1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	E	T	T	D	S	P	S	E	R	Q	P	G	P	A	E	P	E	L	S	S	R	D	P	D	I	A	G	Q	V	F	D	A	A	P	F	D	A	A	P	D	A	D	S	E	G	D	S	K	A	A	K	T	D	E	P	R	P	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	R	S	T	L	R	E	F	A	V	L	A	V	I	A	V	V	L	Y	Y	V	M	L	T	F	V	A	R	P	Y	L	I	P	S	E	S	M	E	P	T	L	H	G	C	S	T	C	V	G	D	R	I	M	V	D	K	L	S	Y	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	G	S	P	Q	P	G	D	V	I	V	F	R	G	P	P	S	W	N	V	G	Y	K	S	I	R	S	H	N	V	A	V	R	W	V	Q	N	A	L	S	F	I	G	F	V	P	P	D	E	N	D	L	V	K	R	V	I	A	V	G
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	Q	T	V	Q	C	R	S	D	T	G	L	T	V	N	G	R	P	L	K	E	P	Y	L	D	P	A	T	M	M	A	D	P	S	I	Y	P	C	L	G	S	E	F	G	P	V	T	V	P	P	G	R	V	W	V	M	G	D	N	R
Secondary structure
SS confidence
Disorder																															?	?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.
Sequence		T	H	S	A	D	S	R	A	H	C	P	L	L	C	T	D	D	P	L	P	G	T	V	P	V	A	N	V	I	G	K	A	R	L	I	V	W	P	P	S	R	W	G	V	V	R	S	V	N	P	Q	Q	G	R
Secondary structure
SS confidence
Disorder														?	?	?	?	?																								?				?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 29%) Alpha helix ( 16%) Beta strand ( 23%) TM helix ( 9%) (View membrane topology prediction)

Rank Aligned region

PDB 4wvi chain A Region: 85 - 282 Aligned: 148 Modelled: 166 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: A: PDB Molecule:maltose-binding periplasmic protein,signal peptidase ib; PDBTitle: crystal structure of the type-i signal peptidase from staphylococcus2 aureus (spsb) in complex with a substrate peptide (pep2). Phyre2 PDB 1b12 chain A Region: 83 - 284 Aligned: 155 Modelled: 167 Confidence: 100.0% Identity: 36% Fold: LexA/Signal peptidase Superfamily: LexA/Signal peptidase Family: Type 1 signal peptidase Phyre2 PDB 4n31 chain A Region: 80 - 278 Aligned: 139 Modelled: 161 Confidence: 100.0% Identity: 27% PDB header:cell adhesion Chain: A: PDB Molecule:sipa; PDBTitle: structure and activity of streptococcus pyogenes sipa: a signal2 peptidase homologue essential for pilus polymerisation Phyre2 PDB 4me8 chain A Region: 121 - 272 Aligned: 109 Modelled: 121 Confidence: 100.0% Identity: 39% PDB header:hydrolase Chain: A: PDB Molecule:signal peptidase i; PDBTitle: crystal structure of a signal peptidase i (ef3073) from enterococcus2 faecalis v583 at 2.27 a resolution Phyre2 PDB 4nv4 chain A Region: 121 - 275 Aligned: 111 Modelled: 123 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: A: PDB Molecule:signal peptidase i; PDBTitle: 1.8 angstrom crystal structure of signal peptidase i from bacillus2 anthracis. Phyre2 PDB 4k8w chain A Region: 109 - 277 Aligned: 114 Modelled: 136 Confidence: 100.0% Identity: 28% PDB header:cell adhesion Chain: A: PDB Molecule:lepa; PDBTitle: an arm-swapped dimer of the s. pyogenes pilin specific assembly factor2 sipa Phyre2 PDB 1f39 chain A Region: 89 - 283 Aligned: 89 Modelled: 99 Confidence: 97.7% Identity: 30% Fold: LexA/Signal peptidase Superfamily: LexA/Signal peptidase Family: LexA-related Phyre2 PDB 6a2r chain D Region: 89 - 190 Aligned: 59 Modelled: 69 Confidence: 97.4% Identity: 20% PDB header:hydrolase Chain: D: PDB Molecule:lexa repressor; PDBTitle: mycobacterium tuberculosis lexa c-domain ii Phyre2 PDB 3k2z chain A Region: 89 - 237 Aligned: 76 Modelled: 81 Confidence: 97.4% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:lexa repressor; PDBTitle: crystal structure of a lexa protein from thermotoga maritima Phyre2 PDB 1umu chain A Region: 89 - 177 Aligned: 47 Modelled: 51 Confidence: 96.9% Identity: 28% Fold: LexA/Signal peptidase Superfamily: LexA/Signal peptidase Family: LexA-related Phyre2 PDB 1jhf chain A domain 2 Region: 89 - 190 Aligned: 59 Modelled: 64 Confidence: 96.9% Identity: 31% Fold: LexA/Signal peptidase Superfamily: LexA/Signal peptidase Family: LexA-related Phyre2 PDB 3jso chain A Region: 89 - 184 Aligned: 54 Modelled: 58 Confidence: 96.8% Identity: 30% PDB header:hydrolase/dna Chain: A: PDB Molecule:lexa repressor; PDBTitle: classic protein with a new twist: crystal structure of a lexa2 repressor dna complex Phyre2 PDB 1jhh chain B Region: 89 - 190 Aligned: 59 Modelled: 64 Confidence: 96.8% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:lexa repressor; PDBTitle: lexa s119a mutant Phyre2 PDB 3bdn chain B Region: 89 - 283 Aligned: 86 Modelled: 90 Confidence: 96.2% Identity: 30% PDB header:transcription/dna Chain: B: PDB Molecule:lambda repressor; PDBTitle: crystal structure of the lambda repressor Phyre2 PDB 2hnf chain A Region: 89 - 184 Aligned: 55 Modelled: 59 Confidence: 96.0% Identity: 25% PDB header:viral protein Chain: A: PDB Molecule:repressor protein ci101-229dm-k192a; PDBTitle: structure of a hyper-cleavable monomeric fragment of phage2 lambda repressor containing the cleavage site region Phyre2 PDB 2fjr chain B Region: 94 - 193 Aligned: 58 Modelled: 67 Confidence: 92.8% Identity: 7% PDB header:transcription regulator Chain: B: PDB Molecule:repressor protein ci; PDBTitle: crystal structure of bacteriophage 186 Phyre2 PDB 1hr0 chain W Region: 106 - 130 Aligned: 22 Modelled: 25 Confidence: 60.5% Identity: 32% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Cold shock DNA-binding domain-like Phyre2 PDB 6c00 chain A Region: 106 - 130 Aligned: 22 Modelled: 25 Confidence: 59.1% Identity: 23% PDB header:translation Chain: A: PDB Molecule:translation initiation factor if-1; PDBTitle: solution structure of translation initiation factor 1 from clostridium2 difficile Phyre2 PDB 2nch chain A Region: 106 - 130 Aligned: 24 Modelled: 25 Confidence: 58.7% Identity: 29% PDB header:translation Chain: A: PDB Molecule:translation initiation factor if-1; PDBTitle: solution structure of translation initiation factor if1 from wolbachia2 endosymbiont strain trs of brugia malayi Phyre2 PDB 4ql5 chain A Region: 106 - 130 Aligned: 22 Modelled: 25 Confidence: 56.9% Identity: 27% PDB header:translation Chain: A: PDB Molecule:translation initiation factor if-1; PDBTitle: crystal structure of translation initiation factor if-1 from2 streptococcus pneumoniae tigr4 Phyre2 1 c4wviA_ 2 d1b12a_ 3 c4n31A_ 4 c4me8A_ 5 c4nv4A_ 6 c4k8wA_ 7 d1f39a_ 8 c6a2rD_ 9 c3k2zA_ 10 d1umua_ 11 d1jhfa2 12 c3jsoA_ 13 c1jhhB_ 14 c3bdnB_ 15 c2hnfA_ 16 c2fjrB_ 17 d1hr0w_ 18 c6c00A_ 19 c2nchA_ 20 c4ql5A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99