1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	E	H	G	N	P	H	D	A	P	Q	L	A	P	A	V	E	R	I	T	T	R	A	G	R	P	P	G	T	V	T	A	D	R	G	Y	G	E	K	R	V	E	D	D	L	H	D	L	G	V	R	T	V	A	I	P	R	K	G	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																																	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	S	Q	A	R	R	A	E	E	Q	R	P	S	F	R	R	T	V	K	W	R	T	G	S	E	G	R	I	S	T	L	K	R	N	Y	G	W	N	R	S	C	I	D	G	T	E	G	T	R	I	W	T	R	H	G	I	L	T	H	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?									?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		L	I	K	I	S	S	L	A	A
Secondary structure
SS confidence
Disorder									?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 63%) Beta strand ( 6%) TM helix ( 12%) (View membrane topology prediction)

Rank Aligned region

PDB 1mus chain A Region: 8 - 118 Aligned: 111 Modelled: 111 Confidence: 97.6% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Transposase inhibitor (Tn5 transposase) Phyre2 PDB 1b7e chain A Region: 8 - 128 Aligned: 120 Modelled: 121 Confidence: 97.5% Identity: 19% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Transposase inhibitor (Tn5 transposase) Phyre2 PDB 1asu chain A Region: 8 - 120 Aligned: 94 Modelled: 95 Confidence: 79.4% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 1cxq chain A Region: 8 - 120 Aligned: 89 Modelled: 91 Confidence: 66.6% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 3nf9 chain A Region: 8 - 120 Aligned: 90 Modelled: 95 Confidence: 47.2% Identity: 17% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:integrase; PDBTitle: structural basis for a new mechanism of inhibition of hiv integrase2 identified by fragment screening and structure based design Phyre2 PDB 5cz1 chain B Region: 8 - 120 Aligned: 91 Modelled: 95 Confidence: 41.0% Identity: 10% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of the catalytic core domain of mmtv integrase Phyre2 PDB 2oq2 chain B Region: 8 - 47 Aligned: 39 Modelled: 40 Confidence: 38.2% Identity: 5% PDB header:oxidoreductase Chain: B: PDB Molecule:phosphoadenosine phosphosulfate reductase; PDBTitle: crystal structure of yeast paps reductase with pap, a product complex Phyre2 PDB 1c0m chain A Region: 8 - 93 Aligned: 67 Modelled: 68 Confidence: 33.3% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:protein (integrase); PDBTitle: crystal structure of rsv two-domain integrase Phyre2 PDB 1zun chain A domain 1 Region: 8 - 47 Aligned: 40 Modelled: 40 Confidence: 32.9% Identity: 8% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: PAPS reductase-like Phyre2 PDB 2etj chain A Region: 34 - 98 Aligned: 61 Modelled: 65 Confidence: 32.6% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease hii; PDBTitle: crystal structure of ribonuclease hii (ec 3.1.26.4) (rnase hii)2 (tm0915) from thermotoga maritima at 1.74 a resolution Phyre2 PDB 2etj chain A domain 1 Region: 34 - 98 Aligned: 61 Modelled: 65 Confidence: 32.6% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Ribonuclease H Phyre2 PDB 1zun chain A Region: 8 - 47 Aligned: 40 Modelled: 40 Confidence: 32.5% Identity: 8% PDB header:transferase Chain: A: PDB Molecule:sulfate adenylyltransferase subunit 2; PDBTitle: crystal structure of a gtp-regulated atp sulfurylase2 heterodimer from pseudomonas syringae Phyre2 PDB 3e0d chain A Region: 12 - 54 Aligned: 42 Modelled: 43 Confidence: 26.2% Identity: 17% PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase iii subunit alpha; PDBTitle: insights into the replisome from the crystral structure of2 the ternary complex of the eubacterial dna polymerase iii3 alpha-subunit Phyre2 PDB 4mq3 chain A Region: 8 - 120 Aligned: 90 Modelled: 95 Confidence: 25.1% Identity: 17% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: the 1.1 angstrom structure of catalytic core domain of fiv integrase Phyre2 PDB 5u1c chain D Region: 8 - 128 Aligned: 82 Modelled: 87 Confidence: 21.8% Identity: 22% PDB header:viral protein Chain: D: PDB Molecule:hiv-1 integrase, sso7d chimera; PDBTitle: structure of tetrameric hiv-1 strand transfer complex intasome Phyre2 PDB 2o8v chain A Region: 8 - 47 Aligned: 36 Modelled: 40 Confidence: 19.2% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:phosphoadenosine phosphosulfate reductase; PDBTitle: paps reductase in a covalent complex with thioredoxin c35a Phyre2 PDB 5ejk chain G Region: 8 - 52 Aligned: 44 Modelled: 45 Confidence: 18.6% Identity: 11% PDB header:transferase/dna Chain: G: PDB Molecule:gag-pro-pol polyprotein; PDBTitle: crystal structure of the rous sarcoma virus intasome Phyre2 PDB 3jca chain E Region: 8 - 120 Aligned: 93 Modelled: 95 Confidence: 17.6% Identity: 13% PDB header:viral protein Chain: E: PDB Molecule:integrase; PDBTitle: core model of the mouse mammary tumor virus intasome Phyre2 PDB 5u1c chain A Region: 8 - 129 Aligned: 99 Modelled: 104 Confidence: 16.5% Identity: 14% PDB header:viral protein Chain: A: PDB Molecule:hiv-1 integrase, sso7d chimera; PDBTitle: structure of tetrameric hiv-1 strand transfer complex intasome Phyre2 PDB 1exq chain A Region: 8 - 120 Aligned: 83 Modelled: 88 Confidence: 16.3% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 1 d1musa_ 2 d1b7ea_ 3 d1asua_ 4 d1cxqa_ 5 c3nf9A_ 6 c5cz1B_ 7 c2oq2B_ 8 c1c0mA_ 9 d1zuna1 10 c2etjA_ 11 d2etja1 12 c1zunA_ 13 c3e0dA_ 14 c4mq3A_ 15 c5u1cD_ 16 c2o8vA_ 17 c5ejkG_ 18 c3jcaE_ 19 c5u1cA_ 20 d1exqa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59