1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	T	Y	L	K	P	F	E	L	T	L	R	C	L	G	P	V	F	I	G	S	G	E	K	R	T	S	K	E	Y	H	V	E	G	D	R	V	Y	F	P	D	M	E	L	L	Y	A	D	I	P	A	H	K	R	K	S	F	E	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	V	M	N	T	D	G	A	Q	A	T	A	P	L	K	E	W	V	E	P	N	A	V	K	L	D	P	A	K	H	R	G	Y	E	V	K	I	G	S	I	E	P	R	R	A	S	R	G	R	G	G	R	M	T	R	K	K	L	T	L
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?										?	?		?	?	?	?		?	?										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	E	I	H	A	F	I	K	D	P	L	G	R	P	Y	V	P	G	S	T	V	K	G	M	L	R	S	I	Y	L	Q	S	L	V	H	K	R	T	A	Q	P	V	R	V	P	G	H	Q	T	R	E	H	R	Q	Y	G	E	R	F	E
Secondary structure
SS confidence
Disorder																																					?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	K	E	L	R	K	S	G	R	P	N	T	R	P	Q	D	A	V	N	D	L	F	Q	A	I	R	V	T	D	S	P	A	L	R	T	S	D	L	L	I	C	Q	K	M	D	M	N	V	H	G	K	P	D	G	L	P	L	F	R	E
Secondary structure
SS confidence
Disorder							?			?	?	?	?	?	?																															?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		C	L	A	P	G	T	S	I	S	H	R	V	V	V	D	T	S	P	T	A	R	G	G	W	R	E	G	E	R	F	L	E	T	L	A	E	T	A	A	S	V	N	Q	A	R	Y	A	E	Y	R	A	M	Y	P	G	V	N	A	I	V
Secondary structure
SS confidence
Disorder																					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	P	I	V	Y	L	G	G	G	A	G	Y	R	S	K	T	F	V	T	D	Q	D	D	M	A	K	V	L	D	A	Q	F	G	K	V	V	K	H	V	D	K	T	R	E	L	R	V	S	P	L	V	L	K	R	T	K	I	D	N	I
Secondary structure
SS confidence
Disorder																									?														?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.
Sequence		C	Y	E	M	G	Q	C	E	L	S	I	R	R	A	E
Secondary structure
SS confidence
Disorder															?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 38%) Beta strand ( 26%)

Rank Aligned region

PDB 6ig0 chain H Region: 3 - 374 Aligned: 339 Modelled: 372 Confidence: 100.0% Identity: 30% PDB header:rna binding protein Chain: H: PDB Molecule:type iii-a crispr-associated ramp protein csm5; PDBTitle: type iii-a csm complex, cryo-em structure of csm-ctr1, atp bound Phyre2 PDB 6mus chain F Region: 9 - 370 Aligned: 331 Modelled: 342 Confidence: 100.0% Identity: 22% PDB header:rna binding protein/rna Chain: F: PDB Molecule:uncharacterized protein csm5; PDBTitle: cryo-em structure of larger csm-crrna-target rna ternary complex in2 type iii-a crispr-cas system Phyre2 PDB 6mus chain K Region: 2 - 282 Aligned: 174 Modelled: 179 Confidence: 99.6% Identity: 21% PDB header:rna binding protein/rna Chain: K: PDB Molecule:uncharacterized protein csm3; PDBTitle: cryo-em structure of larger csm-crrna-target rna ternary complex in2 type iii-a crispr-cas system Phyre2 PDB 4w8v chain A Region: 1 - 274 Aligned: 181 Modelled: 181 Confidence: 99.6% Identity: 18% PDB header:rna binding protein Chain: A: PDB Molecule:crispr system cmr subunit cmr6; PDBTitle: crystal structure of cmr6 from pyrococcus furiosus Phyre2 PDB 6ifn chain F Region: 1 - 280 Aligned: 166 Modelled: 186 Confidence: 99.5% Identity: 22% PDB header:rna binding protein Chain: F: PDB Molecule:type iii-a crispr-associated ramp protein csm3; PDBTitle: crystal structure of type iii-a crispr csm complex Phyre2 PDB 4qts chain C Region: 7 - 276 Aligned: 118 Modelled: 127 Confidence: 99.4% Identity: 23% PDB header:rna binding protein Chain: C: PDB Molecule:crispr type iii-associated ramp protein csm3; PDBTitle: crystal structure of csm3-csm4 subcomplex in the type iii-a crispr-cas2 interference complex Phyre2 PDB 5yjd chain B Region: 7 - 280 Aligned: 137 Modelled: 151 Confidence: 99.4% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:csm3; PDBTitle: structural insights into the crispr-cas-associated ribonuclease2 activity of staphylococcus epidermidis csm3 Phyre2 PDB 6ae2 chain B Region: 7 - 280 Aligned: 141 Modelled: 150 Confidence: 99.3% Identity: 16% PDB header:rna binding protein Chain: B: PDB Molecule:csm3; PDBTitle: crystal structure of csm3 of the type iii-a crispr-cas effector2 complex Phyre2 PDB 3x1l chain E Region: 1 - 280 Aligned: 184 Modelled: 186 Confidence: 99.3% Identity: 27% PDB header:rna binding protein/rna/dna Chain: E: PDB Molecule:cmr4; PDBTitle: crystal structure of the crispr-cas rna silencing cmr complex bound to2 a target analog Phyre2 PDB 4n0l chain B Region: 125 - 282 Aligned: 150 Modelled: 158 Confidence: 99.0% Identity: 18% PDB header:rna binding protein Chain: B: PDB Molecule:predicted component of a thermophile-specific dna repair PDBTitle: methanopyrus kandleri csm3 crystal structure Phyre2 PDB 4w8w chain B Region: 5 - 149 Aligned: 46 Modelled: 46 Confidence: 99.0% Identity: 39% PDB header:hydrolase Chain: B: PDB Molecule:crispr system cmr subunit cmr4; PDBTitle: crystal structure of oligomeric cmr4 from pyrococcus furiosus Phyre2 PDB 3x1l chain H Region: 104 - 281 Aligned: 164 Modelled: 178 Confidence: 98.9% Identity: 13% PDB header:rna binding protein/rna/dna Chain: H: PDB Molecule:cmr6; PDBTitle: crystal structure of the crispr-cas rna silencing cmr complex bound to2 a target analog Phyre2 PDB 4w8x chain A Region: 5 - 24 Aligned: 20 Modelled: 20 Confidence: 83.4% Identity: 5% PDB header:rna binding protein Chain: A: PDB Molecule:crispr system cmr subunit cmr1-1; PDBTitle: crystal structure of cmr1 from pyrococcus furiosus bound to a2 nucleotide Phyre2 PDB 3ije chain B Region: 200 - 317 Aligned: 97 Modelled: 118 Confidence: 77.3% Identity: 15% PDB header:protein binding Chain: B: PDB Molecule:integrin beta-3; PDBTitle: crystal structure of the complete integrin alhavbeta3 ectodomain plus2 an alpha/beta transmembrane fragment Phyre2 PDB 3k6s chain B Region: 242 - 317 Aligned: 62 Modelled: 76 Confidence: 60.2% Identity: 21% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-2; PDBTitle: structure of integrin alphaxbeta2 ectodomain Phyre2 PDB 1u3f chain A Region: 305 - 317 Aligned: 13 Modelled: 13 Confidence: 58.3% Identity: 38% PDB header:ligase Chain: A: PDB Molecule:5,10-methenyltetrahydrofolate synthetase; PDBTitle: structural and functional characterization of a 5,10-2 methenyltetrahydrofolate synthetase from mycoplasma3 pneumoniae (gi: 13508087) Phyre2 PDB 1sbq chain A Region: 305 - 317 Aligned: 13 Modelled: 13 Confidence: 58.3% Identity: 38% Fold: NagB/RpiA/CoA transferase-like Superfamily: NagB/RpiA/CoA transferase-like Family: Methenyltetrahydrofolate synthetase Phyre2 PDB 2jcb chain A Region: 305 - 317 Aligned: 13 Modelled: 13 Confidence: 52.2% Identity: 31% PDB header:ligase Chain: A: PDB Molecule:5-formyltetrahydrofolate cyclo-ligase family protein; PDBTitle: the crystal structure of 5-formyl-tetrahydrofolate2 cycloligase from bacillus anthracis (ba4489) Phyre2 PDB 3hy4 chain A Region: 305 - 317 Aligned: 13 Modelled: 13 Confidence: 50.1% Identity: 38% PDB header:ligase Chain: A: PDB Molecule:5-formyltetrahydrofolate cyclo-ligase; PDBTitle: structure of human mthfs with n5-iminium phosphate Phyre2 PDB 1wkc chain A Region: 305 - 317 Aligned: 13 Modelled: 13 Confidence: 48.7% Identity: 31% Fold: NagB/RpiA/CoA transferase-like Superfamily: NagB/RpiA/CoA transferase-like Family: Methenyltetrahydrofolate synthetase Phyre2 1 c6ig0H_ 2 c6musF_ 3 c6musK_ 4 c4w8vA_ 5 c6ifnF_ 6 c4qtsC_ 7 c5yjdB_ 8 c6ae2B_ 9 c3x1lE_ 10 c4n0lB_ 11 c4w8wB_ 12 c3x1lH_ 13 c4w8xA_ 14 c3ijeB_ 15 c3k6sB_ 16 c1u3fA_ 17 d1sbqa_ 18 c2jcbA_ 19 c3hy4A_ 20 d1wkca_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99