1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	H	F	A	V	G	F	L	T	L	G	L	L	V	P	V	L	T	W	P	V	S	A	P	L	L	V	I	P	V	A	L	S	A	S	I	I	R	L	R	T	L	A	D	E	R	G	V	T	V	R	T	L	V	G	S	R	A	V
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.
Sequence		R	W	D	D	I	D	G	L	R	F	H	R	G	S	W	A	R	A	T	L	K	D	G	T	E	L	R	L	P	A	V	T	F	A	T	L	P	H	L	T	E	A	S	S	G	R	V	P	N	P	Y	R
Secondary structure
SS confidence
Disorder																																										?	?	?		?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 44%) Beta strand ( 23%) TM helix ( 21%) (View membrane topology prediction)

Rank Aligned region

PDB 2na7 chain A Region: 18 - 39 Aligned: 19 Modelled: 22 Confidence: 60.8% Identity: 37% PDB header:apoptosis Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of human fas/cd95 death receptor Phyre2 PDB 2na7 chain B Region: 18 - 39 Aligned: 19 Modelled: 19 Confidence: 57.1% Identity: 37% PDB header:apoptosis Chain: B: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of human fas/cd95 death receptor Phyre2 PDB 2na7 chain C Region: 18 - 39 Aligned: 19 Modelled: 22 Confidence: 57.1% Identity: 37% PDB header:apoptosis Chain: C: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of human fas/cd95 death receptor Phyre2 PDB 3kif chain D Region: 62 - 89 Aligned: 28 Modelled: 28 Confidence: 53.6% Identity: 25% PDB header:sugar binding protein Chain: D: PDB Molecule:5-bladed beta-propeller lectin; PDBTitle: the crystal structures of two fragments truncated from 5-bladed beta-2 propeller lectin, tachylectin-2 (lib1-b7-18 and lib2-d2-15) Phyre2 PDB 1e5w chain A domain 2 Region: 44 - 73 Aligned: 30 Modelled: 30 Confidence: 31.5% Identity: 17% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Third domain of FERM Phyre2 PDB 4cvu chain A Region: 80 - 111 Aligned: 28 Modelled: 32 Confidence: 29.6% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:beta-mannosidase; PDBTitle: structure of fungal beta-mannosidase from glycoside hydrolase family 22 of trichoderma harzianum Phyre2 PDB 1j19 chain A domain 2 Region: 44 - 73 Aligned: 30 Modelled: 30 Confidence: 25.7% Identity: 17% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Third domain of FERM Phyre2 PDB 3k8r chain A Region: 66 - 103 Aligned: 35 Modelled: 38 Confidence: 25.6% Identity: 26% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function (yp_427503.1) from2 rhodospirillum rubrum atcc 11170 at 2.75 a resolution Phyre2 PDB 1tl2 chain A Region: 62 - 96 Aligned: 35 Modelled: 35 Confidence: 23.1% Identity: 17% Fold: 5-bladed beta-propeller Superfamily: Tachylectin-2 Family: Tachylectin-2 Phyre2 PDB 1ef1 chain A domain 2 Region: 44 - 85 Aligned: 41 Modelled: 42 Confidence: 22.9% Identity: 15% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Third domain of FERM Phyre2 PDB 3kih chain C Region: 62 - 112 Aligned: 50 Modelled: 51 Confidence: 22.7% Identity: 14% PDB header:sugar binding protein Chain: C: PDB Molecule:5-bladed beta-propeller lectin; PDBTitle: the crystal structures of two fragments truncated from 5-bladed beta-2 propeller lectin, tachylectin-2 (lib2-d2-15) Phyre2 PDB 1isn chain A domain 2 Region: 44 - 73 Aligned: 30 Modelled: 30 Confidence: 21.7% Identity: 13% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Third domain of FERM Phyre2 PDB 1gg3 chain A domain 2 Region: 44 - 84 Aligned: 40 Modelled: 41 Confidence: 19.6% Identity: 13% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Third domain of FERM Phyre2 PDB 2cx1 chain A domain 2 Region: 68 - 107 Aligned: 40 Modelled: 40 Confidence: 18.6% Identity: 23% Fold: Cystatin-like Superfamily: Pre-PUA domain Family: Hypothetical protein APE0525, N-terminal domain Phyre2 PDB 5c2m chain A Region: 62 - 95 Aligned: 34 Modelled: 34 Confidence: 18.3% Identity: 15% PDB header:structural protein Chain: A: PDB Molecule:predicted protein; PDBTitle: the de novo evolutionary emergence of a symmetrical protein is shaped2 by folding constraints Phyre2 PDB 2zpy chain A domain 2 Region: 44 - 85 Aligned: 41 Modelled: 42 Confidence: 18.1% Identity: 15% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Third domain of FERM Phyre2 PDB 1h4r chain A domain 2 Region: 44 - 88 Aligned: 44 Modelled: 45 Confidence: 16.4% Identity: 11% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Third domain of FERM Phyre2 PDB 2x8n chain A Region: 71 - 103 Aligned: 30 Modelled: 30 Confidence: 9.1% Identity: 17% PDB header:structural genomics Chain: A: PDB Molecule:cv0863; PDBTitle: solution nmr structure of uncharacterized protein cv0863 from2 chromobacterium violaceum. northeast structural genomics target3 (nesg) target cvt3. ocsp target cv0863. Phyre2 PDB 2i1j chain A Region: 44 - 73 Aligned: 30 Modelled: 30 Confidence: 9.0% Identity: 17% PDB header:cell adhesion, membrane protein Chain: A: PDB Molecule:moesin; PDBTitle: moesin from spodoptera frugiperda at 2.1 angstroms resolution Phyre2 PDB 3nqn chain B Region: 38 - 78 Aligned: 41 Modelled: 39 Confidence: 8.6% Identity: 17% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a protein with unknown function. (dr_2006) from2 deinococcus radiodurans at 1.88 a resolution Phyre2 1 c2na7A_ 2 c2na7B_ 3 c2na7C_ 4 c3kifD_ 5 d1e5wa2 6 c4cvuA_ 7 d1j19a2 8 c3k8rA_ 9 d1tl2a_ 10 d1ef1a2 11 c3kihC_ 12 d1isna2 13 d1gg3a2 14 d2cx1a2 15 c5c2mA_ 16 d2zpya2 17 d1h4ra2 18 c2x8nA_ 19 c2i1jA_ 20 c3nqnB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40