1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	R	I	L	T	H	V	P	G	R	T	V	N	R	S	Y	A	L	P	A	L	V	G	S	A	A	G	R	L	S	G	N	H	S	H	G	R	E	A	Y	I	A	L	P	Q	W	A	C	S	R	Q	P	S	T	P	P	L	Q	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																	?	?	?	?	?		?	?	?	?	?	?			?											?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	G	R	I	N	A	L	W	S	L	R	P	V	L	P	M	P	G	R	G	C	Q	L	L	R	L	G	G	R	W	L	S	V	V	C	C	R	N	G	S	M	N	L	V	V	W	A	E	G	N	G	V	A	R	V	I	A	Y	R	W
Secondary structure
SS confidence
Disorder																																							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	R	V	G	R	L	P	V	P	A	R	R	V	G	R	V	I	L	V	D	E	P	A	G	Q	P	G	R	W	G	R	T	A	V	C	A	R	L	S	S	A	D	Q	K	V	D	L	D	R	Q	V	V	G	V	T	A	W	A	T	A
Secondary structure
SS confidence
Disorder												?			?	?					?	?	?	?	?	?	?	?	?															?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	Q	I	P	V	G	K	V	V	T	E	V	G	S	A	L	Y	G	R	R	R	T	F	L	T	L	L	G	D	P	T	V	R	R	I	V	M	K	R	R	D	R	L	G	R	F	G	F	E	C	V	Q	A	V	L	A	A	D	G	R
Secondary structure
SS confidence
Disorder																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.
Sequence		E	L	V	V	V	D	S	A	D	V	D	D	D	V	V	G	D	I	T	E	I	L	T	S	I	C	A	R	L	Y	G	K	R	A	A	G	N	R	A	A	R	A	V	A	A	A	A	R	A	G	G	H	E	A	R
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?																																					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 38%) Beta strand ( 21%)

Rank Aligned region

PDB 6dgb chain A Region: 152 - 289 Aligned: 133 Modelled: 138 Confidence: 100.0% Identity: 54% PDB header:hydrolase Chain: A: PDB Molecule:is607 family transposase is1535; PDBTitle: crystal structure of the c-terminal catalytic domain of is1535 tnpa,2 an is607-like serine recombinase Phyre2 PDB 3lhk chain A Region: 150 - 292 Aligned: 140 Modelled: 143 Confidence: 99.9% Identity: 24% PDB header:dna binding protein Chain: A: PDB Molecule:putative dna binding protein mj0014; PDBTitle: crystal structure of putative dna binding protein from2 methanocaldococcus jannaschii. Phyre2 PDB 3lhf chain C Region: 149 - 287 Aligned: 135 Modelled: 139 Confidence: 99.9% Identity: 36% PDB header:recombination Chain: C: PDB Molecule:serine recombinase; PDBTitle: the crystal structure of a serine recombinase from sulfolobus2 solfataricus to 2.3a Phyre2 PDB 6dgc chain A Region: 151 - 289 Aligned: 139 Modelled: 139 Confidence: 99.9% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:isc1926 tnpa c-terminal catalytic domain; PDBTitle: crystal structure of the c-terminal catalytic domain of isc1926 tnpa,2 an is607-like serine recombinase Phyre2 PDB 1gdt chain A domain 2 Region: 151 - 291 Aligned: 134 Modelled: 141 Confidence: 99.8% Identity: 23% Fold: Resolvase-like Superfamily: Resolvase-like Family: gamma,delta resolvase, catalytic domain Phyre2 PDB 3bvp chain B Region: 150 - 275 Aligned: 122 Modelled: 126 Confidence: 99.8% Identity: 19% PDB header:recombination Chain: B: PDB Molecule:tp901-1 integrase; PDBTitle: crystal structure of the n-terminal catalytic domain of tp901-12 integrase Phyre2 PDB 3g13 chain B Region: 151 - 274 Aligned: 123 Modelled: 124 Confidence: 99.8% Identity: 15% PDB header:recombination Chain: B: PDB Molecule:putative conjugative transposon recombinase; PDBTitle: crystal structure of putative conjugative transposon recombinase from2 clostridium difficile Phyre2 PDB 3guv chain A Region: 151 - 289 Aligned: 136 Modelled: 139 Confidence: 99.8% Identity: 17% PDB header:recombination Chain: A: PDB Molecule:site-specific recombinase, resolvase family protein; PDBTitle: crystal structure of a resolvase family site-specific recombinase from2 streptococcus pneumoniae Phyre2 PDB 2gm4 chain B Region: 152 - 295 Aligned: 133 Modelled: 144 Confidence: 99.8% Identity: 24% PDB header:recombination, dna Chain: B: PDB Molecule:transposon gamma-delta resolvase; PDBTitle: an activated, tetrameric gamma-delta resolvase: hin chimaera bound to2 cleaved dna Phyre2 PDB 2gm4 chain A domain 2 Region: 151 - 291 Aligned: 130 Modelled: 141 Confidence: 99.8% Identity: 24% Fold: Resolvase-like Superfamily: Resolvase-like Family: gamma,delta resolvase, catalytic domain Phyre2 PDB 2mhc chain A Region: 148 - 253 Aligned: 106 Modelled: 106 Confidence: 99.7% Identity: 19% PDB header:recombination Chain: A: PDB Molecule:tnpx; PDBTitle: nmr structure of the catalytic domain of the large serine resolvase2 tnpx Phyre2 PDB 4bqq chain B Region: 151 - 282 Aligned: 131 Modelled: 132 Confidence: 99.7% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: protein crystal structure of the n-terminal and recombinase domains of2 the streptomyces temperate phage serine recombinase, fc31 integrase. Phyre2 PDB 3plo chain X Region: 152 - 279 Aligned: 119 Modelled: 122 Confidence: 99.6% Identity: 17% PDB header:recombination Chain: X: PDB Molecule:dna-invertase; PDBTitle: crystal structure of the fis-independent mutant of gin Phyre2 PDB 2rsl chain A Region: 151 - 275 Aligned: 111 Modelled: 125 Confidence: 99.6% Identity: 24% Fold: Resolvase-like Superfamily: Resolvase-like Family: gamma,delta resolvase, catalytic domain Phyre2 PDB 3pkz chain K Region: 151 - 269 Aligned: 111 Modelled: 119 Confidence: 99.6% Identity: 24% PDB header:recombination Chain: K: PDB Molecule:recombinase sin; PDBTitle: structural basis for catalytic activation of a serine recombinase Phyre2 PDB 2r0q chain F Region: 151 - 295 Aligned: 131 Modelled: 145 Confidence: 99.5% Identity: 21% PDB header:recombination/dna Chain: F: PDB Molecule:putative transposon tn552 dna-invertase bin3; PDBTitle: crystal structure of a serine recombinase- dna regulatory2 complex Phyre2 PDB 4m6f chain A Region: 155 - 295 Aligned: 132 Modelled: 141 Confidence: 99.5% Identity: 20% PDB header:hydrolase/dna Chain: A: PDB Molecule:dna-invertase; PDBTitle: dimer of the g-segment invertase bound to a dna substrate Phyre2 PDB 1hx7 chain A Region: 151 - 256 Aligned: 100 Modelled: 106 Confidence: 99.5% Identity: 26% Fold: Resolvase-like Superfamily: Resolvase-like Family: gamma,delta resolvase, catalytic domain Phyre2 PDB 1pm6 chain A Region: 101 - 143 Aligned: 43 Modelled: 43 Confidence: 82.7% Identity: 28% Fold: Putative DNA-binding domain Superfamily: Putative DNA-binding domain Family: Excisionase-like Phyre2 PDB 1rh6 chain A Region: 101 - 144 Aligned: 44 Modelled: 44 Confidence: 73.5% Identity: 30% Fold: Putative DNA-binding domain Superfamily: Putative DNA-binding domain Family: Excisionase-like Phyre2 1 c6dgbA_ 2 c3lhkA_ 3 c3lhfC_ 4 c6dgcA_ 5 d1gdta2 6 c3bvpB_ 7 c3g13B_ 8 c3guvA_ 9 c2gm4B_ 10 d2gm4a2 11 c2mhcA_ 12 c4bqqB_ 13 c3ploX_ 14 d2rsla_ 15 c3pkzK_ 16 c2r0qF_ 17 c4m6fA_ 18 d1hx7a_ 19 d1pm6a_ 20 d1rh6a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99