1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	L	L	D	A	H	I	P	Q	L	I	A	S	H	T	A	F	A	A	K	A	G	L	M	R	H	T	I	G	Q	A	E	Q	Q	A	M	S	A	Q	A	F	H	Q	G	E	S	A	A	A	F	Q	G	A	H	A	R	F	V	A
Secondary structure
SS confidence
Disorder		?	?	?	?									?		?	?	?																				?	?					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.
Sequence		A	A	A	K	V	N	T	L	L	D	I	A	Q	A	N	L	G	E	A	A	G	T	Y	V	A	A	D	A	A	A	A	S	S	Y	T	G	F
Secondary structure
SS confidence
Disorder														?	?	?											?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 93%) Beta strand ( 0%)

Rank Aligned region

PDB 2kg7 chain A Region: 1 - 97 Aligned: 97 Modelled: 97 Confidence: 100.0% Identity: 92% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein esxg (pe family protein); PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288 Phyre2 PDB 3h6p chain B Region: 14 - 80 Aligned: 67 Modelled: 67 Confidence: 100.0% Identity: 100% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:esat-6 like protein esxs; PDBTitle: crystal structure of rv3019c-rv3020c from mycobacterium tuberculosis Phyre2 PDB 2kg7 chain B Region: 1 - 96 Aligned: 96 Modelled: 96 Confidence: 95.7% Identity: 18% PDB header:unknown function Chain: B: PDB Molecule:esat-6-like protein esxh; PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288 Phyre2 PDB 1wa8 chain A domain 1 Region: 10 - 93 Aligned: 84 Modelled: 84 Confidence: 95.3% Identity: 30% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 1wa8 chain B domain 1 Region: 9 - 94 Aligned: 86 Modelled: 86 Confidence: 95.3% Identity: 16% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 3zbh chain C Region: 10 - 96 Aligned: 87 Modelled: 87 Confidence: 93.9% Identity: 20% PDB header:unknown function Chain: C: PDB Molecule:esxa; PDBTitle: geobacillus thermodenitrificans esxa crystal form i Phyre2 PDB 4lws chain A Region: 9 - 93 Aligned: 85 Modelled: 84 Confidence: 93.1% Identity: 21% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 3gvm chain A Region: 1 - 93 Aligned: 93 Modelled: 93 Confidence: 90.3% Identity: 17% PDB header:viral protein Chain: A: PDB Molecule:putative uncharacterized protein sag1039; PDBTitle: structure of the homodimeric wxg-100 family protein from streptococcus2 agalactiae Phyre2 PDB 4lws chain B Region: 9 - 83 Aligned: 75 Modelled: 75 Confidence: 88.2% Identity: 17% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 2vs0 chain B Region: 10 - 87 Aligned: 78 Modelled: 78 Confidence: 74.2% Identity: 14% PDB header:cell invasion Chain: B: PDB Molecule:virulence factor esxa; PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa Phyre2 PDB 4iog chain D Region: 1 - 86 Aligned: 86 Modelled: 86 Confidence: 66.9% Identity: 19% PDB header:unknown function Chain: D: PDB Molecule:secreted protein esxb; PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne Phyre2 PDB 2v0x chain B Region: 12 - 38 Aligned: 25 Modelled: 27 Confidence: 11.2% Identity: 52% PDB header:cell cycle Chain: B: PDB Molecule:lamina-associated polypeptide 2 isoforms alpha/zeta; PDBTitle: the dimerization domain of lap2alpha Phyre2 PDB 2q6m chain A Region: 51 - 94 Aligned: 44 Modelled: 44 Confidence: 9.3% Identity: 30% PDB header:toxin Chain: A: PDB Molecule:cholix toxin; PDBTitle: catalytic fragment of cholix toxin from vibrio cholerae in complex2 with the pj34 inhibitor Phyre2 PDB 1xrx chain D Region: 43 - 48 Aligned: 6 Modelled: 6 Confidence: 7.9% Identity: 83% PDB header:replication inhibitor Chain: D: PDB Molecule:seqa protein; PDBTitle: crystal structure of a dna-binding protein Phyre2 PDB 1xrx chain A domain 1 Region: 43 - 48 Aligned: 6 Modelled: 6 Confidence: 7.9% Identity: 83% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: SeqA N-terminal domain-like Phyre2 PDB 3u0c chain A Region: 24 - 73 Aligned: 50 Modelled: 50 Confidence: 6.8% Identity: 18% PDB header:cell invasion Chain: A: PDB Molecule:invasin ipab; PDBTitle: crystal structure of n-terminal region of type iii secretion first2 translocator ipab (residues 74-224) Phyre2 PDB 1hbn chain A domain 1 Region: 43 - 75 Aligned: 32 Modelled: 33 Confidence: 6.7% Identity: 44% Fold: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Superfamily: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Family: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Phyre2 PDB 5v6h chain C Region: 59 - 70 Aligned: 12 Modelled: 12 Confidence: 6.1% Identity: 42% PDB header:protein binding Chain: C: PDB Molecule:pdz domain-containing protein gipc2; PDBTitle: crystal structure of myosin vi in complex with gh2 domain of gipc2 Phyre2 PDB 1e6v chain A domain 1 Region: 43 - 75 Aligned: 32 Modelled: 33 Confidence: 5.7% Identity: 38% Fold: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Superfamily: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Family: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Phyre2 PDB 4e1r chain A Region: 46 - 65 Aligned: 20 Modelled: 20 Confidence: 5.4% Identity: 30% PDB header:dna binding protein Chain: A: PDB Molecule:protein lsr2; PDBTitle: crystal structure of the dimerization domain of lsr2 from2 mycobacterium tuberculosis in the p 31 2 1 space group Phyre2 1 c2kg7A_ 2 c3h6pB_ 3 c2kg7B_ 4 d1wa8a1 5 d1wa8b1 6 c3zbhC_ 7 c4lwsA_ 8 c3gvmA_ 9 c4lwsB_ 10 c2vs0B_ 11 c4iogD_ 12 c2v0xB_ 13 c2q6mA_ 14 c1xrxD_ 15 d1xrxa1 16 c3u0cA_ 17 d1hbna1 18 c5v6hC_ 19 d1e6va1 20 c4e1rA_ 21 22