1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	L	Q	T	G	E	P	R	T	L	A	E	K	I	W	D	D	H	I	V	V	S	G	G	G	C	A	P	D	L	I	Y	I	D	L	H	L	V	H	E	V	T	S	P	Q	A	F	D	G	L	R	L	A	G	R	R	V	R	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?													?	?	?	?	?		?																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	E	L	T	L	A	T	E	D	H	N	V	P	T	V	D	I	D	Q	P	I	A	D	P	V	S	R	T	Q	V	E	T	L	R	R	N	C	A	E	F	G	I	R	L	H	S	M	G	D	I	E	Q	G	I	V	H	V	V	G	P
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	L	G	L	T	Q	P	G	M	T	I	V	C	G	D	S	H	T	S	T	H	G	A	F	G	A	L	A	M	G	I	G	T	S	E	V	E	H	V	L	A	T	Q	T	L	P	L	R	P	F	K	T	M	A	V	N	V	D	G	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	P	D	G	V	S	A	K	D	I	I	L	A	L	I	A	K	I	G	T	G	G	G	Q	G	H	V	I	E	Y	R	G	S	A	I	E	S	L	S	M	E	G	R	M	T	I	C	N	M	S	I	E	A	G	A	R	A	G	M	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	P	D	E	T	T	Y	A	F	L	R	G	R	P	H	A	P	T	G	A	Q	W	D	T	A	L	V	Y	W	Q	R	L	R	T	D	V	G	A	V	F	D	T	E	V	Y	L	D	A	A	S	L	S	P	F	V	T	W	G	T	N
Secondary structure
SS confidence
Disorder																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	G	Q	G	V	P	L	A	A	A	V	P	D	P	Q	L	M	T	D	D	A	E	R	Q	A	A	E	K	A	L	A	Y	M	D	L	R	P	G	T	A	M	R	D	I	A	V	D	A	V	F	V	G	S	C	T	N	G	R	I	E
Secondary structure
SS confidence
Disorder												?						?		?		?	?	?	?	?		?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		D	L	R	V	V	A	E	V	L	R	G	R	K	V	A	D	G	V	R	M	L	I	V	P	G	S	M	R	V	R	A	Q	A	E	A	E	G	L	G	E	I	F	T	D	A	G	A	Q	W	R	Q	A	G	C	S	M	C	L	G	M
Secondary structure
SS confidence
Disorder											?																																																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.
Sequence		N	P	D	Q	L	A	S	G	E	R	C	A	A	T	S	N	R	N	F	E	G	R	Q	G	A	G	G	R	T	H	L	V	S	P	A	V	A	A	A	T	A	V	R	G	T	L	S	S	P	A	D	L	N
Secondary structure
SS confidence
Disorder		?	?	?	?																																											?	?				?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 32%) Beta strand ( 21%)

Rank Aligned region

PDB 4kp1 chain A Region: 8 - 472 Aligned: 419 Modelled: 434 Confidence: 100.0% Identity: 36% PDB header:isomerase Chain: A: PDB Molecule:isopropylmalate/citramalate isomerase large subunit; PDBTitle: crystal structure of ipm isomerase large subunit from methanococcus2 jannaschii (mj0499) Phyre2 PDB 4kp2 chain A Region: 9 - 468 Aligned: 416 Modelled: 429 Confidence: 100.0% Identity: 34% PDB header:lyase Chain: A: PDB Molecule:homoaconitase large subunit; PDBTitle: crystal structure of homoaconitase large subunit from methanococcus2 jannaschii (mj1003) Phyre2 PDB 1aco chain A domain 2 Region: 7 - 470 Aligned: 432 Modelled: 441 Confidence: 100.0% Identity: 26% Fold: Aconitase iron-sulfur domain Superfamily: Aconitase iron-sulfur domain Family: Aconitase iron-sulfur domain Phyre2 PDB 1l5j chain A domain 3 Region: 4 - 472 Aligned: 421 Modelled: 437 Confidence: 100.0% Identity: 24% Fold: Aconitase iron-sulfur domain Superfamily: Aconitase iron-sulfur domain Family: Aconitase iron-sulfur domain Phyre2 PDB 5acn chain A Region: 7 - 473 Aligned: 435 Modelled: 444 Confidence: 100.0% Identity: 26% PDB header:lyase(carbon-oxygen) Chain: A: PDB Molecule:aconitase; PDBTitle: structure of activated aconitase. formation of the (4fe-4s) cluster in2 the crystal Phyre2 PDB 2b3y chain A domain 2 Region: 11 - 470 Aligned: 456 Modelled: 460 Confidence: 100.0% Identity: 22% Fold: Aconitase iron-sulfur domain Superfamily: Aconitase iron-sulfur domain Family: Aconitase iron-sulfur domain Phyre2 PDB 2b3y chain B Region: 13 - 473 Aligned: 457 Modelled: 461 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: B: PDB Molecule:iron-responsive element binding protein 1; PDBTitle: structure of a monoclinic crystal form of human cytosolic aconitase2 (irp1) Phyre2 PDB 1l5j chain B Region: 4 - 472 Aligned: 419 Modelled: 438 Confidence: 100.0% Identity: 25% PDB header:lyase Chain: B: PDB Molecule:aconitate hydratase 2; PDBTitle: crystal structure of e. coli aconitase b. Phyre2 PDB 3bol chain B Region: 350 - 410 Aligned: 61 Modelled: 61 Confidence: 63.7% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:5-methyltetrahydrofolate s-homocysteine PDBTitle: cobalamin-dependent methionine synthase (1-566) from2 thermotoga maritima complexed with zn2+ Phyre2 PDB 3bof chain A domain 2 Region: 350 - 379 Aligned: 30 Modelled: 30 Confidence: 57.7% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: Homocysteine S-methyltransferase Family: Homocysteine S-methyltransferase Phyre2 PDB 4ccz chain A Region: 350 - 376 Aligned: 27 Modelled: 27 Confidence: 57.2% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:methionine synthase; PDBTitle: crystal structure of human 5-methyltetrahydrofolate-homocysteine2 methyltransferase, the homocysteine and folate binding domains Phyre2 PDB 4oc8 chain A Region: 198 - 269 Aligned: 72 Modelled: 72 Confidence: 41.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:restriction endonuclease aspbhi; PDBTitle: dna modification-dependent restriction endonuclease aspbhi Phyre2 PDB 2e21 chain A Region: 44 - 105 Aligned: 52 Modelled: 62 Confidence: 39.8% Identity: 17% PDB header:ligase Chain: A: PDB Molecule:trna(ile)-lysidine synthase; PDBTitle: crystal structure of tils in a complex with amppnp from aquifex2 aeolicus. Phyre2 PDB 1ni5 chain A Region: 44 - 105 Aligned: 52 Modelled: 62 Confidence: 37.8% Identity: 15% PDB header:cell cycle Chain: A: PDB Molecule:putative cell cycle protein mesj; PDBTitle: structure of the mesj pp-atpase from escherichia coli Phyre2 PDB 4yaj chain A Region: 377 - 435 Aligned: 59 Modelled: 57 Confidence: 32.6% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:alpha subunit of acetyl-coenzyme a synthetase PDBTitle: ca. korarchaeum cryptofilum dinucleotide forming acetyl-coenzyme a2 synthetase 1 (apo form) Phyre2 PDB 1lt7 chain A Region: 350 - 373 Aligned: 24 Modelled: 24 Confidence: 29.3% Identity: 25% Fold: TIM beta/alpha-barrel Superfamily: Homocysteine S-methyltransferase Family: Homocysteine S-methyltransferase Phyre2 PDB 4rzl chain A Region: 200 - 256 Aligned: 57 Modelled: 57 Confidence: 27.5% Identity: 7% PDB header:dna binding protein Chain: A: PDB Molecule:restriction endonuclease lpnpi; PDBTitle: dna recognition domain of the cytosine modification-dependent2 restriction endonuclease lpnpi Phyre2 PDB 1umy chain A Region: 350 - 376 Aligned: 27 Modelled: 27 Confidence: 26.2% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Homocysteine S-methyltransferase Family: Homocysteine S-methyltransferase Phyre2 PDB 4oc8 chain D Region: 198 - 269 Aligned: 72 Modelled: 72 Confidence: 25.3% Identity: 17% PDB header:hydrolase Chain: D: PDB Molecule:restriction endonuclease aspbhi; PDBTitle: dna modification-dependent restriction endonuclease aspbhi Phyre2 PDB 5wus chain A Region: 350 - 378 Aligned: 29 Modelled: 29 Confidence: 24.5% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:chitinase; PDBTitle: crystal structure of a insect group iii chitinase (cad2) from ostrinia2 furnacalis Phyre2 1 c4kp1A_ 2 c4kp2A_ 3 d1acoa2 4 d1l5ja3 5 c5acnA_ 6 d2b3ya2 7 c2b3yB_ 8 c1l5jB_ 9 c3bolB_ 10 d3bofa2 11 c4cczA_ 12 c4oc8A_ 13 c2e21A_ 14 c1ni5A_ 15 c4yajA_ 16 d1lt7a_ 17 c4rzlA_ 18 d1umya_ 19 c4oc8D_ 20 c5wusA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99