1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	I	Q	N	S	S	A	R	R	R	S	A	G	R	I	V	Y	A	A	G	A	V	L	W	R	P	G	S	A	D	S	E	G	P	V	E	I	A	V	I	H	R	P	R	Y	D	D	W	S	L	P	K	G	K	V	D	P	G	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?																	?	?	?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	A	P	V	G	A	V	R	E	I	L	E	E	T	G	H	R	A	N	L	G	R	R	L	L	T	V	T	Y	P	T	D	S	P	F	R	G	V	K	K	V	H	Y	W	A	A	R	S	T	G	G	E	F	T	P	G	S	E	V	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	L	I	W	L	P	V	P	D	A	M	N	K	L	D	Y	A	Q	D	R	K	V	L	C	R	F	A	K	H	P	A	D	T	Q	T	V	L	V	V	R	H	G	T	A	G	S	K	A	H	F	S	G	D	D	S	K	R	P	L	D
Secondary structure
SS confidence
Disorder																																				?					?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	R	G	R	A	Q	A	E	A	L	V	P	Q	L	L	A	F	G	A	T	D	V	Y	A	A	D	R	V	R	C	H	Q	T	M	E	P	L	A	A	E	L	N	V	T	I	H	N	E	P	T	L	T	E	E	S	Y	A	N	N	P
Secondary structure
SS confidence
Disorder			?	?																																																?		?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	R	G	R	H	R	V	L	Q	I	V	E	Q	V	G	T	P	V	I	C	T	Q	G	K	V	I	P	D	L	I	T	W	W	C	E	R	D	G	V	H	P	D	K	S	R	N	R	K	G	S	T	W	V	L	S	L	S	A	G	R
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.
Sequence		L	V	T	A	D	H	I	G	G	A	L	A	A	N	V	R	A
Secondary structure
SS confidence
Disorder							?	?				?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 30%) Beta strand ( 25%)

Rank Aligned region

PDB 5gg7 chain A Region: 16 - 310 Aligned: 287 Modelled: 295 Confidence: 100.0% Identity: 69% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase, nudix family protein; PDBTitle: crystal structure of mycobacterium smegmatis mutt1 in complex with 8-2 oxo-dgtp, 8-oxo-dgmp and pyrophosphate (i) Phyre2 PDB 3fjy chain B Region: 17 - 306 Aligned: 290 Modelled: 290 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: B: PDB Molecule:probable mutt1 protein; PDBTitle: crystal structure of a probable mutt1 protein from bifidobacterium2 adolescentis Phyre2 PDB 1ktg chain A Region: 16 - 151 Aligned: 132 Modelled: 136 Confidence: 100.0% Identity: 28% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 3mxo chain B Region: 152 - 308 Aligned: 154 Modelled: 157 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:serine/threonine-protein phosphatase pgam5, mitochondrial; PDBTitle: crystal structure oh human phosphoglycerate mutase family member 52 (pgam5) Phyre2 PDB 2rfl chain B Region: 153 - 302 Aligned: 145 Modelled: 150 Confidence: 99.9% Identity: 18% PDB header:hydrolase, isomerase Chain: B: PDB Molecule:putative phosphohistidine phosphatase sixa; PDBTitle: crystal structure of the putative phosphohistidine phosphatase sixa2 from agrobacterium tumefaciens Phyre2 PDB 4hbz chain A Region: 150 - 299 Aligned: 140 Modelled: 150 Confidence: 99.9% Identity: 22% PDB header:hydrolase, isomerase Chain: A: PDB Molecule:putative phosphohistidine phosphatase, sixa; PDBTitle: the structure of putative phosphohistidine phosphatase sixa from2 nakamurella multipartitia. Phyre2 PDB 1e58 chain A Region: 155 - 310 Aligned: 155 Modelled: 156 Confidence: 99.9% Identity: 21% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 1ujc chain A Region: 155 - 310 Aligned: 148 Modelled: 156 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:phosphohistidine phosphatase sixa; PDBTitle: structure of the protein histidine phosphatase sixa2 complexed with tungstate Phyre2 PDB 2pq1 chain B Region: 15 - 148 Aligned: 125 Modelled: 134 Confidence: 99.9% Identity: 33% PDB header:hydrolase Chain: B: PDB Molecule:ap4a hydrolase; PDBTitle: crystal structure of ap4a hydrolase complexed with amp and2 atp (aq_158) from aquifex aeolicus vf5 Phyre2 PDB 3f2i chain D Region: 156 - 299 Aligned: 139 Modelled: 144 Confidence: 99.9% Identity: 17% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:alr0221 protein; PDBTitle: crystal structure of the alr0221 protein from nostoc, northeast2 structural genomics consortium target nsr422. Phyre2 PDB 2yn0 chain A Region: 154 - 299 Aligned: 146 Modelled: 145 Confidence: 99.9% Identity: 27% PDB header:transcription Chain: A: PDB Molecule:transcription factor tau 55 kda subunit; PDBTitle: tau55 histidine phosphatase domain Phyre2 PDB 1xsb chain A Region: 16 - 148 Aligned: 133 Modelled: 133 Confidence: 99.9% Identity: 22% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 4emb chain D Region: 155 - 299 Aligned: 144 Modelled: 145 Confidence: 99.9% Identity: 20% PDB header:isomerase Chain: D: PDB Molecule:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; PDBTitle: crystal structure of a phosphoglycerate mutase gpma from borrelia2 burgdorferi b31 Phyre2 PDB 1rii chain A Region: 151 - 299 Aligned: 148 Modelled: 149 Confidence: 99.9% Identity: 18% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 4pz9 chain B Region: 154 - 299 Aligned: 144 Modelled: 146 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:glucosyl-3-phosphoglycerate phosphatase; PDBTitle: the native structure of mycobacterial glucosyl-3-phosphoglycerate2 phosphatase rv2419c Phyre2 PDB 4ilq chain A Region: 17 - 148 Aligned: 132 Modelled: 132 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:ct771; PDBTitle: 2.60a resolution structure of ct771 from chlamydia trachomatis Phyre2 PDB 1yjx chain D Region: 154 - 299 Aligned: 145 Modelled: 146 Confidence: 99.9% Identity: 17% PDB header:isomerase, hydrolase Chain: D: PDB Molecule:phosphoglycerate mutase 1; PDBTitle: crystal structure of human b type phosphoglycerate mutase Phyre2 PDB 1xq9 chain A Region: 151 - 299 Aligned: 148 Modelled: 149 Confidence: 99.9% Identity: 22% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 1vcd chain A domain 1 Region: 16 - 151 Aligned: 125 Modelled: 136 Confidence: 99.9% Identity: 26% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 5um0 chain A Region: 153 - 307 Aligned: 154 Modelled: 155 Confidence: 99.9% Identity: 18% PDB header:isomerase Chain: A: PDB Molecule:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; PDBTitle: crystal structure of 2,3-bisphosphoglycerate-dependent2 phosphoglycerate mutase from neisseria gonorrhoeae Phyre2 1 c5gg7A_ 2 c3fjyB_ 3 d1ktga_ 4 c3mxoB_ 5 c2rflB_ 6 c4hbzA_ 7 d1e58a_ 8 c1ujcA_ 9 c2pq1B_ 10 c3f2iD_ 11 c2yn0A_ 12 d1xsba_ 13 c4embD_ 14 d1riia_ 15 c4pz9B_ 16 c4ilqA_ 17 c1yjxD_ 18 d1xq9a_ 19 d1vcda1 20 c5um0A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177