1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	N	T	S	A	S	P	V	P	G	L	F	T	L	V	L	H	T	H	L	P	W	L	A	H	H	G	R	W	P	V	G	E	E	W	L	Y	Q	S	W	A	A	A	Y	L	P	L	L	Q	V	L	A	A	L	A	D	E	N	R	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																					?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	L	I	T	L	G	M	T	P	V	V	N	A	Q	L	D	D	P	Y	C	L	N	G	V	H	H	W	L	A	N	W	Q	L	R	A	E	E	A	A	S	V	R	Y	A	R	Q	S	K	S	A	D	Y	P	S	C	T	P	E	A	L
Secondary structure
SS confidence
Disorder																																						?	?												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	A	F	G	I	R	E	C	A	D	A	A	R	A	L	D	N	F	A	T	R	W	R	H	G	G	S	P	L	L	R	G	L	I	D	A	G	T	V	E	L	L	G	G	P	L	A	H	P	F	Q	P	L	L	A	P	R	L	R	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	A	L	R	E	G	L	A	D	A	Q	L	R	L	A	H	R	P	K	G	I	W	A	P	E	C	A	Y	A	P	G	M	E	V	D	Y	A	T	A	G	V	S	H	F	M	V	D	G	P	S	L	H	G	D	T	A	L	G	R	P
Secondary structure
SS confidence
Disorder																																																					?	?	?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	G	K	T	D	V	V	A	F	G	R	D	L	Q	V	S	Y	R	V	W	S	P	K	S	G	Y	P	G	H	A	A	Y	R	D	F	H	T	Y	D	H	L	T	G	L	K	P	A	R	V	T	G	R	N	V	P	S	E	Q	K	A
Secondary structure
SS confidence
Disorder																																										?											?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	Y	D	P	E	R	A	D	R	A	V	D	V	H	V	A	D	F	V	D	V	V	R	N	R	L	L	S	E	S	E	R	I	G	R	P	A	H	V	I	A	A	F	D	T	E	L	F	G	H	W	W	Y	E	G	P	T	W	L	Q
Secondary structure
SS confidence
Disorder																																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	V	L	R	A	L	P	A	A	G	V	R	V	G	T	L	S	D	A	I	A	D	G	F	V	G	D	P	V	E	L	P	P	S	S	W	G	S	G	K	D	W	Q	V	W	S	G	A	K	V	A	D	L	V	Q	L	N	S	E	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		V	D	T	A	L	T	T	I	D	K	A	L	A	Q	T	A	S	L	D	G	P	L	P	R	D	H	V	A	D	Q	I	L	R	E	T	L	L	T	V	S	S	D	W	P	F	M	V	S	K	D	S	A	A	D	Y	A	R	Y	R	A
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.
Sequence		H	L	H	A	H	A	T	R	E	I	A	G	A	L	A	A	G	R	R	D	T	A	R	R	L	A	E	G	W	N	R	A	D	G	L	F	G	A	L	D	A	R	R	L	P	K
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?										?	?	?		?						?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 53%) Beta strand ( 9%)

Rank Aligned region

PDB 3n92 chain A Region: 8 - 526 Aligned: 495 Modelled: 519 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:alpha-amylase, gh57 family; PDBTitle: crystal structure of tk1436, a gh57 branching enzyme from2 hyperthermophilic archaeon thermococcus kodakaraensis, in complex3 with glucose Phyre2 PDB 5wu7 chain A Region: 8 - 526 Aligned: 491 Modelled: 502 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of gh57-type branching enzyme from hyperthermophilic2 archaeon pyrococcus horikoshii Phyre2 PDB 2b5d chain X Region: 8 - 526 Aligned: 486 Modelled: 519 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: X: PDB Molecule:alpha-amylase; PDBTitle: crystal structure of the novel alpha-amylase amyc from thermotoga2 maritima Phyre2 PDB 1ufa chain A Region: 11 - 524 Aligned: 476 Modelled: 490 Confidence: 100.0% Identity: 33% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:tt1467 protein; PDBTitle: crystal structure of tt1467 from thermus thermophilus hb8 Phyre2 PDB 2b5d chain X domain 2 Region: 8 - 397 Aligned: 374 Modelled: 390 Confidence: 100.0% Identity: 26% Fold: 7-stranded beta/alpha barrel Superfamily: Glycoside hydrolase/deacetylase Family: AmyC N-terminal domain-like Phyre2 PDB 1ufa chain A domain 2 Region: 11 - 404 Aligned: 373 Modelled: 378 Confidence: 100.0% Identity: 34% Fold: 7-stranded beta/alpha barrel Superfamily: Glycoside hydrolase/deacetylase Family: AmyC N-terminal domain-like Phyre2 PDB 1k1y chain A Region: 8 - 486 Aligned: 333 Modelled: 333 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:4-alpha-glucanotransferase; PDBTitle: crystal structure of thermococcus litoralis 4-alpha-glucanotransferase2 complexed with acarbose Phyre2 PDB 1k1x chain A domain 3 Region: 8 - 424 Aligned: 281 Modelled: 295 Confidence: 100.0% Identity: 22% Fold: 7-stranded beta/alpha barrel Superfamily: Glycoside hydrolase/deacetylase Family: 4-alpha-glucanotransferase, N-terminal domain Phyre2 PDB 2b5d chain X domain 1 Region: 410 - 526 Aligned: 111 Modelled: 117 Confidence: 100.0% Identity: 23% Fold: immunoglobulin/albumin-binding domain-like Superfamily: Families 57/38 glycoside transferase middle domain Family: AmyC C-terminal domain-like Phyre2 PDB 1ufa chain A domain 1 Region: 405 - 524 Aligned: 103 Modelled: 111 Confidence: 100.0% Identity: 28% Fold: immunoglobulin/albumin-binding domain-like Superfamily: Families 57/38 glycoside transferase middle domain Family: AmyC C-terminal domain-like Phyre2 PDB 1hty chain A Region: 8 - 494 Aligned: 388 Modelled: 406 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase ii; PDBTitle: golgi alpha-mannosidase ii Phyre2 PDB 2ow7 chain A Region: 8 - 494 Aligned: 397 Modelled: 417 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase 2; PDBTitle: golgi alpha-mannosidase ii complex with (1r,6s,7r,8s)-1-2 thioniabicyclo[4.3.0]nonan-7,8-diol chloride Phyre2 PDB 2wyh chain A Region: 3 - 494 Aligned: 377 Modelled: 408 Confidence: 99.9% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase; PDBTitle: structure of the streptococcus pyogenes family gh38 alpha-2 mannosidase Phyre2 PDB 6b9p chain A Region: 3 - 494 Aligned: 388 Modelled: 407 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase from canavalia ensiformis (jack bean); PDBTitle: structure of gh 38 jack bean alpha-mannosidase in complex with a 36-2 valent iminosugar cluster inhibitor Phyre2 PDB 5jm0 chain A Region: 7 - 521 Aligned: 381 Modelled: 407 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase,alpha-mannosidase,alpha-mannosidase; PDBTitle: structure of the s. cerevisiae alpha-mannosidase 1 Phyre2 PDB 3lvt chain A Region: 6 - 494 Aligned: 326 Modelled: 384 Confidence: 99.8% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:glycosyl hydrolase, family 38; PDBTitle: the crystal structure of a protein in the glycosyl hydrolase family 382 from enterococcus faecalis to 2.55a Phyre2 PDB 3bvu chain A domain 3 Region: 8 - 382 Aligned: 298 Modelled: 306 Confidence: 99.7% Identity: 15% Fold: 7-stranded beta/alpha barrel Superfamily: Glycoside hydrolase/deacetylase Family: alpha-mannosidase Phyre2 PDB 1o7d chain A Region: 2 - 226 Aligned: 152 Modelled: 161 Confidence: 99.4% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:lysosomal alpha-mannosidase; PDBTitle: the structure of the bovine lysosomal a-mannosidase suggests a novel2 mechanism for low ph activation Phyre2 PDB 4cmr chain B Region: 12 - 382 Aligned: 251 Modelled: 258 Confidence: 99.2% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:glycosyl hydrolase/deacetylase family protein; PDBTitle: the crystal structure of novel exo-type maltose-forming2 amylase(py04_0872) from pyrococcus sp. st04 Phyre2 PDB 3qbu chain D Region: 35 - 381 Aligned: 245 Modelled: 263 Confidence: 99.0% Identity: 13% PDB header:hydrolase Chain: D: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of putative peptidoglycan deactelyase (hp0310) from2 helicobacter pylori Phyre2 1 c3n92A_ 2 c5wu7A_ 3 c2b5dX_ 4 c1ufaA_ 5 d2b5dx2 6 d1ufaa2 7 c1k1yA_ 8 d1k1xa3 9 d2b5dx1 10 d1ufaa1 11 c1htyA_ 12 c2ow7A_ 13 c2wyhA_ 14 c6b9pA_ 15 c5jm0A_ 16 c3lvtA_ 17 d3bvua3 18 c1o7dA_ 19 c4cmrB_ 20 c3qbuD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99