1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	A	A	R	P	A	E	R	S	G	D	P	A	A	V	R	V	P	V	P	S	A	W	W	V	L	I	G	G	V	I	G	L	F	A	S	M	T	L	T	V	E	K	V	R	I	L	L	D	P	I	Y	V	P	S	C	N	V	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																																		?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	I	V	S	C	G	S	V	M	T	T	P	Q	A	S	L	L	G	F	P	N	P	L	L	G	I	A	G	F	T	V	V	V	V	T	G	V	L	A	V	A	K	V	P	L	P	R	W	Y	W	I	G	L	A	V	G	I	L	V	G
Secondary structure
SS confidence
Disorder		?																																							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	A	F	V	H	W	L	I	F	Q	S	L	Y	R	I	G	A	L	C	P	Y	C	M	V	V	W	A	V	I	A	T	L	L	V	V	V	A	S	I	V	F	G	P	M	R	E	N	R	G	S	Q	E	R	V	G	A	R	L	L	Y
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence		Q	W	R	W	S	L	A	T	L	W	F	T	T	V	F	L	L	I	M	V	R	F	W	D	Y	W	S	T	L	I
Secondary structure
SS confidence
Disorder																														?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 70%) Beta strand ( 0%) TM helix ( 53%) (View membrane topology prediction)

Rank Aligned region

PDB 3kp9 chain A Region: 20 - 205 Aligned: 157 Modelled: 168 Confidence: 100.0% Identity: 23% PDB header:blood coagulation,oxidoreductase Chain: A: PDB Molecule:vkorc1/thioredoxin domain protein; PDBTitle: structure of a bacterial homolog of vitamin k epoxide reductase Phyre2 PDB 2k74 chain A Region: 19 - 107 Aligned: 85 Modelled: 89 Confidence: 93.4% Identity: 24% PDB header:membrane protein, oxidoreductase Chain: A: PDB Molecule:disulfide bond formation protein b; PDBTitle: solution nmr structure of dsbb-ubiquinone complex Phyre2 PDB 5ir6 chain A Region: 74 - 128 Aligned: 55 Modelled: 55 Confidence: 82.9% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:bd-type quinol oxidase subunit i; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 3e9j chain C Region: 14 - 100 Aligned: 82 Modelled: 87 Confidence: 70.6% Identity: 13% PDB header:oxidoreductase Chain: C: PDB Molecule:thiol/disulfide oxidoreductase dsbb; PDBTitle: structure of the charge-transfer intermediate of the2 transmembrane redox catalyst dsbb Phyre2 PDB 2hi7 chain B domain 1 Region: 14 - 100 Aligned: 86 Modelled: 87 Confidence: 64.4% Identity: 16% Fold: Bromodomain-like Superfamily: DsbB-like Family: DsbB-like Phyre2 PDB 5y7i chain B Region: 135 - 148 Aligned: 13 Modelled: 14 Confidence: 30.3% Identity: 38% PDB header:transport protein Chain: B: PDB Molecule:chloride intracellular channel protein 2; PDBTitle: structure of tilapia fish clic2 Phyre2 PDB 2voy chain G Region: 136 - 150 Aligned: 15 Modelled: 15 Confidence: 20.7% Identity: 20% PDB header:hydrolase Chain: G: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium atpase 1; PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus Phyre2 PDB 2n1p chain A Region: 106 - 123 Aligned: 18 Modelled: 18 Confidence: 17.8% Identity: 28% PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 5b, ns5b; PDBTitle: structure of the c-terminal membrane domain of hcv ns5b protein Phyre2 PDB 1v54 chain J Region: 100 - 133 Aligned: 34 Modelled: 34 Confidence: 17.0% Identity: 6% Fold: Single transmembrane helix Superfamily: Mitochondrial cytochrome c oxidase subunit VIIa Family: Mitochondrial cytochrome c oxidase subunit VIIa Phyre2 PDB 2dlk chain A domain 1 Region: 55 - 73 Aligned: 16 Modelled: 19 Confidence: 14.9% Identity: 31% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: Classic zinc finger, C2H2 Phyre2 PDB 6f46 chain A Region: 103 - 124 Aligned: 22 Modelled: 22 Confidence: 14.3% Identity: 32% PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-like protein 1; PDBTitle: structure of the transmembrane helix of bclxl in phospholipid2 nanodiscs Phyre2 PDB 1wjp chain A domain 2 Region: 137 - 142 Aligned: 6 Modelled: 6 Confidence: 14.1% Identity: 83% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: Classic zinc finger, C2H2 Phyre2 PDB 5hfi chain A Region: 138 - 142 Aligned: 5 Modelled: 5 Confidence: 11.1% Identity: 60% PDB header:oxidoreductase Chain: A: PDB Molecule:uncharacterized protein, cytosolic disulfide reductase PDBTitle: cytosolic disulfide reductase dsbm from pseudomonas aeruginosa with2 gsh Phyre2 PDB 2y69 chain W Region: 100 - 133 Aligned: 34 Modelled: 34 Confidence: 10.9% Identity: 6% PDB header:electron transport Chain: W: PDB Molecule:cytochrome c oxidase polypeptide 7a1; PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular oxygen Phyre2 PDB 5z62 chain J Region: 100 - 133 Aligned: 34 Modelled: 34 Confidence: 10.7% Identity: 6% PDB header:electron transport Chain: J: PDB Molecule:cytochrome c oxidase subunit 7a2, mitochondrial; PDBTitle: structure of human cytochrome c oxidase Phyre2 PDB 6ith chain A Region: 106 - 137 Aligned: 32 Modelled: 32 Confidence: 10.1% Identity: 22% PDB header:membrane protein Chain: A: PDB Molecule:syndecan-2; PDBTitle: structure of the transmembrane domain of syndecan 2 in micelles Phyre2 PDB 2k9h chain A Region: 139 - 143 Aligned: 5 Modelled: 5 Confidence: 9.3% Identity: 100% PDB header:metal binding protein Chain: A: PDB Molecule:glycoprotein; PDBTitle: the hantavirus glycoprotein g1 tail contains a dual cchc-2 type classical zinc fingers Phyre2 PDB 6hwh chain X Region: 147 - 210 Aligned: 64 Modelled: 64 Confidence: 9.1% Identity: 9% PDB header:electron transport Chain: X: PDB Molecule:cytochrome c oxidase polypeptide 4; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 3kzq chain E Region: 138 - 142 Aligned: 5 Modelled: 5 Confidence: 8.9% Identity: 40% PDB header:structural genomics, unknown function Chain: E: PDB Molecule:putative uncharacterized protein vp2116; PDBTitle: the crystal structure of the protein with unknown function from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 2in3 chain A Region: 138 - 142 Aligned: 5 Modelled: 4 Confidence: 8.8% Identity: 40% PDB header:isomerase Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a putative protein disulfide isomerase from2 nitrosomonas europaea Phyre2 1 c3kp9A_ 2 c2k74A_ 3 c5ir6A_ 4 c3e9jC_ 5 d2hi7b1 6 c5y7iB_ 7 c2voyG_ 8 c2n1pA_ 9 d1v54j_ 10 d2dlka1 11 c6f46A_ 12 d1wjpa2 13 c5hfiA_ 14 c2y69W_ 15 c5z62J_ 16 c6ithA_ 17 c2k9hA_ 18 c6hwhX_ 19 c3kzqE_ 20 c2in3A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57