1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	T	R	S	R	E	E	Y	F	N	L	P	L	K	V	D	E	S	S	G	T	I	G	K	M	F	V	L	V	I	Y	D	I	S	D	N	R	R	R	A	S	L	A	K	I	L	A	G	F	G	Y	R	V	Q	E	S	A	F	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?				?			?	?					?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.
Sequence		A	M	L	T	K	G	Q	L	A	K	L	V	A	R	I	D	R	F	A	I	D	C	D	N	I	R	I	Y	K	I	R	G	V	A	A	V	T	F	Y	G	R	G	R	L	V	S	A	E	E	F	V	F	F
Secondary structure
SS confidence
Disorder																																																						?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 34%) Beta strand ( 33%)

Rank Aligned region

PDB 1zpw chain X domain 1 Region: 24 - 106 Aligned: 81 Modelled: 83 Confidence: 100.0% Identity: 41% Fold: Ferredoxin-like Superfamily: TTP0101/SSO1404-like Family: TTP0101/SSO1404-like Phyre2 PDB 3oq2 chain A Region: 26 - 112 Aligned: 87 Modelled: 87 Confidence: 99.9% Identity: 32% PDB header:immune system Chain: A: PDB Molecule:crispr-associated protein cas2; PDBTitle: structure of a crispr associated protein cas2 from desulfovibrio2 vulgaris Phyre2 PDB 4es2 chain A Region: 26 - 103 Aligned: 77 Modelled: 78 Confidence: 99.9% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:bh0342 protein; PDBTitle: double-stranded endonuclease activity in b. halodurans clustered2 regularly interspaced short palindromic repeats (crispr)-associated3 cas2 protein Phyre2 PDB 2i0x chain A domain 1 Region: 26 - 108 Aligned: 82 Modelled: 83 Confidence: 99.9% Identity: 24% Fold: Ferredoxin-like Superfamily: TTP0101/SSO1404-like Family: TTP0101/SSO1404-like Phyre2 PDB 5h1p chain B Region: 26 - 104 Aligned: 79 Modelled: 79 Confidence: 99.9% Identity: 32% PDB header:hydrolase Chain: B: PDB Molecule:crispr-associated endoribonuclease cas2; PDBTitle: crispr-associated protein Phyre2 PDB 4qr1 chain B Region: 26 - 94 Aligned: 69 Modelled: 69 Confidence: 99.9% Identity: 32% PDB header:hydrolase Chain: B: PDB Molecule:crispr-associated endoribonuclease cas2; PDBTitle: crystal structure of streptococcus pyogenes cas2 at ph 6.5 Phyre2 PDB 2ivy chain A domain 1 Region: 26 - 102 Aligned: 77 Modelled: 77 Confidence: 99.9% Identity: 27% Fold: Ferredoxin-like Superfamily: TTP0101/SSO1404-like Family: TTP0101/SSO1404-like Phyre2 PDB 3exc chain X Region: 28 - 101 Aligned: 72 Modelled: 74 Confidence: 99.8% Identity: 32% PDB header:hydrolase Chain: X: PDB Molecule:uncharacterized protein; PDBTitle: structure of the rna'se sso8090 from sulfolobus solfataricus Phyre2 PDB 5xvn chain M Region: 26 - 90 Aligned: 65 Modelled: 65 Confidence: 98.6% Identity: 22% PDB header:immune system Chain: M: PDB Molecule:crispr-associated endoribonuclease cas2; PDBTitle: e. far cas1-cas2/prespacer binary complex Phyre2 PDB 4p6i chain B Region: 26 - 103 Aligned: 73 Modelled: 78 Confidence: 91.7% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:crispr-associated endoribonuclease cas2; PDBTitle: crystal structure of the cas1-cas2 complex from escherichia coli Phyre2 PDB 4mak chain A Region: 26 - 102 Aligned: 72 Modelled: 77 Confidence: 90.3% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:crispr-associated endoribonuclease cas2; PDBTitle: crystal structure of a putative ssrna endonuclease cas2, crispr2 adaptation protein from e.coli Phyre2 PDB 3ui3 chain A Region: 43 - 94 Aligned: 52 Modelled: 52 Confidence: 87.6% Identity: 21% PDB header:rna binding protein Chain: A: PDB Molecule:immunoglobulin g-binding protein g, virulence-associated PDBTitle: structural and biochemical characterization of hp0315 from2 helicobacter pylori as a vapd protein with an endoribonuclease3 activity Phyre2 PDB 3ui3 chain B Region: 43 - 94 Aligned: 52 Modelled: 52 Confidence: 84.8% Identity: 15% PDB header:rna binding protein Chain: B: PDB Molecule:immunoglobulin g-binding protein g, virulence-associated PDBTitle: structural and biochemical characterization of hp0315 from2 helicobacter pylori as a vapd protein with an endoribonuclease3 activity Phyre2 PDB 5dyr chain A Region: 43 - 80 Aligned: 38 Modelled: 38 Confidence: 78.9% Identity: 5% PDB header:dna binding protein Chain: A: PDB Molecule:virulence-associated protein d; PDBTitle: structure of virulence-associated protein d (vapd) from xylella2 fastidiosa Phyre2 PDB 5b7i chain A Region: 35 - 104 Aligned: 70 Modelled: 70 Confidence: 48.1% Identity: 20% PDB header:hydrolase/unknown function Chain: A: PDB Molecule:crispr-associated nuclease/helicase cas3 subtype i-f/ypest; PDBTitle: cas3-acrf3 complex Phyre2 PDB 1i3o chain C Region: 41 - 111 Aligned: 68 Modelled: 71 Confidence: 25.6% Identity: 13% PDB header:apoptosis Chain: C: PDB Molecule:caspase 3; PDBTitle: crystal structure of the complex of xiap-bir2 and caspase 3 Phyre2 PDB 3edq chain C Region: 41 - 111 Aligned: 68 Modelled: 71 Confidence: 24.3% Identity: 13% PDB header:hydrolase/hydrolase inhibitor Chain: C: PDB Molecule:caspase-3; PDBTitle: crystal structure of caspase-3 with inhibitor ac-ldesd-cho Phyre2 PDB 1f1j chain A Region: 41 - 109 Aligned: 66 Modelled: 69 Confidence: 24.1% Identity: 11% Fold: Caspase-like Superfamily: Caspase-like Family: Caspase catalytic domain Phyre2 PDB 6ia7 chain B Region: 28 - 50 Aligned: 23 Modelled: 23 Confidence: 23.8% Identity: 9% PDB header:cytosolic protein Chain: B: PDB Molecule:intraflagellar transport protein 22; PDBTitle: t. brucei ift22 gtp-bound crystal structure Phyre2 PDB 3hqt chain B Region: 29 - 84 Aligned: 56 Modelled: 56 Confidence: 22.5% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:cai-1 autoinducer synthase; PDBTitle: plp-dependent acyl-coa transferase cqsa Phyre2 1 d1zpwx1 2 c3oq2A_ 3 c4es2A_ 4 d2i0xa1 5 c5h1pB_ 6 c4qr1B_ 7 d2ivya1 8 c3excX_ 9 c5xvnM_ 10 c4p6iB_ 11 c4makA_ 12 c3ui3A_ 13 c3ui3B_ 14 c5dyrA_ 15 c5b7iA_ 16 c1i3oC_ 17 c3edqC_ 18 d1f1ja_ 19 c6ia7B_ 20 c3hqtB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84