Phyre 2 Results for RVBD2940c_(mas)_3276390

Email	mdejesus@rockefeller.edu
Description	RVBD2940c_(mas)_3276390_3282725
Date	Thu Aug 8 16:20:10 BST 2019
Unique Job ID	7aa88e7b02bdf9dc
Sequence	MESRVTPVAV ... Download FASTA
Job Type	normal
Job Expiry

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:111.834 Y:146.739 Z:96.131

Model (left) based on template c2vz8A_

Top template information

PDB header:transferase
Chain: A: PDB Molecule:fatty acid synthase;
PDBTitle: crystal structure of mammalian fatty acid synthase

Confidence and coverage

Confidence:

100.0%

Coverage:

87%

1838 residues ( 87% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

1972 residues ( 93%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in JSmol

For other options to view your downloaded structure offline see the FAQ

Sequence analysis

Download FASTA version

Secondary structure and disorder prediction [Show]

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M E S R V T P V A V I G M G C R L P G G I N S P D K L W E S L L R G D D L V T E I P P D R W D A D D Y Y D P E P G V P G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence R S V S R W G G F L D D V A G F D A E F F G I S E R E A T S I D P Q Q R L L L E T S W E A I E H A G L D P A S L A G S S

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence T A V F T G L T H E D Y L V L T T T A G G L A S P Y V V T G L N N S V A S G R I A H T L G L H G P A M T F D T A C S S G

Secondary structure

SS confidence

Disorder
? ? ? ? ?
? ?
?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence L M A V H L A C R S L H D G E A D L A L A G G C A V L L E P H A S V A A S A Q G M L S S T G R C H S F D A D A D G F V R

Secondary structure

SS confidence

Disorder
? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence S E G C A M V L L K R L P D A L R D G N R I F A V V R G T A T N Q D G R T E T L T M P S E D A Q V A V Y R A A L A A A G

Secondary structure

SS confidence

Disorder
?
?
? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence V Q P E T V G V V E A H G T G T P I G D P I E Y R S L A R V Y G A G T P C A L G S A K S N M G H S T A S A G T V G L I K

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence A I L S L R H G V V P P L L H F N R L P D E L S D V E T G L F V P Q A V T P W P N G N D H T P K R V A V S S F G M S G T

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence N V H A I V E E A P A E A S A P E S S P G D A E V G P R L F M L S S T S S D A L R Q T A R Q L A T W V E E H Q D C V A A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence S D L A Y T L A R G R A H R P V R T A V V A A N L P E L V E G L R E V A D G D A L Y D A A V G H G D R G P V W V F S G Q

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence G S Q W A A M G T Q L L A S E P V F A A T I A K L E P V I A A E S G F S V T E A I T A Q Q T V T G I D K V Q P A V F A V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence Q V A L A A T M E Q T Y G V R P G A V V G H S M G E S A A A V V A G A L S L E D A A R V I C R R S K L M T R I A G A G A

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence M G S V E L P A K Q V N S E L M A R G I D D V V V S V V A S P Q S T V I G G T S D T V R D L I A R W E Q R D V M A R E V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence A V D V A S H S P Q V D P I L D D L A A A L A D I A P M T P K V P Y Y S A T L F D P R E Q P V C D G A Y W V D N L R N T

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence V Q F A A A V Q A A M E D G Y R V F A E L S P H P L L T H A V E Q T G R S L D M S V A A L A G M R R E Q P L P H G L R G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence L L T E L H R A G A A L D Y S A L Y P A G R L V D A P L P A W T H A R L F I D D D G Q E Q R A Q G A C T I T V H P L L G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence S H V R L T E E P E R H V W Q G D V G T S V L S W L S D H Q V H N V A A L P G A A Y C E M A L A A A A E V F G E A A E V

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence R D I T F E Q M L L L D E Q T P I D A V A S I D A P G V V N F T V E T N R D G E T T R H A T A A L R A A E D D C P P P G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence Y D I T A L L Q A H P H A V N G T A M R E S F A E R G V T L G A A F G G L T T A H T A E A G A A T V L A E V A L P A S I

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence R F Q Q G A Y R I H P A L L D A C F Q S V G A G V Q A G T A T G G L L L P L G V R S L R A Y G P T R N A R Y C Y T R L T

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence K A F N D G T R G G E A D L D V L D E H G T V L L A V R G L R M G T G T S E R D E R D R L V S E R L L T L G W Q Q R A L

Secondary structure

SS confidence

Disorder
?
? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence P E V G D G E A G S W L L I D T S N A V D T P D M L A S T L T D A L K S H G P Q G T E C A S L S W S V Q D T P P N D Q A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence G L E K L G S Q L R G R D G V V I V Y G P R V G D P D E H S L L A G R E Q V R H L V R I T R E L A E F E G E L P R L F V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence V T R Q A Q I V K P H D S G E R A N L E Q A G L R G L L R V I S S E H P M L R T T L I D V D E H T D V E R V A Q Q L L S

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence G S E E D E T A W R N G D W Y V A R L T P S P L G H E E R R T A V L D P D H D G M R V Q V R R P G D L Q T L E F V A S D

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . . . . . 1490 . . . . . . . . . 1500

Sequence R V P P G P G Q I E V A V S M S S I N F A D V L I A F G R F P I I D D R E P Q L G M D F V G V V T A V G E G V T G H Q V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1510 . . . . . . . . . 1520 . . . . . . . . . 1530 . . . . . . . . . 1540 . . . . . . . . . 1550 . . . . . . . . . 1560

Sequence G D R V G G F S E G G C W R T F L T C D A N L A V T L P P G L T D E Q A I T A A T A H A T A W Y G L N D L A Q I K A G D

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1570 . . . . . . . . . 1580 . . . . . . . . . 1590 . . . . . . . . . 1600 . . . . . . . . . 1610 . . . . . . . . . 1620

Sequence K V L I H S A T G G V G Q A A I S I A R A K G A E I F A T A G N P A K R A M L R D M G V E H V Y D S R S V E F A E Q I R

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1630 . . . . . . . . . 1640 . . . . . . . . . 1650 . . . . . . . . . 1660 . . . . . . . . . 1670 . . . . . . . . . 1680

Sequence R D T D G Y G V D I V L N S L T G A A Q R A G L E L L A F G G R F V E I G K A D V Y G N T R L G L F P F R R G L T F Y Y

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1690 . . . . . . . . . 1700 . . . . . . . . . 1710 . . . . . . . . . 1720 . . . . . . . . . 1730 . . . . . . . . . 1740

Sequence L D L A L M S V T Q P D R V R E L L A T V F K L T A D G V L T A P Q C T H Y P L A E A A D A I R A M S N A E H T G K L V

Secondary structure

SS confidence

Disorder
? ?
? ? ?

Disorder confidence

. . . . . . . . . 1750 . . . . . . . . . 1760 . . . . . . . . . 1770 . . . . . . . . . 1780 . . . . . . . . . 1790 . . . . . . . . . 1800

Sequence L D V P R S G R R S V A V T P E Q A P L Y R R D G S Y I I T G G L G G L G L F F A S K L A A A G C G R I V L T A R S Q P

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1810 . . . . . . . . . 1820 . . . . . . . . . 1830 . . . . . . . . . 1840 . . . . . . . . . 1850 . . . . . . . . . 1860

Sequence N P K A R Q T I E G L R A A G A D I V V E C G N I A E P D T A D R L V S A A T A T G L P L R G V L H S A A V V E D A T L

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 1870 . . . . . . . . . 1880 . . . . . . . . . 1890 . . . . . . . . . 1900 . . . . . . . . . 1910 . . . . . . . . . 1920

Sequence T N I T D E L I D R D W S P K V F G S W N L H R A T L G Q P L D W F C L F S S G A A L L G S P G Q G A Y A A A N S W V D

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1930 . . . . . . . . . 1940 . . . . . . . . . 1950 . . . . . . . . . 1960 . . . . . . . . . 1970 . . . . . . . . . 1980

Sequence V F A H W R R A Q G L P V S A I A W G A W G E V G R A T F L A E G G E I M I T P E E G A Y A F E T L V R H D R A Y S G Y

Secondary structure

SS confidence

Disorder
?
? ?

Disorder confidence

. . . . . . . . . 1990 . . . . . . . . . 2000 . . . . . . . . . 2010 . . . . . . . . . 2020 . . . . . . . . . 2030 . . . . . . . . . 2040

Sequence I P I L G A P W L A D L V R R S P W G E M F A S T G Q R S R G P S K F R M E L L S L P Q D E W A G R L R R L L V E Q A S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 2050 . . . . . . . . . 2060 . . . . . . . . . 2070 . . . . . . . . . 2080 . . . . . . . . . 2090 . . . . . . . . . 2100

Sequence V I L R R T I D A D R S F I E Y G L D S L G M L E M R T H V E T E T G I R L T P K V I A T N N T A R A L A Q Y L A D T L

Secondary structure

SS confidence

Disorder
? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 2110 .

Sequence A E E Q A A A P A A S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 10%)

Alpha helix ( 37%)

Beta strand ( 19%)

Domain analysis [Show]

Rank Aligned region

PDB 2vz8 chain A

3D model

Region: 6 - 1984
Aligned: 1838
Modelled: 1838
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: A: PDB Molecule:fatty acid synthase;
PDBTitle: crystal structure of mammalian fatty acid synthase

Phyre2

PDB 2vz8 chain B

Region: 6 - 1984
Aligned: 1852
Modelled: 1852
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: B: PDB Molecule:fatty acid synthase;
PDBTitle: crystal structure of mammalian fatty acid synthase

Phyre2

PDB 6fik chain A

3D model

Region: 2 - 892
Aligned: 879
Modelled: 879
Confidence: 100.0%
Identity: 29%
PDB header:biosynthetic protein
Chain: A: PDB Molecule:polyketide synthase;
PDBTitle: acp2 crosslinked to the ks of the loading/condensing region of the2 ctb1 pks

Phyre2

PDB 2qo3 chain A

3D model

Region: 4 - 879
Aligned: 855
Modelled: 855
Confidence: 100.0%
Identity: 43%
PDB header:transferase
Chain: A: PDB Molecule:eryaii erythromycin polyketide synthase modules 3 and 4;
PDBTitle: crystal structure of [ks3][at3] didomain from module 3 of 6-2 deoxyerthronolide b synthase

Phyre2

PDB 6c9u chain A

3D model

Region: 4 - 880
Aligned: 853
Modelled: 853
Confidence: 100.0%
Identity: 43%
PDB header:transferase/immune system
Chain: A: PDB Molecule:6-deoxyerythronolide-b synthase erya2, modules 3 and 4;
PDBTitle: crystal structure of [ks3][at3] didomain from module 3 of 6-2 deoxyerthronolide b synthase in complex with antibody fragment (fab)

Phyre2

PDB 2hg4 chain A

3D model

Region: 3 - 879
Aligned: 846
Modelled: 831
Confidence: 100.0%
Identity: 42%
PDB header:transferase
Chain: A: PDB Molecule:6-deoxyerythronolide b synthase;
PDBTitle: structure of the ketosynthase-acyltransferase didomain of module 52 from debs.

Phyre2

PDB 5bp1 chain A

3D model

Region: 5 - 881
Aligned: 809
Modelled: 809
Confidence: 100.0%
Identity: 67%
PDB header:transferase
Chain: A: PDB Molecule:mycocerosic acid synthase;
PDBTitle: condensing di-domain (ks-at) of a mycocerosic acid synthase-like (mas-2 like) pks

Phyre2

PDB 4mz0 chain B

3D model

Region: 2 - 878
Aligned: 789
Modelled: 789
Confidence: 100.0%
Identity: 40%
PDB header:transferase
Chain: B: PDB Molecule:curl;
PDBTitle: structure of a ketosynthase-acyltransferase di-domain from module curl2 of the curacin a polyketide synthase

Phyre2

PDB 3hhd chain C

3D model

Region: 6 - 887
Aligned: 830
Modelled: 830
Confidence: 100.0%
Identity: 31%
PDB header:transferase, hydrolase
Chain: C: PDB Molecule:fatty acid synthase;
PDBTitle: structure of the human fatty acid synthase ks-mat didomain as a2 framework for inhibitor design.

Phyre2

PDB 4kc5 chain D

3D model

Region: 2 - 1184
Aligned: 874
Modelled: 874
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: D: PDB Molecule:rhie protein;
PDBTitle: crystal structure of the c-terminal part of rhie from burkholderia2 rhizoxinica

Phyre2

PDB 4oqj chain A

3D model

Region: 4 - 882
Aligned: 668
Modelled: 661
Confidence: 100.0%
Identity: 37%
PDB header:hydrolase
Chain: A: PDB Molecule:pks;
PDBTitle: streptomcyes albus ja3453 oxazolomycin ketosynthase domain ozmq ks1

Phyre2

PDB 5erb chain B

Region: 5 - 567
Aligned: 538
Modelled: 538
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: B: PDB Molecule:polyketide synthase;
PDBTitle: ketosynthase from module 5 of the bacillaene synthase from bacillus2 amyloliquefaciens fzb42

Phyre2

PDB 5e5n chain B

3D model

Region: 6 - 590
Aligned: 546
Modelled: 546
Confidence: 100.0%
Identity: 34%
PDB header:hydrolase
Chain: B: PDB Molecule:polyketide synthase pksl;
PDBTitle: ketosynthase from module 6 of the bacillaene synthase from bacillus2 subtilis 168 (c167s mutant, crystal form 1)

Phyre2

PDB 4na3 chain A

3D model

Region: 6 - 590
Aligned: 563
Modelled: 563
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: A: PDB Molecule:polyketide synthase pksj;
PDBTitle: crystal structure of the second ketosynthase from the bacillaene2 polyketide synthase bound to a hexanoyl substrate mimic

Phyre2

PDB 4qyr chain A

3D model

Region: 6 - 592
Aligned: 558
Modelled: 548
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: A: PDB Molecule:at-less polyketide synthase;
PDBTitle: streptomyces platensis isomigrastatin ketosynthase domain mgse ks3

Phyre2

PDB 4tl2 chain A

3D model

Region: 5 - 592
Aligned: 571
Modelled: 565
Confidence: 100.0%
Identity: 35%
PDB header:transferase
Chain: A: PDB Molecule:at-less polyketide synthase;
PDBTitle: crystal structure of ketosynthase domain from mgsf from streptomyces2 platensis

Phyre2

PDB 3hmj chain B

3D model

Region: 2 - 634
Aligned: 617
Modelled: 617
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: B: PDB Molecule:fatty acid synthase subunit alpha;
PDBTitle: saccharomyces cerevisiae fas type i

Phyre2

PDB 4wky chain B

Region: 6 - 554
Aligned: 521
Modelled: 517
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: B: PDB Molecule:beta-ketoacyl synthase;
PDBTitle: streptomcyes albus ja3453 oxazolomycin ketosynthase domain ozmn ks2

Phyre2

PDB 4z37 chain A

3D model

Region: 4 - 567
Aligned: 549
Modelled: 549
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:putative mixed polyketide synthase/non-ribosomal peptide
PDBTitle: structure of the ketosynthase of module 2 of c0zgq5 (trans-at pks)2 from brevibacillus brevis

Phyre2

PDB 4tkt chain A

3D model

Region: 4 - 549
Aligned: 526
Modelled: 518
Confidence: 100.0%
Identity: 39%
PDB header:transferase
Chain: A: PDB Molecule:at-less polyketide synthase;
PDBTitle: streptomyces platensis isomigrastatin ketosynthase domain mgsf ks6

Phyre2

1
c2vz8A_

2
c2vz8B_

3
c6fikA_

4
c2qo3A_

5
c6c9uA_

6
c2hg4A_

7
c5bp1A_

8
c4mz0B_

9
c3hhdC_

10
c4kc5D_

11
c4oqjA_

12
c5erbB_

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c5e5nB_

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c4na3A_

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c4qyrA_

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c4tl2A_

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c3hmjB_

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c4wkyB_

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c4z37A_

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c4tktA_

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	E	S	R	V	T	P	V	A	V	I	G	M	G	C	R	L	P	G	G	I	N	S	P	D	K	L	W	E	S	L	L	R	G	D	D	L	V	T	E	I	P	P	D	R	W	D	A	D	D	Y	Y	D	P	E	P	G	V	P	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?																														?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	R	S	V	S	R	W	G	G	F	L	D	D	V	A	G	F	D	A	E	F	F	G	I	S	E	R	E	A	T	S	I	D	P	Q	Q	R	L	L	L	E	T	S	W	E	A	I	E	H	A	G	L	D	P	A	S	L	A	G	S	S
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	T	A	V	F	T	G	L	T	H	E	D	Y	L	V	L	T	T	T	A	G	G	L	A	S	P	Y	V	V	T	G	L	N	N	S	V	A	S	G	R	I	A	H	T	L	G	L	H	G	P	A	M	T	F	D	T	A	C	S	S	G
Secondary structure
SS confidence
Disorder																?	?	?	?	?		?	?								?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	L	M	A	V	H	L	A	C	R	S	L	H	D	G	E	A	D	L	A	L	A	G	G	C	A	V	L	L	E	P	H	A	S	V	A	A	S	A	Q	G	M	L	S	S	T	G	R	C	H	S	F	D	A	D	A	D	G	F	V	R
Secondary structure
SS confidence
Disorder																																						?	?			?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	S	E	G	C	A	M	V	L	L	K	R	L	P	D	A	L	R	D	G	N	R	I	F	A	V	V	R	G	T	A	T	N	Q	D	G	R	T	E	T	L	T	M	P	S	E	D	A	Q	V	A	V	Y	R	A	A	L	A	A	A	G
Secondary structure
SS confidence
Disorder																																						?		?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	V	Q	P	E	T	V	G	V	V	E	A	H	G	T	G	T	P	I	G	D	P	I	E	Y	R	S	L	A	R	V	Y	G	A	G	T	P	C	A	L	G	S	A	K	S	N	M	G	H	S	T	A	S	A	G	T	V	G	L	I	K
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	A	I	L	S	L	R	H	G	V	V	P	P	L	L	H	F	N	R	L	P	D	E	L	S	D	V	E	T	G	L	F	V	P	Q	A	V	T	P	W	P	N	G	N	D	H	T	P	K	R	V	A	V	S	S	F	G	M	S	G	T
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	N	V	H	A	I	V	E	E	A	P	A	E	A	S	A	P	E	S	S	P	G	D	A	E	V	G	P	R	L	F	M	L	S	S	T	S	S	D	A	L	R	Q	T	A	R	Q	L	A	T	W	V	E	E	H	Q	D	C	V	A	A
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?	?	?	?	?																															?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	S	D	L	A	Y	T	L	A	R	G	R	A	H	R	P	V	R	T	A	V	V	A	A	N	L	P	E	L	V	E	G	L	R	E	V	A	D	G	D	A	L	Y	D	A	A	V	G	H	G	D	R	G	P	V	W	V	F	S	G	Q
Secondary structure
SS confidence
Disorder																																					?			?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	G	S	Q	W	A	A	M	G	T	Q	L	L	A	S	E	P	V	F	A	A	T	I	A	K	L	E	P	V	I	A	A	E	S	G	F	S	V	T	E	A	I	T	A	Q	Q	T	V	T	G	I	D	K	V	Q	P	A	V	F	A	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	Q	V	A	L	A	A	T	M	E	Q	T	Y	G	V	R	P	G	A	V	V	G	H	S	M	G	E	S	A	A	A	V	V	A	G	A	L	S	L	E	D	A	A	R	V	I	C	R	R	S	K	L	M	T	R	I	A	G	A	G	A
Secondary structure
SS confidence
Disorder																																																						?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	M	G	S	V	E	L	P	A	K	Q	V	N	S	E	L	M	A	R	G	I	D	D	V	V	V	S	V	V	A	S	P	Q	S	T	V	I	G	G	T	S	D	T	V	R	D	L	I	A	R	W	E	Q	R	D	V	M	A	R	E	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	A	V	D	V	A	S	H	S	P	Q	V	D	P	I	L	D	D	L	A	A	A	L	A	D	I	A	P	M	T	P	K	V	P	Y	Y	S	A	T	L	F	D	P	R	E	Q	P	V	C	D	G	A	Y	W	V	D	N	L	R	N	T
Secondary structure
SS confidence
Disorder																									?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	V	Q	F	A	A	A	V	Q	A	A	M	E	D	G	Y	R	V	F	A	E	L	S	P	H	P	L	L	T	H	A	V	E	Q	T	G	R	S	L	D	M	S	V	A	A	L	A	G	M	R	R	E	Q	P	L	P	H	G	L	R	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	L	L	T	E	L	H	R	A	G	A	A	L	D	Y	S	A	L	Y	P	A	G	R	L	V	D	A	P	L	P	A	W	T	H	A	R	L	F	I	D	D	D	G	Q	E	Q	R	A	Q	G	A	C	T	I	T	V	H	P	L	L	G
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	S	H	V	R	L	T	E	E	P	E	R	H	V	W	Q	G	D	V	G	T	S	V	L	S	W	L	S	D	H	Q	V	H	N	V	A	A	L	P	G	A	A	Y	C	E	M	A	L	A	A	A	A	E	V	F	G	E	A	A	E	V
Secondary structure
SS confidence
Disorder					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	R	D	I	T	F	E	Q	M	L	L	L	D	E	Q	T	P	I	D	A	V	A	S	I	D	A	P	G	V	V	N	F	T	V	E	T	N	R	D	G	E	T	T	R	H	A	T	A	A	L	R	A	A	E	D	D	C	P	P	P	G
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	Y	D	I	T	A	L	L	Q	A	H	P	H	A	V	N	G	T	A	M	R	E	S	F	A	E	R	G	V	T	L	G	A	A	F	G	G	L	T	T	A	H	T	A	E	A	G	A	A	T	V	L	A	E	V	A	L	P	A	S	I
Secondary structure
SS confidence
Disorder																																																										?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	R	F	Q	Q	G	A	Y	R	I	H	P	A	L	L	D	A	C	F	Q	S	V	G	A	G	V	Q	A	G	T	A	T	G	G	L	L	L	P	L	G	V	R	S	L	R	A	Y	G	P	T	R	N	A	R	Y	C	Y	T	R	L	T
Secondary structure
SS confidence
Disorder		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	K	A	F	N	D	G	T	R	G	G	E	A	D	L	D	V	L	D	E	H	G	T	V	L	L	A	V	R	G	L	R	M	G	T	G	T	S	E	R	D	E	R	D	R	L	V	S	E	R	L	L	T	L	G	W	Q	Q	R	A	L
Secondary structure
SS confidence
Disorder		?		?	?	?	?																									?	?	?	?	?	?	?	?	?	?	?	?	?		?													?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	P	E	V	G	D	G	E	A	G	S	W	L	L	I	D	T	S	N	A	V	D	T	P	D	M	L	A	S	T	L	T	D	A	L	K	S	H	G	P	Q	G	T	E	C	A	S	L	S	W	S	V	Q	D	T	P	P	N	D	Q	A
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?																																												?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	G	L	E	K	L	G	S	Q	L	R	G	R	D	G	V	V	I	V	Y	G	P	R	V	G	D	P	D	E	H	S	L	L	A	G	R	E	Q	V	R	H	L	V	R	I	T	R	E	L	A	E	F	E	G	E	L	P	R	L	F	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	V	T	R	Q	A	Q	I	V	K	P	H	D	S	G	E	R	A	N	L	E	Q	A	G	L	R	G	L	L	R	V	I	S	S	E	H	P	M	L	R	T	T	L	I	D	V	D	E	H	T	D	V	E	R	V	A	Q	Q	L	L	S
Secondary structure
SS confidence
Disorder										?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	G	S	E	E	D	E	T	A	W	R	N	G	D	W	Y	V	A	R	L	T	P	S	P	L	G	H	E	E	R	R	T	A	V	L	D	P	D	H	D	G	M	R	V	Q	V	R	R	P	G	D	L	Q	T	L	E	F	V	A	S	D
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.	.	.	.	1490	.	.	.	.	.	.	.	.	.	1500
Sequence	R	V	P	P	G	P	G	Q	I	E	V	A	V	S	M	S	S	I	N	F	A	D	V	L	I	A	F	G	R	F	P	I	I	D	D	R	E	P	Q	L	G	M	D	F	V	G	V	V	T	A	V	G	E	G	V	T	G	H	Q	V
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?																							?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1510	.	.	.	.	.	.	.	.	.	1520	.	.	.	.	.	.	.	.	.	1530	.	.	.	.	.	.	.	.	.	1540	.	.	.	.	.	.	.	.	.	1550	.	.	.	.	.	.	.	.	.	1560
Sequence	G	D	R	V	G	G	F	S	E	G	G	C	W	R	T	F	L	T	C	D	A	N	L	A	V	T	L	P	P	G	L	T	D	E	Q	A	I	T	A	A	T	A	H	A	T	A	W	Y	G	L	N	D	L	A	Q	I	K	A	G	D
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1570	.	.	.	.	.	.	.	.	.	1580	.	.	.	.	.	.	.	.	.	1590	.	.	.	.	.	.	.	.	.	1600	.	.	.	.	.	.	.	.	.	1610	.	.	.	.	.	.	.	.	.	1620
Sequence	K	V	L	I	H	S	A	T	G	G	V	G	Q	A	A	I	S	I	A	R	A	K	G	A	E	I	F	A	T	A	G	N	P	A	K	R	A	M	L	R	D	M	G	V	E	H	V	Y	D	S	R	S	V	E	F	A	E	Q	I	R
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1630	.	.	.	.	.	.	.	.	.	1640	.	.	.	.	.	.	.	.	.	1650	.	.	.	.	.	.	.	.	.	1660	.	.	.	.	.	.	.	.	.	1670	.	.	.	.	.	.	.	.	.	1680
Sequence	R	D	T	D	G	Y	G	V	D	I	V	L	N	S	L	T	G	A	A	Q	R	A	G	L	E	L	L	A	F	G	G	R	F	V	E	I	G	K	A	D	V	Y	G	N	T	R	L	G	L	F	P	F	R	R	G	L	T	F	Y	Y
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1690	.	.	.	.	.	.	.	.	.	1700	.	.	.	.	.	.	.	.	.	1710	.	.	.	.	.	.	.	.	.	1720	.	.	.	.	.	.	.	.	.	1730	.	.	.	.	.	.	.	.	.	1740
Sequence	L	D	L	A	L	M	S	V	T	Q	P	D	R	V	R	E	L	L	A	T	V	F	K	L	T	A	D	G	V	L	T	A	P	Q	C	T	H	Y	P	L	A	E	A	A	D	A	I	R	A	M	S	N	A	E	H	T	G	K	L	V
Secondary structure
SS confidence
Disorder								?	?																																									?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1750	.	.	.	.	.	.	.	.	.	1760	.	.	.	.	.	.	.	.	.	1770	.	.	.	.	.	.	.	.	.	1780	.	.	.	.	.	.	.	.	.	1790	.	.	.	.	.	.	.	.	.	1800
Sequence	L	D	V	P	R	S	G	R	R	S	V	A	V	T	P	E	Q	A	P	L	Y	R	R	D	G	S	Y	I	I	T	G	G	L	G	G	L	G	L	F	F	A	S	K	L	A	A	A	G	C	G	R	I	V	L	T	A	R	S	Q	P
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1810	.	.	.	.	.	.	.	.	.	1820	.	.	.	.	.	.	.	.	.	1830	.	.	.	.	.	.	.	.	.	1840	.	.	.	.	.	.	.	.	.	1850	.	.	.	.	.	.	.	.	.	1860
Sequence	N	P	K	A	R	Q	T	I	E	G	L	R	A	A	G	A	D	I	V	V	E	C	G	N	I	A	E	P	D	T	A	D	R	L	V	S	A	A	T	A	T	G	L	P	L	R	G	V	L	H	S	A	A	V	V	E	D	A	T	L
Secondary structure
SS confidence
Disorder																																							?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1870	.	.	.	.	.	.	.	.	.	1880	.	.	.	.	.	.	.	.	.	1890	.	.	.	.	.	.	.	.	.	1900	.	.	.	.	.	.	.	.	.	1910	.	.	.	.	.	.	.	.	.	1920
Sequence	T	N	I	T	D	E	L	I	D	R	D	W	S	P	K	V	F	G	S	W	N	L	H	R	A	T	L	G	Q	P	L	D	W	F	C	L	F	S	S	G	A	A	L	L	G	S	P	G	Q	G	A	Y	A	A	A	N	S	W	V	D
Secondary structure
SS confidence
Disorder																																											?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1930	.	.	.	.	.	.	.	.	.	1940	.	.	.	.	.	.	.	.	.	1950	.	.	.	.	.	.	.	.	.	1960	.	.	.	.	.	.	.	.	.	1970	.	.	.	.	.	.	.	.	.	1980
Sequence	V	F	A	H	W	R	R	A	Q	G	L	P	V	S	A	I	A	W	G	A	W	G	E	V	G	R	A	T	F	L	A	E	G	G	E	I	M	I	T	P	E	E	G	A	Y	A	F	E	T	L	V	R	H	D	R	A	Y	S	G	Y
Secondary structure
SS confidence
Disorder																																	?			?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1990	.	.	.	.	.	.	.	.	.	2000	.	.	.	.	.	.	.	.	.	2010	.	.	.	.	.	.	.	.	.	2020	.	.	.	.	.	.	.	.	.	2030	.	.	.	.	.	.	.	.	.	2040
Sequence	I	P	I	L	G	A	P	W	L	A	D	L	V	R	R	S	P	W	G	E	M	F	A	S	T	G	Q	R	S	R	G	P	S	K	F	R	M	E	L	L	S	L	P	Q	D	E	W	A	G	R	L	R	R	L	L	V	E	Q	A	S
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	2050	.	.	.	.	.	.	.	.	.	2060	.	.	.	.	.	.	.	.	.	2070	.	.	.	.	.	.	.	.	.	2080	.	.	.	.	.	.	.	.	.	2090	.	.	.	.	.	.	.	.	.	2100
Sequence	V	I	L	R	R	T	I	D	A	D	R	S	F	I	E	Y	G	L	D	S	L	G	M	L	E	M	R	T	H	V	E	T	E	T	G	I	R	L	T	P	K	V	I	A	T	N	N	T	A	R	A	L	A	Q	Y	L	A	D	T	L
Secondary structure
SS confidence
Disorder							?	?	?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	2110	.
Sequence	A	E	E	Q	A	A	A	P	A	A	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?
Disorder confidence