1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	V	L	A	A	M	S	G	G	V	D	S	S	V	A	A	A	R	M	V	D	A	G	H	E	V	V	G	V	H	M	A	L	S	T	A	P	G	T	L	R	T	G	S	R	G	C	C	S	K	E	D	A	A	D	A	R	R	V
Secondary structure
SS confidence
Disorder		?																																						?	?	?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	D	V	L	G	I	P	F	Y	V	W	D	F	A	E	K	F	K	E	D	V	I	N	D	F	V	S	S	Y	A	R	G	E	T	P	N	P	C	V	R	C	N	Q	Q	I	K	F	A	A	L	S	A	R	A	V	A	L	G	F	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	V	A	T	G	H	Y	A	R	L	S	G	G	R	L	R	R	A	V	D	R	D	K	D	Q	S	Y	V	L	A	V	L	T	A	Q	Q	L	R	H	A	A	F	P	I	G	D	T	P	K	R	Q	I	R	A	E	A	A	R	R	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	A	V	A	N	K	P	D	S	H	D	I	C	F	I	P	S	G	N	T	K	A	F	L	G	E	R	I	G	V	R	R	G	V	V	V	D	A	D	G	V	V	L	A	S	H	D	G	V	H	G	F	T	I	G	Q	R	R	G	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	I	A	G	P	G	P	N	G	R	P	R	Y	V	T	A	I	D	A	D	T	A	T	V	H	V	G	D	V	T	D	L	D	V	Q	T	L	T	G	R	A	P	V	F	T	A	G	A	A	P	S	G	P	V	D	C	V	V	Q	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	A	H	G	E	T	V	S	A	V	A	E	L	I	G	D	A	L	F	V	Q	L	H	A	P	L	R	G	V	A	R	G	Q	T	L	V	L	Y	R	P	D	P	A	G	D	E	V	L	G	S	A	T	I	A	G	A	S	G	L	S
Secondary structure
SS confidence
Disorder																																																								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		T	G	G	N	P	G	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 25%) Beta strand ( 29%)

Rank Aligned region

PDB 2hma chain A Region: 2 - 359 Aligned: 343 Modelled: 358 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:probable trna (5-methylaminomethyl-2-thiouridylate)- PDBTitle: the crystal structure of trna (5-methylaminomethyl-2-thiouridylate)-2 methyltransferase trmu from streptococcus pneumoniae Phyre2 PDB 2der chain A Region: 2 - 359 Aligned: 334 Modelled: 342 Confidence: 100.0% Identity: 35% PDB header:transferase/rna Chain: A: PDB Molecule:trna-specific 2-thiouridylase mnma; PDBTitle: cocrystal structure of an rna sulfuration enzyme mnma and2 trna-glu in the initial trna binding state Phyre2 PDB 2vxo chain B Region: 2 - 187 Aligned: 172 Modelled: 174 Confidence: 100.0% Identity: 25% PDB header:ligase Chain: B: PDB Molecule:gmp synthase [glutamine-hydrolyzing]; PDBTitle: human gmp synthetase in complex with xmp Phyre2 PDB 4kr7 chain A Region: 2 - 198 Aligned: 166 Modelled: 174 Confidence: 100.0% Identity: 20% PDB header:transferase/rna Chain: A: PDB Molecule:probable trna sulfurtransferase; PDBTitle: crystal structure of a 4-thiouridine synthetase - rna complex with2 bound atp Phyre2 PDB 3q4g chain A Region: 2 - 194 Aligned: 164 Modelled: 164 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: A: PDB Molecule:nh(3)-dependent nad(+) synthetase; PDBTitle: structure of nad synthetase from vibrio cholerae Phyre2 PDB 2c5s chain A Region: 2 - 181 Aligned: 149 Modelled: 180 Confidence: 100.0% Identity: 21% PDB header:rna-binding protein Chain: A: PDB Molecule:probable thiamine biosynthesis protein thii; PDBTitle: crystal structure of bacillus anthracis thii, a trna-2 modifying enzyme containing the predicted rna-binding3 thump domain Phyre2 PDB 5huj chain B Region: 2 - 194 Aligned: 158 Modelled: 158 Confidence: 99.9% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:nh(3)-dependent nad(+) synthetase; PDBTitle: crystal structure of nade from streptococcus pyogenes Phyre2 PDB 3fiu chain D Region: 2 - 193 Aligned: 159 Modelled: 176 Confidence: 99.9% Identity: 19% PDB header:ligase Chain: D: PDB Molecule:nh(3)-dependent nad(+) synthetase; PDBTitle: structure of nmn synthetase from francisella tularensis Phyre2 PDB 3k32 chain D Region: 3 - 229 Aligned: 188 Modelled: 213 Confidence: 99.9% Identity: 19% PDB header:transferase Chain: D: PDB Molecule:uncharacterized protein mj0690; PDBTitle: the crystal structure of predicted subunit of trna methyltransferase2 from methanocaldococcus jannaschii dsm Phyre2 PDB 5udw chain B Region: 2 - 192 Aligned: 142 Modelled: 164 Confidence: 99.9% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:lactate racemization operon protein lare; PDBTitle: lare, a sulfur transferase involved in synthesis of the cofactor for2 lactate racemase, in complex with nickel Phyre2 PDB 2e21 chain A Region: 2 - 208 Aligned: 178 Modelled: 205 Confidence: 99.9% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:trna(ile)-lysidine synthase; PDBTitle: crystal structure of tils in a complex with amppnp from aquifex2 aeolicus. Phyre2 PDB 1wy5 chain A domain 1 Region: 2 - 208 Aligned: 178 Modelled: 207 Confidence: 99.9% Identity: 21% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: PP-loop ATPase Phyre2 PDB 3a2k chain B Region: 2 - 208 Aligned: 176 Modelled: 207 Confidence: 99.9% Identity: 19% PDB header:ligase/rna Chain: B: PDB Molecule:trna(ile)-lysidine synthase; PDBTitle: crystal structure of tils complexed with trna Phyre2 PDB 1kh2 chain D Region: 1 - 243 Aligned: 219 Modelled: 229 Confidence: 99.9% Identity: 20% PDB header:ligase Chain: D: PDB Molecule:argininosuccinate synthetase; PDBTitle: crystal structure of thermus thermophilus hb8 argininosuccinate2 synthetase in complex with atp Phyre2 PDB 2c5s chain A domain 1 Region: 2 - 217 Aligned: 190 Modelled: 216 Confidence: 99.9% Identity: 18% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ThiI-like Phyre2 PDB 2nz2 chain A Region: 2 - 189 Aligned: 167 Modelled: 174 Confidence: 99.9% Identity: 22% PDB header:ligase Chain: A: PDB Molecule:argininosuccinate synthase; PDBTitle: crystal structure of human argininosuccinate synthase in complex with2 aspartate and citrulline Phyre2 PDB 1kqp chain A Region: 2 - 202 Aligned: 169 Modelled: 171 Confidence: 99.9% Identity: 19% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: N-type ATP pyrophosphatases Phyre2 PDB 4xfd chain A Region: 2 - 187 Aligned: 156 Modelled: 157 Confidence: 99.9% Identity: 21% PDB header:ligase Chain: A: PDB Molecule:nh(3)-dependent nad(+) synthetase; PDBTitle: crystal structure of a nh(3)-dependent nad(+) synthetase from2 pseudomonas aeruginosa Phyre2 PDB 2e18 chain B Region: 2 - 214 Aligned: 178 Modelled: 178 Confidence: 99.9% Identity: 25% PDB header:ligase Chain: B: PDB Molecule:nh(3)-dependent nad(+) synthetase; PDBTitle: crystal structure of project ph0182 from pyrococcus horikoshii ot3 Phyre2 PDB 3vrh chain A Region: 2 - 213 Aligned: 188 Modelled: 212 Confidence: 99.9% Identity: 25% PDB header:rna binding protein Chain: A: PDB Molecule:putative uncharacterized protein ph0300; PDBTitle: crystal structure of ph0300 Phyre2 1 c2hmaA_ 2 c2derA_ 3 c2vxoB_ 4 c4kr7A_ 5 c3q4gA_ 6 c2c5sA_ 7 c5hujB_ 8 c3fiuD_ 9 c3k32D_ 10 c5udwB_ 11 c2e21A_ 12 d1wy5a1 13 c3a2kB_ 14 c1kh2D_ 15 d2c5sa1 16 c2nz2A_ 17 d1kqpa_ 18 c4xfdA_ 19 c2e18B_ 20 c3vrhA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291