminal domain Phyre2 PDB 5cz1 chain B Region: 84 - 118 Aligned: 35 Modelled: 35 Confidence: 32.3% Identity: 6% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of the catalytic core domain of mmtv integrase Phyre2 PDB 3nf9 chain A Region: 84 - 122 Aligned: 39 Modelled: 39 Confidence: 28.9% Identity: 15% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:integrase; PDBTitle: structural basis for a new mechanism of inhibition of hiv integrase2 identified by fragment screening and structure based design Phyre2 PDB 1st6 chain A domain 4 Region: 61 - 132 Aligned: 71 Modelled: 72 Confidence: 25.1% Identity: 17% Fold: Four-helical up-and-down bundle Superfamily: alpha-catenin/vinculin-like Family: alpha-catenin/vinculin Phyre2 PDB 4mq3 chain A Region: 84 - 121 Aligned: 38 Modelled: 38 Confidence: 24.8% Identity: 13% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: the 1.1 angstrom structure of catalytic core domain of fiv integrase Phyre2 PDB 5u1c chain A Region: 84 - 105 Aligned: 22 Modelled: 22 Confidence: 24.6% Identity: 18% PDB header:viral protein Chain: A: PDB Molecule:hiv-1 integrase, sso7d chimera; PDBTitle: structure of tetrameric hiv-1 strand transfer complex intasome Phyre2 PDB 2oc5 chain A domain 1 Region: 51 - 81 Aligned: 31 Modelled: 31 Confidence: 23.3% Identity: 29% Fold: Ferritin-like Superfamily: Ferritin-like Family: PMT1231-like Phyre2 PDB 1asu chain A Region: 84 - 105 Aligned: 22 Modelled: 22 Confidence: 20.9% Identity: 18% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 5m0r chain F Region: 84 - 105 Aligned: 22 Modelled: 22 Confidence: 19.8% Identity: 14% PDB header:hydrolase Chain: F: PDB Molecule:integrase; PDBTitle: cryo-em reconstruction of the maedi-visna virus (mvv) strand transfer2 complex Phyre2 PDB 3d19 chain A domain 2 Region: 45 - 122 Aligned: 78 Modelled: 78 Confidence: 19.7% Identity: 4% Fold: Bromodomain-like Superfamily: Bacillus cereus metalloprotein-like Family: Bacillus cereus metalloprotein-like Phyre2 PDB 1t06 chain A Region: 56 - 86 Aligned: 29 Modelled: 31 Confidence: 18.6% Identity: 7% Fold: alpha-alpha superhelix Superfamily: ARM repeat Family: BC3264-like Phyre2 PDB 3jca chain E Region: 84 - 121 Aligned: 38 Modelled: 38 Confidence: 17.5% Identity: 13% PDB header:viral protein Chain: E: PDB Molecule:integrase; PDBTitle: core model of the mouse mammary tumor virus intasome Phyre2 PDB 2da7 chain A Region: 59 - 85 Aligned: 27 Modelled: 27 Confidence: 16.2% Identity: 19% PDB header:dna binding protein Chain: A: PDB Molecule:zinc finger homeobox protein 1b; PDBTitle: solution structure of the homeobox domain of zinc finger2 homeobox protein 1b (smad interacting protein 1) Phyre2 PDB 6ivu chain B Region: 26 - 82 Aligned: 55 Modelled: 57 Confidence: 15.6% Identity: 25% PDB header:transcription Chain: B: PDB Molecule:rna polymerase sigma factor sigi1; PDBTitle: solution structure of the sigma-anti-sigma factor complex rsgi1n-2 sigi1c from clostridium thermocellum Phyre2 PDB 1cxq chain A Region: 84 - 103 Aligned: 20 Modelled: 20 Confidence: 15.1% Identity: 20% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 1st6 chain A domain 3 Region: 61 - 132 Aligned: 70 Modelled: 72 Confidence: 15.0% Identity: 17% Fold: Four-helical up-and-down bundle Superfamily: alpha-catenin/vinculin-like Family: alpha-catenin/vinculin Phyre2 PDB 1k8b chain A Region: 56 - 93 Aligned: 38 Modelled: 38 Confidence: 13.6% Identity: 18% Fold: Ribosome binding domain-like Superfamily: Translation initiation factor 2 beta, aIF2beta, N-terminal domain Family: Translation initiation factor 2 beta, aIF2beta, N-terminal domain Phyre2 1 d1hyva_ 2 c3f9kV_ 3 c1k6yB_ 4 c1ex4A_ 5 c5cz1B_ 6 c3nf9A_ 7 d1st6a4 8 c4mq3A_ 9 c5u1cA_ 10 d2oc5a1 11 d1asua_ 12 c5m0rF_ 13 d3d19a2 14 d1t06a_ 15 c3jcaE_ 16 c2da7A_ 17 c6ivuB_ 18 d1cxqa_ 19 d1st6a3 20 d1k8ba_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76