Phyre Home Retrieve Phyre Job Id
Emailmdejesus@rockefeller.edu
DescriptionRVBD2971_(-)_3326111_3326959
DateThu Aug 8 16:20:13 BST 2019
Unique Job ID2f24eb50da7c6709
SequenceVTGESGAAAA ... Download FASTA
Job Typenormal
Job Expiry

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:48.795 Y:50.689 Z:43.625
Model (left) based on template c4otkA_
Top template information
PDB header:oxidoreductase
Chain: A: PDB Molecule:mycobacterial enzyme rv2971;
PDBTitle: a structural characterization of the isoniazid mycobacterium2 tuberculosis drug target, rv2971, in its unliganded form
Confidence and coverage
Confidence:100.0% Coverage: 98%
276 residues ( 98% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in JSmol
For other options to view your downloaded structure offline see the FAQ

Sequence analysis 

Download FASTA version

Secondary structure and disorder prediction [Show] 

Domain analysis [Show] 

Detailed template information [Hide] 

 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c4otkA_
100.0 100
PDB header:oxidoreductase
Chain: A: PDB Molecule:mycobacterial enzyme rv2971;
PDBTitle: a structural characterization of the isoniazid mycobacterium2 tuberculosis drug target, rv2971, in its unliganded form
2d1mzra_
100.0 48
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
3c3f7jB_
100.0 43
PDB header:oxidoreductase
Chain: B: PDB Molecule:yvgn protein;
PDBTitle: b.subtilis yvgn
4d1frba_
100.0 37
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
5c4fziA_
100.0 43
PDB header:oxidoreductase
Chain: A: PDB Molecule:prostaglandin f synthase;
PDBTitle: crystal structure of prostaglandin f synthase from trypanosoma cruzi
6c3wbwA_
100.0 42
PDB header:oxidoreductase
Chain: A: PDB Molecule:putative 2,5-diketo-d-gluconic acid reductase;
PDBTitle: crystal structure of gox0644 in complex with nadph
7d1mi3a_
100.0 36
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
8c3h7uA_
100.0 38
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldo-keto reductase;
PDBTitle: crystal structure of the plant stress-response enzyme akr4c9
9c2wztA_
100.0 67
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldo-keto reductase;
PDBTitle: crystal structure of a mycobacterium aldo-keto reductase in its apo2 and liganded form
10d1hqta_
100.0 38
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
11c4mhbF_
100.0 39
PDB header:oxidoreductase
Chain: F: PDB Molecule:putative aldo/keto reductase;
PDBTitle: structure of a putative reductase from yersinia pestis
12d1qwka_
100.0 38
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
13c3up8B_
100.0 34
PDB header:oxidoreductase
Chain: B: PDB Molecule:putative 2,5-diketo-d-gluconic acid reductase b;
PDBTitle: crystal structure of a putative 2,5-diketo-d-gluconic acid reductase b
14c5az0A_
100.0 34
PDB header:oxidoreductase
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of aldo-keto reductase (akr2e5) of the silkworm,2 bombyx mori
15d1q5ma_
100.0 35
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
16d2alra_
100.0 39
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
17d1c9wa_
100.0 38
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
18c3wczA_
100.0 41
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldo-keto reductase 2e;
PDBTitle: crystal structure of bombyx mori aldo-keto reductase (akr2e4) in2 complex with nadp
19d1vp5a_
100.0 42
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
20c5ketA_
100.0 37
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldo-keto reductase 1;
PDBTitle: structure of the aldo-keto reductase from coptotermes gestroi
21c1vbjB_
not modelled 100.0 44
PDB header:oxidoreductase
Chain: B: PDB Molecule:prostaglandin f synthase;
PDBTitle: the crystal structure of prostaglandin f synthase from trypanosoma2 brucei
22c3b3dA_
not modelled 100.0 41
PDB header:oxidoreductase
Chain: A: PDB Molecule:putative morphine dehydrogenase;
PDBTitle: b.subtilis ytbe
23c4q3mF_
not modelled 100.0 39
PDB header:hydrolase
Chain: F: PDB Molecule:mgs-m4;
PDBTitle: crystal structure of mgs-m4, an aldo-keto reductase enzyme from a2 medee basin deep-sea metagenome library
24c3o0kB_
not modelled 100.0 48
PDB header:oxidoreductase
Chain: B: PDB Molecule:aldo/keto reductase;
PDBTitle: crystal structure of aldo/keto reductase from brucella melitensis
25d1j96a_
not modelled 100.0 38
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
26d1hw6a_
not modelled 100.0 49
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
27d1ah4a_
not modelled 100.0 40
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
28c2bgsA_
not modelled 100.0 35
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldose reductase;
PDBTitle: holo aldose reductase from barley
29c4f40B_
not modelled 100.0 44
PDB header:oxidoreductase
Chain: B: PDB Molecule:prostaglandin f2-alpha synthase/d-arabinose dehydrogenase;
PDBTitle: x-ray crystal structure of apo prostaglandin f synthase from2 leishmania major friedlin
30d1afsa_
not modelled 100.0 37
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
31d1s1pa_
not modelled 100.0 37
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
32c1zgdB_
not modelled 100.0 35
PDB header:plant protein
Chain: B: PDB Molecule:chalcone reductase;
PDBTitle: chalcone reductase complexed with nadp+ at 1.7 angstrom2 resolution
33d1us0a_
not modelled 100.0 41
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
34c3wg6C_
not modelled 100.0 32
PDB header:oxidoreductase
Chain: C: PDB Molecule:conjugated polyketone reductase c1;
PDBTitle: crystal structure of conjugated polyketone reductase c1 from candida2 parapsilosis complexed with nadph
35c3h7rA_
not modelled 100.0 37
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldo-keto reductase;
PDBTitle: crystal structure of the plant stress-response enzyme akr4c8
36c3buvB_
not modelled 100.0 37
PDB header:oxidoreductase
Chain: B: PDB Molecule:3-oxo-5-beta-steroid 4-dehydrogenase;
PDBTitle: crystal structure of human delta(4)-3-ketosteroid 5-beta-reductase in2 complex with nadp and hepes. resolution: 1.35 a.
37c4hbkA_
not modelled 100.0 40
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldo-keto reductase family 1, member b4 (aldose reductase);
PDBTitle: structure of the aldose reductase from schistosoma japonicum
38d1lqaa_
not modelled 100.0 25
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
39c4pmjA_
not modelled 100.0 31
PDB header:oxidoreductase
Chain: A: PDB Molecule:putative oxidoreductase;
PDBTitle: crystal structure of a putative oxidoreductase from sinorhizobium2 meliloti 1021 in complex with nadp
40c3krbB_
not modelled 100.0 34
PDB header:oxidoreductase
Chain: B: PDB Molecule:aldose reductase;
PDBTitle: structure of aldose reductase from giardia lamblia at 1.75a resolution
41d1ur3m_
not modelled 100.0 25
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
42c4xk2A_
not modelled 100.0 28
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldo/keto reductase;
PDBTitle: crystal structure of aldo-keto reductase from polaromonas sp. js666
43c3erpA_
not modelled 100.0 23
PDB header:oxidoreductase
Chain: A: PDB Molecule:putative oxidoreductase;
PDBTitle: structure of idp01002, a putative oxidoreductase from and essential2 gene of salmonella typhimurium
44c3vxgA_
not modelled 100.0 31
PDB header:oxidoreductase
Chain: A: PDB Molecule:conjugated polyketone reductase c2;
PDBTitle: crystal structure of conjugated polyketone reductase c2 from candida2 parapsilosis
45c6hg6A_
not modelled 100.0 23
PDB header:oxidoreductase
Chain: A: PDB Molecule:l-glyceraldehyde 3-phosphate reductase;
PDBTitle: clostridium beijerinckii aldo-keto reductase cbei_3974 with nadph
46d3eaua1
not modelled 100.0 24
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
47d1pyfa_
not modelled 100.0 27
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
48c3lutA_
not modelled 100.0 24
PDB header:membrane protein
Chain: A: PDB Molecule:voltage-gated potassium channel subunit beta-2;
PDBTitle: a structural model for the full-length shaker potassium channel kv1.2
49c3n2tA_
not modelled 100.0 29
PDB header:oxidoreductase
Chain: A: PDB Molecule:putative oxidoreductase;
PDBTitle: structure of the glycerol dehydrogenase akr11b4 from gluconobacter2 oxydans
50c3n6qF_
not modelled 100.0 21
PDB header:oxidoreductase
Chain: F: PDB Molecule:yghz aldo-keto reductase;
PDBTitle: crystal structure of yghz from e. coli
51d1pz1a_
not modelled 100.0 25
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
52c3v0tA_
not modelled 100.0 24
PDB header:oxidoreductase
Chain: A: PDB Molecule:perakine reductase;
PDBTitle: crystal structure of perakine reductase, founder member of a novel akr2 subfamily with unique conformational changes during nadph binding
53c5danA_
not modelled 100.0 31
PDB header:oxidoreductase
Chain: A: PDB Molecule:2,5-diketo-d-gluconic acid reductase;
PDBTitle: crystal structure of a novel aldo keto reductase tm1743 from2 thermotoga maritima in complex with nadp+
54c4wghA_
not modelled 100.0 28
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldehyde reductase;
PDBTitle: crystal structure of aldo/keto reductase from klebsiella pneumoniae in2 complex with nadp and acetate at 1.8 a resolution
55c4ijrA_
not modelled 100.0 38
PDB header:oxidoreductase
Chain: A: PDB Molecule:d-arabinose dehydrogenase [nad(p)+] heavy chain;
PDBTitle: crystal structure of saccharomyces cerevisiae arabinose dehydrogenase2 ara1 complexed with nadph
56d1gvea_
not modelled 100.0 23
Fold:TIM beta/alpha-barrel
Superfamily:NAD(P)-linked oxidoreductase
Family:Aldo-keto reductases (NADP)
57c6gtmA_
not modelled 100.0 19
PDB header:signaling protein
Chain: A: PDB Molecule:aldo-keto reductase family protein;
PDBTitle: crystal structure of smba in complex with ppgpp.
58c1ynpA_
not modelled 100.0 23
PDB header:oxidoreductase
Chain: A: PDB Molecule:oxidoreductase;
PDBTitle: aldo-keto reductase akr11c1 from bacillus halodurans (apo form)
59c2bp1C_
not modelled 100.0 23
PDB header:oxidoreductase
Chain: C: PDB Molecule:aflatoxin b1 aldehyde reductase member 2;
PDBTitle: structure of the aflatoxin aldehyde reductase in complex with nadph
60c4exaD_
not modelled 100.0 23
PDB header:oxidoreductase
Chain: D: PDB Molecule:putative uncharacterized protein;
PDBTitle: crystal structure of the pa4992, the putative aldo-keto reductase from2 pseudomona aeruginosa
61c3ln3A_
not modelled 100.0 34
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrodiol dehydrogenase;
PDBTitle: crystal structure of putative reductase (np_038806.2) from mus2 musculus at 1.18 a resolution
62c3l2iB_
not modelled 85.7 14
PDB header:lyase
Chain: B: PDB Molecule:3-dehydroquinate dehydratase;
PDBTitle: 1.85 angstrom crystal structure of the 3-dehydroquinate dehydratase2 (arod) from salmonella typhimurium lt2.
63c4ph6A_
not modelled 85.1 17
PDB header:lyase
Chain: A: PDB Molecule:3-dehydroquinate dehydratase;
PDBTitle: structure of 3-dehydroquinate dehydratase from enterococcus faecalis
64c3g8rA_
not modelled 84.6 15
PDB header:biosynthetic protein
Chain: A: PDB Molecule:probable spore coat polysaccharide biosynthesis protein e;
PDBTitle: crystal structure of putative spore coat polysaccharide biosynthesis2 protein e from chromobacterium violaceum atcc 12472
65d1gqna_
not modelled 80.0 15
Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
66c3js3C_
not modelled 78.6 15
PDB header:lyase
Chain: C: PDB Molecule:3-dehydroquinate dehydratase;
PDBTitle: crystal structure of type i 3-dehydroquinate dehydratase (arod) from2 clostridium difficile with covalent reaction intermediate
67c1xuzA_
not modelled 68.6 18
PDB header:biosynthetic protein
Chain: A: PDB Molecule:polysialic acid capsule biosynthesis protein siac;
PDBTitle: crystal structure analysis of sialic acid synthase (neub)from2 neisseria meningitidis, bound to mn2+, phosphoenolpyruvate, and n-3 acetyl mannosaminitol
68c1vliA_
not modelled 63.8 12
PDB header:biosynthetic protein
Chain: A: PDB Molecule:spore coat polysaccharide biosynthesis protein spse;
PDBTitle: crystal structure of spore coat polysaccharide biosynthesis protein2 spse (bsu37870) from bacillus subtilis at 2.38 a resolution
69c5c6mD_
not modelled 58.0 19
PDB header:lyase
Chain: D: PDB Molecule:deoxyribose-phosphate aldolase;
PDBTitle: crystal structure of deoxyribose-phosphate aldolase from shewanella2 halifaxensis
70c6ncsB_
not modelled 57.9 13
PDB header:biosynthetic protein
Chain: B: PDB Molecule:n-acetylneuraminic acid (sialic acid) synthetase;
PDBTitle: crystal structure of n-acetylneuraminic acid (sialic acid) synthetase2 from leptospira borgpetersenii serovar hardjo-bovis in complex with3 citrate
71d1vlia2
not modelled 57.9 14
Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:NeuB-like
72d1jpma1
not modelled 57.5 10
Fold:TIM beta/alpha-barrel
Superfamily:Enolase C-terminal domain-like
Family:D-glucarate dehydratase-like
73d2zdra2
not modelled 50.0 18
Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:NeuB-like
74c3oa3A_
not modelled 44.3 21
PDB header:lyase
Chain: A: PDB Molecule:aldolase;
PDBTitle: crystal structure of a putative deoxyribose-phosphate aldolase from2 coccidioides immitis
75c4xbsA_
not modelled 43.5 21
PDB header:lyase
Chain: A: PDB Molecule:deoxyribose-phosphate aldolase;
PDBTitle: 2-deoxyribose-5-phosphate aldolase mutant - e78k
76c2nqlB_
not modelled 42.2 11
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:isomerase/lactonizing enzyme;
PDBTitle: crystal structure of a member of the enolase superfamily from2 agrobacterium tumefaciens
77d1sfla_
not modelled 40.8 12
Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
78c5dbuI_
not modelled 39.1 23
PDB header:lyase
Chain: I: PDB Molecule:deoxyribose-phosphate aldolase;
PDBTitle: crystal structure of 2-deoxyribose-5-phosphate aldolase (1-220) from2 streptococcus suis
79d1r0ma1
not modelled 38.8 16
Fold:TIM beta/alpha-barrel
Superfamily:Enolase C-terminal domain-like
Family:D-glucarate dehydratase-like
80d1ub3a_
not modelled 38.4 22
Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
81c2ph5A_
not modelled 37.1 15
PDB header:transferase
Chain: A: PDB Molecule:homospermidine synthase;
PDBTitle: crystal structure of the homospermidine synthase hss from legionella2 pneumophila in complex with nad, northeast structural genomics target3 lgr54
82c5c2xB_
not modelled 36.9 20
PDB header:lyase
Chain: B: PDB Molecule:deoxyribose-phosphate aldolase;
PDBTitle: crystal structure of deoxyribose-phosphate aldolase from colwellia2 psychrerythraea (tetragonal form)
83d2ijqa1
not modelled 36.6 16
Fold:Hyaluronidase domain-like
Superfamily:TTHA0068-like
Family:TTHA0068-like
84c4plpB_
not modelled 34.3 19
PDB header:transferase
Chain: B: PDB Molecule:homospermidine synthase;
PDBTitle: crystal structure of the homospermidine synthase (hss) from2 blastochloris viridis in complex with nad
85d1o0ya_
not modelled 33.8 22
Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
86c3ngjC_
not modelled 32.4 17
PDB header:lyase
Chain: C: PDB Molecule:deoxyribose-phosphate aldolase;
PDBTitle: crystal structure of a putative deoxyribose-phosphate aldolase from2 entamoeba histolytica
87c5m31A_
not modelled 31.9 32
PDB header:antitoxin
Chain: A: PDB Molecule:appr-1-p processing domain protein;
PDBTitle: macrodomain of thermus aquaticus darg
88d1i27a_
not modelled 29.8 15
Fold:DNA/RNA-binding 3-helical bundle
Superfamily:"Winged helix" DNA-binding domain
Family:C-terminal domain of the rap74 subunit of TFIIF
89c6ei9A_
not modelled 27.2 11
PDB header:flavoprotein
Chain: A: PDB Molecule:trna-dihydrouridine synthase b;
PDBTitle: crystal structure of e. coli trna-dihydrouridine synthase b (dusb)
90c2o7qA_
not modelled 26.2 16
PDB header:oxidoreductase,transferase
Chain: A: PDB Molecule:bifunctional 3-dehydroquinate dehydratase/shikimate
PDBTitle: crystal structure of the a. thaliana dhq-dehydroshikimate-sdh-2 shikimate-nadp(h)
91c6ewvA_
not modelled 26.0 38
PDB header:peptide binding protein
Chain: A: PDB Molecule:nrps kj12c-ndd, nrps kj12b-cdd;
PDBTitle: solution structure of docking domain complex of rxp nrps: kj12c ndd -2 kj12b cdd
92c2eeeA_
not modelled 25.9 15
PDB header:gene regulation
Chain: A: PDB Molecule:uncharacterized protein c6orf130;
PDBTitle: solution structure of the a1pp domain from human protein2 c6orf130
93c3c5yD_
not modelled 25.5 13
PDB header:isomerase
Chain: D: PDB Molecule:ribose/galactose isomerase;
PDBTitle: crystal structure of a putative ribose 5-phosphate isomerase2 (saro_3514) from novosphingobium aromaticivorans dsm at 1.81 a3 resolution
94d1mzha_
not modelled 24.9 21
Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
95c3ejfA_
not modelled 24.3 30
PDB header:hydrolase
Chain: A: PDB Molecule:non-structural protein 3;
PDBTitle: crystal structure of ibv x-domain at ph 8.5
96c3smaD_
not modelled 23.8 17
PDB header:transferase
Chain: D: PDB Molecule:frbf;
PDBTitle: a new n-acetyltransferase fold in the structure and mechanism of the2 phosphonate biosynthetic enzyme frbf
97d1vcva1
not modelled 23.3 30
Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
98d2fg1a1
not modelled 22.8 19
Fold:Macro domain-like
Superfamily:Macro domain-like
Family:Macro domain
99c5d88A_
not modelled 22.1 34
PDB header:hydrolase
Chain: A: PDB Molecule:predicted protease of the collagenase family;
PDBTitle: the structure of the u32 peptidase mk0906
100d1p1xa_
not modelled 21.7 21
Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
101c1tx2A_
not modelled 21.1 15
PDB header:transferase
Chain: A: PDB Molecule:dhps, dihydropteroate synthase;
PDBTitle: dihydropteroate synthetase, with bound inhibitor manic, from bacillus2 anthracis
102d1tx2a_
not modelled 21.1 15
Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Dihydropteroate synthetase
103d1wlza1
not modelled 20.5 19
Fold:EF Hand-like
Superfamily:EF-hand
Family:EF-hand modules in multidomain proteins

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite