1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	R	D	P	T	G	V	G	A	R	W	A	I	M	I	V	S	L	G	V	T	A	S	S	F	L	F	I	N	G	V	A	F	L	I	P	R	L	E	N	A	R	G	T	P	L	S	H	A	G	L	L	A	S	M	P	S	W	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	V	T	M	F	A	W	G	Y	L	L	D	H	V	G	E	R	M	V	M	A	V	G	S	A	L	T	A	A	A	A	Y	A	A	A	S	V	H	S	L	L	W	I	G	V	F	L	F	L	G	G	M	A	A	G	G	C	N	S
Secondary structure
SS confidence
Disorder																																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	G	G	R	L	V	S	G	W	F	P	P	Q	Q	R	G	L	A	M	G	I	R	Q	T	A	Q	P	L	G	I	A	S	G	A	L	V	I	P	E	L	A	E	R	G	V	H	A	G	L	M	F	P	A	V	V	C	T	L	A	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	A	S	V	L	G	I	V	D	P	P	R	K	S	R	T	K	A	S	E	Q	E	L	A	S	P	Y	R	G	S	S	I	L	W	R	I	H	A	A	S	A	L	L	M	M	P	Q	T	V	T	V	T	F	M	L	V	W	L	I	N
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		H	H	G	W	S	V	A	Q	A	G	V	L	V	T	I	S	Q	L	L	G	A	L	G	R	V	A	V	G	R	W	S	D	H	V	G	S	R	M	R	P	V	R	L	I	A	A	A	A	A	A	T	L	F	L	L	A	A	V	D	N
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	G	S	R	Y	D	V	L	L	M	I	A	I	S	V	I	A	V	L	D	N	G	L	E	A	T	A	I	T	E	Y	A	G	P	Y	W	S	G	R	A	L	G	I	Q	N	T	T	Q	R	L	M	A	A	A	G	P	P	L	F	G
Secondary structure
SS confidence
Disorder																																?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	L	I	T	T	A	A	Y	P	T	A	W	A	L	C	G	V	F	P	L	A	A	V	P	L	V	P	V	R	L	L	P	P	G	L	E	T	R	A	R	R	Q	S	V	R	R	H	R	W	W	Q	A	V	R	C	H	A	W	P	N
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.
Sequence		G	P	R	R	P	G	P	P	G	Q	P	R	R	V	R	Q	G	G	T	A	I	T	P	P	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 59%) (View membrane topology prediction)

Rank Aligned region

PDB 6e9o chain A Region: 6 - 395 Aligned: 390 Modelled: 390 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 1pw4 chain A Region: 2 - 407 Aligned: 401 Modelled: 406 Confidence: 100.0% Identity: 18% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 3wdo chain A Region: 4 - 407 Aligned: 403 Modelled: 404 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 4zp0 chain A Region: 6 - 391 Aligned: 385 Modelled: 386 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 6g9x chain B Region: 12 - 395 Aligned: 367 Modelled: 384 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 4lds chain B Region: 14 - 396 Aligned: 382 Modelled: 383 Confidence: 100.0% Identity: 15% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 2gfp chain A Region: 14 - 387 Aligned: 373 Modelled: 374 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 1pv7 chain A Region: 10 - 405 Aligned: 396 Modelled: 396 Confidence: 100.0% Identity: 12% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 PDB 1pv7 chain B Region: 10 - 405 Aligned: 396 Modelled: 396 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:lactose permease; PDBTitle: crystal structure of lactose permease with tdg Phyre2 PDB 4j05 chain A Region: 11 - 408 Aligned: 398 Modelled: 398 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 4iu8 chain A Region: 2 - 386 Aligned: 385 Modelled: 384 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter (selenomethionine2 derivative) Phyre2 PDB 6h7d chain A Region: 8 - 421 Aligned: 414 Modelled: 414 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 4cl5 chain B Region: 3 - 399 Aligned: 397 Modelled: 397 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 4aps chain B Region: 12 - 386 Aligned: 375 Modelled: 375 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 PDB 3o7p chain A Region: 10 - 387 Aligned: 373 Modelled: 378 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 4iu9 chain A Region: 6 - 386 Aligned: 375 Modelled: 381 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter Phyre2 PDB 5c65 chain A Region: 6 - 412 Aligned: 402 Modelled: 407 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: structure of the human glucose transporter glut3 / slc2a3 Phyre2 PDB 6exs chain A Region: 1 - 386 Aligned: 386 Modelled: 386 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 6gs7 chain A Region: 9 - 388 Aligned: 380 Modelled: 380 Confidence: 100.0% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:dipeptide and tripeptide permease a; PDBTitle: crystal structure of peptide transporter dtpa-nanobody in glycine2 buffer Phyre2 PDB 4w6v chain A Region: 2 - 392 Aligned: 391 Modelled: 391 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 1 c6e9oA_ 2 d1pw4a_ 3 c3wdoA_ 4 c4zp0A_ 5 c6g9xB_ 6 c4ldsB_ 7 c2gfpA_ 8 d1pv7a_ 9 c1pv7B_ 10 c4j05A_ 11 c4iu8A_ 12 c6h7dA_ 13 c4cl5B_ 14 c4apsB_ 15 c3o7pA_ 16 c4iu9A_ 17 c5c65A_ 18 c6exsA_ 19 c6gs7A_ 20 c4w6vA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52