1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	T	T	Q	L	I	N	P	A	T	E	E	V	L	A	S	V	D	H	T	D	A	N	A	V	D	D	A	V	Q	R	A	R	A	A	Q	R	R	W	A	R	L	A	P	A	Q	R	A	A	G	L	R	A	F	A	A	A	V	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	H	L	D	E	L	A	A	L	E	V	A	N	S	G	H	P	I	V	S	A	E	W	E	A	G	H	V	R	D	V	L	A	F	Y	A	A	S	P	E	R	L	S	G	R	Q	I	P	V	A	G	G	V	D	V	T	F	N	E	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	G	V	V	G	V	I	T	P	W	N	F	P	M	V	I	A	S	W	A	I	A	P	A	L	A	A	G	N	A	V	L	V	K	P	A	E	L	T	P	L	T	T	M	R	L	G	E	L	A	V	E	A	G	L	D	E	D	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	V	L	P	G	K	G	T	V	V	G	E	R	F	V	T	H	P	D	I	R	K	I	V	F	T	G	S	T	E	V	G	K	R	V	M	A	G	A	A	A	Q	V	K	R	V	T	L	E	L	G	G	K	S	A	N	I	V	F	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	C	D	L	E	R	A	A	T	T	A	P	A	G	V	F	D	N	A	G	Q	D	C	C	A	R	S	R	I	L	V	Q	R	S	V	Y	D	R	F	M	E	L	L	E	P	A	V	H	S	I	V	V	G	D	P	G	S	R	A	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	M	G	P	L	V	S	R	A	H	R	D	K	V	A	G	Y	V	P	D	D	A	P	V	A	F	R	G	T	A	P	A	G	R	G	F	W	F	P	P	T	V	L	T	P	K	R	G	D	R	T	V	T	D	E	I	F	G	P	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	V	V	L	T	F	D	D	E	A	D	A	I	S	L	A	N	D	T	A	Y	G	L	S	G	S	I	W	T	D	D	L	S	R	A	L	R	V	A	R	A	V	E	S	G	N	L	S	V	N	S	H	S	S	V	R	F	N	T	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.
Sequence		F	G	G	F	K	Q	S	G	V	G	R	E	L	G	P	D	A	P	L	Q	F	T	E	T	K	N	V	F	I	A	V	G	E	E	M
Secondary structure
SS confidence
Disorder																																?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 3%) Alpha helix ( 42%) Beta strand ( 20%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 4f9i chain A Region: 3 - 451 Aligned: 449 Modelled: 449 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase Chain: A: PDB Molecule:proline dehydrogenase/delta-1-pyrroline-5-carboxylate PDBTitle: crystal structure of proline utilization a (puta) from geobacter2 sulfurreducens pca Phyre2 PDB 5ur2 chain C Region: 2 - 451 Aligned: 450 Modelled: 450 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase Chain: C: PDB Molecule:bifunctional protein puta; PDBTitle: crystal structure of proline utilization a (puta) from bdellovibrio2 bacteriovorus inactivated by n-propargylglycine Phyre2 PDB 4o5h chain D Region: 3 - 451 Aligned: 449 Modelled: 449 Confidence: 100.0% Identity: 40% PDB header:oxidoreductase Chain: D: PDB Molecule:phenylacetaldehyde dehydrogenase; PDBTitle: x-ray crystal structure of a putative phenylacetaldehyde dehydrogenase2 from burkholderia cenocepacia Phyre2 PDB 6fk3 chain B Region: 2 - 455 Aligned: 454 Modelled: 454 Confidence: 100.0% Identity: 31% PDB header:oxidoreductase Chain: B: PDB Molecule:aldehyde dehydrogenase; PDBTitle: structure and function of aldehyde dehydrogenase from thermus2 thermophilus: an enzyme with an evolutionarily-distinct c-terminal3 arm (recombinant full-length protein in complex with propanal) Phyre2 PDB 1a4s chain A Region: 3 - 453 Aligned: 450 Modelled: 451 Confidence: 100.0% Identity: 39% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 3u4j chain B Region: 2 - 453 Aligned: 452 Modelled: 452 Confidence: 100.0% Identity: 37% PDB header:oxidoreductase Chain: B: PDB Molecule:nad-dependent aldehyde dehydrogenase; PDBTitle: crystal structure of nad-dependent aldehyde dehydrogenase from2 sinorhizobium meliloti Phyre2 PDB 2d4e chain B Region: 2 - 453 Aligned: 452 Modelled: 452 Confidence: 100.0% Identity: 38% PDB header:oxidoreductase Chain: B: PDB Molecule:5-carboxymethyl-2-hydroxymuconate semialdehyde PDBTitle: crystal structure of the hpcc from thermus thermophilus hb8 Phyre2 PDB 3ed6 chain B Region: 3 - 455 Aligned: 453 Modelled: 453 Confidence: 100.0% Identity: 37% PDB header:oxidoreductase Chain: B: PDB Molecule:betaine aldehyde dehydrogenase; PDBTitle: 1.7 angstrom resolution crystal structure of betaine aldehyde2 dehydrogenase (betb) from staphylococcus aureus Phyre2 PDB 1bxs chain A Region: 3 - 454 Aligned: 452 Modelled: 452 Confidence: 100.0% Identity: 38% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 4pt3 chain C Region: 3 - 452 Aligned: 450 Modelled: 450 Confidence: 100.0% Identity: 39% PDB header:oxidoreductase Chain: C: PDB Molecule:aldehyde dehydrogenase; PDBTitle: nadph complex structure of aldehyde dehydrogenase from bacillus cereus Phyre2 PDB 2jg7 chain G Region: 3 - 455 Aligned: 452 Modelled: 453 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: G: PDB Molecule:antiquitin; PDBTitle: crystal structure of seabream antiquitin and elucidation of2 its substrate specificity Phyre2 PDB 1o9j chain A Region: 2 - 454 Aligned: 453 Modelled: 453 Confidence: 100.0% Identity: 37% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 4go4 chain E Region: 3 - 455 Aligned: 453 Modelled: 453 Confidence: 100.0% Identity: 38% PDB header:oxidoreductase Chain: E: PDB Molecule:putative gamma-hydroxymuconic semialdehyde dehydrogenase; PDBTitle: crystal structure of pnpe in complex with nicotinamide adenine2 dinucleotide Phyre2 PDB 4pxl chain B Region: 2 - 453 Aligned: 452 Modelled: 452 Confidence: 100.0% Identity: 37% PDB header:oxidoreductase Chain: B: PDB Molecule:cytosolic aldehyde dehydrogenase rf2c; PDBTitle: structure of zm aldh2-3 (rf2c) in complex with nad Phyre2 PDB 2o2q chain A Region: 2 - 451 Aligned: 450 Modelled: 450 Confidence: 100.0% Identity: 36% PDB header:oxidoreductase Chain: A: PDB Molecule:formyltetrahydrofolate dehydrogenase; PDBTitle: crystal structure of the c-terminal domain of rat2 10'formyltetrahydrofolate dehydrogenase in complex with nadp Phyre2 PDB 5x5u chain B Region: 2 - 450 Aligned: 449 Modelled: 449 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase Chain: B: PDB Molecule:alpha-ketoglutaric semialdehyde dehydrogenase; PDBTitle: crystal strcuture of alpha-ketoglutarate-semialdehyde dehydrogenase2 (kgsadh) complexed with nad Phyre2 PDB 3iwk chain B Region: 3 - 454 Aligned: 452 Modelled: 452 Confidence: 100.0% Identity: 38% PDB header:oxidoreductase Chain: B: PDB Molecule:aminoaldehyde dehydrogenase; PDBTitle: crystal structure of aminoaldehyde dehydrogenase 1 from pisum sativum2 (psamadh1) Phyre2 PDB 2ve5 chain H Region: 3 - 453 Aligned: 451 Modelled: 451 Confidence: 100.0% Identity: 40% PDB header:oxidoreductase Chain: H: PDB Molecule:betaine aldehyde dehydrogenase; PDBTitle: crystallographic structure of betaine aldehyde2 dehydrogenase from pseudomonas aeruginosa Phyre2 PDB 3ifg chain H Region: 3 - 451 Aligned: 449 Modelled: 449 Confidence: 100.0% Identity: 36% PDB header:oxidoreductase Chain: H: PDB Molecule:succinate-semialdehyde dehydrogenase (nadp+); PDBTitle: crystal structure of succinate-semialdehyde dehydrogenase from2 burkholderia pseudomallei, part 1 of 2 Phyre2 PDB 3ek1 chain C Region: 3 - 453 Aligned: 451 Modelled: 451 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase Chain: C: PDB Molecule:aldehyde dehydrogenase; PDBTitle: crystal structure of aldehyde dehydrogenase from brucella2 melitensis biovar abortus 2308 Phyre2 1 c4f9iA_ 2 c5ur2C_ 3 c4o5hD_ 4 c6fk3B_ 5 d1a4sa_ 6 c3u4jB_ 7 c2d4eB_ 8 c3ed6B_ 9 d1bxsa_ 10 c4pt3C_ 11 c2jg7G_ 12 d1o9ja_ 13 c4go4E_ 14 c4pxlB_ 15 c2o2qA_ 16 c5x5uB_ 17 c3iwkB_ 18 c2ve5H_ 19 c3ifgH_ 20 c3ek1C_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122