1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	F	V	D	T	N	V	F	M	Y	A	V	G	R	D	H	P	L	R	M	P	A	R	E	F	L	E	H	S	L	E	H	Q	D	R	L	V	T	S	A	E	A	M	Q	E	L	L	N	A	Y	V	P	V	G	R	N	S	T	L
Secondary structure
SS confidence
Disorder		?				?														?																?																			?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	S	A	L	T	L	V	R	A	L	T	E	I	W	P	V	E	A	A	D	V	A	H	A	R	T	L	H	H	R	H	P	G	L	G	A	R	D	L	L	H	L	A	C	C	Q	R	R	G	V	T	R	I	K	T	F	D	H	T	L
Secondary structure
SS confidence
Disorder													?																		?				?																										?
Disorder confidence
		.	.	.	.	.	.
Sequence		A	S	A	F	R	S
Secondary structure
SS confidence
Disorder					?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 58%) Beta strand ( 13%)

Rank Aligned region

PDB 5wzf chain B Region: 2 - 123 Aligned: 119 Modelled: 122 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:23s rrna-specific endonuclease vapc20; PDBTitle: crystal structure of mycobacterium tuberculosis vapc20 (rv2549c),2 sarcin-ricin loop cleaving toxin Phyre2 PDB 5x3t chain D Region: 2 - 126 Aligned: 122 Modelled: 121 Confidence: 99.8% Identity: 22% PDB header:antitoxin/toxin Chain: D: PDB Molecule:ribonuclease vapc26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 1w8i chain A Region: 2 - 120 Aligned: 117 Modelled: 119 Confidence: 99.8% Identity: 13% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3zvk chain C Region: 1 - 120 Aligned: 115 Modelled: 120 Confidence: 99.6% Identity: 18% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 2fe1 chain A domain 1 Region: 2 - 126 Aligned: 119 Modelled: 125 Confidence: 99.6% Identity: 18% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 2fe1 chain A Region: 2 - 126 Aligned: 119 Modelled: 125 Confidence: 99.6% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 4xgr chain G Region: 1 - 120 Aligned: 114 Modelled: 118 Confidence: 99.6% Identity: 13% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 6nkl chain A Region: 1 - 124 Aligned: 119 Modelled: 124 Confidence: 99.6% Identity: 16% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 6a7v chain G Region: 2 - 122 Aligned: 118 Modelled: 121 Confidence: 99.6% Identity: 19% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 2h1c chain A domain 1 Region: 1 - 124 Aligned: 119 Modelled: 124 Confidence: 99.6% Identity: 20% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3tnd chain C Region: 2 - 125 Aligned: 117 Modelled: 124 Confidence: 99.5% Identity: 15% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 5l6m chain C Region: 3 - 120 Aligned: 111 Modelled: 118 Confidence: 99.4% Identity: 15% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 4chg chain C Region: 2 - 122 Aligned: 117 Modelled: 117 Confidence: 99.3% Identity: 18% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 1v96 chain A domain 1 Region: 2 - 125 Aligned: 112 Modelled: 124 Confidence: 99.3% Identity: 13% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3h87 chain B Region: 2 - 122 Aligned: 111 Modelled: 121 Confidence: 99.3% Identity: 12% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 1y82 chain A domain 1 Region: 2 - 125 Aligned: 114 Modelled: 124 Confidence: 99.2% Identity: 14% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 5sv2 chain A Region: 2 - 125 Aligned: 113 Modelled: 124 Confidence: 99.2% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 1v8p chain A Region: 1 - 126 Aligned: 114 Modelled: 126 Confidence: 99.1% Identity: 15% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1v8p chain K Region: 1 - 126 Aligned: 114 Modelled: 126 Confidence: 99.1% Identity: 15% PDB header:structural genomics, unknown function Chain: K: PDB Molecule:hypothetical protein pae2754; PDBTitle: crystal structure of pae2754 from pyrobaculum aerophilum Phyre2 PDB 3dbo chain B Region: 2 - 120 Aligned: 103 Modelled: 104 Confidence: 99.0% Identity: 20% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 1 c5wzfB_ 2 c5x3tD_ 3 d1w8ia_ 4 c3zvkC_ 5 d2fe1a1 6 c2fe1A_ 7 c4xgrG_ 8 c6nklA_ 9 c6a7vG_ 10 d2h1ca1 11 c3tndC_ 12 c5l6mC_ 13 c4chgC_ 14 d1v96a1 15 c3h87B_ 16 d1y82a1 17 c5sv2A_ 18 d1v8pa_ 19 c1v8pK_ 20 c3dboB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38