1

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10

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20

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30

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40

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50

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60

Sequence

M

F

T

A

R

I

R

A

L

A

G

M

S

L

L

A

S

A

I

G

L

A

A

F

G

A

A

T

G

T

A

N

A

A

P

T

H

Q

P

E

W

G

T

Y

T

C

Y

D

Y

A

T

Q

T

F

Y

E

C

F

D

P

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

Sequence

S

Secondary structure

SS confidence

Disorder

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 46%) Alpha helix ( 67%) Beta strand ( 5%)

Rank Aligned region

PDB 1hgv chain A Region: 8 - 24 Aligned: 17 Modelled: 17 Confidence: 21.3% Identity: 59% PDB header:virus Chain: A: PDB Molecule:ph75 inovirus major coat protein; PDBTitle: filamentous bacteriophage ph75 Phyre2 PDB 5jyx chain B Region: 36 - 45 Aligned: 10 Modelled: 10 Confidence: 19.8% Identity: 0% PDB header:transferase Chain: B: PDB Molecule:archeaosine synthase quef-like; PDBTitle: crystal structure of the covalent thioimide intermediate of the2 archaeosine synthase quef-like Phyre2 PDB 1hgz chain A Region: 8 - 24 Aligned: 17 Modelled: 17 Confidence: 15.8% Identity: 59% PDB header:virus Chain: A: PDB Molecule:ph75 inovirus major coat protein; PDBTitle: filamentous bacteriophage ph75 Phyre2 PDB 3zhe chain C Region: 52 - 59 Aligned: 8 Modelled: 8 Confidence: 13.4% Identity: 75% PDB header:mrna-binding protein Chain: C: PDB Molecule:nonsense-mediated mrna decay protein; PDBTitle: structure of the c. elegans smg5-smg7 complex Phyre2 PDB 1xmw chain A domain 1 Region: 40 - 47 Aligned: 8 Modelled: 8 Confidence: 11.6% Identity: 50% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: I set domains Phyre2 PDB 1c55 chain A Region: 45 - 60 Aligned: 16 Modelled: 16 Confidence: 9.7% Identity: 50% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Scorpion toxin-like Family: Short-chain scorpion toxins Phyre2 PDB 3oai chain B Region: 38 - 47 Aligned: 10 Modelled: 10 Confidence: 8.8% Identity: 40% PDB header:membrane protein, cell adhesion Chain: B: PDB Molecule:maltose-binding periplasmic protein, myelin protein p0; PDBTitle: crystal structure of the extra-cellular domain of human myelin protein2 zero Phyre2 PDB 6idv chain B Region: 1 - 54 Aligned: 53 Modelled: 54 Confidence: 8.2% Identity: 15% PDB header:ligase Chain: B: PDB Molecule:peptide asparaginyl ligases; PDBTitle: peptide asparaginyl ligases from viola yedoensis Phyre2 PDB 3bp1 chain A Region: 38 - 45 Aligned: 8 Modelled: 8 Confidence: 7.6% Identity: 38% PDB header:oxidoreductase Chain: A: PDB Molecule:nadph-dependent 7-cyano-7-deazaguanine reductase; PDBTitle: crystal structure of putative 7-cyano-7-deazaguanine reductase quef2 from vibrio cholerae o1 biovar eltor Phyre2 PDB 1wwb chain X Region: 40 - 46 Aligned: 7 Modelled: 7 Confidence: 7.6% Identity: 43% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: I set domains Phyre2 PDB 1kl8 chain B Region: 51 - 57 Aligned: 7 Modelled: 7 Confidence: 7.5% Identity: 71% PDB header:toxin Chain: B: PDB Molecule:neuronal acetylcholine receptor protein, alpha-7 PDBTitle: nmr structural analysis of the complex formed between alpha-2 bungarotoxin and the principal alpha-neurotoxin binding3 sequence on the alpha7 subunit of a neuronal nicotinic4 acetylcholine receptor Phyre2 PDB 1kc4 chain B Region: 51 - 57 Aligned: 7 Modelled: 7 Confidence: 7.5% Identity: 71% PDB header:toxin Chain: B: PDB Molecule:neuronal acetylcholine receptor protein, alpha-7 PDBTitle: nmr structural analysis of the complex formed between alpha-2 bungarotoxin and the principal alpha-neurotoxin binding3 sequence on the alpha7 subunit of a neuronal nicotinic4 acetylcholine receptor Phyre2 PDB 5h0i chain B Region: 1 - 54 Aligned: 53 Modelled: 54 Confidence: 7.3% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:asparaginyl endopeptidase; PDBTitle: name to be released when published Phyre2 PDB 1xiw chain B Region: 42 - 55 Aligned: 14 Modelled: 14 Confidence: 6.8% Identity: 36% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: I set domains Phyre2 PDB 2vra chain D Region: 40 - 46 Aligned: 7 Modelled: 7 Confidence: 6.0% Identity: 43% PDB header:cell adhesion Chain: D: PDB Molecule:roundabout 1; PDBTitle: drosophila robo ig1-2 (monoclinic form) Phyre2 PDB 4f8b chain E Region: 36 - 45 Aligned: 10 Modelled: 10 Confidence: 6.0% Identity: 40% PDB header:oxidoreductase Chain: E: PDB Molecule:nadph-dependent 7-cyano-7-deazaguanine reductase; PDBTitle: crystal structure of the covalent thioimide intermediate of unimodular2 nitrile reductase quef Phyre2 PDB 1m4k chain A domain 2 Region: 40 - 47 Aligned: 8 Modelled: 8 Confidence: 5.9% Identity: 50% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: I set domains Phyre2 PDB 1oll chain A domain 2 Region: 40 - 47 Aligned: 8 Modelled: 8 Confidence: 5.6% Identity: 50% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: I set domains Phyre2 PDB 1f97 chain A domain 1 Region: 40 - 46 Aligned: 7 Modelled: 7 Confidence: 5.5% Identity: 57% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: V set domains (antibody variable domain-like) Phyre2 PDB 1cdh chain A Region: 40 - 46 Aligned: 7 Modelled: 7 Confidence: 5.3% Identity: 57% PDB header:t-cell surface glycoprotein Chain: A: PDB Molecule:t cell surface glycoprotein cd4; PDBTitle: structures of an hiv and mhc binding fragment from human cd4 as2 refined in two crystal lattices Phyre2 1 c1hgvA_ 2 c5jyxB_ 3 c1hgzA_ 4 c3zheC_ 5 d1xmwa1 6 d1c55a_ 7 c3oaiB_ 8 c6idvB_ 9 c3bp1A_ 10 d1wwbx_ 11 c1kl8B_ 12 c1kc4B_ 13 c5h0iB_ 14 d1xiwb_ 15 c2vraD_ 16 c4f8bE_ 17 d1m4ka2 18 d1olla2 19 d1f97a1 20 c1cdhA_ 21 22 23 24 25 26 27 28 29 30