1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	M	S	N	D	R	K	V	T	E	I	E	N	S	P	V	T	E	V	R	P	E	E	H	A	W	Y	P	D	D	S	A	L	A	A	P	P	A	A	T	P	A	A	I	S	D	Q	L	P	S	D	R	Y	L	N	R	E	L	S	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?		?	?	?	?	?		?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	D	F	N	A	R	V	L	A	L	A	A	D	K	S	M	P	L	L	E	R	A	K	F	L	A	I	F	A	S	N	L	D	E	F	Y	M	V	R	V	A	G	L	K	R	R	D	E	M	G	L	S	V	R	S	A	D	G	L	T
Secondary structure
SS confidence
Disorder																																																		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	R	E	Q	L	G	R	I	G	E	Q	T	Q	Q	L	A	S	R	H	A	R	V	F	L	D	S	V	L	P	A	L	G	E	E	G	I	Y	I	V	T	W	A	D	L	D	Q	A	E	R	D	R	L	S	T	Y	F	N	E	Q	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	P	V	L	T	P	L	A	V	D	P	A	H	P	F	P	F	V	S	G	L	S	L	N	L	A	V	T	V	R	Q	P	E	D	G	T	Q	H	F	A	R	V	K	V	P	D	N	V	D	R	F	V	E	L	A	A	R	E	A	S
Secondary structure
SS confidence
Disorder																																?	?	?	?	?	?	?																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	E	A	A	G	T	E	G	R	T	A	L	R	F	L	P	M	E	E	L	I	A	A	F	L	P	V	L	F	P	G	M	E	I	V	E	H	H	A	F	R	I	T	R	N	A	D	F	E	V	E	E	D	R	D	E	D	L	L	Q
Secondary structure
SS confidence
Disorder		?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	L	E	R	E	L	A	R	R	R	F	G	S	P	V	R	L	E	I	A	D	D	M	T	E	S	M	L	E	L	L	L	R	E	L	D	V	H	P	G	D	V	I	E	V	P	G	L	L	D	L	S	S	L	W	Q	I	Y	A	V
Secondary structure
SS confidence
Disorder										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		D	R	P	T	L	K	D	R	T	F	V	P	A	T	H	P	A	F	A	E	R	E	T	P	K	S	I	F	A	T	L	R	E	G	D	V	L	V	H	H	P	Y	D	S	F	S	T	S	V	Q	R	F	I	E	Q	A	A	A	D	P
Secondary structure
SS confidence
Disorder																?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		N	V	L	A	I	K	Q	T	L	Y	R	T	S	G	D	S	P	I	V	R	A	L	I	D	A	A	E	A	G	K	Q	V	V	A	L	V	E	I	K	A	R	F	D	E	Q	A	N	I	A	W	A	R	A	L	E	Q	A	G	V	H
Secondary structure
SS confidence
Disorder																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		V	A	Y	G	L	V	G	L	K	T	H	C	K	T	A	L	V	V	R	R	E	G	P	T	I	R	R	Y	C	H	V	G	T	G	N	Y	N	S	K	T	A	R	L	Y	E	D	V	G	L	L	T	A	A	P	D	I	G	A	D	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		T	D	L	F	N	S	L	T	G	Y	S	R	K	L	S	Y	R	N	L	L	V	A	P	H	G	I	R	A	G	I	I	D	R	V	E	R	E	V	A	A	H	R	A	E	G	A	H	N	G	K	G	R	I	R	L	K	M	N	A	L
Secondary structure
SS confidence
Disorder												?																															?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		V	D	E	Q	V	I	D	A	L	Y	R	A	S	R	A	G	V	R	I	E	V	V	V	R	G	I	C	A	L	R	P	G	A	Q	G	I	S	E	N	I	I	V	R	S	I	L	G	R	F	L	E	H	S	R	I	L	H	F	R	A
Secondary structure
SS confidence
Disorder			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence		I	D	E	F	W	I	G	S	A	D	M	M	H	R	N	L	D	R	R	V	E	V	M	A	Q	V	K	N	P	R	L	T	A	Q	L	D	E	L	F	E	S	A	L	D	P	C	T	R	C	W	E	L	G	P	D	G	Q	W	T	A
Secondary structure
SS confidence
Disorder																																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.
Sequence		S	P	Q	E	G	H	S	V	R	D	H	Q	E	S	L	M	E	R	H	R	S	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?									?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 36%) Beta strand ( 23%)

Rank Aligned region

PDB 1xdo chain B Region: 48 - 741 Aligned: 674 Modelled: 694 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: B: PDB Molecule:polyphosphate kinase; PDBTitle: crystal structure of escherichia coli polyphosphate kinase Phyre2 PDB 2o8r chain A Region: 49 - 741 Aligned: 637 Modelled: 659 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:polyphosphate kinase; PDBTitle: crystal structure of polyphosphate kinase from porphyromonas2 gingivalis Phyre2 PDB 2o8r chain A domain 3 Region: 367 - 557 Aligned: 182 Modelled: 191 Confidence: 100.0% Identity: 36% Fold: Phospholipase D/nuclease Superfamily: Phospholipase D/nuclease Family: Polyphosphate kinase C-terminal domain Phyre2 PDB 2o8r chain A domain 4 Region: 558 - 741 Aligned: 179 Modelled: 184 Confidence: 100.0% Identity: 33% Fold: Phospholipase D/nuclease Superfamily: Phospholipase D/nuclease Family: Polyphosphate kinase C-terminal domain Phyre2 PDB 1xdp chain A domain 4 Region: 558 - 741 Aligned: 180 Modelled: 184 Confidence: 100.0% Identity: 32% Fold: Phospholipase D/nuclease Superfamily: Phospholipase D/nuclease Family: Polyphosphate kinase C-terminal domain Phyre2 PDB 1xdp chain A domain 2 Region: 156 - 368 Aligned: 202 Modelled: 213 Confidence: 100.0% Identity: 22% Fold: PHP14-like Superfamily: PHP14-like Family: PPK middle domain-like Phyre2 PDB 1xdp chain A domain 3 Region: 369 - 557 Aligned: 185 Modelled: 189 Confidence: 100.0% Identity: 43% Fold: Phospholipase D/nuclease Superfamily: Phospholipase D/nuclease Family: Polyphosphate kinase C-terminal domain Phyre2 PDB 2o8r chain A domain 2 Region: 156 - 367 Aligned: 182 Modelled: 191 Confidence: 100.0% Identity: 27% Fold: PHP14-like Superfamily: PHP14-like Family: PPK middle domain-like Phyre2 PDB 1xdp chain A domain 1 Region: 48 - 154 Aligned: 104 Modelled: 107 Confidence: 100.0% Identity: 40% Fold: Spectrin repeat-like Superfamily: PPK N-terminal domain-like Family: PPK N-terminal domain-like Phyre2 PDB 2o8r chain A domain 1 Region: 49 - 155 Aligned: 94 Modelled: 107 Confidence: 100.0% Identity: 44% Fold: Spectrin repeat-like Superfamily: PPK N-terminal domain-like Family: PPK N-terminal domain-like Phyre2 PDB 3hsi chain C Region: 397 - 708 Aligned: 285 Modelled: 305 Confidence: 100.0% Identity: 12% PDB header:transferase Chain: C: PDB Molecule:phosphatidylserine synthase; PDBTitle: crystal structure of phosphatidylserine synthase haemophilus2 influenzae rd kw20 Phyre2 PDB 1v0s chain A Region: 436 - 704 Aligned: 241 Modelled: 269 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:phospholipase d; PDBTitle: uninhibited form of phospholipase d from streptomyces sp.2 strain pmf Phyre2 PDB 4ggk chain A Region: 550 - 705 Aligned: 143 Modelled: 156 Confidence: 99.6% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:mitochondrial cardiolipin hydrolase; PDBTitle: crystal structure of zucchini from mouse (mzuc / pld6 / mitopld) bound2 to tungstate Phyre2 PDB 1byr chain A Region: 558 - 705 Aligned: 135 Modelled: 148 Confidence: 99.5% Identity: 16% Fold: Phospholipase D/nuclease Superfamily: Phospholipase D/nuclease Family: Nuclease Phyre2 PDB 6ehi chain I Region: 557 - 704 Aligned: 135 Modelled: 148 Confidence: 99.5% Identity: 10% PDB header:dna binding protein Chain: I: PDB Molecule:nuclease nuct; PDBTitle: nuct from helicobacter pylori Phyre2 PDB 4gel chain A Region: 562 - 704 Aligned: 131 Modelled: 143 Confidence: 99.5% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:mitochondrial cardiolipin hydrolase; PDBTitle: crystal structure of zucchini Phyre2 PDB 5lzk chain B Region: 565 - 704 Aligned: 125 Modelled: 140 Confidence: 99.4% Identity: 18% PDB header:structural genomics Chain: B: PDB Molecule:protein fam83b; PDBTitle: structure of the domain of unknown function duf1669 from human fam83b Phyre2 PDB 1v0w chain A domain 2 Region: 569 - 704 Aligned: 131 Modelled: 136 Confidence: 99.3% Identity: 27% Fold: Phospholipase D/nuclease Superfamily: Phospholipase D/nuclease Family: Phospholipase D Phyre2 PDB 4urj chain A Region: 565 - 714 Aligned: 135 Modelled: 150 Confidence: 99.3% Identity: 16% PDB header:unknown function Chain: A: PDB Molecule:protein fam83a; PDBTitle: crystal structure of human bj-tsa-9 Phyre2 PDB 1v0w chain A domain 1 Region: 405 - 550 Aligned: 130 Modelled: 145 Confidence: 99.2% Identity: 18% Fold: Phospholipase D/nuclease Superfamily: Phospholipase D/nuclease Family: Phospholipase D Phyre2 1 c1xdoB_ 2 c2o8rA_ 3 d2o8ra3 4 d2o8ra4 5 d1xdpa4 6 d1xdpa2 7 d1xdpa3 8 d2o8ra2 9 d1xdpa1 10 d2o8ra1 11 c3hsiC_ 12 c1v0sA_ 13 c4ggkA_ 14 d1byra_ 15 c6ehiI_ 16 c4gelA_ 17 c5lzkB_ 18 d1v0wa2 19 c4urjA_ 20 d1v0wa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208