1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	A	R	E	I	A	E	H	P	F	G	T	P	T	F	T	G	R	S	W	P	L	A	D	V	R	L	L	A	P	I	L	A	S	K	V	V	C	V	G	K	N	Y	A	D	H	I	A	E	M	G	G	R	P	P	A	D	P	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?					?			?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	F	L	K	P	N	T	A	I	I	G	P	N	T	P	I	R	L	P	A	N	A	S	P	V	H	F	E	G	E	L	A	I	V	I	G	R	A	C	K	D	V	P	A	A	Q	A	V	D	N	I	L	G	Y	T	I	G	N	D	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	A	R	D	Q	Q	Q	S	D	G	Q	W	T	R	A	K	G	H	D	T	F	C	P	V	G	P	W	I	V	T	D	L	A	P	F	D	P	A	D	L	E	L	R	T	V	V	N	G	D	V	K	Q	H	A	R	T	S	L	M	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.
Sequence		H	D	I	G	A	I	V	E	W	I	S	A	I	M	T	L	L	P	G	D	L	I	L	T	G	T	P	A	G	V	G	P	I	E	D	G	D	T	V	S	I	T	I	E	G	I	G	T	L	T	N	P	V	V	R	K	G	K	P
Secondary structure
SS confidence
Disorder																																																									?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 6%) Alpha helix ( 16%) Beta strand ( 37%)

Rank Aligned region

PDB 4dbh chain A Region: 2 - 236 Aligned: 235 Modelled: 235 Confidence: 100.0% Identity: 55% PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of cg1458 with inhibitor Phyre2 PDB 6iym chain B Region: 6 - 236 Aligned: 230 Modelled: 231 Confidence: 100.0% Identity: 46% PDB header:hydrolase Chain: B: PDB Molecule:5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase; PDBTitle: fumarylacetoacetate hydrolase (eafah) from psychrophilic2 exiguobacterium antarcticum Phyre2 PDB 2dfu chain B Region: 1 - 238 Aligned: 233 Modelled: 238 Confidence: 100.0% Identity: 39% PDB header:isomerase Chain: B: PDB Molecule:probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of the 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase2 from thermus thermophilus hb8 Phyre2 PDB 3qdf chain A Region: 1 - 238 Aligned: 225 Modelled: 238 Confidence: 100.0% Identity: 95% PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PDBTitle: crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase2 from mycobacterium marinum Phyre2 PDB 3r6o chain A Region: 6 - 237 Aligned: 222 Modelled: 232 Confidence: 100.0% Identity: 36% PDB header:isomerase Chain: A: PDB Molecule:2-hydroxyhepta-2,4-diene-1, 7-dioateisomerase; PDBTitle: crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7-2 dioateisomerase from mycobacterium abscessus Phyre2 PDB 1wzo chain C Region: 15 - 236 Aligned: 212 Modelled: 222 Confidence: 100.0% Identity: 43% PDB header:isomerase Chain: C: PDB Molecule:hpce; PDBTitle: crystal structure of the hpce from thermus thermophilus hb8 Phyre2 PDB 1i7o chain C Region: 27 - 239 Aligned: 205 Modelled: 213 Confidence: 100.0% Identity: 36% PDB header:isomerase, lyase Chain: C: PDB Molecule:4-hydroxyphenylacetate degradation bifunctional PDBTitle: crystal structure of hpce Phyre2 PDB 3lzk chain C Region: 17 - 238 Aligned: 222 Modelled: 222 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: C: PDB Molecule:fumarylacetoacetate hydrolase family protein; PDBTitle: the crystal structure of a probably aromatic amino acid2 degradation protein from sinorhizobium meliloti 1021 Phyre2 PDB 3s52 chain A Region: 31 - 233 Aligned: 202 Modelled: 203 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: A: PDB Molecule:putative fumarylacetoacetate hydrolase family protein; PDBTitle: crystal structure of a putative fumarylacetoacetate hydrolase family2 protein from yersinia pestis co92 Phyre2 PDB 4maq chain B Region: 13 - 236 Aligned: 213 Modelled: 224 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: B: PDB Molecule:putative fumarylpyruvate hydrolase; PDBTitle: crystal structure of a putative fumarylpyruvate hydrolase from2 burkholderia cenocepacia Phyre2 PDB 2q1d chain X Region: 21 - 238 Aligned: 208 Modelled: 218 Confidence: 100.0% Identity: 27% PDB header:lyase Chain: X: PDB Molecule:2-keto-3-deoxy-d-arabinonate dehydratase; PDBTitle: 2-keto-3-deoxy-d-arabinonate dehydratase complexed with magnesium and2 2,5-dioxopentanoate Phyre2 PDB 1gtt chain A domain 2 Region: 29 - 239 Aligned: 203 Modelled: 211 Confidence: 100.0% Identity: 36% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 6jvw chain A Region: 13 - 237 Aligned: 205 Modelled: 212 Confidence: 100.0% Identity: 43% PDB header:hydrolase Chain: A: PDB Molecule:maleylpyruvate hydrolase; PDBTitle: crystal structure of maleylpyruvate hydrolase from sphingobium sp.2 syk-6 in complex with manganese (ii) ion and pyruvate Phyre2 PDB 3l53 chain F Region: 30 - 233 Aligned: 204 Modelled: 204 Confidence: 100.0% Identity: 34% PDB header:structural genomics, unknown function Chain: F: PDB Molecule:putative fumarylacetoacetate isomerase/hydrolase; PDBTitle: crystal structure of a putative fumarylacetoacetate2 isomerase/hydrolase from oleispira antarctica Phyre2 PDB 1gtt chain A domain 1 Region: 34 - 239 Aligned: 200 Modelled: 206 Confidence: 100.0% Identity: 31% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 1nr9 chain A Region: 19 - 233 Aligned: 203 Modelled: 215 Confidence: 100.0% Identity: 37% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 1saw chain A Region: 34 - 236 Aligned: 191 Modelled: 203 Confidence: 100.0% Identity: 43% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 1nkq chain A Region: 33 - 239 Aligned: 203 Modelled: 203 Confidence: 100.0% Identity: 34% Fold: FAH Superfamily: FAH Family: FAH Phyre2 PDB 4qku chain C Region: 21 - 238 Aligned: 215 Modelled: 218 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: C: PDB Molecule:hydrolase; PDBTitle: crystal structure of a putative hydrolase from burkholderia2 cenocepacia Phyre2 PDB 1hyo chain B Region: 21 - 236 Aligned: 213 Modelled: 216 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: B: PDB Molecule:fumarylacetoacetate hydrolase; PDBTitle: crystal structure of fumarylacetoacetate hydrolase2 complexed with 4-(hydroxymethylphosphinoyl)-3-oxo-butanoic3 acid Phyre2 1 c4dbhA_ 2 c6iymB_ 3 c2dfuB_ 4 c3qdfA_ 5 c3r6oA_ 6 c1wzoC_ 7 c1i7oC_ 8 c3lzkC_ 9 c3s52A_ 10 c4maqB_ 11 c2q1dX_ 12 d1gtta2 13 c6jvwA_ 14 c3l53F_ 15 d1gtta1 16 d1nr9a_ 17 d1sawa_ 18 d1nkqa_ 19 c4qkuC_ 20 c1hyoB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99