Phyre 2 Results for RVBD2934_(ppsD)_3262258

Email	mdejesus@rockefeller.edu
Description	RVBD2934_(ppsD)_3262258_3267741
Date	Thu Aug 8 16:20:09 BST 2019
Unique Job ID	23c2d1f208cf25c7
Sequence	MTSLAERAAQ ... Download FASTA
Job Type	normal
Job Expiry

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:110.148 Y:146.733 Z:97.996

Model (left) based on template c2vz8A_

Top template information

PDB header:transferase
Chain: A: PDB Molecule:fatty acid synthase;
PDBTitle: crystal structure of mammalian fatty acid synthase

Confidence and coverage

Confidence:

100.0%

Coverage:

83%

1520 residues ( 83% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

1645 residues ( 90%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in JSmol

For other options to view your downloaded structure offline see the FAQ

Sequence analysis

Download FASTA version

Secondary structure and disorder prediction [Show]

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M T S L A E R A A Q L S P N A R A A L A R E L V R A G T T F P T D I C E P V A V V G I G C R F P G N V T G P E S F W Q L

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence L A D G V D T I E Q V P P D R W D A D A F Y D P D P S A S G R M T T K W G G F V S D V D A F D A D F F G I T P R E A V A

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence M D P Q H R M L L E V A W E A L E H A G I P P D S L S G T R T G V M M G L S S W D Y T I V N I E R R A D I D A Y L S T G

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence T P H C A A V G R I A Y L L G L R G P A V A V D T A C S S S L V A I H L A C Q S L R L R E T D V A L A G G V Q L T L S P

Secondary structure

SS confidence

Disorder ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence F T A I A L S K W S A L S P T G R C N S F D A N A D G F V R G E G C G V V V L K R L A D A V R D Q D R V L A V V R G S A

Secondary structure

SS confidence

Disorder ?
?
? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence T N S D G R S N G M T A P N A L A Q R D V I T S A L K L A D V T P D S V N Y V E T H G T G T V L G D P I E F E S L A A T

Secondary structure

SS confidence

Disorder
?
?
? ?
?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence Y G L G K G Q G E S P C A L G S V K T N I G H L E A A A G V A G F I K A V L A V Q R G H I P R N L H F T R W N P A I D A

Secondary structure

SS confidence

Disorder
? ? ?
? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence S A T R L F V P T E S A P W P A A A G P R R A A V S S F G L S G T N A H V V V E Q A P D T A V A A A G G M P Y V S A L N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence V S G K T A A R V A S A A A V L A D W M S G P G A A A P L A D V A H T L N R H R A R H A K F A T V I A R D R A E A I A G

Secondary structure

SS confidence

Disorder
?
?
?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence L R A L A A G Q P R V G V V D C D Q H A G G P G R V F V Y S G Q G S Q W A S M G Q Q L L A N E P A F A K A V A E L D P I

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence F V D Q V G F S L Q Q T L I D G D E V V G I D R I Q P V L V G M Q L A L T E L W R S Y G V I P D A V I G H S M G E V S A

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence A V V A G A L T P E Q G L R V I T T R S R L M A R L S G Q G A M A L L E L D A D A A E A L I A G Y P Q V T L A V H A S P

Secondary structure

SS confidence

Disorder
? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence R Q T V I A G P P E Q V D T V I A A V A T Q N R L A R R V E V D V A S H H P I I D P I L P E L R S A L A D L T P Q P P S

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence I P I I S T T Y E S A Q P V A D A D Y W S A N L R N P V R F H Q A V T A A G V D H N T F I E I S P H P V L T H A L T D T

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence L D P D G S H T V M S T M N R E L D Q T L Y F H A Q L A A V G V A A S E H T T G R L V D L P P T P W H H Q R F W V T D R

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence S A M S E L A A T H P L L G A H I E M P R N G D H V W Q T D V G T E V C P W L A D H K V F G Q P I M P A A G F A E I A L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence A A A S E A L G T A A D A V A P N I V I N Q F E V E Q M L P L D G H T P L T T Q L I R G G D S Q I R V E I Y S R T R G G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence E F C R H A T A K V E Q S P R E C A H A H P E A Q G P A T G T T V S P A D F Y A L L R Q T G Q H H G P A F A A L S R I V

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence R L A D G S A E T E I S I P D E A P R H P G Y R L H P V V L D A A L Q S V G A A I P D G E I A G S A E A S Y L P V S F E

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence T I R V Y R D I G R H V R C R A H L T N L D G G T G K M G R I V L I N D A G H I A A E V D G I Y L R R V E R R A V P L P

Secondary structure

SS confidence

Disorder
?
? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence L E Q K I F D A E W T E S P I A A V P A P E P A A E T T R G S W L V L A D A T V D A P G K A Q A K S M A D D F V Q Q W R

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence S P M R R V H T A D I H D E S A V L A A F A E T A G D P E H P P V G V V V F V G G A S S R L D D E L A A A R D T V W S I

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence T T V V R A V V G T W H G R S P R L W L V T G G G L S V A D D E P G T P A A A S L K G L V R V L A F E H P D M R T T L V

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence D L D I T Q D P L T A L S A E L R N A G S G S R H D D V I A W R G E R R F V E R L S R A T I D V S K G H P V V R Q G A S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . . . . . 1490 . . . . . . . . . 1500

Sequence Y V V T G G L G G L G L V V A R W L V D R G A G R V V L G G R S D P T D E Q C N V L A E L Q T R A E I V V V R G D V A S

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1510 . . . . . . . . . 1520 . . . . . . . . . 1530 . . . . . . . . . 1540 . . . . . . . . . 1550 . . . . . . . . . 1560

Sequence P G V A E K L I E T A R Q S G G Q L R G V V H A A A V I E D S L V F S M S R D N L E R V W A P K A T G A L R M H E A T A

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1570 . . . . . . . . . 1580 . . . . . . . . . 1590 . . . . . . . . . 1600 . . . . . . . . . 1610 . . . . . . . . . 1620

Sequence D C E L D W W L G F S S A A S L L G S P G Q A A Y A C A S A W L D A L V G W R R A S G L P A A V I N W G P W S E V G V A

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1630 . . . . . . . . . 1640 . . . . . . . . . 1650 . . . . . . . . . 1660 . . . . . . . . . 1670 . . . . . . . . . 1680

Sequence Q A L V G S V L D T I S V A E G I E A L D S L L A A D R I R T G V A R L R A D R A L V A F P E I R S I S Y F T Q V V E E

Secondary structure

SS confidence

Disorder
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1690 . . . . . . . . . 1700 . . . . . . . . . 1710 . . . . . . . . . 1720 . . . . . . . . . 1730 . . . . . . . . . 1740

Sequence L D S A G D L G D W G G P D A L A D L D P G E A R R A V T E R M C A R I A A V M G Y T D Q S T V E P A V P L D K P L T E

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ?
? ? ?
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1750 . . . . . . . . . 1760 . . . . . . . . . 1770 . . . . . . . . . 1780 . . . . . . . . . 1790 . . . . . . . . . 1800

Sequence L G L D S L M A V R I R N G A R A D F G V E P P V A L I L Q G A S L H D L T A D L M R Q L G L N D P D P A L N N A D T I

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1810 . . . . . . . . . 1820 . . . . . . .

Sequence R D R A R Q R A A A R H G A A M R R R P K P E V Q G G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 12%)

Alpha helix ( 38%)

Beta strand ( 17%)

TM helix ( 1%)
(View membrane topology prediction)

Domain analysis [Show]

Rank Aligned region

PDB 2vz8 chain A

3D model

Region: 36 - 1654
Aligned: 1520
Modelled: 1585
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:fatty acid synthase;
PDBTitle: crystal structure of mammalian fatty acid synthase

Phyre2

PDB 2vz8 chain B

Region: 36 - 1657
Aligned: 1539
Modelled: 1575
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: B: PDB Molecule:fatty acid synthase;
PDBTitle: crystal structure of mammalian fatty acid synthase

Phyre2

PDB 6fik chain A

3D model

Region: 31 - 912
Aligned: 878
Modelled: 882
Confidence: 100.0%
Identity: 29%
PDB header:biosynthetic protein
Chain: A: PDB Molecule:polyketide synthase;
PDBTitle: acp2 crosslinked to the ks of the loading/condensing region of the2 ctb1 pks

Phyre2

PDB 2qo3 chain A

3D model

Region: 35 - 898
Aligned: 850
Modelled: 864
Confidence: 100.0%
Identity: 42%
PDB header:transferase
Chain: A: PDB Molecule:eryaii erythromycin polyketide synthase modules 3 and 4;
PDBTitle: crystal structure of [ks3][at3] didomain from module 3 of 6-2 deoxyerthronolide b synthase

Phyre2

PDB 6c9u chain A

3D model

Region: 36 - 899
Aligned: 848
Modelled: 864
Confidence: 100.0%
Identity: 42%
PDB header:transferase/immune system
Chain: A: PDB Molecule:6-deoxyerythronolide-b synthase erya2, modules 3 and 4;
PDBTitle: crystal structure of [ks3][at3] didomain from module 3 of 6-2 deoxyerthronolide b synthase in complex with antibody fragment (fab)

Phyre2

PDB 2hg4 chain A

3D model

Region: 6 - 898
Aligned: 866
Modelled: 893
Confidence: 100.0%
Identity: 41%
PDB header:transferase
Chain: A: PDB Molecule:6-deoxyerythronolide b synthase;
PDBTitle: structure of the ketosynthase-acyltransferase didomain of module 52 from debs.

Phyre2

PDB 4mz0 chain B

3D model

Region: 11 - 897
Aligned: 810
Modelled: 843
Confidence: 100.0%
Identity: 43%
PDB header:transferase
Chain: B: PDB Molecule:curl;
PDBTitle: structure of a ketosynthase-acyltransferase di-domain from module curl2 of the curacin a polyketide synthase

Phyre2

PDB 3hhd chain C

3D model

Region: 34 - 907
Aligned: 828
Modelled: 857
Confidence: 100.0%
Identity: 30%
PDB header:transferase, hydrolase
Chain: C: PDB Molecule:fatty acid synthase;
PDBTitle: structure of the human fatty acid synthase ks-mat didomain as a2 framework for inhibitor design.

Phyre2

PDB 5bp1 chain A

3D model

Region: 35 - 899
Aligned: 795
Modelled: 826
Confidence: 100.0%
Identity: 51%
PDB header:transferase
Chain: A: PDB Molecule:mycocerosic acid synthase;
PDBTitle: condensing di-domain (ks-at) of a mycocerosic acid synthase-like (mas-2 like) pks

Phyre2

PDB 4kc5 chain D

3D model

Region: 35 - 1207
Aligned: 870
Modelled: 886
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: D: PDB Molecule:rhie protein;
PDBTitle: crystal structure of the c-terminal part of rhie from burkholderia2 rhizoxinica

Phyre2

PDB 4oqj chain A

3D model

Region: 34 - 899
Aligned: 668
Modelled: 692
Confidence: 100.0%
Identity: 39%
PDB header:hydrolase
Chain: A: PDB Molecule:pks;
PDBTitle: streptomcyes albus ja3453 oxazolomycin ketosynthase domain ozmq ks1

Phyre2

PDB 5erb chain B

Region: 36 - 898
Aligned: 580
Modelled: 591
Confidence: 100.0%
Identity: 41%
PDB header:transferase
Chain: B: PDB Molecule:polyketide synthase;
PDBTitle: ketosynthase from module 5 of the bacillaene synthase from bacillus2 amyloliquefaciens fzb42

Phyre2

PDB 5e5n chain B

3D model

Region: 36 - 623
Aligned: 553
Modelled: 587
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: B: PDB Molecule:polyketide synthase pksl;
PDBTitle: ketosynthase from module 6 of the bacillaene synthase from bacillus2 subtilis 168 (c167s mutant, crystal form 1)

Phyre2

PDB 4na3 chain A

3D model

Region: 36 - 623
Aligned: 570
Modelled: 588
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:polyketide synthase pksj;
PDBTitle: crystal structure of the second ketosynthase from the bacillaene2 polyketide synthase bound to a hexanoyl substrate mimic

Phyre2

PDB 4wky chain B

3D model

Region: 34 - 900
Aligned: 564
Modelled: 573
Confidence: 100.0%
Identity: 45%
PDB header:transferase
Chain: B: PDB Molecule:beta-ketoacyl synthase;
PDBTitle: streptomcyes albus ja3453 oxazolomycin ketosynthase domain ozmn ks2

Phyre2

PDB 4ope chain D

3D model

Region: 36 - 905
Aligned: 560
Modelled: 575
Confidence: 100.0%
Identity: 43%
PDB header:ligase, transferase
Chain: D: PDB Molecule:nrps/pks;
PDBTitle: streptomcyes albus ja3453 oxazolomycin ketosynthase domain ozmh ks7

Phyre2

PDB 4tl2 chain A

3D model

Region: 34 - 899
Aligned: 577
Modelled: 588
Confidence: 100.0%
Identity: 41%
PDB header:transferase
Chain: A: PDB Molecule:at-less polyketide synthase;
PDBTitle: crystal structure of ketosynthase domain from mgsf from streptomyces2 platensis

Phyre2

PDB 4qyr chain A

3D model

Region: 35 - 587
Aligned: 531
Modelled: 553
Confidence: 100.0%
Identity: 41%
PDB header:transferase
Chain: A: PDB Molecule:at-less polyketide synthase;
PDBTitle: streptomyces platensis isomigrastatin ketosynthase domain mgse ks3

Phyre2

PDB 3hmj chain B

3D model

Region: 24 - 665
Aligned: 630
Modelled: 638
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: B: PDB Molecule:fatty acid synthase subunit alpha;
PDBTitle: saccharomyces cerevisiae fas type i

Phyre2

PDB 4b3y chain B

Region: 26 - 504
Aligned: 468
Modelled: 479
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: B: PDB Molecule:fatty acid synthase;
PDBTitle: cryo-em structure of the mycobacterial fatty acid synthase

Phyre2

1
c2vz8A_

2
c2vz8B_

3
c6fikA_

4
c2qo3A_

5
c6c9uA_

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c2hg4A_

7
c4mz0B_

8
c3hhdC_

9
c5bp1A_

10
c4kc5D_

11
c4oqjA_

12
c5erbB_

13
c5e5nB_

14
c4na3A_

15
c4wkyB_

16
c4opeD_

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c4tl2A_

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c4qyrA_

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c3hmjB_

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c4b3yB_

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	T	S	L	A	E	R	A	A	Q	L	S	P	N	A	R	A	A	L	A	R	E	L	V	R	A	G	T	T	F	P	T	D	I	C	E	P	V	A	V	V	G	I	G	C	R	F	P	G	N	V	T	G	P	E	S	F	W	Q	L
Secondary structure
SS confidence
Disorder	?	?	?	?																				?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	L	A	D	G	V	D	T	I	E	Q	V	P	P	D	R	W	D	A	D	A	F	Y	D	P	D	P	S	A	S	G	R	M	T	T	K	W	G	G	F	V	S	D	V	D	A	F	D	A	D	F	F	G	I	T	P	R	E	A	V	A
Secondary structure
SS confidence
Disorder						?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	M	D	P	Q	H	R	M	L	L	E	V	A	W	E	A	L	E	H	A	G	I	P	P	D	S	L	S	G	T	R	T	G	V	M	M	G	L	S	S	W	D	Y	T	I	V	N	I	E	R	R	A	D	I	D	A	Y	L	S	T	G
Secondary structure
SS confidence
Disorder																																															?	?	?	?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	T	P	H	C	A	A	V	G	R	I	A	Y	L	L	G	L	R	G	P	A	V	A	V	D	T	A	C	S	S	S	L	V	A	I	H	L	A	C	Q	S	L	R	L	R	E	T	D	V	A	L	A	G	G	V	Q	L	T	L	S	P
Secondary structure
SS confidence
Disorder	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	F	T	A	I	A	L	S	K	W	S	A	L	S	P	T	G	R	C	N	S	F	D	A	N	A	D	G	F	V	R	G	E	G	C	G	V	V	V	L	K	R	L	A	D	A	V	R	D	Q	D	R	V	L	A	V	V	R	G	S	A
Secondary structure
SS confidence
Disorder	?								?			?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	T	N	S	D	G	R	S	N	G	M	T	A	P	N	A	L	A	Q	R	D	V	I	T	S	A	L	K	L	A	D	V	T	P	D	S	V	N	Y	V	E	T	H	G	T	G	T	V	L	G	D	P	I	E	F	E	S	L	A	A	T
Secondary structure
SS confidence
Disorder								?		?		?	?																	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	Y	G	L	G	K	G	Q	G	E	S	P	C	A	L	G	S	V	K	T	N	I	G	H	L	E	A	A	A	G	V	A	G	F	I	K	A	V	L	A	V	Q	R	G	H	I	P	R	N	L	H	F	T	R	W	N	P	A	I	D	A
Secondary structure
SS confidence
Disorder			?	?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	S	A	T	R	L	F	V	P	T	E	S	A	P	W	P	A	A	A	G	P	R	R	A	A	V	S	S	F	G	L	S	G	T	N	A	H	V	V	V	E	Q	A	P	D	T	A	V	A	A	A	G	G	M	P	Y	V	S	A	L	N
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?																										?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	V	S	G	K	T	A	A	R	V	A	S	A	A	A	V	L	A	D	W	M	S	G	P	G	A	A	A	P	L	A	D	V	A	H	T	L	N	R	H	R	A	R	H	A	K	F	A	T	V	I	A	R	D	R	A	E	A	I	A	G
Secondary structure
SS confidence
Disorder																					?			?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	L	R	A	L	A	A	G	Q	P	R	V	G	V	V	D	C	D	Q	H	A	G	G	P	G	R	V	F	V	Y	S	G	Q	G	S	Q	W	A	S	M	G	Q	Q	L	L	A	N	E	P	A	F	A	K	A	V	A	E	L	D	P	I
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	F	V	D	Q	V	G	F	S	L	Q	Q	T	L	I	D	G	D	E	V	V	G	I	D	R	I	Q	P	V	L	V	G	M	Q	L	A	L	T	E	L	W	R	S	Y	G	V	I	P	D	A	V	I	G	H	S	M	G	E	V	S	A
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	A	V	V	A	G	A	L	T	P	E	Q	G	L	R	V	I	T	T	R	S	R	L	M	A	R	L	S	G	Q	G	A	M	A	L	L	E	L	D	A	D	A	A	E	A	L	I	A	G	Y	P	Q	V	T	L	A	V	H	A	S	P
Secondary structure
SS confidence
Disorder																										?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	R	Q	T	V	I	A	G	P	P	E	Q	V	D	T	V	I	A	A	V	A	T	Q	N	R	L	A	R	R	V	E	V	D	V	A	S	H	H	P	I	I	D	P	I	L	P	E	L	R	S	A	L	A	D	L	T	P	Q	P	P	S
Secondary structure
SS confidence
Disorder																																																						?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	I	P	I	I	S	T	T	Y	E	S	A	Q	P	V	A	D	A	D	Y	W	S	A	N	L	R	N	P	V	R	F	H	Q	A	V	T	A	A	G	V	D	H	N	T	F	I	E	I	S	P	H	P	V	L	T	H	A	L	T	D	T
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	L	D	P	D	G	S	H	T	V	M	S	T	M	N	R	E	L	D	Q	T	L	Y	F	H	A	Q	L	A	A	V	G	V	A	A	S	E	H	T	T	G	R	L	V	D	L	P	P	T	P	W	H	H	Q	R	F	W	V	T	D	R
Secondary structure
SS confidence
Disorder																																																												?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	S	A	M	S	E	L	A	A	T	H	P	L	L	G	A	H	I	E	M	P	R	N	G	D	H	V	W	Q	T	D	V	G	T	E	V	C	P	W	L	A	D	H	K	V	F	G	Q	P	I	M	P	A	A	G	F	A	E	I	A	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	A	A	A	S	E	A	L	G	T	A	A	D	A	V	A	P	N	I	V	I	N	Q	F	E	V	E	Q	M	L	P	L	D	G	H	T	P	L	T	T	Q	L	I	R	G	G	D	S	Q	I	R	V	E	I	Y	S	R	T	R	G	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	E	F	C	R	H	A	T	A	K	V	E	Q	S	P	R	E	C	A	H	A	H	P	E	A	Q	G	P	A	T	G	T	T	V	S	P	A	D	F	Y	A	L	L	R	Q	T	G	Q	H	H	G	P	A	F	A	A	L	S	R	I	V
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?	?	?								?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	R	L	A	D	G	S	A	E	T	E	I	S	I	P	D	E	A	P	R	H	P	G	Y	R	L	H	P	V	V	L	D	A	A	L	Q	S	V	G	A	A	I	P	D	G	E	I	A	G	S	A	E	A	S	Y	L	P	V	S	F	E
Secondary structure
SS confidence
Disorder																			?																								?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	T	I	R	V	Y	R	D	I	G	R	H	V	R	C	R	A	H	L	T	N	L	D	G	G	T	G	K	M	G	R	I	V	L	I	N	D	A	G	H	I	A	A	E	V	D	G	I	Y	L	R	R	V	E	R	R	A	V	P	L	P
Secondary structure
SS confidence
Disorder																					?																																?	?		?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	L	E	Q	K	I	F	D	A	E	W	T	E	S	P	I	A	A	V	P	A	P	E	P	A	A	E	T	T	R	G	S	W	L	V	L	A	D	A	T	V	D	A	P	G	K	A	Q	A	K	S	M	A	D	D	F	V	Q	Q	W	R
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	S	P	M	R	R	V	H	T	A	D	I	H	D	E	S	A	V	L	A	A	F	A	E	T	A	G	D	P	E	H	P	P	V	G	V	V	V	F	V	G	G	A	S	S	R	L	D	D	E	L	A	A	A	R	D	T	V	W	S	I
Secondary structure
SS confidence
Disorder																																													?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	T	T	V	V	R	A	V	V	G	T	W	H	G	R	S	P	R	L	W	L	V	T	G	G	G	L	S	V	A	D	D	E	P	G	T	P	A	A	A	S	L	K	G	L	V	R	V	L	A	F	E	H	P	D	M	R	T	T	L	V
Secondary structure
SS confidence
Disorder											?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	D	L	D	I	T	Q	D	P	L	T	A	L	S	A	E	L	R	N	A	G	S	G	S	R	H	D	D	V	I	A	W	R	G	E	R	R	F	V	E	R	L	S	R	A	T	I	D	V	S	K	G	H	P	V	V	R	Q	G	A	S
Secondary structure
SS confidence
Disorder																																												?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.	.	.	.	1490	.	.	.	.	.	.	.	.	.	1500
Sequence	Y	V	V	T	G	G	L	G	G	L	G	L	V	V	A	R	W	L	V	D	R	G	A	G	R	V	V	L	G	G	R	S	D	P	T	D	E	Q	C	N	V	L	A	E	L	Q	T	R	A	E	I	V	V	V	R	G	D	V	A	S
Secondary structure
SS confidence
Disorder																																			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1510	.	.	.	.	.	.	.	.	.	1520	.	.	.	.	.	.	.	.	.	1530	.	.	.	.	.	.	.	.	.	1540	.	.	.	.	.	.	.	.	.	1550	.	.	.	.	.	.	.	.	.	1560
Sequence	P	G	V	A	E	K	L	I	E	T	A	R	Q	S	G	G	Q	L	R	G	V	V	H	A	A	A	V	I	E	D	S	L	V	F	S	M	S	R	D	N	L	E	R	V	W	A	P	K	A	T	G	A	L	R	M	H	E	A	T	A
Secondary structure
SS confidence
Disorder													?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1570	.	.	.	.	.	.	.	.	.	1580	.	.	.	.	.	.	.	.	.	1590	.	.	.	.	.	.	.	.	.	1600	.	.	.	.	.	.	.	.	.	1610	.	.	.	.	.	.	.	.	.	1620
Sequence	D	C	E	L	D	W	W	L	G	F	S	S	A	A	S	L	L	G	S	P	G	Q	A	A	Y	A	C	A	S	A	W	L	D	A	L	V	G	W	R	R	A	S	G	L	P	A	A	V	I	N	W	G	P	W	S	E	V	G	V	A
Secondary structure
SS confidence
Disorder																																																									?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1630	.	.	.	.	.	.	.	.	.	1640	.	.	.	.	.	.	.	.	.	1650	.	.	.	.	.	.	.	.	.	1660	.	.	.	.	.	.	.	.	.	1670	.	.	.	.	.	.	.	.	.	1680
Sequence	Q	A	L	V	G	S	V	L	D	T	I	S	V	A	E	G	I	E	A	L	D	S	L	L	A	A	D	R	I	R	T	G	V	A	R	L	R	A	D	R	A	L	V	A	F	P	E	I	R	S	I	S	Y	F	T	Q	V	V	E	E
Secondary structure
SS confidence
Disorder						?			?																																	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1690	.	.	.	.	.	.	.	.	.	1700	.	.	.	.	.	.	.	.	.	1710	.	.	.	.	.	.	.	.	.	1720	.	.	.	.	.	.	.	.	.	1730	.	.	.	.	.	.	.	.	.	1740
Sequence	L	D	S	A	G	D	L	G	D	W	G	G	P	D	A	L	A	D	L	D	P	G	E	A	R	R	A	V	T	E	R	M	C	A	R	I	A	A	V	M	G	Y	T	D	Q	S	T	V	E	P	A	V	P	L	D	K	P	L	T	E
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?							?	?	?																										?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1750	.	.	.	.	.	.	.	.	.	1760	.	.	.	.	.	.	.	.	.	1770	.	.	.	.	.	.	.	.	.	1780	.	.	.	.	.	.	.	.	.	1790	.	.	.	.	.	.	.	.	.	1800
Sequence	L	G	L	D	S	L	M	A	V	R	I	R	N	G	A	R	A	D	F	G	V	E	P	P	V	A	L	I	L	Q	G	A	S	L	H	D	L	T	A	D	L	M	R	Q	L	G	L	N	D	P	D	P	A	L	N	N	A	D	T	I
Secondary structure
SS confidence
Disorder																																													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1810	.	.	.	.	.	.	.	.	.	1820	.	.	.	.	.	.	.
Sequence	R	D	R	A	R	Q	R	A	A	A	R	H	G	A	A	M	R	R	R	P	K	P	E	V	Q	G	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?
Disorder confidence