1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	K	T	W	P	P	R	T	V	I	R	K	S	G	G	L	R	G	M	R	T	L	E	S	A	L	H	R	G	G	L	G	P	V	A	G	V	D	E	V	G	R	G	A	C	A	G	P	L	V	V	A	A	C	V	L	G	P	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	I	A	S	L	A	A	L	D	D	S	K	K	L	S	E	Q	A	R	E	K	L	F	P	L	I	C	R	Y	A	V	A	Y	H	V	V	F	I	P	S	A	E	V	D	R	R	G	V	H	V	A	N	I	E	G	M	R	R	A	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	G	L	A	V	R	P	G	Y	V	L	S	D	G	F	R	V	P	G	L	P	M	P	S	L	P	V	I	G	G	D	A	A	A	A	C	I	A	A	A	S	V	L	A	K	V	S	R	D	R	V	M	V	A	L	D	A	D	H	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	Y	G	F	A	E	H	K	G	Y	S	T	P	A	H	S	R	A	L	A	R	L	G	P	C	P	Q	H	R	Y	S	F	I	N	V	R	R	V	A	S	G	S	N	T	A	E	V	A	D	G	Q	P	D	P	R	D	G	T	A	Q
Secondary structure
SS confidence
Disorder																																													?					?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.
Sequence		T	G	E	G	R	W	S	K	S	S	H	P	A	T	M	R	A	T	G	R	A	Q	G	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?							?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 46%) Beta strand ( 13%)

Rank Aligned region

PDB 5y9p chain A Region: 11 - 219 Aligned: 201 Modelled: 209 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease hii; PDBTitle: staphylococcus aureus rnase hii Phyre2 PDB 2etj chain A domain 1 Region: 26 - 220 Aligned: 179 Modelled: 181 Confidence: 100.0% Identity: 39% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Ribonuclease H Phyre2 PDB 2etj chain A Region: 26 - 220 Aligned: 179 Modelled: 181 Confidence: 100.0% Identity: 39% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease hii; PDBTitle: crystal structure of ribonuclease hii (ec 3.1.26.4) (rnase hii)2 (tm0915) from thermotoga maritima at 1.74 a resolution Phyre2 PDB 3kio chain A Region: 32 - 219 Aligned: 188 Modelled: 188 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease h2 subunit a; PDBTitle: mouse rnase h2 complex Phyre2 PDB 1io2 chain A Region: 34 - 219 Aligned: 186 Modelled: 186 Confidence: 100.0% Identity: 28% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Ribonuclease H Phyre2 PDB 1uax chain A Region: 34 - 219 Aligned: 184 Modelled: 186 Confidence: 100.0% Identity: 29% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Ribonuclease H Phyre2 PDB 1i39 chain A Region: 34 - 221 Aligned: 187 Modelled: 188 Confidence: 100.0% Identity: 26% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Ribonuclease H Phyre2 PDB 1i3a chain A Region: 34 - 219 Aligned: 185 Modelled: 186 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease hii; PDBTitle: rnase hii from archaeoglobus fulgidus with cobalt hexammine2 chloride Phyre2 PDB 1eke chain A Region: 33 - 219 Aligned: 181 Modelled: 182 Confidence: 100.0% Identity: 22% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Ribonuclease H Phyre2 PDB 2d0b chain A Region: 31 - 220 Aligned: 186 Modelled: 190 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease hiii; PDBTitle: crystal structure of bst-rnase hiii in complex with mg2+ Phyre2 PDB 3vn5 chain A Region: 23 - 212 Aligned: 185 Modelled: 190 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease hiii; PDBTitle: crystal structure of aquifex aeolicus rnase h3 Phyre2 PDB 4py5 chain A Region: 21 - 213 Aligned: 187 Modelled: 193 Confidence: 100.0% Identity: 24% PDB header:hydrolase/dna/rna Chain: A: PDB Molecule:ribonuclease; PDBTitle: thermovibrio ammonificans rnase h3 in complex with 19-mer rna/dna Phyre2 PDB 3goc chain B Region: 1 - 137 Aligned: 109 Modelled: 113 Confidence: 92.0% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:endonuclease v; PDBTitle: crystal structure of the endonuclease v (sav1684) from streptomyces2 avermitilis. northeast structural genomics consortium target svr196 Phyre2 PDB 2w36 chain B Region: 115 - 137 Aligned: 23 Modelled: 23 Confidence: 55.7% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:endonuclease v; PDBTitle: structures of endonuclease v with dna reveal initiation of2 deaminated adenine repair Phyre2 PDB 3ga2 chain A Region: 115 - 137 Aligned: 23 Modelled: 23 Confidence: 52.9% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease v; PDBTitle: crystal structure of the endonuclease_v (bsu36170) from bacillus2 subtilis, northeast structural genomics consortium target sr624 Phyre2 PDB 4xpu chain A Region: 115 - 137 Aligned: 23 Modelled: 23 Confidence: 52.9% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease v; PDBTitle: the crystal structure of endov from e.coli Phyre2 PDB 5us5 chain B Region: 159 - 179 Aligned: 21 Modelled: 21 Confidence: 40.6% Identity: 24% PDB header:structural genomics Chain: B: PDB Molecule:upf0297 protein ef_1202; PDBTitle: solution structure of the ireb homodimer Phyre2 PDB 1c8b chain A Region: 49 - 116 Aligned: 66 Modelled: 68 Confidence: 24.8% Identity: 20% Fold: Phosphorylase/hydrolase-like Superfamily: HybD-like Family: Germination protease Phyre2 PDB 1zec chain A Region: 243 - 250 Aligned: 8 Modelled: 8 Confidence: 23.3% Identity: 75% PDB header:viral peptide Chain: A: PDB Molecule:nef1-25; PDBTitle: nmr solution structure of nef1-25, 20 structures Phyre2 PDB 2nrz chain B Region: 109 - 156 Aligned: 47 Modelled: 48 Confidence: 23.0% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:uvrabc system protein c; PDBTitle: crystal structure of the c-terminal half of uvrc bound to its2 catalytic divalent cation Phyre2 1 c5y9pA_ 2 d2etja1 3 c2etjA_ 4 c3kioA_ 5 d1io2a_ 6 d1uaxa_ 7 d1i39a_ 8 c1i3aA_ 9 d1ekea_ 10 c2d0bA_ 11 c3vn5A_ 12 c4py5A_ 13 c3gocB_ 14 c2w36B_ 15 c3ga2A_ 16 c4xpuA_ 17 c5us5B_ 18 d1c8ba_ 19 c1zecA_ 20 c2nrzB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99