1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	S	Y	L	L	R	I	E	L	A	D	R	P	G	S	L	G	S	L	A	V	A	L	G	S	V	G	A	D	I	L	S	L	D	V	V	E	R	G	N	G	Y	A	I	D	D	L	V	V	E	L	P	P	G	A	M	P	D	T
Secondary structure
SS confidence
Disorder		?	?	?								?	?	?													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	I	T	A	A	E	A	L	N	G	V	R	V	D	S	V	R	P	H	T	G	L	L	E	A	H	R	E	L	E	L	L	D	H	V	A	A	A	E	G	A	T	A	R	L	Q	V	L	V	N	E	A	P	R	V	L	R	V	S	W
Secondary structure
SS confidence
Disorder							?												?		?	?	?	?	?	?	?									?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		C	T	V	L	R	S	S	G	G	E	L	H	R	L	A	G	S	P	G	A	P	E	T	R	A	N	S	A	P	W	L	P	I	E	R	A	A	A	L	D	G	G	A	D	W	V	P	Q	A	W	R	D	M	D	T	T	M	V	A	A
Secondary structure
SS confidence
Disorder						?		?		?						?	?	?	?	?	?	?	?	?	?	?	?							?	?		?	?	?	?	?	?	?	?										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.
Sequence		P	L	G	D	T	H	T	A	V	V	L	G	R	P	G	P	E	F	R	P	S	E	V	A	R	L	G	Y	L	A	G	I	V	A	T	M	L	R
Secondary structure
SS confidence
Disorder																																						?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 31%) Beta strand ( 30%)

Rank Aligned region

PDB 3ibw chain A Region: 3 - 72 Aligned: 69 Modelled: 70 Confidence: 98.4% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:gtp pyrophosphokinase; PDBTitle: crystal structure of the act domain from gtp pyrophosphokinase of2 chlorobium tepidum. northeast structural genomics consortium target3 ctr148a Phyre2 PDB 1sc6 chain A domain 3 Region: 3 - 76 Aligned: 71 Modelled: 74 Confidence: 97.5% Identity: 20% Fold: Ferredoxin-like Superfamily: ACT-like Family: Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain Phyre2 PDB 1ygy chain A domain 3 Region: 2 - 80 Aligned: 76 Modelled: 76 Confidence: 97.4% Identity: 29% Fold: Ferredoxin-like Superfamily: ACT-like Family: Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain Phyre2 PDB 1u8s chain A domain 2 Region: 3 - 68 Aligned: 65 Modelled: 66 Confidence: 97.3% Identity: 14% Fold: Ferredoxin-like Superfamily: ACT-like Family: Glycine cleavage system transcriptional repressor Phyre2 PDB 1u8s chain B Region: 2 - 68 Aligned: 67 Modelled: 67 Confidence: 97.0% Identity: 13% PDB header:transcription Chain: B: PDB Molecule:glycine cleavage system transcriptional PDBTitle: crystal structure of putative glycine cleavage system2 transcriptional repressor Phyre2 PDB 2lvw chain A Region: 2 - 92 Aligned: 88 Modelled: 91 Confidence: 96.9% Identity: 9% PDB header:transferase Chain: A: PDB Molecule:acetolactate synthase isozyme 1 small subunit; PDBTitle: solution nmr studies of the dimeric regulatory subunit ilvn of the2 e.coli acetohydroxyacid synthase i (ahas i) Phyre2 PDB 3n0v chain D Region: 3 - 68 Aligned: 66 Modelled: 66 Confidence: 96.7% Identity: 9% PDB header:hydrolase Chain: D: PDB Molecule:formyltetrahydrofolate deformylase; PDBTitle: crystal structure of a formyltetrahydrofolate deformylase (pp_0327)2 from pseudomonas putida kt2440 at 2.25 a resolution Phyre2 PDB 1zpv chain A domain 1 Region: 4 - 68 Aligned: 64 Modelled: 65 Confidence: 96.6% Identity: 16% Fold: Ferredoxin-like Superfamily: ACT-like Family: SP0238-like Phyre2 PDB 5usc chain B Region: 2 - 67 Aligned: 65 Modelled: 66 Confidence: 96.1% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of prephenate dehydrogenase tyra from bacillus2 anthracis in complex with nad and l-tyrosine Phyre2 PDB 6dzs chain D Region: 3 - 72 Aligned: 67 Modelled: 70 Confidence: 96.0% Identity: 25% PDB header:oxidoreductase Chain: D: PDB Molecule:homoserine dehydrogenase; PDBTitle: mycobacterial homoserine dehydrogenase thra in complex with nadp Phyre2 PDB 2f06 chain A domain 2 Region: 6 - 67 Aligned: 56 Modelled: 62 Confidence: 95.8% Identity: 21% Fold: Ferredoxin-like Superfamily: ACT-like Family: BT0572-like Phyre2 PDB 2nyi chain B Region: 2 - 74 Aligned: 72 Modelled: 73 Confidence: 95.6% Identity: 19% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:unknown protein; PDBTitle: crystal structure of an unknown protein from galdieria sulphuraria Phyre2 PDB 1u8s chain A domain 1 Region: 3 - 81 Aligned: 77 Modelled: 79 Confidence: 95.2% Identity: 13% Fold: Ferredoxin-like Superfamily: ACT-like Family: Glycine cleavage system transcriptional repressor Phyre2 PDB 1tdj chain A Region: 2 - 67 Aligned: 64 Modelled: 66 Confidence: 95.1% Identity: 14% PDB header:allostery Chain: A: PDB Molecule:biosynthetic threonine deaminase; PDBTitle: threonine deaminase (biosynthetic) from e. coli Phyre2 PDB 2f1f chain A domain 1 Region: 4 - 72 Aligned: 69 Modelled: 69 Confidence: 94.3% Identity: 16% Fold: Ferredoxin-like Superfamily: ACT-like Family: IlvH-like Phyre2 PDB 2f06 chain A domain 1 Region: 6 - 67 Aligned: 56 Modelled: 56 Confidence: 94.0% Identity: 23% Fold: Ferredoxin-like Superfamily: ACT-like Family: BT0572-like Phyre2 PDB 2f1f chain A Region: 4 - 89 Aligned: 84 Modelled: 86 Confidence: 93.9% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:acetolactate synthase isozyme iii small subunit; PDBTitle: crystal structure of the regulatory subunit of acetohydroxyacid2 synthase isozyme iii from e. coli Phyre2 PDB 3o1l chain B Region: 2 - 68 Aligned: 67 Modelled: 67 Confidence: 93.9% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:formyltetrahydrofolate deformylase; PDBTitle: crystal structure of a formyltetrahydrofolate deformylase (pspto_4314)2 from pseudomonas syringae pv. tomato str. dc3000 at 2.20 a resolution Phyre2 PDB 1ygy chain A Region: 3 - 76 Aligned: 72 Modelled: 74 Confidence: 92.8% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:d-3-phosphoglycerate dehydrogenase; PDBTitle: crystal structure of d-3-phosphoglycerate dehydrogenase from2 mycobacterium tuberculosis Phyre2 PDB 2fgc chain A domain 2 Region: 1 - 72 Aligned: 72 Modelled: 72 Confidence: 91.9% Identity: 18% Fold: Ferredoxin-like Superfamily: ACT-like Family: IlvH-like Phyre2 1 c3ibwA_ 2 d1sc6a3 3 d1ygya3 4 d1u8sa2 5 c1u8sB_ 6 c2lvwA_ 7 c3n0vD_ 8 d1zpva1 9 c5uscB_ 10 c6dzsD_ 11 d2f06a2 12 c2nyiB_ 13 d1u8sa1 14 c1tdjA_ 15 d2f1fa1 16 d2f06a1 17 c2f1fA_ 18 c3o1lB_ 19 c1ygyA_ 20 d2fgca2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99