1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	N	V	Q	A	K	P	A	A	A	A	S	L	A	A	I	A	I	A	F	L	A	G	C	S	S	T	K	P	V	S	Q	D	T	S	P	K	P	A	T	S	P	A	A	P	V	T	T	A	A	M	A	D	P	A	A	D	L	I
Secondary structure
SS confidence
Disorder		?	?	?	?			?	?	?	?	?	?								?	?		?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	R	G	C	A	Q	Y	A	A	Q	N	P	T	G	P	G	S	V	A	G	M	A	Q	D	P	V	A	T	A	A	S	N	N	P	M	L	S	T	L	T	S	A	L	S	G	K	L	N	P	D	V	N	L	V	D	T	L	N	G	G
Secondary structure
SS confidence
Disorder			?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?											?													?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	Y	T	V	F	A	P	T	N	A	A	F	D	K	L	P	A	A	T	I	D	Q	L	K	T	D	A	K	L	L	S	S	I	L	T	Y	H	V	I	A	G	Q	A	S	P	S	R	I	D	G	T	H	Q	T	L	Q	G	A	D	L
Secondary structure
SS confidence
Disorder																																																	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220
Sequence		T	V	I	G	A	R	D	D	L	M	V	N	N	A	G	L	V	C	G	G	V	H	T	A	N	A	T	V	Y	M	I	D	T	V	L	M	P	P	A	Q
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 38%) Alpha helix ( 31%) Beta strand ( 20%)

Rank Aligned region

PDB 1nyo chain A Region: 57 - 219 Aligned: 163 Modelled: 163 Confidence: 100.0% Identity: 74% Fold: FAS1 domain Superfamily: FAS1 domain Family: FAS1 domain Phyre2 PDB 5nv6 chain A Region: 76 - 219 Aligned: 139 Modelled: 144 Confidence: 100.0% Identity: 34% PDB header:structural protein Chain: A: PDB Molecule:transforming growth factor-beta-induced protein ig-h3; PDBTitle: structure of human transforming growth factor beta-induced protein2 (tgfbip). Phyre2 PDB 1x3b chain A Region: 76 - 220 Aligned: 140 Modelled: 145 Confidence: 100.0% Identity: 33% PDB header:cell adhesion Chain: A: PDB Molecule:transforming growth factor-beta induced protein PDBTitle: solution structure of the fas1 domain of human transforming2 growth factor-beta induced protein ig-h3 Phyre2 PDB 5yjh chain A Region: 77 - 217 Aligned: 136 Modelled: 136 Confidence: 100.0% Identity: 26% PDB header:cell adhesion Chain: A: PDB Molecule:periostin; PDBTitle: structural insights into periostin functions Phyre2 PDB 5wt7 chain A Region: 80 - 218 Aligned: 134 Modelled: 139 Confidence: 100.0% Identity: 26% PDB header:cell adhesion Chain: A: PDB Molecule:periostin; PDBTitle: fas1-iv domain of human periostin Phyre2 PDB 1w7e chain A Region: 85 - 217 Aligned: 127 Modelled: 133 Confidence: 100.0% Identity: 39% PDB header:cell adhesion Chain: A: PDB Molecule:beta-ig-h3/fasciclin; PDBTitle: nmr ensemble of fasciclin-like protein from rhodobacter sphaeroides Phyre2 PDB 2mxa chain A Region: 85 - 214 Aligned: 124 Modelled: 130 Confidence: 100.0% Identity: 36% PDB header:membrane protein Chain: A: PDB Molecule:ndh-1 complex sensory subunit cups; PDBTitle: solution structure of the ndh-1 complex subunit cups from2 thermosynechococcus elongatus Phyre2 PDB 1o70 chain A domain 2 Region: 85 - 220 Aligned: 131 Modelled: 136 Confidence: 100.0% Identity: 17% Fold: FAS1 domain Superfamily: FAS1 domain Family: FAS1 domain Phyre2 PDB 5n86 chain A Region: 85 - 218 Aligned: 123 Modelled: 134 Confidence: 100.0% Identity: 17% PDB header:cell adhesion Chain: A: PDB Molecule:stabilin-2; PDBTitle: crystal structure of fas1 domain of hyaluronic acid receptor stabilin-2 2 Phyre2 PDB 1o70 chain A domain 1 Region: 91 - 218 Aligned: 122 Modelled: 128 Confidence: 99.9% Identity: 25% Fold: FAS1 domain Superfamily: FAS1 domain Family: FAS1 domain Phyre2 PDB 1o70 chain A Region: 91 - 220 Aligned: 122 Modelled: 130 Confidence: 99.9% Identity: 26% PDB header:cell adhesion Chain: A: PDB Molecule:fasciclin i; PDBTitle: novel fold revealed by the structure of a fas1 domain pair2 from the insect cell adhesion molecule fasciclin i Phyre2 PDB 2ag3 chain A Region: 148 - 158 Aligned: 11 Modelled: 11 Confidence: 22.0% Identity: 45% PDB header:de novo protein Chain: A: PDB Molecule:gcn4-pli; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: substitution of the k(15)-l(16) amide with a triazole Phyre2 PDB 1u9f chain A Region: 148 - 158 Aligned: 11 Modelled: 11 Confidence: 13.3% Identity: 45% PDB header:transcription Chain: A: PDB Molecule:general control protein gcn4; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: replacement of k(15)l(16) Phyre2 PDB 1j5y chain A domain 2 Region: 90 - 142 Aligned: 50 Modelled: 53 Confidence: 12.7% Identity: 16% Fold: HPr-like Superfamily: Putative transcriptional regulator TM1602, C-terminal domain Family: Putative transcriptional regulator TM1602, C-terminal domain Phyre2 PDB 1u9f chain B Region: 148 - 158 Aligned: 11 Modelled: 11 Confidence: 12.6% Identity: 45% PDB header:transcription Chain: B: PDB Molecule:general control protein gcn4; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: replacement of k(15)l(16) Phyre2 PDB 1u9f chain C Region: 148 - 158 Aligned: 11 Modelled: 11 Confidence: 12.6% Identity: 45% PDB header:transcription Chain: C: PDB Molecule:general control protein gcn4; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: replacement of k(15)l(16) Phyre2 PDB 1u9f chain D Region: 148 - 158 Aligned: 11 Modelled: 11 Confidence: 12.4% Identity: 45% PDB header:transcription Chain: D: PDB Molecule:general control protein gcn4; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: replacement of k(15)l(16) Phyre2 PDB 4v19 chain P Region: 123 - 135 Aligned: 13 Modelled: 13 Confidence: 8.2% Identity: 23% PDB header:ribosome Chain: P: PDB Molecule:mitoribosomal protein ul15m, mrpl15; PDBTitle: structure of the large subunit of the mammalian mitoribosome, part 12 of 2 Phyre2 PDB 1q42 chain A Region: 156 - 212 Aligned: 50 Modelled: 57 Confidence: 6.6% Identity: 24% Fold: Cystatin-like Superfamily: NTF2-like Family: NTF2-like Phyre2 PDB 1gso chain A domain 2 Region: 111 - 131 Aligned: 21 Modelled: 21 Confidence: 6.3% Identity: 33% Fold: PreATP-grasp domain Superfamily: PreATP-grasp domain Family: BC N-terminal domain-like Phyre2 1 d1nyoa_ 2 c5nv6A_ 3 c1x3bA_ 4 c5yjhA_ 5 c5wt7A_ 6 c1w7eA_ 7 c2mxaA_ 8 d1o70a2 9 c5n86A_ 10 d1o70a1 11 c1o70A_ 12 c2ag3A_ 13 c1u9fA_ 14 d1j5ya2 15 c1u9fB_ 16 c1u9fC_ 17 c1u9fD_ 18 c4v19P_ 19 d1q42a_ 20 d1gsoa2 21 22