1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	E	A	F	H	T	H	S	G	I	G	V	P	L	R	R	S	N	V	D	T	D	Q	I	I	P	A	V	F	L	K	R	V	T	R	T	G	F	E	D	G	L	F	A	G	W	R	S	D	P	A	F	V	L	N	L	S	P	F	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	G	S	V	L	V	A	G	P	D	F	G	T	G	S	S	R	E	H	A	V	W	A	L	M	D	Y	G	F	R	V	V	I	S	S	R	F	G	D	I	F	R	G	N	A	G	K	A	G	L	L	A	A	E	V	A	Q	D	D	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	L	L	W	K	L	I	E	Q	S	P	G	L	E	I	T	A	N	L	Q	D	R	I	I	T	A	A	T	V	V	L	P	F	K	I	D	D	H	S	A	W	R	L	L	E	G	L	D	D	I	A	L	T	L	R	K	L	D	E	I
Secondary structure
SS confidence
Disorder																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.
Sequence		E	A	F	E	G	A	C	A	Y	W	K	P	R	T	L	P	A	P
Secondary structure
SS confidence
Disorder								?					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 42%) Beta strand ( 21%)

Rank Aligned region

PDB 3h5j chain A Region: 2 - 168 Aligned: 167 Modelled: 167 Confidence: 100.0% Identity: 100% PDB header:lyase Chain: A: PDB Molecule:3-isopropylmalate dehydratase small subunit; PDBTitle: leud_1-168 small subunit of isopropylmalate isomerase (rv2987c) from2 mycobacterium tuberculosis Phyre2 PDB 3q3w chain B Region: 1 - 172 Aligned: 172 Modelled: 171 Confidence: 100.0% Identity: 43% PDB header:transferase Chain: B: PDB Molecule:3-isopropylmalate dehydratase small subunit; PDBTitle: isopropylmalate isomerase small subunit from campylobacter jejuni. Phyre2 PDB 2hcu chain A Region: 1 - 168 Aligned: 165 Modelled: 168 Confidence: 100.0% Identity: 42% PDB header:lyase Chain: A: PDB Molecule:3-isopropylmalate dehydratase small subunit; PDBTitle: crystal structure of smu.1381 (or leud) from streptococcus mutans Phyre2 PDB 1v7l chain A Region: 6 - 166 Aligned: 146 Modelled: 161 Confidence: 100.0% Identity: 31% Fold: The "swivelling" beta/beta/alpha domain Superfamily: LeuD/IlvD-like Family: LeuD-like Phyre2 PDB 3vba chain E Region: 5 - 166 Aligned: 149 Modelled: 162 Confidence: 100.0% Identity: 33% PDB header:lyase Chain: E: PDB Molecule:isopropylmalate/citramalate isomerase small subunit; PDBTitle: crystal structure of methanogen 3-isopropylmalate isomerase small2 subunit Phyre2 PDB 2pkp chain A Region: 6 - 166 Aligned: 146 Modelled: 161 Confidence: 100.0% Identity: 32% PDB header:lyase Chain: A: PDB Molecule:homoaconitase small subunit; PDBTitle: crystal structure of 3-isopropylmalate dehydratase (leud)2 from methhanocaldococcus jannaschii dsm2661 (mj1271) Phyre2 PDB 1aco chain A domain 1 Region: 1 - 166 Aligned: 160 Modelled: 166 Confidence: 100.0% Identity: 21% Fold: The "swivelling" beta/beta/alpha domain Superfamily: LeuD/IlvD-like Family: LeuD-like Phyre2 PDB 2b3y chain A domain 1 Region: 2 - 166 Aligned: 162 Modelled: 165 Confidence: 100.0% Identity: 24% Fold: The "swivelling" beta/beta/alpha domain Superfamily: LeuD/IlvD-like Family: LeuD-like Phyre2 PDB 1l5j chain A domain 2 Region: 6 - 166 Aligned: 146 Modelled: 161 Confidence: 100.0% Identity: 23% Fold: The "swivelling" beta/beta/alpha domain Superfamily: LeuD/IlvD-like Family: LeuD-like Phyre2 PDB 2b3y chain B Region: 6 - 166 Aligned: 161 Modelled: 161 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: B: PDB Molecule:iron-responsive element binding protein 1; PDBTitle: structure of a monoclinic crystal form of human cytosolic aconitase2 (irp1) Phyre2 PDB 5acn chain A Region: 1 - 166 Aligned: 161 Modelled: 166 Confidence: 100.0% Identity: 19% PDB header:lyase(carbon-oxygen) Chain: A: PDB Molecule:aconitase; PDBTitle: structure of activated aconitase. formation of the (4fe-4s) cluster in2 the crystal Phyre2 PDB 1l5j chain B Region: 6 - 149 Aligned: 134 Modelled: 144 Confidence: 99.6% Identity: 20% PDB header:lyase Chain: B: PDB Molecule:aconitate hydratase 2; PDBTitle: crystal structure of e. coli aconitase b. Phyre2 PDB 1t6z chain B Region: 61 - 97 Aligned: 37 Modelled: 37 Confidence: 63.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:riboflavin kinase/fmn adenylyltransferase; PDBTitle: crystal structure of riboflavin bound tm379 Phyre2 PDB 1eo1 chain A Region: 72 - 136 Aligned: 65 Modelled: 65 Confidence: 61.3% Identity: 20% Fold: Ribonuclease H-like motif Superfamily: Nitrogenase accessory factor-like Family: MTH1175-like Phyre2 PDB 2yx6 chain C Region: 58 - 131 Aligned: 74 Modelled: 74 Confidence: 59.5% Identity: 9% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:hypothetical protein ph0822; PDBTitle: crystal structure of ph0822 Phyre2 PDB 1o13 chain A Region: 73 - 131 Aligned: 59 Modelled: 59 Confidence: 54.0% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Nitrogenase accessory factor-like Family: MTH1175-like Phyre2 PDB 2qtd chain A Region: 78 - 136 Aligned: 58 Modelled: 59 Confidence: 51.9% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:uncharacterized protein mj0327; PDBTitle: crystal structure of a putative dinitrogenase (mj0327) from2 methanocaldococcus jannaschii dsm at 1.70 a resolution Phyre2 PDB 3op1 chain A Region: 61 - 96 Aligned: 36 Modelled: 36 Confidence: 51.1% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:macrolide-efflux protein; PDBTitle: crystal structure of macrolide-efflux protein sp_1110 from2 streptococcus pneumoniae Phyre2 PDB 1rdu chain A Region: 64 - 136 Aligned: 73 Modelled: 73 Confidence: 50.7% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Nitrogenase accessory factor-like Family: MTH1175-like Phyre2 PDB 1t3v chain A Region: 72 - 131 Aligned: 60 Modelled: 60 Confidence: 48.3% Identity: 13% Fold: Ribonuclease H-like motif Superfamily: Nitrogenase accessory factor-like Family: MTH1175-like Phyre2 1 c3h5jA_ 2 c3q3wB_ 3 c2hcuA_ 4 d1v7la_ 5 c3vbaE_ 6 c2pkpA_ 7 d1acoa1 8 d2b3ya1 9 d1l5ja2 10 c2b3yB_ 11 c5acnA_ 12 c1l5jB_ 13 c1t6zB_ 14 d1eo1a_ 15 c2yx6C_ 16 d1o13a_ 17 c2qtdA_ 18 c3op1A_ 19 d1rdua_ 20 d1t3va_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99