1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	S	R	T	A	L	S	P	G	V	L	S	P	T	R	P	V	P	N	W	I	A	R	P	E	Y	V	G	K	P	A	A	Q	E	G	S	E	P	W	V	Q	T	P	E	V	I	E	K	M	R	V	A	G	R	I	A	A	G	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?	?									?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	E	A	G	K	A	V	A	P	G	V	T	T	D	E	L	D	R	I	A	H	E	Y	L	V	D	N	G	A	Y	P	S	T	L	G	Y	K	G	F	P	K	S	C	C	T	S	L	N	E	V	I	C	H	G	I	P	D	S	T
Secondary structure
SS confidence
Disorder																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	I	T	D	G	D	I	V	N	I	D	V	T	A	Y	I	G	G	V	H	G	D	T	N	A	T	F	P	A	G	D	V	A	D	E	H	R	L	L	V	D	R	T	R	E	A	T	M	R	A	I	N	T	V	K	P	G	R	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	V	I	G	R	V	I	E	S	Y	A	N	R	F	G	Y	N	V	V	R	D	F	T	G	H	G	I	G	T	T	F	H	N	G	L	V	V	L	H	Y	D	Q	P	A	V	E	T	I	M	Q	P	G	M	T	F	T	I	E	P	M
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.
Sequence		I	N	L	G	A	L	D	Y	E	I	W	D	D	G	W	T	V	V	T	K	D	R	K	W	T	A	Q	F	E	H	T	L	L	V	T	D	T	G	V	E	I	L	T	C	L
Secondary structure
SS confidence
Disorder																																													?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 27%) Beta strand ( 22%)

Rank Aligned region

PDB 1yj3 chain A Region: 4 - 285 Aligned: 282 Modelled: 282 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase; PDBTitle: crystal structure analysis of product bound methionine aminopeptidase2 type 1c from mycobacterium tuberculosis Phyre2 PDB 4fuk chain B Region: 7 - 284 Aligned: 278 Modelled: 278 Confidence: 100.0% Identity: 45% PDB header:hydrolase Chain: B: PDB Molecule:methionine aminopeptidase; PDBTitle: aminopeptidase from trypanosoma brucei Phyre2 PDB 3s6b chain A Region: 7 - 284 Aligned: 278 Modelled: 278 Confidence: 100.0% Identity: 46% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase; PDBTitle: crystal structure of methionine aminopeptidase 1b from plasmodium2 falciparum, pf10_0150 Phyre2 PDB 2g6p chain A Region: 5 - 284 Aligned: 280 Modelled: 280 Confidence: 100.0% Identity: 49% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase 1; PDBTitle: crystal structure of truncated (delta 1-89) human methionine2 aminopeptidase type 1 in complex with pyridyl pyrimidine derivative Phyre2 PDB 2gz5 chain A Region: 5 - 284 Aligned: 280 Modelled: 280 Confidence: 100.0% Identity: 49% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase 1; PDBTitle: human type 1 methionine aminopeptidase in complex with ovalicin at 1.12 ang Phyre2 PDB 3tav chain A Region: 37 - 284 Aligned: 248 Modelled: 248 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase; PDBTitle: crystal structure of a methionine aminopeptidase from mycobacterium2 abscessus Phyre2 PDB 2gg2 chain A domain 1 Region: 40 - 284 Aligned: 245 Modelled: 245 Confidence: 100.0% Identity: 51% Fold: Creatinase/aminopeptidase Superfamily: Creatinase/aminopeptidase Family: Creatinase/aminopeptidase Phyre2 PDB 4fo7 chain B Region: 40 - 284 Aligned: 245 Modelled: 245 Confidence: 100.0% Identity: 49% PDB header:hydrolase Chain: B: PDB Molecule:methionine aminopeptidase; PDBTitle: pseudomonas aeruginosa metap, in mn form Phyre2 PDB 1o0x chain A Region: 38 - 284 Aligned: 247 Modelled: 247 Confidence: 100.0% Identity: 37% Fold: Creatinase/aminopeptidase Superfamily: Creatinase/aminopeptidase Family: Creatinase/aminopeptidase Phyre2 PDB 3mx6 chain A Region: 41 - 284 Aligned: 244 Modelled: 244 Confidence: 100.0% Identity: 46% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase; PDBTitle: crystal structure of methionine aminopeptidase from rickettsia2 prowazekii bound to methionine Phyre2 PDB 1qxy chain A Region: 40 - 285 Aligned: 246 Modelled: 246 Confidence: 100.0% Identity: 36% Fold: Creatinase/aminopeptidase Superfamily: Creatinase/aminopeptidase Family: Creatinase/aminopeptidase Phyre2 PDB 1w7v chain D Region: 16 - 284 Aligned: 250 Modelled: 269 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: D: PDB Molecule:xaa-pro aminopeptidase; PDBTitle: znmg substituted aminopeptidase p from e. coli Phyre2 PDB 5wze chain C Region: 16 - 284 Aligned: 253 Modelled: 269 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: C: PDB Molecule:aminopeptidase p; PDBTitle: the structure of pseudomonas aeruginosa aminopeptidase pepp Phyre2 PDB 4km3 chain B Region: 38 - 284 Aligned: 238 Modelled: 247 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:methionine aminopeptidase; PDBTitle: discovery of a novel structural motif in methionine aminopeptidase2 from streptococci with possible post-translational modification Phyre2 PDB 3rva chain A Region: 35 - 284 Aligned: 244 Modelled: 250 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:organophosphorus acid anhydrolase; PDBTitle: crystal structure of organophosphorus acid anhydrolase from2 alteromonas macleodii Phyre2 PDB 5x49 chain A Region: 28 - 284 Aligned: 239 Modelled: 257 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:probable xaa-pro aminopeptidase 3; PDBTitle: crystal structure of human mitochondrial x-prolyl aminopeptidase2 (xpnpep3) Phyre2 PDB 3l24 chain A Region: 34 - 284 Aligned: 241 Modelled: 251 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal structure of the nerve agent degrading2 organophosphate anhydrolase/prolidase in complex with3 inhibitors Phyre2 PDB 4qr8 chain B Region: 35 - 284 Aligned: 243 Modelled: 250 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal structure of e coli pepq Phyre2 PDB 2okn chain B Region: 32 - 284 Aligned: 249 Modelled: 253 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal strcture of human prolidase Phyre2 PDB 3ig4 chain E Region: 16 - 284 Aligned: 240 Modelled: 253 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: E: PDB Molecule:xaa-pro aminopeptidase; PDBTitle: structure of a putative aminopeptidase p from bacillus anthracis Phyre2 1 c1yj3A_ 2 c4fukB_ 3 c3s6bA_ 4 c2g6pA_ 5 c2gz5A_ 6 c3tavA_ 7 d2gg2a1 8 c4fo7B_ 9 d1o0xa_ 10 c3mx6A_ 11 d1qxya_ 12 c1w7vD_ 13 c5wzeC_ 14 c4km3B_ 15 c3rvaA_ 16 c5x49A_ 17 c3l24A_ 18 c4qr8B_ 19 c2oknB_ 20 c3ig4E_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99