1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	G	E	S	D	G	P	P	R	A	V	L	I	A	A	A	A	L	A	A	A	V	I	G	V	I	L	V	V	A	A	N	R	Q	P	P	E	R	P	V	V	I	P	A	V	P	A	P	Q	A	T	G	P	G	C	K	A	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																										?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	L	P	Q	R	L	G	E	Y	R	R	A	P	V	A	E	P	T	T	A	G	A	T	A	W	R	T	G	P	N	S	T	P	V	I	L	R	C	G	L	D	R	P	A	E	F	V	V	G	S	A	I	Q	V	V	D	R	V	Q
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	F	Q	V	A	A	Q	N	P	D	E	P	G	R	S	T	W	Y	T	V	D	R	P	V	Y	V	A	L	T	L	P	S	G	S	G	P	T	A	I	Q	E	L	S	D	V	I	D	H	T	I	P	A	V	P	I	D	P	A	P	A
Secondary structure
SS confidence
Disorder						?		?	?	?	?																							?	?																	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.
Sequence		R
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 29%) Beta strand ( 19%) TM helix ( 9%) (View membrane topology prediction)

Rank Aligned region

PDB 3a0h chain J Region: 9 - 39 Aligned: 31 Modelled: 31 Confidence: 22.6% Identity: 16% PDB header:electron transport Chain: J: PDB Molecule:photosystem ii reaction center protein j; PDBTitle: crystal structure of i-substituted photosystem ii complex Phyre2 PDB 2axt chain J domain 1 Region: 9 - 39 Aligned: 31 Modelled: 31 Confidence: 22.6% Identity: 16% Fold: Single transmembrane helix Superfamily: Photosystem II reaction center protein J, PsbJ Family: PsbJ-like Phyre2 PDB 1f2q chain A domain 1 Region: 80 - 143 Aligned: 47 Modelled: 64 Confidence: 15.8% Identity: 13% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: I set domains Phyre2 PDB 1su3 chain A domain 1 Region: 98 - 102 Aligned: 5 Modelled: 5 Confidence: 14.0% Identity: 60% Fold: PGBD-like Superfamily: PGBD-like Family: MMP N-terminal domain Phyre2 PDB 1slm chain A domain 1 Region: 98 - 102 Aligned: 5 Modelled: 5 Confidence: 13.6% Identity: 60% Fold: PGBD-like Superfamily: PGBD-like Family: MMP N-terminal domain Phyre2 PDB 1eak chain A domain 1 Region: 98 - 102 Aligned: 5 Modelled: 5 Confidence: 12.7% Identity: 60% Fold: PGBD-like Superfamily: PGBD-like Family: MMP N-terminal domain Phyre2 PDB 6f0k chain A Region: 8 - 42 Aligned: 35 Modelled: 35 Confidence: 11.9% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c family protein; PDBTitle: alternative complex iii Phyre2 PDB 1l6j chain A domain 1 Region: 98 - 102 Aligned: 5 Modelled: 5 Confidence: 11.6% Identity: 60% Fold: PGBD-like Superfamily: PGBD-like Family: MMP N-terminal domain Phyre2 PDB 4xtr chain G Region: 10 - 29 Aligned: 20 Modelled: 20 Confidence: 9.2% Identity: 15% PDB header:hydrolase/transport protein Chain: G: PDB Molecule:pep12p; PDBTitle: structure of get3 bound to the transmembrane domain of pep12 Phyre2 PDB 5eur chain C Region: 90 - 107 Aligned: 18 Modelled: 18 Confidence: 8.6% Identity: 11% PDB header:unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: hypothetical protein sf216 from shigella flexneri 5a m90t Phyre2 PDB 2l2t chain A Region: 10 - 31 Aligned: 22 Modelled: 22 Confidence: 8.3% Identity: 36% PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-4; PDBTitle: solution nmr structure of the erbb4 dimeric membrane domain Phyre2 PDB 2lcx chain B Region: 10 - 31 Aligned: 22 Modelled: 22 Confidence: 8.3% Identity: 36% PDB header:transferase Chain: B: PDB Molecule:receptor tyrosine-protein kinase erbb-4; PDBTitle: spatial structure of the erbb4 dimeric tm domain Phyre2 PDB 3jcu chain J Region: 9 - 39 Aligned: 31 Modelled: 31 Confidence: 8.1% Identity: 10% PDB header:membrane protein Chain: J: PDB Molecule:photosystem ii reaction center protein j; PDBTitle: cryo-em structure of spinach psii-lhcii supercomplex at 3.2 angstrom2 resolution Phyre2 PDB 3kpa chain B Region: 117 - 138 Aligned: 18 Modelled: 22 Confidence: 7.6% Identity: 28% PDB header:ligase Chain: B: PDB Molecule:probable ubiquitin fold modifier conjugating enzyme; PDBTitle: ubiquitin fold modifier conjugating enzyme from leishmania major2 (probable) Phyre2 PDB 6eyv chain B Region: 112 - 122 Aligned: 11 Modelled: 11 Confidence: 7.3% Identity: 36% PDB header:oxidoreductase Chain: B: PDB Molecule:pvdp; PDBTitle: crystal structure of the pyoverdine maturation protein pvdp in complex2 with the mock substrates l-tyrosine and zinc. Phyre2 PDB 1ic9 chain A Region: 94 - 99 Aligned: 6 Modelled: 6 Confidence: 7.2% Identity: 50% PDB header:de novo protein Chain: A: PDB Molecule:th10aox; PDBTitle: nmr solution structure of the designed beta-sheet mini-2 protein th10aox Phyre2 PDB 2knc chain B Region: 8 - 30 Aligned: 23 Modelled: 23 Confidence: 6.9% Identity: 9% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2m20 chain B Region: 10 - 31 Aligned: 22 Modelled: 22 Confidence: 6.4% Identity: 14% PDB header:signaling protein Chain: B: PDB Molecule:epidermal growth factor receptor; PDBTitle: egfr transmembrane - juxtamembrane (tm-jm) segment in bicelles: md2 guided nmr refined structure. Phyre2 PDB 2l8s chain A Region: 3 - 30 Aligned: 28 Modelled: 28 Confidence: 5.8% Identity: 14% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-1; PDBTitle: solution nmr structure of transmembrane and cytosolic regions of2 integrin alpha1 in detergent micelles Phyre2 PDB 1ugn chain A domain 1 Region: 90 - 139 Aligned: 49 Modelled: 50 Confidence: 5.7% Identity: 24% Fold: Immunoglobulin-like beta-sandwich Superfamily: Immunoglobulin Family: I set domains Phyre2 1 c3a0hJ_ 2 d2axtj1 3 d1f2qa1 4 d1su3a1 5 d1slma1 6 d1eaka1 7 c6f0kA_ 8 d1l6ja1 9 c4xtrG_ 10 c5eurC_ 11 c2l2tA_ 12 c2lcxB_ 13 c3jcuj_ 14 c3kpaB_ 15 c6eyvB_ 16 c1ic9A_ 17 c2kncB_ 18 c2m20B_ 19 c2l8sA_ 20 d1ugna1 21 22 23