1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	V	K	N	T	I	A	A	T	S	F	A	A	A	G	L	A	A	L	A	V	A	V	S	P	P	A	A	A	G	D	L	V	G	P	G	C	A	E	Y	A	A	A	N	P	T	G	P	A	S	V	Q	G	M	S	Q	D	P	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	V	A	A	S	N	N	P	E	L	T	T	L	T	A	A	L	S	G	Q	L	N	P	Q	V	N	L	V	D	T	L	N	S	G	Q	Y	T	V	F	A	P	T	N	A	A	F	S	K	L	P	A	S	T	I	D	E	L	K	T	N
Secondary structure
SS confidence
Disorder							?													?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	S	L	L	T	S	I	L	T	Y	H	V	V	A	G	Q	T	S	P	A	N	V	V	G	T	R	Q	T	L	Q	G	A	S	V	T	V	T	G	Q	G	N	S	L	K	V	G	N	A	D	V	V	C	G	G	V	S	T	A	N	A
Secondary structure
SS confidence
Disorder																							?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.
Sequence		T	V	Y	M	I	D	S	V	L	M	P	P	A
Secondary structure
SS confidence
Disorder											?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 40%) Beta strand ( 18%)

Rank Aligned region

PDB 1nyo chain A Region: 31 - 193 Aligned: 163 Modelled: 163 Confidence: 100.0% Identity: 100% Fold: FAS1 domain Superfamily: FAS1 domain Family: FAS1 domain Phyre2 PDB 5nv6 chain A Region: 50 - 193 Aligned: 139 Modelled: 144 Confidence: 100.0% Identity: 32% PDB header:structural protein Chain: A: PDB Molecule:transforming growth factor-beta-induced protein ig-h3; PDBTitle: structure of human transforming growth factor beta-induced protein2 (tgfbip). Phyre2 PDB 1x3b chain A Region: 50 - 193 Aligned: 139 Modelled: 144 Confidence: 100.0% Identity: 30% PDB header:cell adhesion Chain: A: PDB Molecule:transforming growth factor-beta induced protein PDBTitle: solution structure of the fas1 domain of human transforming2 growth factor-beta induced protein ig-h3 Phyre2 PDB 5yjh chain A Region: 55 - 191 Aligned: 132 Modelled: 137 Confidence: 100.0% Identity: 22% PDB header:cell adhesion Chain: A: PDB Molecule:periostin; PDBTitle: structural insights into periostin functions Phyre2 PDB 5wt7 chain A Region: 57 - 192 Aligned: 131 Modelled: 136 Confidence: 100.0% Identity: 22% PDB header:cell adhesion Chain: A: PDB Molecule:periostin; PDBTitle: fas1-iv domain of human periostin Phyre2 PDB 1w7e chain A Region: 59 - 191 Aligned: 127 Modelled: 133 Confidence: 100.0% Identity: 43% PDB header:cell adhesion Chain: A: PDB Molecule:beta-ig-h3/fasciclin; PDBTitle: nmr ensemble of fasciclin-like protein from rhodobacter sphaeroides Phyre2 PDB 2mxa chain A Region: 59 - 188 Aligned: 124 Modelled: 130 Confidence: 100.0% Identity: 40% PDB header:membrane protein Chain: A: PDB Molecule:ndh-1 complex sensory subunit cups; PDBTitle: solution structure of the ndh-1 complex subunit cups from2 thermosynechococcus elongatus Phyre2 PDB 1o70 chain A domain 2 Region: 59 - 193 Aligned: 130 Modelled: 135 Confidence: 100.0% Identity: 18% Fold: FAS1 domain Superfamily: FAS1 domain Family: FAS1 domain Phyre2 PDB 5n86 chain A Region: 59 - 192 Aligned: 123 Modelled: 134 Confidence: 100.0% Identity: 23% PDB header:cell adhesion Chain: A: PDB Molecule:stabilin-2; PDBTitle: crystal structure of fas1 domain of hyaluronic acid receptor stabilin-2 2 Phyre2 PDB 1o70 chain A domain 1 Region: 65 - 192 Aligned: 120 Modelled: 128 Confidence: 99.9% Identity: 23% Fold: FAS1 domain Superfamily: FAS1 domain Family: FAS1 domain Phyre2 PDB 1o70 chain A Region: 65 - 193 Aligned: 121 Modelled: 129 Confidence: 99.9% Identity: 26% PDB header:cell adhesion Chain: A: PDB Molecule:fasciclin i; PDBTitle: novel fold revealed by the structure of a fas1 domain pair2 from the insect cell adhesion molecule fasciclin i Phyre2 PDB 2ag3 chain A Region: 121 - 132 Aligned: 12 Modelled: 12 Confidence: 19.0% Identity: 42% PDB header:de novo protein Chain: A: PDB Molecule:gcn4-pli; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: substitution of the k(15)-l(16) amide with a triazole Phyre2 PDB 1u9f chain A Region: 121 - 132 Aligned: 12 Modelled: 12 Confidence: 10.8% Identity: 42% PDB header:transcription Chain: A: PDB Molecule:general control protein gcn4; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: replacement of k(15)l(16) Phyre2 PDB 1u9f chain C Region: 121 - 132 Aligned: 12 Modelled: 12 Confidence: 10.2% Identity: 42% PDB header:transcription Chain: C: PDB Molecule:general control protein gcn4; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: replacement of k(15)l(16) Phyre2 PDB 1u9f chain B Region: 121 - 132 Aligned: 12 Modelled: 12 Confidence: 10.2% Identity: 42% PDB header:transcription Chain: B: PDB Molecule:general control protein gcn4; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: replacement of k(15)l(16) Phyre2 PDB 1u9f chain D Region: 121 - 132 Aligned: 12 Modelled: 12 Confidence: 10.0% Identity: 42% PDB header:transcription Chain: D: PDB Molecule:general control protein gcn4; PDBTitle: heterocyclic peptide backbone modification in gcn4-pli based coiled2 coils: replacement of k(15)l(16) Phyre2 PDB 4v19 chain P Region: 97 - 109 Aligned: 13 Modelled: 13 Confidence: 7.5% Identity: 23% PDB header:ribosome Chain: P: PDB Molecule:mitoribosomal protein ul15m, mrpl15; PDBTitle: structure of the large subunit of the mammalian mitoribosome, part 12 of 2 Phyre2 PDB 2kwr chain A Region: 179 - 190 Aligned: 12 Modelled: 12 Confidence: 7.5% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: solution nmr structure of the apoform of nare (nmb1343) Phyre2 1 d1nyoa_ 2 c5nv6A_ 3 c1x3bA_ 4 c5yjhA_ 5 c5wt7A_ 6 c1w7eA_ 7 c2mxaA_ 8 d1o70a2 9 c5n86A_ 10 d1o70a1 11 c1o70A_ 12 c2ag3A_ 13 c1u9fA_ 14 c1u9fC_ 15 c1u9fB_ 16 c1u9fD_ 17 c4v19P_ 18 c2kwrA_