1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	Y	A	T	A	H	R	R	V	R	H	L	S	A	D	Q	V	I	T	R	P	E	T	L	A	V	E	E	P	L	E	I	R	V	N	G	T	P	V	T	V	T	M	R	T	P	G	S	D	F	E	L	V	Q	G	F	L	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?										?		?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	G	V	V	A	H	R	E	D	V	L	T	V	S	Y	C	G	R	R	V	E	G	N	A	T	G	A	S	T	Y	N	V	L	D	V	A	L	A	P	G	V	K	P	P	D	V	D	V	T	R	T	F	Y	T	T	S	S	C	G	V
Secondary structure
SS confidence
Disorder																																										?	?	?		?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		C	G	K	A	S	L	Q	A	V	S	Q	V	S	R	F	A	P	G	G	D	P	A	T	V	A	A	D	T	L	K	A	M	P	D	Q	L	R	R	A	Q	K	V	F	A	R	T	G	G	L	H	A	A	A	L	F	G	V	D	G	A
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		M	L	A	V	R	E	D	I	G	R	H	N	A	V	D	K	V	I	G	W	A	F	E	R	D	R	I	P	L	G	A	S	V	L	L	V	S	G	R	A	S	F	E	L	T	Q	K	A	L	M	A	G	I	P	V	L	A	A	V	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.
Sequence		A	P	S	S	L	A	V	S	L	A	D	A	S	G	I	T	L	V	A	F	L	R	G	D	S	M	N	V	Y	T	R	A	D	R	I	T
Secondary structure
SS confidence
Disorder																																		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 28%) Beta strand ( 35%)

Rank Aligned region

PDB 4pde chain A Region: 4 - 276 Aligned: 242 Modelled: 243 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:protein fdhd; PDBTitle: crystal structure of fdhd in complex with gdp Phyre2 PDB 2pw9 chain A domain 1 Region: 3 - 275 Aligned: 230 Modelled: 233 Confidence: 100.0% Identity: 25% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: FdhD/NarQ Phyre2 PDB 2nu7 chain A domain 1 Region: 208 - 259 Aligned: 52 Modelled: 52 Confidence: 89.1% Identity: 21% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: CoA-binding domain Phyre2 PDB 1oi7 chain A domain 1 Region: 198 - 259 Aligned: 60 Modelled: 62 Confidence: 88.9% Identity: 23% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: CoA-binding domain Phyre2 PDB 6hxq chain A Region: 204 - 259 Aligned: 54 Modelled: 56 Confidence: 68.3% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:citryl-coa synthetase small subunit; PDBTitle: structure of citryl-coa synthetase from hydrogenobacter thermophilus Phyre2 PDB 3mwd chain B Region: 204 - 259 Aligned: 54 Modelled: 56 Confidence: 65.9% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:atp-citrate synthase; PDBTitle: truncated human atp-citrate lyase with citrate bound Phyre2 PDB 3evn chain A Region: 157 - 258 Aligned: 96 Modelled: 102 Confidence: 64.6% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:oxidoreductase, gfo/idh/moca family; PDBTitle: crystal structure of putative oxidoreductase from streptococcus2 agalactiae 2603v/r Phyre2 PDB 2duw chain A Region: 213 - 259 Aligned: 47 Modelled: 47 Confidence: 62.6% Identity: 19% PDB header:ligand binding protein Chain: A: PDB Molecule:putative coa-binding protein; PDBTitle: solution structure of putative coa-binding protein of2 klebsiella pneumoniae Phyre2 PDB 1iuk chain A Region: 223 - 259 Aligned: 37 Modelled: 37 Confidence: 60.3% Identity: 16% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: CoA-binding domain Phyre2 PDB 1y88 chain A Region: 234 - 259 Aligned: 26 Modelled: 26 Confidence: 56.4% Identity: 27% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein af1548; PDBTitle: crystal structure of protein of unknown function af1548 Phyre2 PDB 4h3v chain A Region: 202 - 262 Aligned: 60 Modelled: 61 Confidence: 53.6% Identity: 27% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:oxidoreductase domain protein; PDBTitle: crystal structure of oxidoreductase domain protein from kribbella2 flavida Phyre2 PDB 3ff4 chain A Region: 213 - 259 Aligned: 47 Modelled: 47 Confidence: 52.8% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of uncharacterized protein chu_1412 Phyre2 PDB 3dty chain A Region: 194 - 258 Aligned: 64 Modelled: 65 Confidence: 52.6% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:oxidoreductase, gfo/idh/moca family; PDBTitle: crystal structure of an oxidoreductase from pseudomonas2 syringae Phyre2 PDB 1y88 chain A domain 2 Region: 234 - 265 Aligned: 32 Modelled: 32 Confidence: 51.8% Identity: 22% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: MRR-like Phyre2 PDB 2csu chain A domain 1 Region: 213 - 259 Aligned: 47 Modelled: 47 Confidence: 51.5% Identity: 13% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: CoA-binding domain Phyre2 PDB 1y81 chain A domain 1 Region: 213 - 259 Aligned: 47 Modelled: 47 Confidence: 50.8% Identity: 19% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: CoA-binding domain Phyre2 PDB 4xb1 chain B Region: 213 - 257 Aligned: 45 Modelled: 45 Confidence: 50.4% Identity: 24% PDB header:oxidoreductase Chain: B: PDB Molecule:319aa long hypothetical homoserine dehydrogenase; PDBTitle: hyperthermophilic archaeal homoserine dehydrogenase in complex with2 nadph Phyre2 PDB 5yee chain A Region: 147 - 197 Aligned: 45 Modelled: 51 Confidence: 45.9% Identity: 24% PDB header:structural protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of lokiprofilin1/rabbit actin complex Phyre2 PDB 1j5p chain A domain 4 Region: 222 - 258 Aligned: 37 Modelled: 37 Confidence: 44.0% Identity: 11% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1oi7 chain A Region: 201 - 259 Aligned: 57 Modelled: 59 Confidence: 43.2% Identity: 25% PDB header:synthetase Chain: A: PDB Molecule:succinyl-coa synthetase alpha chain; PDBTitle: the crystal structure of succinyl-coa synthetase alpha2 subunit from thermus thermophilus Phyre2 1 c4pdeA_ 2 d2pw9a1 3 d2nu7a1 4 d1oi7a1 5 c6hxqA_ 6 c3mwdB_ 7 c3evnA_ 8 c2duwA_ 9 d1iuka_ 10 c1y88A_ 11 c4h3vA_ 12 c3ff4A_ 13 c3dtyA_ 14 d1y88a2 15 d2csua1 16 d1y81a1 17 c4xb1B_ 18 c5yeeA_ 19 d1j5pa4 20 c1oi7A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114