1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	L	K	T	M	T	R	V	Q	L	G	A	M	G	E	A	L	A	V	D	Y	L	T	S	M	G	L	R	I	L	N	R	N	W	R	C	R	Y	G	E	L	D	V	I	A	C	D	A	A	T	R	T	V	V	F	V	E	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	T	R	T	G	D	G	Y	G	G	L	A	H	A	V	T	E	R	K	V	R	R	L	R	R	L	A	G	L	W	L	A	D	Q	E	E	R	W	A	A	V	R	I	D	V	I	G	V	R	V	G	P	K	N	S	G	R	T	P	E
Secondary structure
SS confidence
Disorder																																																						?		?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		L	T	H	L	Q	G	I	G
Secondary structure
SS confidence
Disorder							?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 30%) Beta strand ( 34%)

Rank Aligned region

PDB 3fov chain A Region: 16 - 126 Aligned: 94 Modelled: 111 Confidence: 100.0% Identity: 41% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0102 protein rpa0323; PDBTitle: crystal structure of protein rpa0323 of unknown function from2 rhodopseudomonas palustris Phyre2 PDB 1gef chain A Region: 13 - 90 Aligned: 68 Modelled: 76 Confidence: 97.4% Identity: 22% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Hjc-like Phyre2 PDB 1ob8 chain A Region: 13 - 90 Aligned: 67 Modelled: 76 Confidence: 96.9% Identity: 24% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Hjc-like Phyre2 PDB 2eo0 chain A Region: 16 - 90 Aligned: 64 Modelled: 75 Confidence: 96.6% Identity: 22% PDB header:dna binding protein Chain: A: PDB Molecule:hypothetical protein st1444; PDBTitle: crystal structure of holliday junction resolvase st1444 Phyre2 PDB 2wj0 chain B Region: 13 - 90 Aligned: 70 Modelled: 76 Confidence: 96.2% Identity: 23% PDB header:hydrolase/dna Chain: B: PDB Molecule:archaeal hjc; PDBTitle: crystal structures of holliday junction resolvases from2 archaeoglobus fulgidus bound to dna substrate Phyre2 PDB 5gke chain B Region: 28 - 66 Aligned: 38 Modelled: 39 Confidence: 95.3% Identity: 26% PDB header:hydrolase/dna Chain: B: PDB Molecule:endonuclease endoms; PDBTitle: structure of endoms-dsdna1 complex Phyre2 PDB 1hh1 chain A Region: 17 - 90 Aligned: 65 Modelled: 72 Confidence: 95.3% Identity: 20% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Hjc-like Phyre2 PDB 2vld chain A Region: 17 - 66 Aligned: 49 Modelled: 50 Confidence: 94.3% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease nucs; PDBTitle: crystal structure of a repair endonuclease from pyrococcus abyssi Phyre2 PDB 4dap chain A Region: 15 - 89 Aligned: 74 Modelled: 75 Confidence: 94.0% Identity: 23% PDB header:dna binding protein Chain: A: PDB Molecule:sugar fermentation stimulation protein a; PDBTitle: the structure of escherichia coli sfsa Phyre2 PDB 3dnx chain A Region: 18 - 62 Aligned: 44 Modelled: 45 Confidence: 93.7% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein spo1766; PDBTitle: spo1766 protein of unknown function from silicibacter pomeroyi. Phyre2 PDB 1y88 chain A domain 2 Region: 17 - 73 Aligned: 55 Modelled: 55 Confidence: 93.7% Identity: 22% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: MRR-like Phyre2 PDB 1y88 chain A Region: 17 - 66 Aligned: 47 Modelled: 48 Confidence: 93.6% Identity: 21% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein af1548; PDBTitle: crystal structure of protein of unknown function af1548 Phyre2 PDB 4dav chain A Region: 14 - 89 Aligned: 74 Modelled: 76 Confidence: 91.2% Identity: 22% PDB header:hydrolase/dna Chain: A: PDB Molecule:sugar fermentation stimulation protein homolog; PDBTitle: the structure of pyrococcus furiosus sfsa in complex with dna Phyre2 PDB 2inb chain A domain 1 Region: 18 - 62 Aligned: 44 Modelled: 45 Confidence: 83.8% Identity: 25% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: XisH-like Phyre2 PDB 2okf chain A domain 1 Region: 18 - 62 Aligned: 44 Modelled: 45 Confidence: 81.9% Identity: 23% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: XisH-like Phyre2 PDB 4qbn chain A Region: 17 - 88 Aligned: 64 Modelled: 72 Confidence: 79.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:nuclease; PDBTitle: vrr_nuc domain Phyre2 PDB 1xmx chain A Region: 13 - 62 Aligned: 48 Modelled: 48 Confidence: 78.4% Identity: 27% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Hypothetical protein VC1899 Phyre2 PDB 1cw0 chain A Region: 17 - 59 Aligned: 40 Modelled: 43 Confidence: 73.9% Identity: 25% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 4oc8 chain A Region: 17 - 86 Aligned: 60 Modelled: 70 Confidence: 73.9% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:restriction endonuclease aspbhi; PDBTitle: dna modification-dependent restriction endonuclease aspbhi Phyre2 PDB 1m0d chain A Region: 17 - 103 Aligned: 65 Modelled: 87 Confidence: 70.2% Identity: 20% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Endonuclease I (Holliday junction resolvase) Phyre2 1 c3fovA_ 2 d1gefa_ 3 d1ob8a_ 4 c2eo0A_ 5 c2wj0B_ 6 c5gkeB_ 7 d1hh1a_ 8 c2vldA_ 9 c4dapA_ 10 c3dnxA_ 11 d1y88a2 12 c1y88A_ 13 c4davA_ 14 d2inba1 15 d2okfa1 16 c4qbnA_ 17 d1xmxa_ 18 d1cw0a_ 19 c4oc8A_ 20 d1m0da_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99