1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	S	S	N	D	S	H	W	Q	R	P	D	D	S	P	G	P	M	P	G	R	P	V	S	A	S	L	V	D	P	E	D	D	L	T	P	A	R	Y	A	G	D	F	G	S	G	T	T	T	V	I	P	P	Y	D	A	A	S	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	V	G	N	S	G	Y	S	L	I	E	A	A	E	P	L	P	Y	V	Q	P	Q	P	G	R	Q	V	P	A	G	S	A	G	I	D	M	D	D	D	E	R	V	R	A	A	G	R	R	G	T	Q	N	L	G	L	L	I	L	R	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	L	G	A	V	L	I	A	H	G	L	Q	K	L	F	G	W	W	D	G	Q	G	L	A	G	F	Q	N	S	L	S	D	I	G	Y	Q	H	A	E	I	L	A	Y	V	S	A	G	G	E	I	V	A	G	V	L	L	V	L	G	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	T	P	L	A	A	A	G	A	L	A	F	L	I	N	G	L	L	A	G	I	S	A	Q	H	S	R	P	V	A	Y	F	L	Q	D	G	H	E	Y	Q	I	T	L	V	V	M	A	V	A	V	I	L	S	G	P	G	R	Y	G	L
Secondary structure
SS confidence
Disorder																												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.
Sequence		D	A	A	R	G	W	A	H	R	P	F	I	G	S	F	V	A	L	L	G	G	I	A	A	G	I	A	V	W	V	L	L	N	G	A	N	P	L	A
Secondary structure
SS confidence
Disorder							?		?																											?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 39%) Alpha helix ( 51%) Beta strand ( 0%) TM helix ( 34%) (View membrane topology prediction)

Rank Aligned region

PDB 2bs2 chain C domain 1 Region: 95 - 274 Aligned: 180 Modelled: 180 Confidence: 55.0% Identity: 13% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Fumarate reductase respiratory complex cytochrome b subunit, FrdC Phyre2 PDB 5gjq chain Z Region: 170 - 240 Aligned: 70 Modelled: 71 Confidence: 47.9% Identity: 16% PDB header:hydrolase Chain: Z: PDB Molecule:26s proteasome non-atpase regulatory subunit 2; PDBTitle: structure of the human 26s proteasome bound to usp14-ubal Phyre2 PDB 6hwh chain B Region: 183 - 277 Aligned: 95 Modelled: 95 Confidence: 34.4% Identity: 15% PDB header:electron transport Chain: B: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 5khr chain A Region: 222 - 262 Aligned: 33 Modelled: 41 Confidence: 34.3% Identity: 33% PDB header:cell cycle Chain: A: PDB Molecule:anaphase-promoting complex subunit 1; PDBTitle: model of human anaphase-promoting complex/cyclosome complex (apc152 deletion mutant) in complex with the e2 ube2c/ubch10 poised for3 ubiquitin ligation to substrate (apc/c-cdc20-substrate-ube2c) Phyre2 PDB 5a31 chain A Region: 222 - 240 Aligned: 19 Modelled: 19 Confidence: 28.3% Identity: 37% PDB header:cell cycle Chain: A: PDB Molecule:anaphase-promoting complex subunit 1; PDBTitle: structure of the human apc-cdh1-hsl1-ubch10 complex. Phyre2 PDB 4ui9 chain A Region: 222 - 240 Aligned: 19 Modelled: 19 Confidence: 27.5% Identity: 37% PDB header:cell cycle Chain: A: PDB Molecule:anaphase-promoting complex subunit 1; PDBTitle: atomic structure of the human anaphase-promoting complex Phyre2 PDB 2lzs chain E Region: 215 - 238 Aligned: 24 Modelled: 24 Confidence: 26.7% Identity: 21% PDB header:protein transport Chain: E: PDB Molecule:sec-independent protein translocase protein tata; PDBTitle: tata oligomer Phyre2 PDB 5xj6 chain A Region: 124 - 232 Aligned: 89 Modelled: 109 Confidence: 26.4% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:glycerol-3-phosphate acyltransferase; PDBTitle: crystal structure of plsy (ygih), an integral membrane glycerol 3-2 phosphate acyltransferase - the glycerol 3-phosphate form Phyre2 PDB 2mi2 chain A Region: 222 - 238 Aligned: 17 Modelled: 17 Confidence: 25.0% Identity: 29% PDB header:transport protein Chain: A: PDB Molecule:sec-independent protein translocase protein tatb; PDBTitle: solution structure of the e. coli tatb protein in dpc micelles Phyre2 PDB 5khu chain A Region: 222 - 240 Aligned: 19 Modelled: 19 Confidence: 24.7% Identity: 37% PDB header:cell cycle Chain: A: PDB Molecule:anaphase-promoting complex subunit 1; PDBTitle: model of human anaphase-promoting complex/cyclosome (apc15 deletion2 mutant), in complex with the mitotic checkpoint complex (apc/c-cdc20-3 mcc) based on cryo em data at 4.8 angstrom resolution Phyre2 PDB 5aww chain G Region: 115 - 183 Aligned: 68 Modelled: 69 Confidence: 23.1% Identity: 19% PDB header:protein transport/immune system Chain: G: PDB Molecule:putative preprotein translocase, secg subunit; PDBTitle: precise resting state of thermus thermophilus secyeg Phyre2 PDB 3vrb chain G Region: 161 - 274 Aligned: 106 Modelled: 114 Confidence: 21.2% Identity: 18% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: G: PDB Molecule:cytochrome b-large subunit; PDBTitle: mitochondrial rhodoquinol-fumarate reductase from the parasitic2 nematode ascaris suum with the specific inhibitor flutolanil and3 substrate fumarate Phyre2 PDB 5l9u chain A Region: 221 - 240 Aligned: 20 Modelled: 20 Confidence: 20.9% Identity: 35% PDB header:signaling protein Chain: A: PDB Molecule:anaphase-promoting complex subunit 1; PDBTitle: model of human anaphase-promoting complex/cyclosome (apc/c-cdh1) with2 a cross linked ubiquitin variant-substrate-ube2c (ubch10) complex3 representing key features of multiubiquitination Phyre2 PDB 4ezd chain B Region: 170 - 273 Aligned: 87 Modelled: 89 Confidence: 20.2% Identity: 20% PDB header:transport protein Chain: B: PDB Molecule:urea transporter 1; PDBTitle: crystal structure of the ut-b urea transporter from bos taurus bound2 to selenourea Phyre2 PDB 6iu3 chain A Region: 186 - 273 Aligned: 83 Modelled: 88 Confidence: 19.7% Identity: 16% PDB header:metal transport Chain: A: PDB Molecule:vit1; PDBTitle: crystal structure of iron transporter vit1 with zinc ions Phyre2 PDB 5xmj chain G Region: 103 - 273 Aligned: 171 Modelled: 171 Confidence: 19.2% Identity: 13% PDB header:electron transport Chain: G: PDB Molecule:fumarate reductase respiratory complex; PDBTitle: crystal structure of quinol:fumarate reductase from desulfovibrio2 gigas Phyre2 PDB 2lcn chain A Region: 255 - 270 Aligned: 16 Modelled: 16 Confidence: 19.1% Identity: 31% PDB header:membrane protein Chain: A: PDB Molecule:walp19-p10 peptide; PDBTitle: 1h and 15n assignments of walp19-p10 peptide in sds micelles Phyre2 PDB 1jvr chain A Region: 43 - 85 Aligned: 43 Modelled: 43 Confidence: 15.3% Identity: 21% Fold: Retroviral matrix proteins Superfamily: Retroviral matrix proteins Family: HTLV-II matrix protein Phyre2 PDB 2lco chain A Region: 255 - 270 Aligned: 16 Modelled: 16 Confidence: 14.7% Identity: 31% PDB header:membrane protein Chain: A: PDB Molecule:walp19-p8 peptide; PDBTitle: 1h and 15n assignments of walp19-p8 peptide in sds micelles Phyre2 PDB 2l16 chain A Region: 215 - 238 Aligned: 24 Modelled: 24 Confidence: 12.7% Identity: 17% PDB header:protein transport Chain: A: PDB Molecule:sec-independent protein translocase protein tatad; PDBTitle: solution structure of bacillus subtilits tatad protein in dpc micelles Phyre2 1 d2bs2c1 2 c5gjqZ_ 3 c6hwhB_ 4 c5khrA_ 5 c5a31A_ 6 c4ui9A_ 7 c2lzsE_ 8 c5xj6A_ 9 c2mi2A_ 10 c5khuA_ 11 c5awwG_ 12 c3vrbG_ 13 c5l9uA_ 14 c4ezdB_ 15 c6iu3A_ 16 c5xmjG_ 17 c2lcnA_ 18 d1jvra_ 19 c2lcoA_ 20 c2l16A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43