1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	K	R	V	D	T	I	R	P	R	S	R	A	V	R	L	H	V	R	G	L	G	L	P	D	E	T	A	I	Q	L	W	I	V	D	G	R	I	S	T	E	P	V	A	G	A	D	T	V	F	D	G	G	W	I	L	P	G	L	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	A	H	C	H	V	G	L	G	K	H	G	N	V	E	L	D	E	A	I	A	Q	A	E	T	E	R	D	V	G	A	L	L	L	R	D	C	G	S	P	T	D	T	R	G	L	D	D	H	E	D	L	P	R	I	I	R	A	G	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	L	A	R	P	K	R	Y	I	A	G	F	A	V	E	L	E	D	E	S	Q	L	P	A	A	V	A	E	Q	A	R	R	G	D	G	W	V	K	L	V	G	D	W	I	D	R	Q	I	G	D	L	A	P	L	W	S	D	D	V	L
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	A	A	I	D	T	A	H	A	Q	G	A	R	V	T	A	H	V	F	S	E	D	A	L	P	G	L	I	N	A	G	I	D	C	I	E	H	G	T	G	L	T	D	D	T	I	A	L	M	L	E	H	G	T	A	L	V	P	T	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	N	L	E	N	F	P	G	I	A	D	A	A	G	R	Y	P	T	Y	A	A	H	M	R	D	L	Y	A	R	G	Y	G	R	V	A	A	A	R	E	A	G	V	P	V	Y	A	G	T	D	A	G	S	T	I	E	H	G	R	I	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	E	V	A	A	L	Q	R	I	G	M	T	A	H	E	A	L	G	A	A	C	W	D	A	R	R	W	L	G	R	P	G	L	D	D	R	A	S	A	D	L	L	C	Y	A	Q	D	P	R	Q	G	P	G	V	L	Q	H	P	D	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370
Sequence		V	I	L	R	G	R	T	F	G	P
Secondary structure
SS confidence
Disorder										?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 3%) Alpha helix ( 35%) Beta strand ( 19%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 3gnh chain A Region: 6 - 369 Aligned: 359 Modelled: 364 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:l-lysine, l-arginine carboxypeptidase cc2672; PDBTitle: crystal structure of l-lysine, l-arginine carboxypeptidase cc2672 from2 caulobacter crescentus cb15 complexed with n-methyl phosphonate3 derivative of l-arginine. Phyre2 PDB 3be7 chain B Region: 5 - 369 Aligned: 359 Modelled: 365 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:zn-dependent arginine carboxypeptidase; PDBTitle: crystal structure of zn-dependent arginine carboxypeptidase Phyre2 PDB 4c65 chain A Region: 5 - 369 Aligned: 356 Modelled: 365 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:ochratoxinase; PDBTitle: crystal structure of a. niger ochratoxinase Phyre2 PDB 2r8c chain B Region: 7 - 368 Aligned: 356 Modelled: 362 Confidence: 100.0% Identity: 24% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative amidohydrolase; PDBTitle: crystal structure of uncharacterized protein eaj56179 Phyre2 PDB 2qs8 chain A Region: 5 - 369 Aligned: 360 Modelled: 361 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal structure of a xaa-pro dipeptidase with bound methionine in2 the active site Phyre2 PDB 4wgx chain D Region: 17 - 369 Aligned: 347 Modelled: 353 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: D: PDB Molecule:molinate hydrolase; PDBTitle: crystal structure of molinate hydrolase Phyre2 PDB 3feq chain B Region: 6 - 369 Aligned: 358 Modelled: 354 Confidence: 100.0% Identity: 20% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative amidohydrolase; PDBTitle: crystal structure of uncharacterized protein eah89906 Phyre2 PDB 4whb chain C Region: 17 - 370 Aligned: 348 Modelled: 354 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:phenylurea hydrolase b; PDBTitle: crystal structure of phenylurea hydrolase b Phyre2 PDB 2bb0 chain A Region: 2 - 369 Aligned: 345 Modelled: 346 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: structure of imidazolonepropionase from bacillus subtilis Phyre2 PDB 2q09 chain A Region: 3 - 368 Aligned: 346 Modelled: 346 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: crystal structure of imidazolonepropionase from environmental sample2 with bound inhibitor 3-(2,5-dioxo-imidazolidin-4-yl)-propionic acid Phyre2 PDB 2paj chain A Region: 5 - 368 Aligned: 336 Modelled: 338 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:putative cytosine/guanine deaminase; PDBTitle: crystal structure of an amidohydrolase from an environmental sample of2 sargasso sea Phyre2 PDB 2gok chain A Region: 4 - 368 Aligned: 345 Modelled: 345 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: crystal structure of the imidazolonepropionase from agrobacterium2 tumefaciens at 1.87 a resolution Phyre2 PDB 2p9b chain A Region: 5 - 369 Aligned: 356 Modelled: 362 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:possible prolidase; PDBTitle: crystal structure of putative prolidase from2 bifidobacterium longum Phyre2 PDB 4dyk chain B Region: 4 - 368 Aligned: 345 Modelled: 365 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an adenosine deaminase from pseudomonas2 aeruginosa pao1 (target nysgrc-200449) with bound zn Phyre2 PDB 3dc8 chain B Region: 6 - 368 Aligned: 344 Modelled: 353 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:dihydropyrimidinase; PDBTitle: crystal structure of dihydropyrimidinase from sinorhizobium meliloti Phyre2 PDB 4dzh chain A Region: 2 - 368 Aligned: 349 Modelled: 363 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an adenosine deaminase from xanthomonas2 campestris (target nysgrc-200456) with bound zn Phyre2 PDB 5e5c chain C Region: 5 - 368 Aligned: 346 Modelled: 357 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:d-hydantoinase/dihydropyrimidinase; PDBTitle: crystal structure of dihydropyrimidinase from pseudomonas aeruginosa2 pao1 Phyre2 PDB 3hpa chain B Region: 5 - 368 Aligned: 331 Modelled: 343 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an amidohydrolase gi:44264246 from an2 evironmental sample of sargasso sea Phyre2 PDB 4f0r chain A Region: 3 - 368 Aligned: 346 Modelled: 363 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:5-methylthioadenosine/s-adenosylhomocysteine deaminase; PDBTitle: crystal structure of an adenosine deaminase homolog from2 chromobacterium violaceum (target nysgrc-019589) bound zn and 5'-3 methylthioadenosine (unproductive complex) Phyre2 PDB 2vr2 chain A Region: 15 - 369 Aligned: 345 Modelled: 355 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:dihydropyrimidinase; PDBTitle: human dihydropyrimidinase Phyre2 1 c3gnhA_ 2 c3be7B_ 3 c4c65A_ 4 c2r8cB_ 5 c2qs8A_ 6 c4wgxD_ 7 c3feqB_ 8 c4whbC_ 9 c2bb0A_ 10 c2q09A_ 11 c2pajA_ 12 c2gokA_ 13 c2p9bA_ 14 c4dykB_ 15 c3dc8B_ 16 c4dzhA_ 17 c5e5cC_ 18 c3hpaB_ 19 c4f0rA_ 20 c2vr2A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238