1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	V	G	L	G	M	P	Q	P	P	A	P	T	L	A	P	R	R	A	T	R	Q	L	M	V	G	N	V	G	V	G	S	D	H	P	V	S	V	Q	S	M	C	T	T	K	T	H	D	V	N	S	T	L	Q	Q	I	A	E	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	A	A	G	C	D	I	V	R	V	A	C	P	R	Q	E	D	A	D	A	L	A	E	I	A	R	H	S	Q	I	P	V	V	A	D	I	H	F	Q	P	R	Y	I	F	A	A	I	D	A	G	C	A	A	V	R	V	N	P	G	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	K	E	F	D	G	R	V	G	E	V	A	K	A	A	G	A	A	G	I	P	I	R	I	G	V	N	A	G	S	L	D	K	R	F	M	E	K	Y	G	K	A	T	P	E	A	L	V	E	S	A	L	W	E	A	S	L	F	E	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		H	G	F	G	D	I	K	I	S	V	K	H	N	D	P	V	V	M	V	A	A	Y	E	L	L	A	A	R	C	D	Y	P	L	H	L	G	V	T	E	A	G	P	A	F	Q	G	T	I	K	S	A	V	A	F	G	A	L	L	S	R
Secondary structure
SS confidence
Disorder																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	I	G	D	T	I	R	V	S	L	S	A	P	P	V	E	E	V	K	V	G	N	Q	V	L	E	S	L	N	L	R	P	R	S	L	E	I	V	S	C	P	S	C	G	R	A	Q	V	D	V	Y	T	L	A	N	E	V	T	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	D	G	L	D	V	P	L	R	V	A	V	M	G	C	V	V	N	G	P	G	E	A	R	E	A	D	L	G	V	A	S	G	N	G	K	G	Q	I	F	V	R	G	E	V	I	K	T	V	P	E	A	Q	I	V	E	T	L	I	E
Secondary structure
SS confidence
Disorder					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.
Sequence		E	A	M	R	L	A	A	E	M	G	E	Q	D	P	G	A	T	P	S	G	S	P	I	V	T	V	S
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 39%) Beta strand ( 20%)

Rank Aligned region

PDB 3noy chain A Region: 15 - 363 Aligned: 348 Modelled: 349 Confidence: 100.0% Identity: 51% PDB header:oxidoreductase Chain: A: PDB Molecule:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; PDBTitle: crystal structure of ispg (gcpe) Phyre2 PDB 2y0f chain D Region: 18 - 370 Aligned: 345 Modelled: 353 Confidence: 100.0% Identity: 39% PDB header:oxidoreductase Chain: D: PDB Molecule:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; PDBTitle: structure of gcpe (ispg) from thermus thermophilus hb27 Phyre2 PDB 4mwa chain A Region: 16 - 273 Aligned: 256 Modelled: 258 Confidence: 100.0% Identity: 49% PDB header:oxidoreductase Chain: A: PDB Molecule:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; PDBTitle: 1.85 angstrom crystal structure of gcpe protein from bacillus2 anthracis Phyre2 PDB 5aop chain A Region: 248 - 374 Aligned: 126 Modelled: 127 Confidence: 99.4% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:sulfite reductase hemoprotein; PDBTitle: sulfite reductase structure reduced with crii edta, 5-coordinate2 siroheme, siroheme feii, [4fe-4s] +1 Phyre2 PDB 5h92 chain A Region: 248 - 370 Aligned: 122 Modelled: 123 Confidence: 99.4% Identity: 20% PDB header:oxidoreductase/electron transport Chain: A: PDB Molecule:sulfite reductase [ferredoxin], chloroplastic; PDBTitle: crystal structure of the complex between maize sulfite reductase and2 ferredoxin in the form-3 crystal Phyre2 PDB 1zj8 chain B Region: 248 - 370 Aligned: 122 Modelled: 123 Confidence: 99.3% Identity: 20% PDB header:oxidoreductase Chain: B: PDB Molecule:probable ferredoxin-dependent nitrite reductase nira; PDBTitle: structure of mycobacterium tuberculosis nira protein Phyre2 PDB 3b0n chain A Region: 248 - 370 Aligned: 122 Modelled: 123 Confidence: 99.3% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:nitrite reductase; PDBTitle: q448k mutant of assimilatory nitrite reductase (nii3) from tobbaco2 leaf Phyre2 PDB 2akj chain A Region: 247 - 370 Aligned: 123 Modelled: 124 Confidence: 99.2% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:ferredoxin--nitrite reductase, chloroplast; PDBTitle: structure of spinach nitrite reductase Phyre2 PDB 1aop chain A domain 4 Region: 276 - 370 Aligned: 94 Modelled: 95 Confidence: 99.2% Identity: 28% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 3c7b chain B domain 3 Region: 276 - 373 Aligned: 97 Modelled: 98 Confidence: 99.1% Identity: 20% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 2v4j chain E Region: 248 - 370 Aligned: 122 Modelled: 123 Confidence: 99.1% Identity: 23% PDB header:oxidoreductase Chain: E: PDB Molecule:sulfite reductase, dissimilatory-type subunit PDBTitle: the crystal structure of desulfovibrio vulgaris2 dissimilatory sulfite reductase bound to dsrc provides3 novel insights into the mechanism of sulfate respiration Phyre2 PDB 3c7b chain A domain 3 Region: 276 - 370 Aligned: 94 Modelled: 95 Confidence: 99.0% Identity: 21% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 2v4j chain B domain 3 Region: 276 - 373 Aligned: 97 Modelled: 98 Confidence: 99.0% Identity: 22% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 2v4j chain A domain 3 Region: 276 - 373 Aligned: 97 Modelled: 97 Confidence: 99.0% Identity: 23% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 1zj8 chain A domain 3 Region: 276 - 370 Aligned: 94 Modelled: 95 Confidence: 99.0% Identity: 23% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 2akj chain A domain 3 Region: 276 - 370 Aligned: 94 Modelled: 95 Confidence: 99.0% Identity: 29% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 1aop chain A domain 3 Region: 276 - 378 Aligned: 102 Modelled: 103 Confidence: 98.9% Identity: 15% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 2akj chain A domain 4 Region: 276 - 378 Aligned: 102 Modelled: 103 Confidence: 98.9% Identity: 16% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 3c7b chain A Region: 248 - 370 Aligned: 122 Modelled: 122 Confidence: 98.9% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:sulfite reductase, dissimilatory-type subunit alpha; PDBTitle: structure of the dissimilatory sulfite reductase from archaeoglobus2 fulgidus Phyre2 PDB 3c7b chain E Region: 248 - 370 Aligned: 122 Modelled: 123 Confidence: 98.9% Identity: 20% PDB header:oxidoreductase Chain: E: PDB Molecule:sulfite reductase, dissimilatory-type subunit beta; PDBTitle: structure of the dissimilatory sulfite reductase from archaeoglobus2 fulgidus Phyre2 1 c3noyA_ 2 c2y0fD_ 3 c4mwaA_ 4 c5aopA_ 5 c5h92A_ 6 c1zj8B_ 7 c3b0nA_ 8 c2akjA_ 9 d1aopa4 10 d3c7bb3 11 c2v4jE_ 12 d3c7ba3 13 d2v4jb3 14 d2v4ja3 15 d1zj8a3 16 d2akja3 17 d1aopa3 18 d2akja4 19 c3c7bA_ 20 c3c7bE_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499