1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	E	D	L	E	K	Y	E	T	E	M	E	L	S	L	Y	R	E	Y	K	D	I	V	G	Q	F	S	Y	V	V	E	T	E	R	R	F	Y	L	A	N	S	V	E	M	V	P	R	N	T	D	G	E	V	Y	F	E	L	R
Secondary structure
SS confidence
Disorder		?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.
Sequence		L	A	D	A	W	V	W	D	M	Y	R	P	A	R	F	V	K	Q	V	R	V	V	T	F	K	D	V	N	I	E	E	V	E	K	P	E	L	R	L	P	E
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 35%) Beta strand ( 46%)

Rank Aligned region

PDB 2cg9 chain A Region: 1 - 67 Aligned: 56 Modelled: 67 Confidence: 61.6% Identity: 21% PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex Phyre2 PDB 5uls chain A Region: 1 - 67 Aligned: 56 Modelled: 67 Confidence: 53.3% Identity: 27% PDB header:chaperone Chain: A: PDB Molecule:endoplasmin; PDBTitle: structure of grp94 in the active conformation Phyre2 PDB 2fa8 chain A domain 1 Region: 42 - 75 Aligned: 31 Modelled: 34 Confidence: 45.9% Identity: 29% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: Selenoprotein W-related Phyre2 PDB 5fwk chain A Region: 1 - 67 Aligned: 56 Modelled: 67 Confidence: 42.6% Identity: 21% PDB header:signaling protein Chain: A: PDB Molecule:heat shock protein hsp 90 beta; PDBTitle: atomic cryoem structure of hsp90-cdc37-cdk4 complex Phyre2 PDB 2ojl chain B Region: 42 - 75 Aligned: 31 Modelled: 34 Confidence: 40.3% Identity: 35% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of q7waf1_borpa from bordetella parapertussis.2 northeast structural genomics target bpr68. Phyre2 PDB 4ipe chain A Region: 1 - 67 Aligned: 56 Modelled: 67 Confidence: 37.1% Identity: 32% PDB header:chaperone Chain: A: PDB Molecule:tnf receptor-associated protein 1; PDBTitle: crystal structure of mitochondrial hsp90 (trap1) with amppnp Phyre2 PDB 2p0g chain B Region: 42 - 75 Aligned: 31 Modelled: 34 Confidence: 36.3% Identity: 26% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:selenoprotein w-related protein; PDBTitle: crystal structure of selenoprotein w-related protein from vibrio2 cholerae. northeast structural genomics target vcr75 Phyre2 PDB 5tth chain A Region: 1 - 67 Aligned: 56 Modelled: 67 Confidence: 29.7% Identity: 34% PDB header:chaperone Chain: A: PDB Molecule:c-terminal spycatcher fusion of wildtype zebrafish tnf PDBTitle: heterodimeric spycatcher/spytag-fused zebrafish trap1 in atp/adp-2 hybrid state Phyre2 PDB 4j0b chain B Region: 1 - 67 Aligned: 58 Modelled: 67 Confidence: 21.6% Identity: 29% PDB header:chaperone Chain: B: PDB Molecule:tnf receptor-associated protein 1; PDBTitle: structure of mitochondrial hsp90 (trap1) with adp-bef3 Phyre2 PDB 3met chain B Region: 38 - 85 Aligned: 45 Modelled: 48 Confidence: 19.4% Identity: 29% PDB header:transcription Chain: B: PDB Molecule:saga-associated factor 29 homolog; PDBTitle: crystal structure of sgf29 in complex with h3k4me2 Phyre2 PDB 2obk chain E Region: 42 - 75 Aligned: 31 Modelled: 34 Confidence: 14.1% Identity: 16% PDB header:structural genomics, unknown function Chain: E: PDB Molecule:selt/selw/selh selenoprotein domain; PDBTitle: x-ray structure of the putative se binding protein from pseudomonas2 fluorescens. northeast structural genomics consortium target plr6. Phyre2 PDB 3peh chain B Region: 1 - 68 Aligned: 59 Modelled: 66 Confidence: 13.2% Identity: 29% PDB header:chaperone Chain: B: PDB Molecule:endoplasmin homolog; PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative Phyre2 PDB 3dup chain B Region: 10 - 55 Aligned: 45 Modelled: 45 Confidence: 11.2% Identity: 33% PDB header:hydrolase Chain: B: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of mutt/nudix family hydrolase from rhodospirillum2 rubrum atcc 11170 Phyre2 PDB 3oq0 chain D Region: 66 - 94 Aligned: 23 Modelled: 29 Confidence: 11.2% Identity: 39% PDB header:cell cycle Chain: D: PDB Molecule:dbf4; PDBTitle: crystal structure of motif n of saccharomyces cerevisiae dbf4 Phyre2 PDB 6qpi chain A Region: 14 - 32 Aligned: 19 Modelled: 19 Confidence: 10.5% Identity: 37% PDB header:membrane protein Chain: A: PDB Molecule:anoctamin-6; PDBTitle: cryo-em structure of calcium-free mtmem16f lipid scramblase in2 nanodisc Phyre2 PDB 6bgi chain A Region: 7 - 32 Aligned: 26 Modelled: 26 Confidence: 9.2% Identity: 27% PDB header:membrane protein Chain: A: PDB Molecule:anoctamin-1; PDBTitle: cryo-em structure of the tmem16a calcium-activated chloride channel in2 nanodisc Phyre2 PDB 5nl2 chain A Region: 2 - 32 Aligned: 31 Modelled: 31 Confidence: 8.8% Identity: 26% PDB header:membrane protein Chain: A: PDB Molecule:anoctamin-1; PDBTitle: cryo-em structure of the mtmem16a ion channel at 6.6 a resolution. Phyre2 PDB 1wwt chain A Region: 66 - 86 Aligned: 21 Modelled: 21 Confidence: 7.9% Identity: 33% PDB header:ligase Chain: A: PDB Molecule:threonyl-trna synthetase, cytoplasmic; PDBTitle: solution structure of the tgs domain from human threonyl-2 trna synthetase Phyre2 PDB 2npb chain A Region: 40 - 76 Aligned: 34 Modelled: 37 Confidence: 7.2% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:selenoprotein w; PDBTitle: nmr solution structure of mouse selw Phyre2 PDB 2o1u chain A Region: 1 - 67 Aligned: 39 Modelled: 67 Confidence: 7.0% Identity: 28% PDB header:chaperone Chain: A: PDB Molecule:endoplasmin; PDBTitle: structure of full length grp94 with amp-pnp bound Phyre2 1 c2cg9A_ 2 c5ulsA_ 3 d2fa8a1 4 c5fwkA_ 5 c2ojlB_ 6 c4ipeA_ 7 c2p0gB_ 8 c5tthA_ 9 c4j0bB_ 10 c3metB_ 11 c2obkE_ 12 c3pehB_ 13 c3dupB_ 14 c3oq0D_ 15 c6qpiA_ 16 c6bgiA_ 17 c5nl2A_ 18 c1wwtA_ 19 c2npbA_ 20 c2o1uA_ 21 22 23 24 25 26 27 28