1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	S	T	K	V	E	D	R	V	T	A	A	V	L	G	A	I	G	H	A	L	A	L	T	A	S	M	T	W	E	I	L	W	A	L	I	L	G	F	A	L	S	A	V	V	Q	A	V	V	R	R	S	T	I	V	T	L	L	G
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	D	R	P	R	T	L	V	I	A	T	G	L	G	A	A	S	S	S	C	S	Y	A	A	V	A	L	A	R	S	L	F	R	K	G	A	N	F	T	A	A	M	A	F	E	I	G	S	T	N	L	V	V	E	L	G	I	I	L	A
Secondary structure
SS confidence
Disorder					?																														?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	L	M	G	W	Q	F	T	A	A	E	F	V	G	G	P	I	M	I	L	V	L	A	V	L	F	R	L	F	V	G	A	R	L	I	D	A	A	R	E	Q	A	E	R	G	L	A	G	S	M	E	G	H	A	A	M	D	M	S	I
Secondary structure
SS confidence
Disorder																																?		?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	R	E	G	S	F	W	R	R	L	L	S	P	P	G	F	T	S	I	A	H	V	F	V	M	E	W	L	A	I	L	R	D	L	I	L	G	L	L	I	A	G	A	I	A	A	W	V	P	E	S	F	W	Q	S	F	F	L	A	N
Secondary structure
SS confidence
Disorder			?	?		?	?	?	?	?	?	?	?	?																																														?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		H	P	A	W	S	A	V	W	G	P	I	I	G	P	I	V	A	I	V	S	F	V	C	S	I	G	N	V	P	L	A	A	V	L	W	N	G	G	I	S	F	G	G	V	I	A	F	I	F	A	D	L	L	I	L	P	I	L	N	I
Secondary structure
SS confidence
Disorder		?	?	?	?		?	?																			?	?										?	?	?	?												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	R	K	Y	Y	G	A	R	M	M	L	V	L	L	G	T	F	Y	A	S	M	V	V	A	G	Y	L	I	E	L	L	F	G	T	T	N	L	I	P	S	Q	R	S	A	T	V	M	T	A	E	I	S	W	N	Y	T	T	W	L	N
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.
Sequence		V	I	F	L	V	I	A	A	A	L	V	V	R	F	I	T	S	G	G	L	P	M	L	R	M	M	G	G	S	P	D	A	P	H	D	H	H	D	R	H	D	D	H	L	G	H
Secondary structure
SS confidence
Disorder																										?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 73%) Beta strand ( 0%) TM helix ( 54%) (View membrane topology prediction)

Rank Aligned region

PDB 4ky0 chain B Region: 30 - 343 Aligned: 277 Modelled: 277 Confidence: 87.0% Identity: 13% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:proton/glutamate symporter, sdf family; PDBTitle: crystal structure of a substrate-free glutamate transporter homologue2 from thermococcus kodakarensis Phyre2 PDB 5l2b chain C Region: 28 - 256 Aligned: 197 Modelled: 201 Confidence: 75.1% Identity: 14% PDB header:transport protein Chain: C: PDB Molecule:nucleoside permease; PDBTitle: structure of cntnw n149s, e332a in an outward-facing state Phyre2 PDB 3tij chain A Region: 4 - 255 Aligned: 220 Modelled: 224 Confidence: 68.4% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:nupc family protein; PDBTitle: crystal structure of a concentrative nucleoside transporter from2 vibrio cholerae Phyre2 PDB 3vu1 chain A Region: 388 - 403 Aligned: 16 Modelled: 16 Confidence: 60.1% Identity: 50% PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein ph0242; PDBTitle: crystal structure of the c-terminal globular domain of2 oligosaccharyltransferase (phaglb-l, o74088_pyrho) from pyrococcus3 horikoshii Phyre2 PDB 4n7w chain A Region: 25 - 159 Aligned: 134 Modelled: 135 Confidence: 58.4% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:transporter, sodium/bile acid symporter family; PDBTitle: crystal structure of the sodium bile acid symporter from yersinia2 frederiksenii Phyre2 PDB 6b2z chain F Region: 302 - 332 Aligned: 31 Modelled: 31 Confidence: 42.7% Identity: 29% PDB header:membrane protein Chain: F: PDB Molecule:atp synthase subunit c, mitochondrial; PDBTitle: cryo-em structure of the dimeric fo region of yeast mitochondrial atp2 synthase Phyre2 PDB 2xq2 chain A Region: 33 - 374 Aligned: 288 Modelled: 292 Confidence: 42.6% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 6b8h chain T Region: 302 - 332 Aligned: 31 Modelled: 31 Confidence: 40.7% Identity: 29% PDB header:membrane protein Chain: T: PDB Molecule:atp synthase subunit 9, mitochondrial; PDBTitle: mosaic model of yeast mitochondrial atp synthase monomer Phyre2 PDB 6gct chain A Region: 27 - 332 Aligned: 248 Modelled: 253 Confidence: 39.4% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:neutral amino acid transporter b(0); PDBTitle: cryo-em structure of the human neutral amino acid transporter asct2 Phyre2 PDB 2nww chain A domain 1 Region: 31 - 306 Aligned: 235 Modelled: 244 Confidence: 33.5% Identity: 16% Fold: Proton glutamate symport protein Superfamily: Proton glutamate symport protein Family: Proton glutamate symport protein Phyre2 PDB 5xbc chain B Region: 384 - 397 Aligned: 14 Modelled: 14 Confidence: 32.0% Identity: 36% PDB header:hydrolase Chain: B: PDB Molecule:nsp1 protein; PDBTitle: crystal structure basis for pedv nsp1 Phyre2 PDB 1kn7 chain A Region: 386 - 406 Aligned: 21 Modelled: 21 Confidence: 25.4% Identity: 38% PDB header:membrane protein Chain: A: PDB Molecule:voltage-gated potassium channel protein kv1.4; PDBTitle: solution structure of the tandem inactivation domain2 (residues 1-75) of potassium channel rck4 (kv1.4) Phyre2 PDB 2jmr chain A Region: 389 - 402 Aligned: 14 Modelled: 14 Confidence: 23.6% Identity: 29% PDB header:cell adhesion Chain: A: PDB Molecule:fimf; PDBTitle: nmr structure of the e. coli type 1 pilus subunit fimf Phyre2 PDB 3nk3 chain C Region: 389 - 402 Aligned: 14 Modelled: 9 Confidence: 21.7% Identity: 36% PDB header:cell adhesion Chain: C: PDB Molecule:zona pellucida 3; PDBTitle: crystal structure of full-length sperm receptor zp3 at 2.6 a2 resolution Phyre2 PDB 2k2b chain A Region: 374 - 397 Aligned: 24 Modelled: 24 Confidence: 21.2% Identity: 29% PDB header:transport protein Chain: A: PDB Molecule:degenerin mec-4; PDBTitle: sparse-constraint solution nmr structure of micelle-2 solublized cytosolic amino terminal domain of c. elegans3 mechanosensory ion channel subunit mec-4. new york4 consortium on membrane protein structure (nycomps) (casp5 target) Phyre2 PDB 3nk4 chain C Region: 389 - 401 Aligned: 13 Modelled: 9 Confidence: 21.0% Identity: 38% PDB header:cell adhesion Chain: C: PDB Molecule:zona pellucida 3; PDBTitle: crystal structure of full-length sperm receptor zp3 at 2.0 a2 resolution Phyre2 PDB 2iif chain A Region: 389 - 397 Aligned: 9 Modelled: 9 Confidence: 19.1% Identity: 33% PDB header:recombination/dna Chain: A: PDB Molecule:integration host factor; PDBTitle: single chain integration host factor mutant protein (scihf2-k45ae) in2 complex with dna Phyre2 PDB 2k74 chain A Region: 339 - 396 Aligned: 58 Modelled: 58 Confidence: 17.2% Identity: 21% PDB header:membrane protein, oxidoreductase Chain: A: PDB Molecule:disulfide bond formation protein b; PDBTitle: solution nmr structure of dsbb-ubiquinone complex Phyre2 PDB 2r6g chain F domain 1 Region: 209 - 262 Aligned: 44 Modelled: 54 Confidence: 14.8% Identity: 14% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 2gj0 chain A Region: 77 - 87 Aligned: 11 Modelled: 11 Confidence: 13.5% Identity: 27% PDB header:plant protein Chain: A: PDB Molecule:cycloviolacin o14; PDBTitle: cycloviolacin o14 Phyre2 1 c4ky0B_ 2 c5l2bC_ 3 c3tijA_ 4 c3vu1A_ 5 c4n7wA_ 6 c6b2zf_ 7 c2xq2A_ 8 c6b8ht_ 9 c6gctA_ 10 d2nwwa1 11 c5xbcB_ 12 c1kn7A_ 13 c2jmrA_ 14 c3nk3C_ 15 c2k2bA_ 16 c3nk4C_ 17 c2iifA_ 18 c2k74A_ 19 d2r6gf1 20 c2gj0A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64