Phyre 2 Results for RVBD2935_(ppsE)_3267747

Email	mdejesus@rockefeller.edu
Description	RVBD2935_(ppsE)_3267747_3272213
Date	Thu Aug 8 16:20:09 BST 2019
Unique Job ID	fa8ed31c135bc45b
Sequence	VSIPENAIAV ... Download FASTA
Job Type	normal
Job Expiry

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:110.345 Y:86.841 Z:66.104

Model (left) based on template c2vz8A_

Top template information

PDB header:transferase
Chain: A: PDB Molecule:fatty acid synthase;
PDBTitle: crystal structure of mammalian fatty acid synthase

Confidence and coverage

Confidence:

100.0%

Coverage:

56%

837 residues ( 56% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

906 residues ( 61%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in JSmol

For other options to view your downloaded structure offline see the FAQ

Sequence analysis

Download FASTA version

Secondary structure and disorder prediction [Show]

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence V S I P E N A I A V V G M A G R F P G A K D V S A F W S N L R R G K E S I V T L S E Q E L R D A G V S D K T L A D P A Y

Secondary structure

SS confidence

Disorder ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence V R R A P L L D G I D E F D A G F F G F P P L A A Q V L D P Q H R L F L Q C A W H A L E D A G A D P A R F D G S I G V Y

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence G T S S P S G Y L L H N L L S H R D P N A V L A E G L N F D Q F S L F L Q N D K D F L A T R I S H A F N L R G P S I A V

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence Q T A C S S S L V A V H L A C L S L L S G E C D M A L A G G S S L C I P H R V G Y F T S P G S M V S A V G H C R P F D V

Secondary structure

SS confidence

Disorder
? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence R A D G T V F G S G V G L V V L K P L A A A I D A G D R I H A V I R G S A I N N D G S A K M G Y A A P N P A A Q A D V I

Secondary structure

SS confidence

Disorder
?
? ?
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence A E A H A V S G I D S S T V S Y V E C H G T G T P L G D P I E I Q G L R A A F E V S Q T S R S A P C V L G S V K S N I G

Secondary structure

SS confidence

Disorder
? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence H L E V A A G I A G L I K T I L C L K N K A L P A T L H Y T S P N P E L R L D Q S P F V V Q S K Y G P W E C D G V R R A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence G V S S F G V G G T N A H V V L E E A P A E A S E V S A H A E P A G P Q V I L L S A Q T A A A L G E S R T A L A A A L E

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence T Q D G P R L S D V A Y T L A R R R K H N V T M A A V V H D R E H A A T V L R A A E H D N V F V G E A A H D G E H G D R

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence A D A A P T S D R V V F L F P G Q G A Q H V G M A K G L Y D T E P V F A Q H F D T C A A G F R D E T G I D L H A E V F D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence G T A T D L E R I D R S Q P A L F T V E Y A L A K L V D T F G V R A G A Y I G Y S T G E Y I A A T L A G V F D L Q T A I

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence K T V S L R A R L M H E S P P G A M V A V A L G P D D V T Q Y L P P E V E L S A V N D P G N C V V A G P K D Q I R A L R

Secondary structure

SS confidence

Disorder
? ?
?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence Q R L T E A G I P V R R V R A T H A F H T S A M D P M L G Q F Q E F L S R Q Q L R P P R T P L L S N L T G S W M S D Q Q

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence V V D P A S W T R Q I S S P I R F A D E L D V V L A A P S R I L V E V G P G G S L T G S A M R H P K W S T T H R T V R L

Secondary structure

SS confidence

Disorder
?
? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence M R H P L Q D V D D R D T F L R A L G E L W S A G V E V D W T P R R P A V P H L V S L P G Y P F A R Q R H W V E P N H T

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence V W A Q A P G A N N G S P A G T A D G S T A A T V D A A R N G E S Q T E V T L Q R I W S Q C L G V S S V D R N A N F F D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
?
?
?
?
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence L G G D S L M A I S I A M A A A N E G L T I T P Q D L Y E Y P T L A S L T A A V D A S F A S S G L A K P P E A Q A N P A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence V P P N V T Y F L D R G L R D T G R C R V P L I L R L D P K I G L P D I R A V L T A V V N H H D A L R L H L V G N D G I

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence W E Q H I A A P A E F T G L S N R S V P N G V A A G S P E E R A A V L G I L A E L L E D Q T D P N A P L A A V H I A A A

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence H G G P H Y L C L A I H A M V T D D S S R Q I L A T D I V T A F G Q R L A G E E I T L E P V S T G W R E W S L R C A A L

Secondary structure

SS confidence

Disorder
? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence A T H P A A L D T R S Y W I E N S T K A T L W L A D A L P N A H T A H P P R A D E L T K L S S T L S V E Q T S E L D D G

Secondary structure

SS confidence

Disorder ? ? ?
?
? ? ?
? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence R R R F R R S I Q T I L L A A L G R T I A Q T V G E G V V A V E L E G E G R S V L R P D V D L R R T V G W F T T Y Y P V

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence P L A C A T G L G A L A Q L D A V H N T L K S V P H Y G I G Y G L L R Y V Y A P T G R V L G A Q R T P D I H F R Y A G V

Secondary structure

SS confidence

Disorder
? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence I P E L P S G D A P V Q F D S D M T L P V R E P I P G M G H A I E L R V Y R F G G S L H L D W W Y D T R R I P A A T A E

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . . . .

Sequence A L E R T F P L A L S A L I Q E A I A A E H T E H D D S E I V G E P E A G A L V D L S S M D A G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 16%)

Alpha helix ( 39%)

Beta strand ( 12%)

TM helix ( 1%)
(View membrane topology prediction)

Domain analysis [Show]

Rank Aligned region

PDB 2vz8 chain A

3D model

Region: 6 - 906
Aligned: 837
Modelled: 879
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:fatty acid synthase;
PDBTitle: crystal structure of mammalian fatty acid synthase

Phyre2

PDB 6fik chain A

Region: 2 - 902
Aligned: 871
Modelled: 879
Confidence: 100.0%
Identity: 28%
PDB header:biosynthetic protein
Chain: A: PDB Molecule:polyketide synthase;
PDBTitle: acp2 crosslinked to the ks of the loading/condensing region of the2 ctb1 pks

Phyre2

PDB 2vz8 chain B

3D model

Region: 6 - 903
Aligned: 834
Modelled: 872
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: B: PDB Molecule:fatty acid synthase;
PDBTitle: crystal structure of mammalian fatty acid synthase

Phyre2

PDB 2qo3 chain A

Region: 5 - 896
Aligned: 856
Modelled: 877
Confidence: 100.0%
Identity: 35%
PDB header:transferase
Chain: A: PDB Molecule:eryaii erythromycin polyketide synthase modules 3 and 4;
PDBTitle: crystal structure of [ks3][at3] didomain from module 3 of 6-2 deoxyerthronolide b synthase

Phyre2

PDB 6c9u chain A

3D model

Region: 5 - 897
Aligned: 857
Modelled: 875
Confidence: 100.0%
Identity: 35%
PDB header:transferase/immune system
Chain: A: PDB Molecule:6-deoxyerythronolide-b synthase erya2, modules 3 and 4;
PDBTitle: crystal structure of [ks3][at3] didomain from module 3 of 6-2 deoxyerthronolide b synthase in complex with antibody fragment (fab)

Phyre2

PDB 2hg4 chain A

3D model

Region: 4 - 896
Aligned: 845
Modelled: 882
Confidence: 100.0%
Identity: 35%
PDB header:transferase
Chain: A: PDB Molecule:6-deoxyerythronolide b synthase;
PDBTitle: structure of the ketosynthase-acyltransferase didomain of module 52 from debs.

Phyre2

PDB 3hhd chain C

3D model

Region: 4 - 905
Aligned: 838
Modelled: 879
Confidence: 100.0%
Identity: 27%
PDB header:transferase, hydrolase
Chain: C: PDB Molecule:fatty acid synthase;
PDBTitle: structure of the human fatty acid synthase ks-mat didomain as a2 framework for inhibitor design.

Phyre2

PDB 5bp1 chain A

3D model

Region: 5 - 897
Aligned: 797
Modelled: 832
Confidence: 100.0%
Identity: 35%
PDB header:transferase
Chain: A: PDB Molecule:mycocerosic acid synthase;
PDBTitle: condensing di-domain (ks-at) of a mycocerosic acid synthase-like (mas-2 like) pks

Phyre2

PDB 4mz0 chain B

3D model

Region: 4 - 895
Aligned: 788
Modelled: 846
Confidence: 100.0%
Identity: 38%
PDB header:transferase
Chain: B: PDB Molecule:curl;
PDBTitle: structure of a ketosynthase-acyltransferase di-domain from module curl2 of the curacin a polyketide synthase

Phyre2

PDB 4oqj chain A

3D model

Region: 3 - 897
Aligned: 677
Modelled: 709
Confidence: 100.0%
Identity: 47%
PDB header:hydrolase
Chain: A: PDB Molecule:pks;
PDBTitle: streptomcyes albus ja3453 oxazolomycin ketosynthase domain ozmq ks1

Phyre2

PDB 4kc5 chain D

Region: 5 - 907
Aligned: 582
Modelled: 587
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: D: PDB Molecule:rhie protein;
PDBTitle: crystal structure of the c-terminal part of rhie from burkholderia2 rhizoxinica

Phyre2

PDB 4wky chain B

3D model

Region: 3 - 576
Aligned: 538
Modelled: 549
Confidence: 100.0%
Identity: 50%
PDB header:transferase
Chain: B: PDB Molecule:beta-ketoacyl synthase;
PDBTitle: streptomcyes albus ja3453 oxazolomycin ketosynthase domain ozmn ks2

Phyre2

PDB 5erb chain B

3D model

Region: 5 - 585
Aligned: 535
Modelled: 538
Confidence: 100.0%
Identity: 39%
PDB header:transferase
Chain: B: PDB Molecule:polyketide synthase;
PDBTitle: ketosynthase from module 5 of the bacillaene synthase from bacillus2 amyloliquefaciens fzb42

Phyre2

PDB 4qyr chain A

3D model

Region: 5 - 607
Aligned: 557
Modelled: 577
Confidence: 100.0%
Identity: 39%
PDB header:transferase
Chain: A: PDB Molecule:at-less polyketide synthase;
PDBTitle: streptomyces platensis isomigrastatin ketosynthase domain mgse ks3

Phyre2

PDB 5e5n chain B

3D model

Region: 6 - 607
Aligned: 550
Modelled: 579
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: B: PDB Molecule:polyketide synthase pksl;
PDBTitle: ketosynthase from module 6 of the bacillaene synthase from bacillus2 subtilis 168 (c167s mutant, crystal form 1)

Phyre2

PDB 5elp chain A

3D model

Region: 5 - 570
Aligned: 506
Modelled: 544
Confidence: 100.0%
Identity: 40%
PDB header:hydrolase
Chain: A: PDB Molecule:nrps/pks protein;
PDBTitle: ketosynthase from module 1 of the bacillaene synthase from bacillus2 amyloliquefaciens fzb42

Phyre2

PDB 4z37 chain A

3D model

Region: 3 - 583
Aligned: 548
Modelled: 569
Confidence: 100.0%
Identity: 38%
PDB header:transferase
Chain: A: PDB Molecule:putative mixed polyketide synthase/non-ribosomal peptide
PDBTitle: structure of the ketosynthase of module 2 of c0zgq5 (trans-at pks)2 from brevibacillus brevis

Phyre2

PDB 4tl2 chain A

3D model

Region: 5 - 571
Aligned: 532
Modelled: 550
Confidence: 100.0%
Identity: 38%
PDB header:transferase
Chain: A: PDB Molecule:at-less polyketide synthase;
PDBTitle: crystal structure of ketosynthase domain from mgsf from streptomyces2 platensis

Phyre2

PDB 4na3 chain A

3D model

Region: 6 - 607
Aligned: 565
Modelled: 602
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:polyketide synthase pksj;
PDBTitle: crystal structure of the second ketosynthase from the bacillaene2 polyketide synthase bound to a hexanoyl substrate mimic

Phyre2

PDB 4tkt chain A

3D model

Region: 4 - 566
Aligned: 523
Modelled: 534
Confidence: 100.0%
Identity: 42%
PDB header:transferase
Chain: A: PDB Molecule:at-less polyketide synthase;
PDBTitle: streptomyces platensis isomigrastatin ketosynthase domain mgsf ks6

Phyre2

1
c2vz8A_

2
c6fikA_

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c2vz8B_

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c2qo3A_

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c6c9uA_

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c2hg4A_

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c3hhdC_

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c5bp1A_

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c4mz0B_

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c4oqjA_

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c4kc5D_

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c4wkyB_

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c5erbB_

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c4qyrA_

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c5e5nB_

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c5elpA_

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c4z37A_

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c4tl2A_

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c4na3A_

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c4tktA_

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466

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	V	S	I	P	E	N	A	I	A	V	V	G	M	A	G	R	F	P	G	A	K	D	V	S	A	F	W	S	N	L	R	R	G	K	E	S	I	V	T	L	S	E	Q	E	L	R	D	A	G	V	S	D	K	T	L	A	D	P	A	Y
Secondary structure
SS confidence
Disorder	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	V	R	R	A	P	L	L	D	G	I	D	E	F	D	A	G	F	F	G	F	P	P	L	A	A	Q	V	L	D	P	Q	H	R	L	F	L	Q	C	A	W	H	A	L	E	D	A	G	A	D	P	A	R	F	D	G	S	I	G	V	Y
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	G	T	S	S	P	S	G	Y	L	L	H	N	L	L	S	H	R	D	P	N	A	V	L	A	E	G	L	N	F	D	Q	F	S	L	F	L	Q	N	D	K	D	F	L	A	T	R	I	S	H	A	F	N	L	R	G	P	S	I	A	V
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	Q	T	A	C	S	S	S	L	V	A	V	H	L	A	C	L	S	L	L	S	G	E	C	D	M	A	L	A	G	G	S	S	L	C	I	P	H	R	V	G	Y	F	T	S	P	G	S	M	V	S	A	V	G	H	C	R	P	F	D	V
Secondary structure
SS confidence
Disorder																																						?	?							?			?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	R	A	D	G	T	V	F	G	S	G	V	G	L	V	V	L	K	P	L	A	A	A	I	D	A	G	D	R	I	H	A	V	I	R	G	S	A	I	N	N	D	G	S	A	K	M	G	Y	A	A	P	N	P	A	A	Q	A	D	V	I
Secondary structure
SS confidence
Disorder			?																																											?	?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	A	E	A	H	A	V	S	G	I	D	S	S	T	V	S	Y	V	E	C	H	G	T	G	T	P	L	G	D	P	I	E	I	Q	G	L	R	A	A	F	E	V	S	Q	T	S	R	S	A	P	C	V	L	G	S	V	K	S	N	I	G
Secondary structure
SS confidence
Disorder							?	?																																	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	H	L	E	V	A	A	G	I	A	G	L	I	K	T	I	L	C	L	K	N	K	A	L	P	A	T	L	H	Y	T	S	P	N	P	E	L	R	L	D	Q	S	P	F	V	V	Q	S	K	Y	G	P	W	E	C	D	G	V	R	R	A
Secondary structure
SS confidence
Disorder																																																		?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	G	V	S	S	F	G	V	G	G	T	N	A	H	V	V	L	E	E	A	P	A	E	A	S	E	V	S	A	H	A	E	P	A	G	P	Q	V	I	L	L	S	A	Q	T	A	A	A	L	G	E	S	R	T	A	L	A	A	A	L	E
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	T	Q	D	G	P	R	L	S	D	V	A	Y	T	L	A	R	R	R	K	H	N	V	T	M	A	A	V	V	H	D	R	E	H	A	A	T	V	L	R	A	A	E	H	D	N	V	F	V	G	E	A	A	H	D	G	E	H	G	D	R
Secondary structure
SS confidence
Disorder			?																																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	A	D	A	A	P	T	S	D	R	V	V	F	L	F	P	G	Q	G	A	Q	H	V	G	M	A	K	G	L	Y	D	T	E	P	V	F	A	Q	H	F	D	T	C	A	A	G	F	R	D	E	T	G	I	D	L	H	A	E	V	F	D
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	G	T	A	T	D	L	E	R	I	D	R	S	Q	P	A	L	F	T	V	E	Y	A	L	A	K	L	V	D	T	F	G	V	R	A	G	A	Y	I	G	Y	S	T	G	E	Y	I	A	A	T	L	A	G	V	F	D	L	Q	T	A	I
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	K	T	V	S	L	R	A	R	L	M	H	E	S	P	P	G	A	M	V	A	V	A	L	G	P	D	D	V	T	Q	Y	L	P	P	E	V	E	L	S	A	V	N	D	P	G	N	C	V	V	A	G	P	K	D	Q	I	R	A	L	R
Secondary structure
SS confidence
Disorder												?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	Q	R	L	T	E	A	G	I	P	V	R	R	V	R	A	T	H	A	F	H	T	S	A	M	D	P	M	L	G	Q	F	Q	E	F	L	S	R	Q	Q	L	R	P	P	R	T	P	L	L	S	N	L	T	G	S	W	M	S	D	Q	Q
Secondary structure
SS confidence
Disorder																																						?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	V	V	D	P	A	S	W	T	R	Q	I	S	S	P	I	R	F	A	D	E	L	D	V	V	L	A	A	P	S	R	I	L	V	E	V	G	P	G	G	S	L	T	G	S	A	M	R	H	P	K	W	S	T	T	H	R	T	V	R	L
Secondary structure
SS confidence
Disorder																																																?					?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	M	R	H	P	L	Q	D	V	D	D	R	D	T	F	L	R	A	L	G	E	L	W	S	A	G	V	E	V	D	W	T	P	R	R	P	A	V	P	H	L	V	S	L	P	G	Y	P	F	A	R	Q	R	H	W	V	E	P	N	H	T
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?																																																		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	V	W	A	Q	A	P	G	A	N	N	G	S	P	A	G	T	A	D	G	S	T	A	A	T	V	D	A	A	R	N	G	E	S	Q	T	E	V	T	L	Q	R	I	W	S	Q	C	L	G	V	S	S	V	D	R	N	A	N	F	F	D
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?		?					?								?							?						?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	L	G	G	D	S	L	M	A	I	S	I	A	M	A	A	A	N	E	G	L	T	I	T	P	Q	D	L	Y	E	Y	P	T	L	A	S	L	T	A	A	V	D	A	S	F	A	S	S	G	L	A	K	P	P	E	A	Q	A	N	P	A
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	V	P	P	N	V	T	Y	F	L	D	R	G	L	R	D	T	G	R	C	R	V	P	L	I	L	R	L	D	P	K	I	G	L	P	D	I	R	A	V	L	T	A	V	V	N	H	H	D	A	L	R	L	H	L	V	G	N	D	G	I
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	W	E	Q	H	I	A	A	P	A	E	F	T	G	L	S	N	R	S	V	P	N	G	V	A	A	G	S	P	E	E	R	A	A	V	L	G	I	L	A	E	L	L	E	D	Q	T	D	P	N	A	P	L	A	A	V	H	I	A	A	A
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	H	G	G	P	H	Y	L	C	L	A	I	H	A	M	V	T	D	D	S	S	R	Q	I	L	A	T	D	I	V	T	A	F	G	Q	R	L	A	G	E	E	I	T	L	E	P	V	S	T	G	W	R	E	W	S	L	R	C	A	A	L
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?																	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	A	T	H	P	A	A	L	D	T	R	S	Y	W	I	E	N	S	T	K	A	T	L	W	L	A	D	A	L	P	N	A	H	T	A	H	P	P	R	A	D	E	L	T	K	L	S	S	T	L	S	V	E	Q	T	S	E	L	D	D	G
Secondary structure
SS confidence
Disorder	?	?	?				?														?	?	?			?	?	?	?	?	?	?							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	R	R	R	F	R	R	S	I	Q	T	I	L	L	A	A	L	G	R	T	I	A	Q	T	V	G	E	G	V	V	A	V	E	L	E	G	E	G	R	S	V	L	R	P	D	V	D	L	R	R	T	V	G	W	F	T	T	Y	Y	P	V
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	P	L	A	C	A	T	G	L	G	A	L	A	Q	L	D	A	V	H	N	T	L	K	S	V	P	H	Y	G	I	G	Y	G	L	L	R	Y	V	Y	A	P	T	G	R	V	L	G	A	Q	R	T	P	D	I	H	F	R	Y	A	G	V
Secondary structure
SS confidence
Disorder				?	?	?																																	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	I	P	E	L	P	S	G	D	A	P	V	Q	F	D	S	D	M	T	L	P	V	R	E	P	I	P	G	M	G	H	A	I	E	L	R	V	Y	R	F	G	G	S	L	H	L	D	W	W	Y	D	T	R	R	I	P	A	A	T	A	E
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.	.	.
Sequence	A	L	E	R	T	F	P	L	A	L	S	A	L	I	Q	E	A	I	A	A	E	H	T	E	H	D	D	S	E	I	V	G	E	P	E	A	G	A	L	V	D	L	S	S	M	D	A	G
Secondary structure
SS confidence
Disorder																?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?
Disorder confidence