1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	T	K	D	H	S	L	A	T	E	S	P	T	L	Q	Q	L	G	E	F	A	V	I	D	R	L	V	R	G	R	R	Q	P	A	T	V	L	L	G	P	G	D	D	A	A	L	V	S	A	G	D	G	R	T	V	V	S	T	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?				?												?			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	L	V	Q	D	S	H	F	R	L	D	W	S	T	P	Q	D	V	G	R	K	A	I	A	Q	N	A	A	D	I	E	A	M	G	A	R	A	T	A	F	V	V	G	F	G	A	P	A	E	T	P	A	A	Q	A	S	A	L	V	D
Secondary structure
SS confidence
Disorder					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	M	W	E	E	A	G	R	I	G	A	G	I	V	G	G	D	L	V	S	C	R	Q	W	V	V	S	V	T	A	I	G	D	L	D	G	R	A	P	V	L	R	S	G	A	K	A	G	S	V	L	A	V	V	G	E	L	G	R	S
Secondary structure
SS confidence
Disorder																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	A	G	Y	A	L	W	C	N	G	I	E	D	F	A	E	L	R	R	R	H	L	V	P	Q	P	P	Y	G	H	G	A	A	A	A	A	V	G	A	Q	A	M	I	D	V	S	D	G	L	L	A	D	L	R	H	I	A	E	A	S
Secondary structure
SS confidence
Disorder										?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	V	R	I	D	L	S	A	A	A	L	A	A	D	R	D	A	L	T	A	A	A	T	A	L	G	T	D	P	W	P	W	V	L	S	G	G	E	D	H	A	L	V	A	C	F	V	G	P	V	P	A	G	W	R	T	I	G	R	V
Secondary structure
SS confidence
Disorder														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.
Sequence		L	D	G	P	A	R	V	L	V	D	G	E	E	W	T	G	Y	A	G	W	Q	S	F	G	E	P	D	N	Q	G	S	L	G
Secondary structure
SS confidence
Disorder																	?	?	?			?	?			?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 31%) Beta strand ( 28%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 3c9u chain B Region: 8 - 323 Aligned: 304 Modelled: 316 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: B: PDB Molecule:thiamine monophosphate kinase; PDBTitle: aathil complexed with adp and tpp Phyre2 PDB 1vqv chain B Region: 15 - 316 Aligned: 286 Modelled: 302 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: B: PDB Molecule:thiamine monophosphate kinase; PDBTitle: crystal structure of thiamine monophosphate kinase (thil)2 from aquifex aeolicus Phyre2 PDB 5cm7 chain A Region: 18 - 323 Aligned: 292 Modelled: 306 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:thiamine-monophosphate kinase; PDBTitle: structure of thiamine-monophosphate kinase from acinetobacter2 baumannii in complex with adenosine diphosphate (adp) and thiamine3 diphosphate (tpp) Phyre2 PDB 2yxz chain A Region: 15 - 315 Aligned: 288 Modelled: 298 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:thiamin-monophosphate kinase; PDBTitle: crystal structure of tt0281 from thermus thermophilus hb8 Phyre2 PDB 5vk4 chain B Region: 21 - 306 Aligned: 283 Modelled: 286 Confidence: 100.0% Identity: 16% PDB header:ligase Chain: B: PDB Molecule:phosphoribosylformylglycinamidine cyclo-ligase; PDBTitle: crystal structure of a phosphoribosylformylglycinamidine cyclo-ligase2 from neisseria gonorrhoeae bound to amppnp and magnesium Phyre2 PDB 3mcq chain A Region: 23 - 312 Aligned: 281 Modelled: 287 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:thiamine-monophosphate kinase; PDBTitle: crystal structure of thiamine-monophosphate kinase (mfla_0573) from2 methylobacillus flagellatus kt at 1.91 a resolution Phyre2 PDB 2btu chain B Region: 17 - 306 Aligned: 285 Modelled: 290 Confidence: 100.0% Identity: 16% PDB header:synthase Chain: B: PDB Molecule:phosphoribosyl-aminoimidazole synthetase; PDBTitle: crystal structure of phosphoribosylformylglycinamidine cyclo-ligase2 from bacillus anthracis at 2.3a resolution. Phyre2 PDB 1cli chain D Region: 23 - 310 Aligned: 285 Modelled: 288 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: D: PDB Molecule:protein (phosphoribosyl-aminoimidazole synthetase); PDBTitle: x-ray crystal structure of aminoimidazole ribonucleotide synthetase2 (purm), from the e. coli purine biosynthetic pathway, at 2.5 a3 resolution Phyre2 PDB 3vti chain D Region: 22 - 318 Aligned: 282 Modelled: 296 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: D: PDB Molecule:hydrogenase maturation factor; PDBTitle: crystal structure of hype-hypf complex Phyre2 PDB 2rb9 chain D Region: 21 - 323 Aligned: 290 Modelled: 303 Confidence: 100.0% Identity: 25% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hype protein; PDBTitle: crystal structure of e.coli hype Phyre2 PDB 2z1t chain A Region: 24 - 323 Aligned: 287 Modelled: 300 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:hydrogenase expression/formation protein hype; PDBTitle: crystal structure of hydrogenase maturation protein hype Phyre2 PDB 3fd5 chain B Region: 21 - 319 Aligned: 286 Modelled: 298 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:selenide, water dikinase 1; PDBTitle: crystal structure of human selenophosphate synthetase 12 complex with ampcp Phyre2 PDB 3vys chain C Region: 17 - 322 Aligned: 297 Modelled: 306 Confidence: 100.0% Identity: 23% PDB header:metal binding protein/transferase Chain: C: PDB Molecule:hydrogenase expression/formation protein hype; PDBTitle: crystal structure of the hypc-hypd-hype complex (form i) Phyre2 PDB 3u0o chain A Region: 34 - 309 Aligned: 269 Modelled: 276 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:selenide, water dikinase; PDBTitle: the crystal structure of selenophosphate synthetase from e. coli Phyre2 PDB 2zod chain B Region: 15 - 308 Aligned: 284 Modelled: 294 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:selenide, water dikinase; PDBTitle: crystal structure of selenophosphate synthetase from aquifex aeolicus Phyre2 PDB 2zau chain B Region: 31 - 308 Aligned: 268 Modelled: 278 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:selenide, water dikinase; PDBTitle: crystal structure of an n-terminally truncated2 selenophosphate synthetase from aquifex aeolicus Phyre2 PDB 2z01 chain A Region: 22 - 311 Aligned: 283 Modelled: 290 Confidence: 100.0% Identity: 17% PDB header:ligase Chain: A: PDB Molecule:phosphoribosylformylglycinamidine cyclo-ligase; PDBTitle: crystal structure of phosphoribosylaminoimidazole synthetase from2 geobacillus kaustophilus Phyre2 PDB 3m84 chain A Region: 3 - 308 Aligned: 301 Modelled: 305 Confidence: 100.0% Identity: 15% PDB header:ligase Chain: A: PDB Molecule:phosphoribosylformylglycinamidine cyclo-ligase; PDBTitle: crystal structure of phosphoribosylaminoimidazole synthetase from2 francisella tularensis Phyre2 PDB 2z1e chain A Region: 40 - 318 Aligned: 270 Modelled: 279 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:hydrogenase expression/formation protein hype; PDBTitle: crystal structure of hype from thermococcus kodakaraensis (outward2 form) Phyre2 PDB 2v9y chain A Region: 44 - 319 Aligned: 272 Modelled: 276 Confidence: 100.0% Identity: 17% PDB header:ligase Chain: A: PDB Molecule:phosphoribosylformylglycinamidine cyclo-ligase; PDBTitle: human aminoimidazole ribonucleotide synthetase Phyre2 1 c3c9uB_ 2 c1vqvB_ 3 c5cm7A_ 4 c2yxzA_ 5 c5vk4B_ 6 c3mcqA_ 7 c2btuB_ 8 c1cliD_ 9 c3vtiD_ 10 c2rb9D_ 11 c2z1tA_ 12 c3fd5B_ 13 c3vysC_ 14 c3u0oA_ 15 c2zodB_ 16 c2zauB_ 17 c2z01A_ 18 c3m84A_ 19 c2z1eA_ 20 c2v9yA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99