1

.

.

.

.

.

.

.

.

10

.

.

.

.

.

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.

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20

.

.

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30

.

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40

.

.

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50

.

.

.

.

.

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.

.

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60

Sequence

M

I

E

L

S

Y

A

P

D

V

A

G

R

R

S

N

W

P

K

G

S

G

V

N

T

W

T

A

I

R

W

T

F

A

E

D

S

P

Y

V

G

T

G

L

E

R

M

A

S

D

T

H

G

G

G

G

G

R

P

V

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

.

.

.

.

.

80

.

.

.

.

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.

.

.

.

90

.

.

.

.

.

.

.

.

.

100

.

.

.

Sequence

T

P

P

P

P

G

M

H

H

L

G

C

S

R

G

V

L

L

I

S

S

Q

R

D

A

G

H

K

T

C

D

P

A

A

G

G

T

L

T

S

V

L

T

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 41%) Alpha helix ( 8%) Beta strand ( 23%)

Rank Aligned region

PDB 5odw chain C Region: 37 - 45 Aligned: 9 Modelled: 9 Confidence: 16.2% Identity: 78% PDB header:protein transport Chain: C: PDB Molecule:pyocin-s2; PDBTitle: structure of the fpvai-pyocin s2 complex Phyre2 PDB 5hy7 chain D Region: 44 - 65 Aligned: 13 Modelled: 22 Confidence: 14.7% Identity: 54% PDB header:protein binding Chain: D: PDB Molecule:ysf3; PDBTitle: sf3b10-sf3b130 from chaetomium thermophilum Phyre2 PDB 1prt chain F Region: 35 - 42 Aligned: 8 Modelled: 8 Confidence: 12.2% Identity: 88% Fold: OB-fold Superfamily: Bacterial enterotoxins Family: Bacterial AB5 toxins, B-subunits Phyre2 PDB 3ks7 chain D Region: 14 - 28 Aligned: 15 Modelled: 15 Confidence: 11.1% Identity: 53% PDB header:hydrolase Chain: D: PDB Molecule:putative putative pngase f; PDBTitle: crystal structure of putative peptide:n-glycosidase f (pngase f)2 (yp_210507.1) from bacteroides fragilis nctc 9343 at 2.30 a3 resolution Phyre2 PDB 5fzv chain A Region: 65 - 76 Aligned: 12 Modelled: 12 Confidence: 9.0% Identity: 58% PDB header:toxin Chain: A: PDB Molecule:venom peptide u3-sytx-sth1a; PDBTitle: high resolution solution nmr structure of the spider venom peptide u3-2 scytotoxin-sth1a Phyre2 PDB 5kzo chain A Region: 59 - 70 Aligned: 12 Modelled: 12 Confidence: 6.6% Identity: 50% PDB header:transcription Chain: A: PDB Molecule:neurogenic locus notch homolog protein 1; PDBTitle: notch1 transmembrane and associated juxtamembrane segment Phyre2 PDB 2jrw chain A Region: 58 - 65 Aligned: 8 Modelled: 8 Confidence: 5.8% Identity: 75% PDB header:immune system Chain: A: PDB Molecule:cyclic extended pep.1; PDBTitle: solution structure of cyclic extended pep1(cyc.ext.pep.1)2 for autoimmune myasthenia gravis Phyre2 PDB 1vqo chain A domain 1 Region: 52 - 83 Aligned: 32 Modelled: 32 Confidence: 5.6% Identity: 31% Fold: SH3-like barrel Superfamily: Translation proteins SH3-like domain Family: C-terminal domain of ribosomal protein L2 Phyre2 PDB 1pb5 chain A Region: 82 - 90 Aligned: 9 Modelled: 9 Confidence: 5.3% Identity: 67% Fold: Notch domain Superfamily: Notch domain Family: Notch domain Phyre2 PDB 5wcv chain A Region: 71 - 90 Aligned: 20 Modelled: 20 Confidence: 5.3% Identity: 40% PDB header:toxin Chain: A: PDB Molecule:shk homolog ask132958; PDBTitle: ask132958: a minimal homologue of shk identified in the transcriptome2 of anemonia sulcata Phyre2 1 c5odwC_ 2 c5hy7D_ 3 d1prtf_ 4 c3ks7D_ 5 c5fzvA_ 6 c5kzoA_ 7 c2jrwA_ 8 d1vqoa1 9 d1pb5a_ 10 c5wcvA_