1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.
Sequence		V	L	I	R	W	H	I	Q	L	G	N	I	V	I	P	K	S	V	N	P	M	R	I	A	S	N	F	D	A	F	D	F	P	R	S	M	T	E	P	G	L	V	R	I	R	K	P	S	I	S	Q	A	G	E	M	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																								?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 38%) Beta strand ( 20%)

Rank Aligned region

PDB 5az0 chain A Region: 1 - 52 Aligned: 50 Modelled: 52 Confidence: 99.2% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of aldo-keto reductase (akr2e5) of the silkworm,2 bombyx mori Phyre2 PDB 3ln3 chain A Region: 1 - 49 Aligned: 48 Modelled: 49 Confidence: 99.2% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrodiol dehydrogenase; PDBTitle: crystal structure of putative reductase (np_038806.2) from mus2 musculus at 1.18 a resolution Phyre2 PDB 1q5m chain A Region: 1 - 52 Aligned: 50 Modelled: 52 Confidence: 99.1% Identity: 24% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 2alr chain A Region: 1 - 49 Aligned: 47 Modelled: 49 Confidence: 99.1% Identity: 38% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 3h7u chain A Region: 1 - 52 Aligned: 50 Modelled: 52 Confidence: 99.1% Identity: 32% PDB header:oxidoreductase Chain: A: PDB Molecule:aldo-keto reductase; PDBTitle: crystal structure of the plant stress-response enzyme akr4c9 Phyre2 PDB 1ah4 chain A Region: 1 - 51 Aligned: 49 Modelled: 51 Confidence: 99.1% Identity: 45% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 1hqt chain A Region: 1 - 52 Aligned: 50 Modelled: 52 Confidence: 99.1% Identity: 38% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 1s1p chain A Region: 1 - 52 Aligned: 50 Modelled: 52 Confidence: 99.1% Identity: 26% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 1c9w chain A Region: 1 - 51 Aligned: 49 Modelled: 51 Confidence: 99.1% Identity: 49% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 1frb chain A Region: 1 - 51 Aligned: 49 Modelled: 51 Confidence: 99.1% Identity: 47% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 4hbk chain A Region: 1 - 56 Aligned: 54 Modelled: 56 Confidence: 99.1% Identity: 37% PDB header:oxidoreductase Chain: A: PDB Molecule:aldo-keto reductase family 1, member b4 (aldose reductase); PDBTitle: structure of the aldose reductase from schistosoma japonicum Phyre2 PDB 1afs chain A Region: 1 - 51 Aligned: 49 Modelled: 51 Confidence: 99.1% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 1j96 chain A Region: 1 - 52 Aligned: 50 Modelled: 52 Confidence: 99.1% Identity: 28% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 4mhb chain F Region: 1 - 53 Aligned: 51 Modelled: 53 Confidence: 99.0% Identity: 27% PDB header:oxidoreductase Chain: F: PDB Molecule:putative aldo/keto reductase; PDBTitle: structure of a putative reductase from yersinia pestis Phyre2 PDB 2bgs chain A Region: 1 - 51 Aligned: 49 Modelled: 51 Confidence: 99.0% Identity: 31% PDB header:oxidoreductase Chain: A: PDB Molecule:aldose reductase; PDBTitle: holo aldose reductase from barley Phyre2 PDB 4otk chain A Region: 1 - 52 Aligned: 50 Modelled: 52 Confidence: 99.0% Identity: 42% PDB header:oxidoreductase Chain: A: PDB Molecule:mycobacterial enzyme rv2971; PDBTitle: a structural characterization of the isoniazid mycobacterium2 tuberculosis drug target, rv2971, in its unliganded form Phyre2 PDB 1us0 chain A Region: 1 - 52 Aligned: 50 Modelled: 52 Confidence: 99.0% Identity: 42% Fold: TIM beta/alpha-barrel Superfamily: NAD(P)-linked oxidoreductase Family: Aldo-keto reductases (NADP) Phyre2 PDB 3buv chain B Region: 1 - 52 Aligned: 50 Modelled: 52 Confidence: 99.0% Identity: 38% PDB header:oxidoreductase Chain: B: PDB Molecule:3-oxo-5-beta-steroid 4-dehydrogenase; PDBTitle: crystal structure of human delta(4)-3-ketosteroid 5-beta-reductase in2 complex with nadp and hepes. resolution: 1.35 a. Phyre2 PDB 5ket chain A Region: 1 - 55 Aligned: 53 Modelled: 55 Confidence: 99.0% Identity: 40% PDB header:oxidoreductase Chain: A: PDB Molecule:aldo-keto reductase 1; PDBTitle: structure of the aldo-keto reductase from coptotermes gestroi Phyre2 PDB 4ijr chain A Region: 1 - 56 Aligned: 52 Modelled: 56 Confidence: 99.0% Identity: 31% PDB header:oxidoreductase Chain: A: PDB Molecule:d-arabinose dehydrogenase [nad(p)+] heavy chain; PDBTitle: crystal structure of saccharomyces cerevisiae arabinose dehydrogenase2 ara1 complexed with nadph Phyre2 1 c5az0A_ 2 c3ln3A_ 3 d1q5ma_ 4 d2alra_ 5 c3h7uA_ 6 d1ah4a_ 7 d1hqta_ 8 d1s1pa_ 9 d1c9wa_ 10 d1frba_ 11 c4hbkA_ 12 d1afsa_ 13 d1j96a_ 14 c4mhbF_ 15 c2bgsA_ 16 c4otkA_ 17 d1us0a_ 18 c3buvB_ 19 c5ketA_ 20 c4ijrA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64