1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	F	L	S	A	E	I	A	A	F	E	N	A	D	R	R	Y	S	A	A	I	T	R	L	A	P	E	T	D	V	R	I	V	T	Y	T	N	P	S	V	H	R	F	D	L	F	V	P	V	F	R	N	H	L	V	E	L	S	A
Secondary structure
SS confidence
Disorder		?			?	?	?				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	F	P	D	R	T	I	L	L	N	T	S	S	G	T	P	A	M	Q	A	A	L	V	A	I	N	V	F	G	I	P	R	T	T	A	V	Q	V	S	T	P	A	R	A	L	S	K	P	G	D	R	E	S	P	D	A	Y	D	L	E
Secondary structure
SS confidence
Disorder																																							?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	M	W	D	A	N	D	D	N	Q	P	G	A	P	N	R	C	F	E	A	T	S	A	A	L	G	A	L	L	E	R	A	N	L	K	Q	L	I	V	S	Y	D	Y	S	A	A	V	T	I	A	A	D	S	R	L	P	D	Q	V	S
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?		?			?	?	?																													?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	L	I	R	G	A	M	H	R	S	R	L	E	H	L	V	A	P	K	F	F	K	D	T	A	F	T	Y	D	P	A	N	K	V	A	E	Y	I	S	A	L	A	L	L	A	K	R	E	Q	W	A	E	F	A	R	S	A	T	P	A
Secondary structure
SS confidence
Disorder														?										?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	T	I	V	L	R	A	A	V	A	K	H	L	P	E	D	R	Y	L	D	D	M	G	R	V	D	R	R	K	L	E	R	E	P	E	I	R	C	A	L	K	H	P	P	K	S	P	N	A	E	W	Y	L	Y	T	K	D	W	L	A
Secondary structure
SS confidence
Disorder																										?					?	?	?	?	?		?	?	?				?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	L	R	Q	F	A	P	D	R	V	G	A	L	E	V	L	G	R	F	E	S	R	V	R	N	T	A	A	H	E	I	V	S	I	S	E	D	R	I	T	K	D	G	G	L	L	P	E	Q	L	L	K	I	L	A	R	E	T	G	A
Secondary structure
SS confidence
Disorder																							?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.
Sequence		D	L	T	L	Y	D	R	L	N	D	E	I	I	R	Q	I	D	M	A	P	L	G
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 62%) Beta strand ( 4%)

Rank Aligned region

PDB 4rgp chain A Region: 151 - 377 Aligned: 227 Modelled: 227 Confidence: 100.0% Identity: 17% PDB header:unknown function Chain: A: PDB Molecule:csm6_iii-a; PDBTitle: crystal structure of uncharacterized crispr/cas system-associated2 protein csm6 from streptococcus mutans Phyre2 PDB 5yjc chain B Region: 139 - 376 Aligned: 234 Modelled: 238 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:csm6; PDBTitle: structural insights into the crispr-cas-associated ribonuclease2 activity of staphylococcus epidermidis csm6 Phyre2 PDB 5fsh chain A Region: 31 - 354 Aligned: 287 Modelled: 303 Confidence: 99.6% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:csm6; PDBTitle: crystal structure of thermus thermophilus csm6 Phyre2 PDB 1xmx chain A Region: 1 - 104 Aligned: 93 Modelled: 104 Confidence: 97.7% Identity: 11% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Hypothetical protein VC1899 Phyre2 PDB 2wte chain B Region: 12 - 96 Aligned: 80 Modelled: 85 Confidence: 91.9% Identity: 13% PDB header:antiviral protein Chain: B: PDB Molecule:csa3; PDBTitle: the structure of the crispr-associated protein, csa3, from2 sulfolobus solfataricus at 1.8 angstrom resolution. Phyre2 PDB 2dpl chain A Region: 49 - 107 Aligned: 58 Modelled: 59 Confidence: 51.0% Identity: 22% PDB header:ligase Chain: A: PDB Molecule:gmp synthase [glutamine-hydrolyzing] subunit b; PDBTitle: crystal structure of the gmp synthase from pyrococcus horikoshii ot3 Phyre2 PDB 2c4m chain A Region: 59 - 82 Aligned: 24 Modelled: 24 Confidence: 35.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:glycogen phosphorylase; PDBTitle: starch phosphorylase: structural studies explain oxyanion-dependent2 kinetic stability and regulatory control. Phyre2 PDB 2ati chain A domain 1 Region: 59 - 82 Aligned: 24 Modelled: 24 Confidence: 34.4% Identity: 29% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Oligosaccharide phosphorylase Phyre2 PDB 3dds chain B Region: 59 - 82 Aligned: 24 Modelled: 24 Confidence: 34.2% Identity: 29% PDB header:transferase Chain: B: PDB Molecule:glycogen phosphorylase, liver form; PDBTitle: crystal structure of glycogen phosphorylase complexed with an2 anthranilimide based inhibitor gsk261 Phyre2 PDB 1l5w chain A Region: 59 - 82 Aligned: 24 Modelled: 24 Confidence: 33.6% Identity: 38% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Oligosaccharide phosphorylase Phyre2 PDB 3jq3 chain A Region: 3 - 66 Aligned: 63 Modelled: 64 Confidence: 33.5% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:lombricine kinase; PDBTitle: crystal structure of lombricine kinase, complexed with substrate adp Phyre2 PDB 4l22 chain A Region: 59 - 82 Aligned: 24 Modelled: 24 Confidence: 33.3% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:phosphorylase; PDBTitle: crystal structure of putative glycogen phosphorylase from2 streptococcus mutans Phyre2 PDB 1ygp chain A Region: 59 - 82 Aligned: 24 Modelled: 24 Confidence: 31.6% Identity: 25% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Oligosaccharide phosphorylase Phyre2 PDB 2gj4 chain A domain 1 Region: 59 - 82 Aligned: 24 Modelled: 24 Confidence: 31.3% Identity: 29% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Oligosaccharide phosphorylase Phyre2 PDB 5lrb chain B Region: 59 - 82 Aligned: 24 Modelled: 24 Confidence: 31.3% Identity: 29% PDB header:transferase Chain: B: PDB Molecule:alpha-1,4 glucan phosphorylase; PDBTitle: plastidial phosphorylase from barley in complex with acarbose Phyre2 PDB 3p52 chain B Region: 43 - 105 Aligned: 62 Modelled: 63 Confidence: 29.5% Identity: 10% PDB header:ligase Chain: B: PDB Molecule:nh(3)-dependent nad(+) synthetase; PDBTitle: nh3-dependent nad synthetase from campylobacter jejuni subsp. jejuni2 nctc 11168 in complex with the nitrate ion Phyre2 PDB 3c65 chain A Region: 37 - 96 Aligned: 60 Modelled: 60 Confidence: 29.4% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:uvrabc system protein c; PDBTitle: crystal structure of bacillus stearothermophilus uvrc 5' endonuclease2 domain Phyre2 PDB 2dt7 chain A Region: 37 - 65 Aligned: 28 Modelled: 29 Confidence: 27.8% Identity: 14% PDB header:rna binding protein Chain: A: PDB Molecule:splicing factor 3a subunit 3; PDBTitle: solution structure of the second surp domain of human2 splicing factor sf3a120 in complex with a fragment of3 human splicing factor sf3a60 Phyre2 PDB 4lw2 chain C Region: 42 - 106 Aligned: 64 Modelled: 65 Confidence: 27.1% Identity: 16% PDB header:lyase Chain: C: PDB Molecule:cysteine sulfinate desulfinase; PDBTitle: structural changes during cysteine desulfurase csda and sulfur-2 acceptor csde interactions provide insight into the trans-3 persulfuration Phyre2 PDB 2yrr chain A Region: 43 - 85 Aligned: 43 Modelled: 43 Confidence: 25.4% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:aminotransferase, class v; PDBTitle: hypothetical alanine aminotransferase (tth0173) from thermus2 thermophilus hb8 Phyre2 1 c4rgpA_ 2 c5yjcB_ 3 c5fshA_ 4 d1xmxa_ 5 c2wteB_ 6 c2dplA_ 7 c2c4mA_ 8 d2atia1 9 c3ddsB_ 10 d1l5wa_ 11 c3jq3A_ 12 c4l22A_ 13 d1ygpa_ 14 d2gj4a1 15 c5lrbB_ 16 c3p52B_ 17 c3c65A_ 18 c2dt7A_ 19 c4lw2C_ 20 c2yrrA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99