1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	A	T	E	T	V	R	V	R	F	C	P	S	P	T	G	T	P	H	V	G	L	V	R	T	A	L	F	N	W	A	Y	A	R	H	T	G	G	T	F	V	F	R	I	E	D	T	D	A	Q	R	D	S	E	E	S	Y	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	D	A	L	R	W	L	G	L	D	W	D	E	G	P	E	V	G	G	P	Y	G	P	Y	R	Q	S	Q	R	A	E	I	Y	R	D	V	L	A	R	L	L	A	A	G	E	A	Y	H	A	F	S	T	P	E	E	V	E	A	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	V	A	A	G	R	N	P	K	L	G	Y	D	N	F	D	R	H	L	T	D	A	Q	R	A	A	Y	L	A	E	G	R	Q	P	V	V	R	L	R	M	P	D	D	D	L	A	W	N	D	L	V	R	G	P	V	T	F	A	A	G
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	V	P	D	F	A	L	T	R	A	S	G	D	P	L	Y	T	L	V	N	P	C	D	D	A	L	M	K	I	T	H	V	L	R	G	E	D	L	L	P	S	T	P	R	Q	L	A	L	H	Q	A	L	I	R	I	G	V	A	E	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	P	K	F	A	H	L	P	T	V	L	G	E	G	T	K	K	L	S	K	R	D	P	Q	S	N	L	F	A	H	R	D	R	G	F	I	P	E	G	L	L	N	Y	L	A	L	L	G	W	S	I	A	D	D	H	D	L	F	G	L
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	E	M	V	A	A	F	D	V	A	D	V	N	S	S	P	A	R	F	D	Q	K	K	A	D	A	L	N	A	E	H	I	R	M	L	D	V	G	D	F	T	V	R	L	R	D	H	L	D	T	H	G	H	H	I	A	L	D	E	A
Secondary structure
SS confidence
Disorder															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	F	A	A	A	A	E	L	V	Q	T	R	I	V	V	L	G	D	A	W	E	L	L	K	F	F	N	D	D	Q	Y	V	I	D	P	K	A	A	A	K	E	L	G	P	D	G	A	A	V	L	D	A	A	L	A	A	L	T	S	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		T	D	W	T	A	P	L	I	E	A	A	L	K	D	A	L	I	E	G	L	A	L	K	P	R	K	A	F	S	P	I	R	V	A	A	T	G	T	T	V	S	P	P	L	F	E	S	L	E	L	L	G	R	D	R	S	M	Q	R	L
Secondary structure
SS confidence
Disorder																					?																		?		?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490
Sequence		R	A	A	R	Q	L	V	G	H	A
Secondary structure
SS confidence
Disorder									?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 49%) Beta strand ( 9%)

Rank Aligned region

PDB 2ja2 chain A Region: 1 - 485 Aligned: 485 Modelled: 485 Confidence: 100.0% Identity: 100% PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: mycobacterium tuberculosis glutamyl-trna synthetase Phyre2 PDB 3al0 chain C Region: 3 - 489 Aligned: 464 Modelled: 471 Confidence: 100.0% Identity: 36% PDB header:ligase/rna Chain: C: PDB Molecule:glutamyl-trna(gln) amidotransferase subunit c,linker, PDBTitle: crystal structure of the glutamine transamidosome from thermotoga2 maritima in the glutamylation state. Phyre2 PDB 4gri chain B Region: 6 - 487 Aligned: 473 Modelled: 482 Confidence: 100.0% Identity: 36% PDB header:ligase Chain: B: PDB Molecule:glutamate--trna ligase; PDBTitle: crystal structure of a glutamyl-trna synthetase glurs from borrelia2 burgdorferi bound to glutamic acid and zinc Phyre2 PDB 3afh chain A Region: 7 - 489 Aligned: 460 Modelled: 467 Confidence: 100.0% Identity: 36% PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 2; PDBTitle: crystal structure of thermotoga maritima nondiscriminating glutamyl-2 trna synthetase in complex with a glutamyl-amp analog Phyre2 PDB 6b1z chain A Region: 5 - 485 Aligned: 467 Modelled: 481 Confidence: 100.0% Identity: 34% PDB header:ligase Chain: A: PDB Molecule:glutamate--trna ligase; PDBTitle: crystal structure of glutamate-trna synthetase from elizabethkingia2 anophelis Phyre2 PDB 5tgt chain A Region: 5 - 490 Aligned: 442 Modelled: 453 Confidence: 100.0% Identity: 38% PDB header:ligase Chain: A: PDB Molecule:glutamate--trna ligase; PDBTitle: crystal structure of glytamyl-trna synthetase glurs from pseudomonas2 aeruginosa Phyre2 PDB 2cfo chain A Region: 6 - 488 Aligned: 469 Modelled: 483 Confidence: 100.0% Identity: 38% PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: non-discriminating glutamyl-trna synthetase from2 thermosynechococcus elongatus in complex with glu Phyre2 PDB 5h4v chain E Region: 7 - 488 Aligned: 461 Modelled: 482 Confidence: 100.0% Identity: 38% PDB header:ligase Chain: E: PDB Molecule:glutamate--trna ligase; PDBTitle: structure of glutamyl-trna synthetase (xoo1504) from xanthomonas2 oryzae pv. oryzae Phyre2 PDB 1g59 chain A Region: 7 - 484 Aligned: 464 Modelled: 473 Confidence: 100.0% Identity: 37% PDB header:ligase/rna Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: glutamyl-trna synthetase complexed with trna(glu). Phyre2 PDB 2o5r chain A Region: 6 - 484 Aligned: 464 Modelled: 478 Confidence: 100.0% Identity: 38% PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 1; PDBTitle: crystal structure of glutamyl-trna synthetase 1 (ec 6.1.1.17)2 (glutamate-trna ligase 1) (glurs 1) (tm1351) from thermotoga maritima3 at 2.5 a resolution Phyre2 PDB 6b1p chain A Region: 5 - 485 Aligned: 429 Modelled: 449 Confidence: 100.0% Identity: 33% PDB header:ligase Chain: A: PDB Molecule:glutamate--trna ligase 1; PDBTitle: crystal structure of glutamate-trna synthetase from helicobacter2 pylori Phyre2 PDB 4g6z chain A Region: 5 - 415 Aligned: 377 Modelled: 391 Confidence: 100.0% Identity: 38% PDB header:ligase Chain: A: PDB Molecule:glutamate-trna ligase; PDBTitle: crystal structure of a glutamyl-trna synthetase glurs from2 burkholderia thailandensis bound to l-glutamate Phyre2 PDB 1j09 chain A domain 2 Region: 7 - 319 Aligned: 303 Modelled: 308 Confidence: 100.0% Identity: 42% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1irx chain A Region: 3 - 483 Aligned: 462 Modelled: 472 Confidence: 100.0% Identity: 14% PDB header:ligase Chain: A: PDB Molecule:lysyl-trna synthetase; PDBTitle: crystal structure of class i lysyl-trna synthetase Phyre2 PDB 1gtr chain A domain 2 Region: 2 - 311 Aligned: 294 Modelled: 310 Confidence: 100.0% Identity: 20% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 2hz7 chain A Region: 2 - 336 Aligned: 283 Modelled: 299 Confidence: 100.0% Identity: 27% PDB header:ligase Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of the glutaminyl-trna synthetase from deinococcus2 radiodurans Phyre2 PDB 1exd chain A Region: 2 - 332 Aligned: 278 Modelled: 295 Confidence: 100.0% Identity: 23% PDB header:ligase/rna Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of a tight-binding glutamine trna bound2 to glutamine aminoacyl trna synthetase Phyre2 PDB 4h3s chain A Region: 6 - 314 Aligned: 280 Modelled: 296 Confidence: 100.0% Identity: 22% PDB header:ligase Chain: A: PDB Molecule:glutamine-trna ligase; PDBTitle: the structure of glutaminyl-trna synthetase from saccharomyces2 cerevisiae Phyre2 PDB 5bnz chain A Region: 2 - 314 Aligned: 283 Modelled: 300 Confidence: 100.0% Identity: 22% PDB header:ligase Chain: A: PDB Molecule:glutamine--trna ligase; PDBTitle: crystal structure of glutamine-trna ligase /glutaminyl-trna synthetase2 (glnrs) from pseudomonas aeruginosa Phyre2 PDB 1nzj chain A Region: 5 - 318 Aligned: 268 Modelled: 297 Confidence: 100.0% Identity: 31% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 1 c2ja2A_ 2 c3al0C_ 3 c4griB_ 4 c3afhA_ 5 c6b1zA_ 6 c5tgtA_ 7 c2cfoA_ 8 c5h4vE_ 9 c1g59A_ 10 c2o5rA_ 11 c6b1pA_ 12 c4g6zA_ 13 d1j09a2 14 c1irxA_ 15 d1gtra2 16 c2hz7A_ 17 c1exdA_ 18 c4h3sA_ 19 c5bnzA_ 20 d1nzja_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133