1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	T	N	D	A	G	T	G	N	P	A	E	Q	P	A	R	G	A	K	Q	Q	P	A	T	E	T	S	R	A	G	R	D	L	R	A	A	I	V	V	G	L	S	I	G	L	V	L	I	A	V	L	V	F	V	P	R	V	W	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	I	V	A	V	A	T	L	V	A	T	H	E	V	V	R	R	L	R	E	A	G	Y	L	I	P	V	I	P	L	L	I	G	G	Q	A	A	V	W	L	T	W	P	F	G	A	V	G	A	L	A	G	F	G	G	M	V	V	V	C
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	I	W	R	L	F	M	Q	D	S	V	T	R	P	T	T	G	G	A	P	S	P	G	N	Y	L	S	D	V	S	A	T	V	F	L	A	V	W	V	P	L	F	C	S	F	G	A	M	L	V	Y	P	E	N	G	S	G	W	V	F
Secondary structure
SS confidence
Disorder																?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		C	M	M	I	A	V	I	A	S	D	V	G	G	Y	A	V	G	V	L	F	G	K	H	P	M	V	P	T	I	S	P	K	K	S	W	E	G	F	A	G	S	L	V	C	G	I	T	A	T	I	I	T	A	T	F	L	V	G	K	T
Secondary structure
SS confidence
Disorder																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	W	I	G	A	L	L	G	V	L	F	V	L	T	T	A	L	G	D	L	V	E	S	Q	V	K	R	D	L	G	I	K	D	M	G	R	L	L	P	G	H	G	G	L	M	D	R	L	D	G	I	L	P	S	A	V	A	A	W	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.
Sequence		V	L	T	L	L	P
Secondary structure
SS confidence
Disorder							?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 73%) Beta strand ( 0%) TM helix ( 58%) (View membrane topology prediction)

Rank Aligned region

PDB 4q2e chain A Region: 39 - 306 Aligned: 252 Modelled: 254 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:phosphatidate cytidylyltransferase; PDBTitle: crystal structure of an intramembrane cdp-dag synthetase central for2 phospholipid biosynthesis (s200c/s258c, active mutant) Phyre2 PDB 4q2g chain A Region: 40 - 305 Aligned: 250 Modelled: 252 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:phosphatidate cytidylyltransferase; PDBTitle: crystal structure of an intramembrane cdp-dag synthetase central for2 phospholipid biosynthesis (s200c/s223c, inactive mutant) Phyre2 PDB 5guf chain A Region: 174 - 306 Aligned: 125 Modelled: 133 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:cdp-archaeol synthase; PDBTitle: structural insight into an intramembrane enzyme for archaeal membrane2 lipids biosynthesis Phyre2 PDB 3b9y chain A Region: 57 - 282 Aligned: 209 Modelled: 225 Confidence: 96.0% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:ammonium transporter family rh-like protein; PDBTitle: crystal structure of the nitrosomonas europaea rh protein Phyre2 PDB 5aex chain J Region: 51 - 283 Aligned: 212 Modelled: 233 Confidence: 88.2% Identity: 12% PDB header:membrane protein Chain: J: PDB Molecule:ammonium transporter mep2; PDBTitle: crystal structure of saccharomyces cerevisiae mep2 Phyre2 PDB 5aex chain B Region: 51 - 282 Aligned: 211 Modelled: 225 Confidence: 85.3% Identity: 17% PDB header:membrane protein Chain: B: PDB Molecule:ammonium transporter mep2; PDBTitle: crystal structure of saccharomyces cerevisiae mep2 Phyre2 PDB 2nuu chain F Region: 113 - 283 Aligned: 153 Modelled: 171 Confidence: 83.0% Identity: 14% PDB header:transport protein/signaling protein Chain: F: PDB Molecule:ammonia channel; PDBTitle: regulating the escherichia coli ammonia channel: the crystal structure2 of the amtb-glnk complex Phyre2 PDB 6eu6 chain A Region: 50 - 282 Aligned: 208 Modelled: 220 Confidence: 77.0% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:ammonium transporter; PDBTitle: sensor amt protein Phyre2 PDB 3hd6 chain A Region: 115 - 282 Aligned: 160 Modelled: 168 Confidence: 75.7% Identity: 12% PDB header:membrane protein, transport protein Chain: A: PDB Molecule:ammonium transporter rh type c; PDBTitle: crystal structure of the human rhesus glycoprotein rhcg Phyre2 PDB 5aez chain A Region: 50 - 283 Aligned: 215 Modelled: 234 Confidence: 62.7% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:mep2; PDBTitle: crystal structure of candida albicans mep2 Phyre2 PDB 3r2u chain C Region: 255 - 282 Aligned: 27 Modelled: 28 Confidence: 61.7% Identity: 22% PDB header:hydrolase Chain: C: PDB Molecule:metallo-beta-lactamase family protein; PDBTitle: 2.1 angstrom resolution crystal structure of metallo-beta-lactamase2 from staphylococcus aureus subsp. aureus col Phyre2 PDB 2p97 chain A domain 1 Region: 259 - 292 Aligned: 33 Modelled: 34 Confidence: 57.4% Identity: 30% Fold: Metallo-hydrolase/oxidoreductase Superfamily: Metallo-hydrolase/oxidoreductase Family: Ava3068-like Phyre2 PDB 2gcu chain D Region: 259 - 282 Aligned: 24 Modelled: 24 Confidence: 57.1% Identity: 21% PDB header:hydrolase Chain: D: PDB Molecule:putative hydroxyacylglutathione hydrolase 3; PDBTitle: x-ray structure of gene product from arabidopsis thaliana at1g53580 Phyre2 PDB 4chl chain A Region: 259 - 282 Aligned: 24 Modelled: 24 Confidence: 55.4% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:persulfide dioxygenase ethe1, mitochondrial; PDBTitle: human ethylmalonic encephalopathy protein 1 (hethe1) Phyre2 PDB 2xf4 chain A Region: 257 - 282 Aligned: 26 Modelled: 26 Confidence: 54.3% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:hydroxyacylglutathione hydrolase; PDBTitle: crystal structure of salmonella enterica serovar2 typhimurium ycbl Phyre2 PDB 5ve5 chain C Region: 257 - 282 Aligned: 26 Modelled: 26 Confidence: 54.1% Identity: 12% PDB header:oxidoreductase, transferase Chain: C: PDB Molecule:bpprf; PDBTitle: crystal structure of persulfide dioxygenase rhodanese fusion protein2 with rhodanese domain inactivating mutation (c314s) from burkholderia3 phytofirmans in complex with glutathione Phyre2 PDB 4ysk chain A Region: 257 - 282 Aligned: 25 Modelled: 26 Confidence: 53.2% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase domain protein; PDBTitle: crystal structure of apo-form sdoa from pseudomonas putida Phyre2 PDB 2mc5 chain A Region: 261 - 273 Aligned: 13 Modelled: 13 Confidence: 51.8% Identity: 62% PDB header:protein binding Chain: A: PDB Molecule:45l; PDBTitle: a bacteriophage transcription regulator inhibits bacterial2 transcription initiation by -factor displacement Phyre2 PDB 3tp9 chain B Region: 257 - 282 Aligned: 25 Modelled: 26 Confidence: 50.8% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase and rhodanese domain protein; PDBTitle: crystal structure of alicyclobacillus acidocaldarius protein with2 beta-lactamase and rhodanese domains Phyre2 PDB 4ysb chain B Region: 259 - 282 Aligned: 24 Modelled: 24 Confidence: 50.6% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:metallo-beta-lactamase family protein; PDBTitle: crystal structure of ethe1 from myxococcus xanthus Phyre2 1 c4q2eA_ 2 c4q2gA_ 3 c5gufA_ 4 c3b9yA_ 5 c5aexJ_ 6 c5aexB_ 7 c2nuuF_ 8 c6eu6A_ 9 c3hd6A_ 10 c5aezA_ 11 c3r2uC_ 12 d2p97a1 13 c2gcuD_ 14 c4chlA_ 15 c2xf4A_ 16 c5ve5C_ 17 c4yskA_ 18 c2mc5A_ 19 c3tp9B_ 20 c4ysbB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99