1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	V	G	D	D	E	E	K	V	R	A	E	R	A	R	A	I	G	L	F	R	Y	Q	L	I	W	E	A	A	D	A	A	H	S	T	K	Q	R	G	K	M	V	R	E	L	A	S	R	E	H	T	D	P	F	G	R	R	V	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?				?	?	?																			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	S	R	Q	T	I	D	R	W	I	R	G	W	R	A	G	G	F	D	A	L	V	P	N	P	R	Q	C	T	P	R	T	P	A	E	V	L	E	L	A	V	A	L	R	R	E	N	P	Q	R	T	A	A	A	I	R	R	I	L	R
Secondary structure
SS confidence
Disorder																			?	?				?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	Q	L	G	W	A	P	D	E	R	T	L	Q	R	N	F	H	R	L	G	L	T	G	A	T	T	G	S	A	P	A	V	F	G	R	F	E	A	E	H	P	N	A	L	W	T	G	D	V	L	H	G	I	R	I	D	L	R	K	T
Secondary structure
SS confidence
Disorder																						?		?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Y	L	F	A	F	L	D	D	H	S	R	L	V	P	G	Y	R	W	G	H	A	E	D	T	V	R	L	A	A	A	L	R	P	A	L	A	S	R	G	V	P	N	A	V	Y	V	D	N	G	S	P	Y	V	D	A	W	L	L	R	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		C	A	K	L	G	V	R	L	V	H	S	T	P	G	R	P	Q	G	R	G	K	I	E	R	F	F	R	T	V	R	E	Q	F	L	V	E	I	T	G	E	P	D	V	V	G	R	H	Y	V	A	D	L	A	E	L	N	R	L	F	T
Secondary structure
SS confidence
Disorder																																								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	W	V	E	T	V	Y	H	R	S	V	H	S	E	T	G	Q	T	P	L	A	R	W	S	A	G	G	P	I	P	L	P	A	P	E	T	L	T	E	A	F	L	W	E	E	H	R	R	V	T	K	T	A	T	V	S	L	H	G	N
Secondary structure
SS confidence
Disorder																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	Y	E	I	D	P	A	L	V	G	R	K	V	E	L	V	F	D	P	F	D	L	T	R	I	E	V	R	L	A	G	A	P	M	R	R	A	I	P	Y	H	I	G	R	H	S	H	P	K	A	K	P	E	T	P	T	A	P	P	K
Secondary structure
SS confidence
Disorder																																													?	?	?		?	?	?	?	?	?	?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.
Sequence		P	S	G	I	D	Y	A	Q	L	I	E	T	A	H	A	A	E	L	A	R	G	V	N	Y	T	A	L	T	G	A	A	D	Q	I	P	G	Q	L	D	L	L	T	G	Q	E	A	Q	P	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?														?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?		?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 41%) Beta strand ( 16%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 4fcy chain A Region: 6 - 419 Aligned: 394 Modelled: 413 Confidence: 100.0% Identity: 13% PDB header:dna binding protein/dna Chain: A: PDB Molecule:transposase; PDBTitle: crystal structure of the bacteriophage mu transpososome Phyre2 PDB 1bco chain A Region: 157 - 399 Aligned: 243 Modelled: 243 Confidence: 100.0% Identity: 16% PDB header:transposase Chain: A: PDB Molecule:bacteriophage mu transposase; PDBTitle: bacteriophage mu transposase core domain Phyre2 PDB 1bco chain A domain 2 Region: 157 - 331 Aligned: 174 Modelled: 175 Confidence: 100.0% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: mu transposase, core domain Phyre2 PDB 1c0m chain A Region: 157 - 323 Aligned: 160 Modelled: 167 Confidence: 99.9% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:protein (integrase); PDBTitle: crystal structure of rsv two-domain integrase Phyre2 PDB 1asu chain A Region: 152 - 319 Aligned: 161 Modelled: 168 Confidence: 99.9% Identity: 20% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 1c0m chain A domain 2 Region: 154 - 323 Aligned: 163 Modelled: 170 Confidence: 99.9% Identity: 20% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 3jca chain E Region: 98 - 323 Aligned: 202 Modelled: 226 Confidence: 99.9% Identity: 20% PDB header:viral protein Chain: E: PDB Molecule:integrase; PDBTitle: core model of the mouse mammary tumor virus intasome Phyre2 PDB 5cz1 chain B Region: 160 - 323 Aligned: 147 Modelled: 163 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of the catalytic core domain of mmtv integrase Phyre2 PDB 5u1c chain A Region: 117 - 328 Aligned: 186 Modelled: 207 Confidence: 99.9% Identity: 17% PDB header:viral protein Chain: A: PDB Molecule:hiv-1 integrase, sso7d chimera; PDBTitle: structure of tetrameric hiv-1 strand transfer complex intasome Phyre2 PDB 3f9k chain V Region: 116 - 325 Aligned: 173 Modelled: 182 Confidence: 99.9% Identity: 15% PDB header:viral protein, recombination Chain: V: PDB Molecule:integrase; PDBTitle: two domain fragment of hiv-2 integrase in complex with ledgf ibd Phyre2 PDB 5m0r chain F Region: 117 - 323 Aligned: 173 Modelled: 207 Confidence: 99.8% Identity: 16% PDB header:hydrolase Chain: F: PDB Molecule:integrase; PDBTitle: cryo-em reconstruction of the maedi-visna virus (mvv) strand transfer2 complex Phyre2 PDB 3hpg chain C Region: 117 - 323 Aligned: 171 Modelled: 193 Confidence: 99.8% Identity: 16% PDB header:transferase Chain: C: PDB Molecule:integrase; PDBTitle: visna virus integrase (residues 1-219) in complex with ledgf2 ibd: examples of open integrase dimer-dimer interfaces Phyre2 PDB 3nf9 chain A Region: 163 - 324 Aligned: 143 Modelled: 150 Confidence: 99.8% Identity: 20% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:integrase; PDBTitle: structural basis for a new mechanism of inhibition of hiv integrase2 identified by fragment screening and structure based design Phyre2 PDB 1cxq chain A Region: 157 - 308 Aligned: 142 Modelled: 150 Confidence: 99.8% Identity: 21% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 3kks chain B Region: 163 - 325 Aligned: 143 Modelled: 163 Confidence: 99.8% Identity: 21% PDB header:dna binding protein Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of catalytic core domain of biv integrase in crystal2 form ii Phyre2 PDB 4mq3 chain A Region: 164 - 296 Aligned: 125 Modelled: 133 Confidence: 99.8% Identity: 17% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: the 1.1 angstrom structure of catalytic core domain of fiv integrase Phyre2 PDB 1ex4 chain A Region: 159 - 325 Aligned: 143 Modelled: 167 Confidence: 99.8% Identity: 20% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: hiv-1 integrase catalytic core and c-terminal domain Phyre2 PDB 5ejk chain G Region: 128 - 322 Aligned: 167 Modelled: 193 Confidence: 99.8% Identity: 16% PDB header:transferase/dna Chain: G: PDB Molecule:gag-pro-pol polyprotein; PDBTitle: crystal structure of the rous sarcoma virus intasome Phyre2 PDB 3l2t chain B Region: 157 - 332 Aligned: 162 Modelled: 176 Confidence: 99.8% Identity: 17% PDB header:recombination/dna Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of the prototype foamy virus (pfv) intasome in2 complex with magnesium and mk0518 (raltegravir) Phyre2 PDB 1exq chain A Region: 159 - 325 Aligned: 139 Modelled: 147 Confidence: 99.8% Identity: 20% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 1 c4fcyA_ 2 c1bcoA_ 3 d1bcoa2 4 c1c0mA_ 5 d1asua_ 6 d1c0ma2 7 c3jcaE_ 8 c5cz1B_ 9 c5u1cA_ 10 c3f9kV_ 11 c5m0rF_ 12 c3hpgC_ 13 c3nf9A_ 14 d1cxqa_ 15 c3kksB_ 16 c4mq3A_ 17 c1ex4A_ 18 c5ejkG_ 19 c3l2tB_ 20 d1exqa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209