1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	S	Y	A	K	I	E	I	T	G	T	L	T	V	L	T	G	L	Q	I	G	A	G	D	G	F	S	A	I	G	A	V	D	K	P	V	V	R	D	P	L	S	R	L	P	M	I	P	G	T	S	L	K	G	K	V	R	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																						?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	S	R	Q	Y	G	A	D	T	E	T	F	Y	R	K	P	N	E	D	H	A	H	I	R	R	L	F	G	D	T	E	E	Y	M	T	G	R	L	V	F	R	D	T	K	L	T	N	K	D	D	L	E	A	R	G	A	K	T	L
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?																																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	E	V	K	F	E	N	A	I	N	R	V	T	A	K	A	N	L	R	Q	M	E	R	V	I	P	G	S	E	F	A	F	S	L	V	Y	E	V	S	F	G	T	P	G	E	E	Q	K	A	S	L	P	S	S	D	E	I	I	E	D
Secondary structure
SS confidence
Disorder												?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.
Sequence		F	N	A	I	A	R	G	L	K	L	L	E	L	D	Y	L	G	G	S	G	T	R	G	Y	G	Q	V	K	F	S	N	L	K	A	R	A	A	V	G	A	L	D	G	S	L	L	E	K	L	N	H	E	L	A	A	V
Secondary structure
SS confidence
Disorder																						?																																		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 23%) Beta strand ( 31%)

Rank Aligned region

PDB 6ifn chain F Region: 4 - 231 Aligned: 214 Modelled: 228 Confidence: 100.0% Identity: 50% PDB header:rna binding protein Chain: F: PDB Molecule:type iii-a crispr-associated ramp protein csm3; PDBTitle: crystal structure of type iii-a crispr csm complex Phyre2 PDB 4n0l chain B Region: 6 - 219 Aligned: 201 Modelled: 201 Confidence: 100.0% Identity: 30% PDB header:rna binding protein Chain: B: PDB Molecule:predicted component of a thermophile-specific dna repair PDBTitle: methanopyrus kandleri csm3 crystal structure Phyre2 PDB 6mus chain K Region: 3 - 215 Aligned: 188 Modelled: 200 Confidence: 100.0% Identity: 40% PDB header:rna binding protein/rna Chain: K: PDB Molecule:uncharacterized protein csm3; PDBTitle: cryo-em structure of larger csm-crrna-target rna ternary complex in2 type iii-a crispr-cas system Phyre2 PDB 5yjd chain B Region: 7 - 227 Aligned: 177 Modelled: 196 Confidence: 100.0% Identity: 40% PDB header:hydrolase Chain: B: PDB Molecule:csm3; PDBTitle: structural insights into the crispr-cas-associated ribonuclease2 activity of staphylococcus epidermidis csm3 Phyre2 PDB 4qts chain C Region: 3 - 236 Aligned: 167 Modelled: 175 Confidence: 100.0% Identity: 38% PDB header:rna binding protein Chain: C: PDB Molecule:crispr type iii-associated ramp protein csm3; PDBTitle: crystal structure of csm3-csm4 subcomplex in the type iii-a crispr-cas2 interference complex Phyre2 PDB 6ae2 chain B Region: 7 - 218 Aligned: 171 Modelled: 187 Confidence: 100.0% Identity: 32% PDB header:rna binding protein Chain: B: PDB Molecule:csm3; PDBTitle: crystal structure of csm3 of the type iii-a crispr-cas effector2 complex Phyre2 PDB 4w8v chain A Region: 8 - 207 Aligned: 176 Modelled: 185 Confidence: 100.0% Identity: 21% PDB header:rna binding protein Chain: A: PDB Molecule:crispr system cmr subunit cmr6; PDBTitle: crystal structure of cmr6 from pyrococcus furiosus Phyre2 PDB 3x1l chain E Region: 3 - 210 Aligned: 195 Modelled: 208 Confidence: 100.0% Identity: 27% PDB header:rna binding protein/rna/dna Chain: E: PDB Molecule:cmr4; PDBTitle: crystal structure of the crispr-cas rna silencing cmr complex bound to2 a target analog Phyre2 PDB 4w8w chain B Region: 3 - 214 Aligned: 170 Modelled: 199 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:crispr system cmr subunit cmr4; PDBTitle: crystal structure of oligomeric cmr4 from pyrococcus furiosus Phyre2 PDB 3x1l chain H Region: 13 - 208 Aligned: 157 Modelled: 165 Confidence: 99.9% Identity: 24% PDB header:rna binding protein/rna/dna Chain: H: PDB Molecule:cmr6; PDBTitle: crystal structure of the crispr-cas rna silencing cmr complex bound to2 a target analog Phyre2 PDB 6ig0 chain H Region: 11 - 191 Aligned: 157 Modelled: 165 Confidence: 99.7% Identity: 24% PDB header:rna binding protein Chain: H: PDB Molecule:type iii-a crispr-associated ramp protein csm5; PDBTitle: type iii-a csm complex, cryo-em structure of csm-ctr1, atp bound Phyre2 PDB 4w8x chain A Region: 9 - 235 Aligned: 186 Modelled: 195 Confidence: 99.6% Identity: 18% PDB header:rna binding protein Chain: A: PDB Molecule:crispr system cmr subunit cmr1-1; PDBTitle: crystal structure of cmr1 from pyrococcus furiosus bound to a2 nucleotide Phyre2 PDB 6mus chain F Region: 11 - 157 Aligned: 134 Modelled: 147 Confidence: 99.5% Identity: 26% PDB header:rna binding protein/rna Chain: F: PDB Molecule:uncharacterized protein csm5; PDBTitle: cryo-em structure of larger csm-crrna-target rna ternary complex in2 type iii-a crispr-cas system Phyre2 PDB 4l6u chain B Region: 9 - 235 Aligned: 164 Modelled: 186 Confidence: 99.5% Identity: 21% PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of af1868: cmr1 subunit of the cmr rna silencing2 complex Phyre2 PDB 6muu chain E Region: 105 - 215 Aligned: 94 Modelled: 94 Confidence: 98.4% Identity: 19% PDB header:rna binding protein/rna Chain: E: PDB Molecule:uncharacterized protein csm4; PDBTitle: cryo-em structure of csm-crrna binary complex in type iii-a crispr-cas2 system Phyre2 PDB 6ig0 chain B Region: 12 - 210 Aligned: 142 Modelled: 143 Confidence: 97.9% Identity: 18% PDB header:rna binding protein Chain: B: PDB Molecule:type iii-a crispr-associated ramp protein csm4; PDBTitle: type iii-a csm complex, cryo-em structure of csm-ctr1, atp bound Phyre2 PDB 4qts chain B Region: 124 - 210 Aligned: 70 Modelled: 70 Confidence: 97.7% Identity: 24% PDB header:rna binding protein Chain: B: PDB Molecule:crispr type iii-associated ramp protein csm4; PDBTitle: crystal structure of csm3-csm4 subcomplex in the type iii-a crispr-cas2 interference complex Phyre2 PDB 6fjw chain A Region: 150 - 211 Aligned: 46 Modelled: 62 Confidence: 94.7% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:cas6 protein; PDBTitle: streptococcus thermophilus cas6 Phyre2 PDB 4c97 chain B Region: 150 - 211 Aligned: 47 Modelled: 47 Confidence: 92.1% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:cas6a; PDBTitle: cas6 (ttha0078) h37a mutant Phyre2 PDB 4ilm chain H Region: 178 - 214 Aligned: 37 Modelled: 37 Confidence: 92.1% Identity: 16% PDB header:hydrolase/rna Chain: H: PDB Molecule:crispr-associated endoribonuclease cas6 2; PDBTitle: crispr rna processing endoribonuclease Phyre2 1 c6ifnF_ 2 c4n0lB_ 3 c6musK_ 4 c5yjdB_ 5 c4qtsC_ 6 c6ae2B_ 7 c4w8vA_ 8 c3x1lE_ 9 c4w8wB_ 10 c3x1lH_ 11 c6ig0H_ 12 c4w8xA_ 13 c6musF_ 14 c4l6uB_ 15 c6muuE_ 16 c6ig0B_ 17 c4qtsB_ 18 c6fjwA_ 19 c4c97B_ 20 c4ilmH_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68