1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	E	A	L	I	G	L	A	F	A	A	G	L	V	A	A	L	N	P	C	G	F	A	M	L	P	A	Y	L	L	L	V	V	Y	G	Q	D	S	A	G	R	T	G	P	L	S	A	V	G	R	A	A	A	A	T	V	G	M	A
Secondary structure
SS confidence
Disorder		?	?	?	?																														?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	G	F	L	T	V	F	G	I	F	G	A	L	T	I	S	A	A	T	A	V	Q	R	Y	L	P	Y	A	T	V	L	I	G	L	A	L	I	A	L	G	G	W	L	L	L	G	R	G	L	T	A	L	T	P	R	S	L	G	V	R
Secondary structure
SS confidence
Disorder																																																?	?	?	?	?	?	?	?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	A	P	T	V	R	L	G	S	M	Y	G	Y	G	I	S	Y	A	V	A	S	L	S	C	T	I	G	P	F	L	A	V	T	G	A	G	L	R	G	G	S	V	V	G	S	V	A	I	Y	L	A	Y	V	A	G	L	T	L	V	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																														?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	V	L	A	V	A	A	A	T	A	S	S	A	L	A	D	R	L	R	R	I	L	P	F	V	N	R	I	S	G	A	L	L	V	V	V	G	L	Y	V	G	Y	Y	G	L	Y	E	L	R	L	I	A	G	V	G	A	N	P	Q	D
Secondary structure
SS confidence
Disorder											?	?								?																																		?	?			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.
Sequence		A	V	I	A	A	A	G	R	L	Q	G	A	L	A	G	W	V	N	Q	H	G	A	W	P	W	A	V	L	L	V	V	L	V	V	G	A	F	A	G	T	W	F	R	R	V	R	R
Secondary structure
SS confidence
Disorder				?	?	?																																								?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 86%) Beta strand ( 0%) TM helix ( 56%) (View membrane topology prediction)

Rank Aligned region

PDB 5vkv chain A Region: 3 - 222 Aligned: 199 Modelled: 220 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccda; PDBTitle: solution nmr structure of the membrane electron transporter ccda Phyre2 PDB 2n4x chain A Region: 8 - 222 Aligned: 181 Modelled: 199 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c-type biogenesis protein (ccda); PDBTitle: structure of the transmembrane electron transporter ccda Phyre2 PDB 1v54 chain L Region: 166 - 183 Aligned: 18 Modelled: 18 Confidence: 13.5% Identity: 11% Fold: Single transmembrane helix Superfamily: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) Family: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) Phyre2 PDB 4zjv chain D Region: 19 - 26 Aligned: 8 Modelled: 8 Confidence: 11.6% Identity: 25% PDB header:transferase/inhibitor Chain: D: PDB Molecule:erbb receptor feedback inhibitor 1; PDBTitle: crystal structure of egfr kinase domain in complex with mitogen-2 inducible gene 6 protein Phyre2 PDB 2y69 chain Y Region: 166 - 183 Aligned: 18 Modelled: 18 Confidence: 11.0% Identity: 11% PDB header:electron transport Chain: Y: PDB Molecule:cytochrome c oxidase subunit 7c; PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular oxygen Phyre2 PDB 2l6s chain A Region: 141 - 148 Aligned: 8 Modelled: 8 Confidence: 10.3% Identity: 38% PDB header:antiviral protein Chain: A: PDB Molecule:vir-576; PDBTitle: efficacy of an hiv-1 entry inhibitor targeting the gp41 fusion peptide Phyre2 PDB 2l6t chain A Region: 141 - 148 Aligned: 8 Modelled: 8 Confidence: 10.3% Identity: 38% PDB header:antiviral protein Chain: A: PDB Molecule:vir-576; PDBTitle: efficacy of an hiv-1 entry inhibitor targeting the gp41 fusion peptide Phyre2 PDB 2l9d chain A Region: 200 - 212 Aligned: 13 Modelled: 13 Confidence: 10.2% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of the protein yp_546394.1, the first structural2 representative of the pfam family pf12112 Phyre2 PDB 1eak chain A domain 5 Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 8.5% Identity: 50% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 PDB 2jnr chain A Region: 141 - 148 Aligned: 8 Modelled: 8 Confidence: 8.3% Identity: 38% PDB header:viral protein Chain: A: PDB Molecule:vir165; PDBTitle: discovery and optimization of a natural hiv-1 entry2 inhibitor targeting the gp41 fusion peptide Phyre2 PDB 1j7m chain A Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 8.1% Identity: 50% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 PDB 1eak chain A domain 4 Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 7.9% Identity: 50% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 PDB 1e88 chain A domain 1 Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 7.7% Identity: 33% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 PDB 1l6j chain A domain 5 Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 7.6% Identity: 33% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 PDB 1xyr chain 6 Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 7.4% Identity: 33% PDB header:virus Chain: 6: PDB Molecule:genome polyprotein, coat protein vp3; PDB Fragment:residues 620-630 PDBTitle: poliovirus 135s cell entry intermediate Phyre2 PDB 1l6j chain A domain 3 Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 7.1% Identity: 33% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 PDB 1l6j chain A domain 4 Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 7.0% Identity: 50% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 PDB 1ks0 chain A Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 7.0% Identity: 33% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 PDB 1e88 chain A domain 2 Region: 19 - 24 Aligned: 6 Modelled: 6 Confidence: 6.8% Identity: 33% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 PDB 5ir6 chain B Region: 71 - 282 Aligned: 204 Modelled: 212 Confidence: 6.5% Identity: 11% PDB header:oxidoreductase Chain: B: PDB Molecule:bd-type quinol oxidase subunit ii; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 1 c5vkvA_ 2 c2n4xA_ 3 d1v54l_ 4 c4zjvD_ 5 c2y69Y_ 6 c2l6sA_ 7 c2l6tA_ 8 c2l9dA_ 9 d1eaka5 10 c2jnrA_ 11 d1j7ma_ 12 d1eaka4 13 d1e88a1 14 d1l6ja5 15 c1xyr6_ 16 d1l6ja3 17 d1l6ja4 18 d1ks0a_ 19 d1e88a2 20 c5ir6B_ 21 22