1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	V	F	A	T	A	T	G	I	G	S	W	P	G	T	A	A	R	E	A	A	Q	V	V	V	G	E	L	A	G	A	L	A	Y	L	T	E	L	P	A	R	G	V	G	A	D	M	L	G	R	A	G	G	L	L	V	D	V	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	D	T	V	P	R	G	Y	R	I	A	A	R	P	G	A	V	T	R	R	A	A	S	L	L	D	E	D	M	D	A	L	E	E	A	W	E	T	A	G	L	R	G	C	G	R	A	V	K	V	Q	A	P	G	P	V	T	L	V	A
Secondary structure
SS confidence
Disorder				?										?																										?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	L	E	L	A	N	G	H	R	A	I	T	D	P	G	A	V	R	D	L	A	A	S	L	A	E	G	V	A	A	H	R	A	A	L	A	R	R	L	D	T	P	V	V	V	Q	F	D	E	P	S	L	P	A	A	L	G	G	R	L
Secondary structure
SS confidence
Disorder			?			?																																																				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	G	V	T	A	L	S	P	V	A	P	L	D	E	T	V	A	E	A	L	L	D	T	C	I	A	A	V	D	A	D	V	A	L	H	S	C	S	P	D	L	P	W	D	L	L	Q	R	S	R	I	S	A	V	S	V	D	A	S	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	Q	A	A	D	L	D	A	V	A	A	F	V	E	S	G	R	T	V	V	L	G	L	V	P	V	T	A	P	E	R	A	P	S	M	E	E	V	A	A	A	A	V	A	V	T	D	R	L	G	V	P	R	S	A	L	R	D	R	L
Secondary structure
SS confidence
Disorder				?																									?	?	?	?	?																					?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.
Sequence		G	V	S	P	A	C	G	L	A	N	A	T	G	Q	W	A	R	T	A	V	G	L	A	R	D	V	A	E	A	F	A	R	D	P	E	A	I
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 46%) Beta strand ( 15%)

Rank Aligned region

PDB 1u22 chain A Region: 1 - 332 Aligned: 294 Modelled: 332 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:5-methyltetrahydropteroyltriglutamate-- PDBTitle: a. thaliana cobalamine independent methionine synthase Phyre2 PDB 1t7l chain A Region: 1 - 332 Aligned: 297 Modelled: 325 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:5-methyltetrahydropteroyltriglutamate--homocysteine PDBTitle: crystal structure of cobalamin-independent methionine synthase from t.2 maritima Phyre2 PDB 4ztx chain A Region: 1 - 332 Aligned: 297 Modelled: 332 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:cobalamin-independent methionine synthase; PDBTitle: neurospora crassa cobalamin-independent methionine synthase complexed2 with zn2+ Phyre2 PDB 3l7s chain A Region: 1 - 332 Aligned: 297 Modelled: 325 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:5-methyltetrahydropteroyltriglutamate--homocysteine PDBTitle: crystal structure of mete coordinated with zinc from streptococcus2 mutans Phyre2 PDB 2nq5 chain A Region: 1 - 332 Aligned: 277 Modelled: 277 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:5-methyltetrahydropteroyltriglutamate--homocysteine PDBTitle: crystal structure of methyltransferase from streptococcus mutans Phyre2 PDB 1u1h chain A domain 2 Region: 1 - 332 Aligned: 295 Modelled: 312 Confidence: 100.0% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: UROD/MetE-like Family: Cobalamin-independent methionine synthase Phyre2 PDB 3ppg chain A Region: 1 - 332 Aligned: 274 Modelled: 331 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:5-methyltetrahydropteroyltriglutamate--homocysteine PDBTitle: crystal structure of the candida albicans methionine synthase by2 surface entropy reduction, alanine variant with zinc Phyre2 PDB 3rpd chain B Region: 2 - 337 Aligned: 296 Modelled: 322 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:methionine synthase (b12-independent); PDBTitle: the structure of a b12-independent methionine synthase from shewanella2 sp. w3-18-1 in complex with selenomethionine. Phyre2 PDB 1ypx chain A Region: 1 - 331 Aligned: 284 Modelled: 331 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:putative vitamin-b12 independent methionine synthase family PDBTitle: crystal structure of the putative vitamin-b12 independent methionine2 synthase from listeria monocytogenes, northeast structural genomics3 target lmr13 Phyre2 PDB 1u1h chain A domain 1 Region: 7 - 336 Aligned: 299 Modelled: 317 Confidence: 100.0% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: UROD/MetE-like Family: Cobalamin-independent methionine synthase Phyre2 PDB 4ay8 chain B Region: 90 - 331 Aligned: 213 Modelled: 231 Confidence: 99.7% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:methylcobalamin\: coenzyme m methyltransferase; PDBTitle: semet-derivative of a methyltransferase from m. mazei Phyre2 PDB 1j93 chain A Region: 86 - 331 Aligned: 219 Modelled: 246 Confidence: 99.7% Identity: 13% Fold: TIM beta/alpha-barrel Superfamily: UROD/MetE-like Family: Uroporphyrinogen decarboxylase, UROD Phyre2 PDB 3cyv chain A Region: 87 - 332 Aligned: 216 Modelled: 234 Confidence: 99.6% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:uroporphyrinogen decarboxylase; PDBTitle: crystal structure of uroporphyrinogen decarboxylase from2 shigella flexineri: new insights into its catalytic3 mechanism Phyre2 PDB 4exq chain A Region: 103 - 331 Aligned: 202 Modelled: 216 Confidence: 99.6% Identity: 19% PDB header:biosynthetic protein Chain: A: PDB Molecule:uroporphyrinogen decarboxylase; PDBTitle: crystal structure of uroporphyrinogen decarboxylase (upd) from2 burkholderia thailandensis e264 Phyre2 PDB 1jpk chain A Region: 90 - 332 Aligned: 222 Modelled: 243 Confidence: 99.5% Identity: 14% PDB header:lyase Chain: A: PDB Molecule:uroporphyrinogen decarboxylase; PDBTitle: gly156asp mutant of human urod, human uroporphyrinogen iii2 decarboxylase Phyre2 PDB 4zr8 chain B Region: 87 - 333 Aligned: 223 Modelled: 247 Confidence: 99.5% Identity: 14% PDB header:lyase Chain: B: PDB Molecule:uroporphyrinogen decarboxylase; PDBTitle: structure of uroporphyrinogen decarboxylase from acinetobacter2 baumannii Phyre2 PDB 1r3s chain A Region: 90 - 332 Aligned: 222 Modelled: 243 Confidence: 99.5% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: UROD/MetE-like Family: Uroporphyrinogen decarboxylase, UROD Phyre2 PDB 2inf chain B Region: 86 - 333 Aligned: 220 Modelled: 241 Confidence: 99.5% Identity: 10% PDB header:lyase Chain: B: PDB Molecule:uroporphyrinogen decarboxylase; PDBTitle: crystal structure of uroporphyrinogen decarboxylase from bacillus2 subtilis Phyre2 PDB 2eja chain B Region: 87 - 328 Aligned: 213 Modelled: 242 Confidence: 99.4% Identity: 18% PDB header:lyase Chain: B: PDB Molecule:uroporphyrinogen decarboxylase; PDBTitle: crystal structure of uroporphyrinogen decarboxylase from2 aquifex aeolicus Phyre2 PDB 3rhg chain A Region: 177 - 334 Aligned: 152 Modelled: 158 Confidence: 86.2% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:putative phophotriesterase; PDBTitle: crystal structure of amidohydrolase pmi1525 (target efi-500319) from2 proteus mirabilis hi4320 Phyre2 1 c1u22A_ 2 c1t7lA_ 3 c4ztxA_ 4 c3l7sA_ 5 c2nq5A_ 6 d1u1ha2 7 c3ppgA_ 8 c3rpdB_ 9 c1ypxA_ 10 d1u1ha1 11 c4ay8B_ 12 d1j93a_ 13 c3cyvA_ 14 c4exqA_ 15 c1jpkA_ 16 c4zr8B_ 17 d1r3sa_ 18 c2infB_ 19 c2ejaB_ 20 c3rhgA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99